Are Your Hormones Making

You Sick ?Presented by

Eldred B. Taylor, M.D.

Medical Director of the Taylor Medical Group

Don’t Be ACaterpillar

Get Out of Line

Women’s WisdomWomen have an innate sense

of spirituality an ability to attune to the wisdom within themselves and the larger

whole that has been systematically ignored by

medicine Joan Borysensko, Ph.D.Author of Minding the Body Mending the Mind

Goals

Become an Honorary Gynecologist

Be able to diagnose yourself Amaze your friends and

family Identify and avoid all

caterpillar lines

Women in the U.S.

80% of women complain of PMS

20%-50% of women have fibroids

80%-90% complain of perimenopausal symptoms

Premenopausal breast cancer has increased by 30% in the last 30 years

Women in the U.S.

90 % of women have menopausal symptoms

Osteoporosis effects more than 45% of women over age 50

Hysterectomy and breast surgery are the most common surgeries done in most hospitals

Heart disease and breast cancer

What is normal?

Cycles

Balance

Transiti

ons

The Menstrual Cycle

Estrogen = GrowProgesterone=Develop

The Menstrual Cycle

Estrogen is dominant the first two weeks

Progesterone should be dominant the second two weeks

E/P Ratio in theMenstrual Cycle

What is estrogen?

Phytoestrogens-Plant estrogen

Estriol-highest amount in pregnancy

Estrone-made in fat tissue Estradiol- made by the

ovary Xenoestrogens-Man made

estrogen

What is the function of estrogen?

Regrowth of menstrual tissue

Growth of follicle into an egg

Growth of breast

Support vaginal tissue

Develop sex characteristics

Stores Fat Decreases

thyroid hormone

What is Progesterone?

Progesterone-made by the ovary after ovulation

Progesterone-can be made from wild yam and soy beans

Provera and Depo Provera-Are not progesterone

Functions of Progesterone

Pro-Gestation Natural Diuretic Uses fat for energy Natural

antidepressant Restores sex drive Protects against

cancer

This Is Biochemisty

Bio-Identical

What is Premarin? Pregnant Mare Urine

Effects of Progestins(Provera) Secretory endometrium No positive effects on gestation,

teratogenicCreates progesterone

deficiency Increases sodium and water

retention Depression Weight gain Hair loss Increased risk of breast cancer

Balance Of Actions

The ultimate biologic response reflects the Balance of Actions of the different hormones with their respective receptors…

Speroff L, Glass R, Kase N. Clinical Gynecologic Endocrinology and Infertility. 7th Edition, Lippincott Williams and Wilkins, Baltimore, MD, 2005, Pg. 61

Excess Estrogen Causes

Breast tenderness

Depression,Fatigue, Poor concentration

Endometriosis Fibrocystic

breasts PMS

Fibroids Water

retention and bloating

Fat gain around hips and thighs

Breast and Uterinecancer

Progesterone Deficiency Cause?

Breast tenderness

Depression,Fatigue, Poor concentration

Endometriosis Fibrocystic

breasts PMS

Fibroids Water

retention and bloating

Fat gain around hips and thighs

Breast and Uterinecancer

How Do You Measure Balance?

Gynecology Made Simple

Key Question How Old Are You? < 45…….Birth Control Pills > 45…….Hormone

Replacement < or > 45 …..Antidepressant No response to

therapy…….Surgery

How Do I Know If I’m Out of Balance?

Salivary Testing -Oil and Water

Oil and water don’t mix Measures the packages that are

delivered Accurately diagnoses hormone

imbalances Allows the doctor to monitor

hormone levels

What Increases Delivery

Excess weight Low fiber diet Stress Insulin/carbohydrates Provera Male hormones

Other Factors That Effect Balance

Poor Diet Sedentary Lifestyle

External Estrogen Delayed Childbearing Alcohol Abuse

What Are the Results of This Hormonal

Imbalance? PMS

Fibroids

Endometriosis/Infertility

Fibrocystic Breast

Perimenopause

Menopause

Osteoporosis

Breast, uterine and ovarian cancer

PMS-Premenstrual Syndrome

68%-100% complain of:

Tension Nervousness

Anxiety IrritabilityMood Swings

44%-55% complain of:

Sweet CravingsHeadaches Increased

Appetite36% complain of: DepressionConfusionCryingForgetfulness

60%-65% complain of :

Weight gainAbdominal

bloatingBreast tendernessSwelling of

extremities

E/P Ratio in theMenstrual Cycle

What are fibroids?

Non-cancerous tumors in the uterus

Occurs after age 30 Growth stimulated by

decliningprogesterone

What Is Endometriosis?

