Supplementary data

Figure S1. CBCT follow-up. (A, D) At presentation: radiolucencies within the trabecular bone; bone

loss between the upper left first molar and upper left second molar (white asterix) . (B, E) Six months

after MRONJ diagnosis: formation of a maxillary bone sequestrum (orange arrows in B); cortical

lingual resorption and the formation of bony sequestra adjacent of the lower right first molar ( thin

orange arrows in E) and alveolar crest bone loss between the lower left second molar and lower left

first molar (thick orange arrow in E). (C, F) Three years after presentation, at the time of gum healing:

vestibular cortical bone loss, from the upper right second premolar to the upper right premolar and

mild bone loss in the posterior mandibular sectors.

Figure S2: Miscroscopic findings

Histopathology examination shows necrotic bone with empty osteocytic lacunae and absence of

osteoblastic rimming and osteoclasts. Inflammatory cells and bacterial colonies were noted.