www.osteosys.com

As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of

becoming a world-top company and seeks after healthy life of human beings through

continued technology innovation and challenges.

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1. Definition of Term

Hollowed

Bone

Osteo

porosis

Остеопороз

骨多孔症

骨质疏

松症골다공증

骨粗鬆症

Ostéo

porose

Normal Bone

Osteoporosis

Images from L. Mosekilde, Technology and Health Care. 1998

Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.In Latin, ‘Osteoporosis’ means ‘hollowed bone symptom’, and it is same for many modern languages.

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2. Why Osteoporosis Happens?Human bone repeats a cycle of creation and destruction.Osteoporosis is due to slow bone production and fast bone loss.When the balance between resorption(osteoclast) and formation(osteoblast)is broken…

Images from https://3c1703fe8d.site.internapcdn.net/newman/gfx/news/hires/2017/noncodingrna.jpg3

2. Why Osteoporosis Happens?

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2535

Menopause

Fracture ThresholdBone D

ensity

Age

Women bone is aging faster especially after menopause. This leads to great danger of fracture, and collapse your body and life.

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Osteoporosis is fatal disease.It is like a mine planted in your body, and when there is some shock...

3. Why Osteoporosis is Dangerous?Osteoporosis itself has no symptoms, but its main consequence is the increased risk of fractures.Lack of bone density leads to collapse of whole body structure.

BONE

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3. Why Osteoporosis is Dangerous?Osteoporotic fractures can be happened anywhere, anytime.It happens more often than heart attack or stroke.

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Image Source: National Osteoporosis Foundation, Washington, DC <Osteoporosis: What is it?> 2004 Mar 1

20%30%

40%

80%

0%

20%

40%

60%

80%

100%

Consequences of Hip Fracture

Data Source: Cooper. Am J Med 1997; 103(2A): 12s-19s

Most frequent osteoporotic fracture

3. Why Osteoporosis is Dangerous?Chronic pain caused by osteoporosis in the elderly is often attributed to fractures and can lead to further disability and early mortality.

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Osteopenia & OsteoporosisPrevalence Rate (Women)

Osteopenia & Osteoporosis Prevalence Rate(Men)

Age over 50Osteoporosis + Osteopenia

Age over 50Osteoporosis + Osteopenia

8 out of 10 women suffer from osteopenia or osteoporosis.

5 out of 10 men suffer from osteopenia or osteoporosis.

NormalOsteopeniaOsteoporosis

NormalOsteopeniaOsteoporosis

Source: National Health Stastics 20084th Korea National Health and Nutrition Examination Survey 2008

3. Why Osteoporosis is Dangerous?

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3. Why Osteoporosis is Dangerous?

Source: National Health Stastics 20084th Korea National Health and Nutrition Examination Survey 2008

Source: ‘A Study on the Medical Utilization and Prescription Pattern of Osteoporosis’The Health Insurance Review and Assessment Service, Korea 2009

Age GroupIn

cidence

s (p

er 10,0

00 c

apita) 2008

VertebraClavicleHumerusCarpalTarsusFemur

Osteoporosis Awareness andCure Rate

Prevalence Rate ofFraction

8 out of 10 female osteoporosis patientwere not diagnosed well,and 9 out of 10 could not be cured.Furthermore, 9 out of 10 male patientcould not be diagnosed nor cured.

Awareness rateCure rate

Age of 60; VertebraAge of 70; Femur

Female Male

people could be cured on time

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1 Year Mortalityafter Femur Fraction

35% of male femur fraction patientover 70 years old pass away within a year

1 y

ear m

ortalit

y (2

007, %

)Population ofFemur Fraction Patient (est. 2050)

Source: ‘A Study on the Medical Utilization and Prescription Pattern of Osteoporosis’The Health Insurance Review and Assessment Service, Korea 2009

Male Female

Age Group

Estimation of worldwide osteoporotic femur fraction(thousand people)

Asia

Total

1950 1.66 mil2050 6.26 mil

1950 0.57 mil2050 3.25 mil

3. Why Osteoporosis is Dangerous?

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4. How Can We Prevent Osteoporosis?

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2535

Menopause

Bone D

ensity

Age

Good lifestyle and

timely diagnosiscan prevent serious osteoporosis.

Lifestyle prevention of osteoporosis is the inverse of the modifiable risk factors.But also timely diagnosis is really important factor, because 90% of people could not be diagnosed nor cured.

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5. How to Diagnose Osteoporosis?Bone mineral density (BMD) has to be measured by more specialized techniques,and that is what Osteosys is researching.

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6. T-Score & Z-ScoreThe T-Score is a comparison of a patient's BMD to that of a healthy 30-year-old.The Z-score is the comparison to the age-matched normal and is usually used in cases of severe osteoporosis.