Uterine tissue outside the uterus

Causes cyclic pain Painful menses

Infertility

Fibrocystic Breast

Caused by overstimulation of estrogen

Estrogen causes increased cell growth

Estrogen causes swelling

What is perimenopause ?

Begins 10-15 years prior to menopause

Erratic hormone production Annovulatory Cycles Increasing estrogen Declining progesterone

Perimenopausal Symptoms

Menstrual Irregularities Estrogen Excess Symptoms Initiation of bone loss Growth of fibroids Increased cancer risk

Eggs and Age

Menstrual Irregularities

Missed Periods Heavy Bleeding Prolonged

Menses–Cause- Fewer eggs, no ovulation, no progesterone,

–Progesterone is the menstrual timekeeper

Estrogen Excess Symptoms

What Is Menopause?

Permanent cessation of menstruation

Caused by decreased production of ovarian hormones

Most commonly occurs between ages of 48-52

Significant Estrogen in Menopause

Speroff L, Glass R, Kase N. Clinical Gynecologic Endocrinology and Infertility. 7th Edition, Lippincott Williams and Wilkins, Baltimore, MD, 2005, Pg. 636

Menopausal

Cancer-Uncontrolled Growth

Estrogen increases cell growth

Progesterone increases normal development and slows cell growth

Breast Cancer Detection

Speroff L, Glass R, Kase N. Clinical Gynecologic Endocrinology and Infertility. 7th Edition, Lippincott Williams and Wilkins, Baltimore, MD, 2005, Pg. 610

Breast Cancer Incidence and Death…

About 40,170 women will die from breast cancer each year

In the United States, DCIS incidence rose from 1.87 per 100 000 in 1973-1975 to 32.5 in 2004.

• Breast cancer is the second leading cause of death in women ages 20-59.• It is estimated one in every 8 women will be diagnosed with breast cancer in their

lifetime.• 8 out of 9 women who develop breast cancer have no family history.

• In the United States a new breast cancer diagnosis occurs every 3 minutes.• Approximately 192,370 new cases of invasive breast cancer were diagnosed in 2009• Approximately 62,280 new cases of carcinoma in situ (CIS) were diagnosed (CIS is non-

invasive and is the earliest form of breast cancer) in 2009.

New or Old Theory?Louis Pasteur

1895“The cell is nothing, the matrix is everything”

Old Ideas Spur New Approaches in Cancer FightNew York Times article December 29, 2009

“The new focus on a cancer’s surroundings, researchers say is a major shift in thinking about why

cancer occurs and how to stop it”

Mary Claire King and BRCA 1 and 2 “The lifetime risk of breast cancer among female mutation

carriers is presently 82%. Risks appear to be increasing with time. Before 1940 it was 24%. Lack of physical exercise and obesity in adolescence may be important modulating factors

for risk in carriers”. Science 2003; 302: 643‐50.

Decrease in Breast Cancerafter WHI

Initial Thermogram

Thermogram 30 days post application of Cream

PtJG

50 patients enrolled to access the effect of transdermal synergistic cream on breasts using sequential thermography.

Indications for Estrogen

High risk for osteoporosis

Symptoms of menopause

That’s it !

Dr. Taylor’sIndications for EstrogenSalivary testing that

indicates a deficiency

Dietary Changes Organic fruits and vegetables Increase fiber Omega 3 and 9 fatty acids Low glycemic index foods Decrease animal protein Organic or hormone free meats Increase plant protein-Soy, and

other beans

Lifestyle Changes

Increase activityReduce stress- Prayer &Meditation

Consider career changes

Supplements

Whole FoodsVitamin B complex-150

mg/dayFolic acid 1mg/dayMagnesium, vitamin D,

Boron 2mg

Hormonal Choices:Estrogenic

Bio-identical estrogens Biest

–Estriol 2mg, Estradiol .5mg Triest

–Estriol 2mg, Estradiol .25mg, Estrone .25mg

Produced by compounding pharmacies

Estrace, Climara, Alora

Hormonal Choices:Estrogenic

Black Cohash-Remifemin–Well studied in Germany–Effective for menopausal

symptom relief–not estrogenic

Red clover-Promensil–contains plant estrogens–2 unpublished studies revealed

not effective for hot flashes as compared to placebo

Hormonal Choices: Progestogenic

Micronized Progesterone ( cream or oral)–Bioavailable, safe, prescription –Effective from puberty throughout

life–20mg-40mg/ day cream 100mg-

200 mg oral–Maintains or increases quality of

life–No disruptive side effects–No increased cancer risks or heart

disease–May help prevent degenerative

diseases

Goals Become an Honorary

Gynecologist Be able to diagnose yourself Amaze your friends and

family Identify and avoid all

caterpillar lines

Don’t Be A Caterpillar

Get out of line

Other Hormones that May Make You Sick