approaches driven by clinicians ......disorder test menu of more than 75 coagulation-specific...
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COAGULATIONADVANCING THE DIAGNOSIS AND MANAGEMENT OF BLEEDING AND THROMBOSING DISORDERS
H E M A T O L O G Y A T M A Y O C L I N I C
M A Y O M E D I C A L L A B O R A T O R I E S . C O M / H E M A T O L O G Y
COMPREHENSIVE TESTING APPROACHES DRIVEN BY MAYO CLINIC RESEARCH AND PRACTICE FINDINGS
The Mayo Clinic Special Coagulation
Laboratory has been at the forefront of
research, testing, and treatment of patients
with bleeding and thrombosing disorders
for nearly 90 years. From pioneering
studies in thrombosis, hirudin, warfarin,
and vitamin K physiology to cutting-edge
platelet physiology, our reputation in the field
continues to grow.
WE ARE ABLE TO PROVIDE ACCURATE DIAGNOSES, IDENTIFY CLINICAL SIGNIFICANCE, AND PROVIDE OPTIMAL TREATMENT PATH BY:
} Offering a comprehensive coagulation disorder test menu of more than 75 coagulation-specific tests.
} Accessing the experience and large coagulation-specific test volume, over 350,000 performed annually, of Mayo Clinic clinicians and laboratorians to ensure broad expertise with rare cases.
} Integrating Mayo Clinic coagulation research to develop state-of-the-art tests and new testing procedures.
} Collaborating with the Mayo Comprehensive Hemophilia and Mayo Thrombophilia Centers, which treat more than 170 patients and 700 patients each year respectively, to assist in diagnosis and management of patients with hereditary or acquired bleeding or thrombosing disorders.
COLLEGIAL ACCESS TO MAYO CLINIC CLINICIANS, LABORATORIANS, AND GENETIC COUNSELORS
Mayo Medical Laboratories supports the local delivery of health care services, so when assistance with testing options, result interpretation, or case review and coordination is needed, Mayo Clinic clinicians, laboratorians, and genetic counselors are available to provide assistance. This rapport also provides the opportunity for general practice discussions among colleagues.
Telephone 855-516-8404Email [email protected]
CONSULTATIVE TEST PANELS FOR COMPLEX OR DIFFICULT DIAGNOSTIC PROBLEMS
THROMBOPHILIA PROFILE
ADAMTS13 ACTIVITY AND INHIBITOR PROFILE
BLEEDING DIATHESIS PROFILE
LUPUS ANTICOAGULANT PROFILE
PROLONGED CLOT TIME PROFILE
VON WILLEBRAND DISEASE PROFILE
8 0 0 - 5 3 3 - 1 7 1 0 o r + 5 0 7 - 2 6 6 - 5 7 0 0
C O A G U L A T I O N
ADAMTS13 ACTIVITY AND INHIBITOR PROFILE (MAYO ID: ADM13)
} ADAMTS13 Activity Assay } ADAMTS13 Interpretation
Reflex Testing (performed if indicated): ADAMTS13 Inhibitor Screen, ADAMTS13 Inhibitor Bethesda Titer
BLEEDING DIATHESIS PROFILE (MAYO ID: BDIAL)
} Prothrombin Time
} Activated Partial Thromboplastin Time
} Thrombin Time
} Fibrinogen
} D-Dimer
} Soluble Fibrin Monomer
} Factor VIII Activity Assay
} von Willebrand Factor Antigen
} von Willebrand Factor Activity
} Factor XIII Screen
} Consultant Interpretation
Reflex Tests (performed if indicated): PT Mix 1:1, APTT Mix 1:1, Dilute Russell’s Viper Venom Time, DRVVT Mix, DRVVT Confirmation, Platelet
Neutralization Procedure, Reptilase Time, Coag Factor Assays (II, V, VII, X, VIII, IX, XI, XII), Factor Inhib Screens (II, V, VII, X, VIII, IX, XI), Bethesda
Units, Staclot LA, Alpha-2 Plasmin Inhibitor, Ristocetin Cofactor, von Willebrand Factor Multimer
LUPUS ANTICOAGULANT PROFILE (MAYO ID: LUPPR)
} Prothrombin Time
} Activated Partial Thromboplastin Time