-4

-3.5

-3

-2.5

-2

-1.5

-1

-0.5

0

0.5

1

1.5

2

//severe

osteoporosis

Non -Osteoporotic

(normal)

osteopenia

osteoporosis

T-Score -1 SD

T-Score -2.5 SD

Z-Score T-ScoreAge of 50

or menopause

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Osteoporosis

Better product for better life9F, JnK Digital Tower, 111 Digital-ro 26, Guro Seoul Korea

T: +82 2 6124 5900 F: +82 2 6124 5958 E: info@osteosys.com

7. Osteosys against Osteoporosis We provide the most efficient BMD solution, and more.The company name itself explains what we are looking for.We want to get rid of ‘pore’ from your bone.

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www.osteosys.com

As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of

becoming a world-top company and seeks after healthy life of human beings through

continued technology innovation and challenges.

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1. Importance of ScanningEvidence suggests that many people who sustain a fragility fracture are not appropriately diagnosed and treated for probable osteoporosis .

WE ARE UNDERESTIMATING THE DANGER OF OSTEOPOROSIS!!!

people could be cured on time

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1. Importance of ScanningOnce it is diagnosed, there are several way to take care of osteoporosis.So timely diagnosis is the most important factor to prevent osteoporotic fracture.

BUT HOW?

Normal X-ray image can see through body,but cannot see through the bone.

Then should we wait until the bone is broken?

We have the solution.

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2. DXA (Dual-energy X-ray Absorptiometry)DXA is a low radiation X-ray capable of detecting quite small percentages of bone loss.It is used to measure spine and hip bone density, or the whole skeleton.

DEXXUM T• Pencil beam• Central BMD• Compact size• Low cost

PRIMUS• Fan beam• Whole body Composition• High speed scan • High resolution• High cost

EXCELLUS• Fan beam• Central Body Composition• Compact size• High speed scan• Middle cost

DEXXUM T EXCELLUS PRIMUS

Scanning Time 85~187 sec 20~35 sec 25~30 sec

Size Compact Compact Wide18

2. DXA (Dual-energy X-ray Absorptiometry)Osteosys’ DXA devices give you accurate diagnosis, and more.All of this progress is done really quickly.

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3. pDXA (Peripheral Dual-energy X-ray Absorptiometry)pDXA is a kind of DXA but measures only peripheral (forearm, calcaneus) areas.It has moderate accuracy and price compared to DXA and QUS.

EXA-3000 EXA-PRESTO

Scanning Time 5 sec 5 sec

Weight 34.5 kg 18.6 kg

EXA-3000• Forearm/Calcaneus• Lifter (Optional)• Compact size• CCD

EXA-PRESTO• Forearm only• 3D image analysis• Compact size• CMOS

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3. pDXA (Peripheral Dual-energy X-ray Absorptiometry)pDXA is a kind of DXA but measures only peripheral (forearm, calcaneus) areas.It has moderate accuracy and price compared to DXA and QUS.

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4. QUS (Quantitative Ultrasound System)QUS bone densitometer can be used anywhere, anytime without limitation.It is highly cost-effective and convenient.

SONOST-2000• Water balloon coupling• External PC/printer required• Compact size• Low cost• Data managing program

BEETLE• Automatic positioning probe• Waterless probe• Portable (Built-in Battery

and supplement available)• Connectable with Smartphone

(Bluetooth, NFC, GPS)

SONOST-3000• Automatic positioning probe• Waterless probe• Temperature compensation• Embedded PC interface

with touchscreen• Thermal printer

SONOST-2000 SONOST-3000 BEETLE

Scanning Time 15 sec 15 sec 5 sec

Weight 7.8kg 12.6kg 3.8kg22

4. QUS (Quantitative Ultrasound System)Osteosys’ QUS devices are market-leading product since the launching.You will know why when you use it.

Report

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5. DXA / QUS ComparisonDXA is gold standard device and the most recommendable device.If there is limitation of cost or space, QUS is recommended.

DXA(Dual X-ray Absorptiometry)

QUS(Quantitative Ultrasound System)

pDXA(Peripheral Dual-energy X-ray Absorptiometry)

Prescreening Cost-effective

Radiation-freeEasy to

use & carry

QUS

High accuracy High precision

Body

Composition

Microstructure

information

DXA

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6. Scanning Methods Traditional X-rays cannot measure bone density. A number of different types of BMD tests are available, but the gold standard is DXA.