} Dilute Russell’s Viper Venom Time
} Interpretation
Reflex Tests (performed if indicated): PT Mix 1:1, APTT Mix 1:1, DRVVT Mix, DRVVT Confirmation, Platelet Neutralization Procedure, Thrombin
Time (Bovine), Reptilase Time, Coag Factor Assays (II, V, VII, X, VIII, IX, XI, XII), Coag Factor VIII Assay Inhib Screen, Bethesda Units, Staclot LA,
Fibrinogen, D-Dimer, Soluble Fibrin Monomer, Consultant Interpretation
PROLONGED CLOT TIME PROFILE (MAYO ID: PROCT)
} Prothrombin Time
} Activated Partial Thromboplastin Time
} Dilute Russell’s Viper Venom Time
} Thrombin Time
} Fibrinogen
} D-Dimer
} Soluble Fibrin Monomer
} Consultant Interpretation
Reflex Tests (performed if indicated): PT Mix 1:1, APTT Mix 1:1, DRVVT Mix, DRVVT Confirmation, Platelet Neutralization Procedure, Reptilase
Time, Coag Factor Assays (II, V, VII, X, VIII, IX, XI, XII), Coag Factor VIII Assay Inhib Screen, Bethesda Units, Staclot LA
THROMBOPHILIA PROFILE (MAYO ID: THRMP)
} Prothrombin Time
} Activated Partial Thromboplastin Time
} Dilute Russell’s Viper Venom Time
} Thrombin Time
} Fibrinogen
} D-Dimer
} Soluble Fibrin Monomer
} Antithrombin Activity
} Protein C Activity
} Protein S Antigen, Free
} Prothrombin G20210A Mutation
} Activated Protein C Resistance
} Consultant Interpretation
Reflex Tests (performed if indicated): PT Mix 1:1, APTT Mix 1:1, Dilute Russell’s Viper Venom Time, DRVVT Mix, DRVVT
Confirmation, Platelet Neutralization Procedure, Reptilase Time, Coag Factor Assays (II, V, VII, X, VIII, IX, XI, XII), Factor Inhib Screens (II, V, VII, X,
VIII, IX, XI), Bethesda Units, Staclot LA, Alpha-2 Plasmin Inhibitor, Ristocetin Cofactor, von Willebrand Factor Multimer
VON WILLEBRAND PROFILE (MAYO ID: VWPR)
} Factor VIII Activity Assay
} Von Willebrand Factor Antigen
} Von Willebrand Activity
} Interpretation
Reflex Tests (performed if indicated): Coag Factor VIII Assay Inhib Screen, Bethesda Units, Ristocetin Cofactor, von Willebrand Factor Multimer,
Consultant Interpretation
COAGULATION DISORDER PROFILES
MC2775-44rev1114
@mayocliniclabs/mayocliniclabsnews.mayomedicallaboratories.commayomedicallaboratories.com
HEMATOPATHOLOGISTS1 DONG CHEN, M.D., PH.D., Co-Director RONG HE, M.D.
HEMATOLOGISTS ANEEL A. ASHRANI, M.D. MICHELLE A. ELLIOT, M.D. CHRISTOPHER C. HOOK, M.D. JOHN A. LUST, M.D., PH.D. MRINAL S. PATNAIK, MBBS WILLIAM L. NICHOLS, JR., M.D. ANIMESH PARDANANI, MBBS, PH.D.2 RAJIV K. PRUTHI, MBBS, Co-Director
CARDIOLOGISTS3 JOHN A. HEIT, M.D., Co-Director ROBERT D. MCBANE, M.D. WALDEMAR E. WYSOKINSKI, M.D., PH.D.
CLINICAL PATHOLOGIST4 GRETCHEN JOHNS, M.D., Co-Director, Florida
PEDIATRIC HEMATOLOGY/ONCOLOGY DEEPTI M. WARAD, MBBS
EXPERTISE AT MAYO CLINIC
The Mayo Clinic Special Coagulation Laboratory
is led by the expertise of:
} Physician directors with experience in hematology, hematopathology, cardiovascular, molecular genetics, platelet function and electron microscopy, and protein chemistry.
} Consulting hematologists, cardiovascular specialists, and hematopathologists with expertise and interest in clinical and laboratory hemostasis and thrombosis to provide test panel interpretation and consultation.
} Clinical technical coagulation specialists able to assist clients with questions regarding appropriate testing, specimen requirements, and interpretation of results.
FOR MORE INFORMATION ABOUT COAGULATION TESTING, VISITMayoMedicalLaboratories.com/hematology
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