1) DXA (Dual-energy X-ray Absorptiometry) measures the spine, hip or total body

2) SXA (single-energy X-ray absorptiometry) measures the heel or wrist

3) DPA (dual photon absorptiometry) measures the spine, hip or total body

4) SPA (single photon absorptiometry) measures the wrist

5) QCT (Quantitative Computed Tomography) measures the spine or hip

6) PQCT (peripheral QCT) measures the forearm

7) QUS (Quantitative Ultrasound) uses sound waves to measure the heel or finger

WHO Gold standard

Cost-effective prescreening method

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www.osteosys.com

As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of

becoming a world-top company and seeks after healthy life of human beings through

continued technology innovation and challenges.

26

Passion

1. CORE VALUE

"Better product for better life"

Innovation

Trust

PassionPassion is the driving force and one of the prerequisites for achieving our goal. We try to reach our goal through an efficient cooperation with talented employees who have the passion and responsibility for their mission.

InnovationIn order to meet our customer 's satisfaction, we produce more effective and differentiated product through the innovationwhich is impetus of the foundation of company growth.

TrustWe operate the company by honest and transparent management which is based on the trust. As employees, customers, and the company strive for creation of win-win corporate culture.

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2. COMPANY HISTORY; ENTHUSIASTIC RESEARCHER

An enthusiastic young professor wanted to make a “better product for better life”for the people who were suffered by osteoporosis.To realize his dream, our strong R&D center launches a new product every 2 years.

1998 2000 2001 2004 2005 2008 2011 2013 2015 2018

Studied BMD Technology at small Lab. In KonKukUniversity

Established Osteosys with1st Gen. QUS

Launched 1st Gen. pDXA(Peripheral Cone Beam DXA)

Launched2nd Gen. QUS (Waterless probe)

Launched1st Central DXA(First pencil

DXA)

Launched 2nd Gen. Pencil beam

beam table type DXA(compact design& fold wing bedDown)

Launched 2nd Gen. pDXA

Launched 1st Gen. Whole body DXA(with Body composition & Assessment)

Launched1st GenCentral smart Fan beam DXA

Launched 3rd GenQUS (Mobile accessibility)

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3. BMD-HOLIC, and More

Osteosys is specialized in BMD. What Osteosys interested in is BMD.And now we are expanding our area into body composition.

QUS

Peripheral

Central

Whole Body

Cone Beam

Pencil Beam

Fan Beam

DXA

SONOST 2000 SONOST 3000 EXA 3000 EXA Presto DEXXUM T EXCELLUS PRIMUSBeeTLe

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4. COMPETITIVE FUNCTION & MODERN DESIGNOsteosys BMD line-up has competitive quality and price.We are making a new product with considering our end user’s need.

Foldable table

Swing arm

User-friendlyInterface

Mobile accessibility

Body composition& Detailed analysis

EXCELLUS

PRIMUS

DEXXUM-T30

5. CLEAR IMAGE & DETAILED ANALYSISOsteosys DXA BMD not only provides you clear image and bone density but also many additional information such as body composition and angle analysis.

Vertebrae / FemurImage & Angle Analysis

Whole body composition& Small Area Analysis

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6. SORRY TO COMPARE, BUT WE SHOULDSeeing is believing, these are on sale in the market in 2018.They are on our price range, and are not second-handed product.

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7. FAST GROWING; BMD Market Share (2016)

China : Approx. 60% (QUS)

Color distribution in Korea

> > > > >> >

Korea market : 80%

With the good quality and cost-effective BMD devices,Osteosys is dominant in the domestic market, and main player in Chinese market.

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8. SHARE IT WORLDWIDE

We would like to share our BMD with the people around the world.

98 countries 135 worldwide sales networks

6,000 DXA 10,000 QUS installation reference

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9. RESPONSIBILTY; Global Service

Hub network service center

Middle East and Africa

We do not just make BMD, but also take care of it.This is not only for our reputation, but also for public health.

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10. REAL-TIME MANAGEMENTTo maximize our R&D ability, and to achieve 0% defect rate,we Osteosys has own management system.

Zero Defect manufacturing

• Built and realized production line based on the ISO 13485 standard

• Retains highly skilled manpower

Perfect quality control

• 0% defect rate control as Best quality

• QA activity is aggressively implemented to meet the need of the customer and enforcing Total Quality Management

Customer satisfaction

• Business activities to maximize customer satisfaction as a priority based on the Customer-oriented thinking and habits

Powerful R&D Center

• Is composed of more than 30% of all employees in the company

• To research and development to meet the world market demands

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11. WHAT THE COMPANY NAME MEANSIf you get rid of pore from osteoporosis, it will be our name.We want to prevent the ‘poro’s in your bone.Without it, you may enjoy your life much better.

Osteo

Better product for better life9F, JnK Digital Tower, 111 Digital-ro 26, Guro Seoul Korea

T: +82 2 6124 5900 F: +82 2 6124 5958 E: info@osteosys.com

porosis

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