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Appendix 1: Systematic Review Summary FormGuideline Title: Guidelines for the management of nausea and vomiting in palliative care
Systematic Review Summary Form - AprepitantReviewers: Sian Rae (Pharmacist) Tania Forrester (Palliative Care CNS)
Aprepitant
Records identified through database
searching (n = )
Records identified through Embase
database searching (n = 211 )
Selection of databases and search terms (e.g. Web of Knowledge, SCOPUS, MEDLINE, PsycINFO, CINAHL, Cochrane)
Studies included in final literature review
(n = 7 )
Full-text articles excluded, with reasons (n = 3 )
Full-text articles assessed for eligibility (n = 10 )
Records excluded (n = 250 )Records screened
(n = 260 )
Records after duplicates removed (n = 260 )
Additional records identified through
other sources (n = )
IDENTIFICATION
ELIGIBILITY
INCLUDED
SCREENING
Records identified through Medline
database searching
(n = 227 )
Systematic Review Summary Form - CyclizineReviewers: Sian Rae (Pharmacist) Tania Forrester (Palliative Care CNS)
Cyclizine
Records identified through database
searching (n = )
Records identified through Embase
database searching (n = 76 )
Selection of databases and search terms (e.g. Web of Knowledge, SCOPUS, MEDLINE, PsycINFO, CINAHL, Cochrane)
Studies included in final literature review
(n = 1 )
Full-text articles excluded, with reasons (n = 3 )
Full-text articles assessed for eligibility
(n = 4 )
Records excluded (n = 47 )Records screened
(n = 51 )
Records after duplicates removed (n = 51 )
Additional records identified through
other sources (n = )
IDENTIFICATION
ELIGIBILITY
INCLUDED
SCREENING
Records identified through Medline
database searching
(n = 21 )
Systematic Review Summary Form - DexamethasoneReviewers: Ann Griffiths (Macmillan Palliative Care CNS) Agnes Noble (Palliative Care CNS)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Full-text articles assessed for eligibility
(n = 0)
Studies included in final literature review
(n =0 )
What is the evidence for the use of Dexamethasone in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - DomperidoneReviewers: Ann Griffiths (Macmillan Palliative Care CNS) Agnes Noble (Palliative Care CNS)
Records identified
(n =838 )
Records excluded (n = )
Chemotherapy = 108Not relevant = 153
Not Dexamethasone = 1Children = 27
Post operative = 45Case Reports/Review Articles =
26Unable to access full article = 1
Full-text articles excluded, with reasons (n =14 )
Dexamethasone not main focus = 7
Not treatment related = 1Not nausea/Vomiting = 3Randomized control = 2
Case Report = 1
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Full-text articles assessed for eligibility
(n = 0)
Studies included in final literature review
(n =0 )
What is the evidence for the use of Domperidone in the management of nausea and vomiting in palliative care?
Records screened (n = 97)
Search criteria and search terms used Nausea” OR “Vomiting” AND “Dexamethasone” NOT “chemotherapy”
Systematic Review Summary Form - GranisetronReviewers: Dr Séamus Coyle, Dr James Barfield
Records identified
(n =329 )
Records screened (n = 97)
Records excluded (n = 97)
+ reasons why excludedPost Operative N+V = 3
Chemotherapy related N+V = 2Children = 7
Does not meet search criteria =51 Review/Case Report = 34
Full-text articles excluded, with reasons
(n = )
Search criteria and search terms used Nausea” OR “Vomiting” AND “Domperidone” NOT “chemotherapy”
Records identified
(n = 51)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 51)
Records excluded (n = 43)
n= 32 treatment relatedn=4 wrong medicationn=4 different symptom
n=3 unrelated
Full-text articles assessed for eligibility
(n = 8)
Full-text articles excluded, with reasons
(n = 0)
Studies included in final literature review
(n = 8)
Search criteria and search terms used Nausea” OR “Vomiting” AND “Granisetron” NOT “chemotherapy”
What is the evidence for the use of Granisetron in the management of nausea and vomiting in palliative care?
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Systematic Review Summary Form - Haloperidol
Reviewers: Ann Griffiths (Macmillan Palliative Care CNS) Agnes Noble (Palliative Care CNS)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Full-text articles assessed for eligibility
(n = 12)
Studies included in final literature review
(n = 4)
MEDLINEWhat is the evidence for the use of Haloperidol in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - Hyoscine ButylbromideReviewers: Ann Griffiths (Macmillan Palliative Care CNS) Agnes Noble (Palliative Care CNS)
Records identified
(n =12 )
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n =3 )
Records excluded (n = )
Not relevant = 3
Full-text articles assessed for eligibility
(n = 0) Full-text articles excluded, with reasons
(n = )
Studies included in final literature review
(n = 0)
Search criteria and search terms used Nausea” OR “Vomiting” AND “Hyoscine Butylbromide” NOT “chemotherapy”
What is the evidence for the use of “Hyoscine Butylbromide” in the management of nausea and vomiting in palliative care?
Records identified
(n = 269 )
Records screened (n =88 )
Records excluded (n =84)
Duplicates = 1Chemotherapy = 18Not relevant = 36
Review = 15Case Report = 11
Post-Operative = 3
Full-text articles excluded, with reasons
(n =8)Not specific to search
criteria
Search criteria and search terms used “nausea” OR “vomiting” AND “Haloperidol” Filters: Humans, English, Adults, Evidence
base, Clinical Trials
Systematic Review Summary Form - Hyoscine Hydrobromide
Reviewers: Dr Laura McGlynn, Dr Richard Latten
Records identified (n = 15 )
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 15 )
Records excluded (n = 15 )
Irrelevant to search – 10Duplicates - 5
Full-text articles assessed for eligibility
(n = 15 ) Full-text articles excluded, with reasons
(n = 15)
Studies included in final literature review
(n = 0 )
Nausea” OR “Vomiting” AND “Hyoscine Hydrobromide” NOT “chemotherapy”
What is the evidence for the use of Hyoscine Hydrobromide in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - Levomepromazine
Reviewers: Dr Séamus Coyle, Dr James Barfield
Records identified
(n = 10)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 10)
Records excluded (n = 7)
n=1 not englishn=2 reviews
n=1 chemotherapy relatedn=4 other symptoms
Full-text articles assessed for eligibility
(n = 2)Full-text articles excluded
n = 1 (a case report)
Studies included in final literature review
(n = 1)
Search criteria and search terms used Nausea” OR “Vomiting” AND “Levomepromazine” NOT “chemotherapy”
What is the evidence for the use of Levomepromazine in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - Lorazepam
Reviewers: Dr Paula Powell, Tracy Hindley (RN)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 91)
Full-text articles assessed for eligibility
(n = 1)
Studies included in final literature review
(n = 0)
Systematic Review Summary Form - MetoclopramideReviewers: Dr Laura McGlynn and Dr Richard Latten
Records identified (n = 450)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 450 )
Records excluded (n = 426)
Not Metoclopramide = 4Post Operative N+V = 19Chemotherapy related N+V = 176Children = 24Does not meet search criteria = 175Unable to access full article = 28
Full-text articles assessed for eligibility
(n = 24 )
Full-text articles excluded, with reasons
(n = 15)Not specific to search
criteria
Studies included in final literature review
(n = 9 )
MEDLINE Search Nausea” OR “Vomiting” AND “Metoclopramide” NOT “chemotherapy” “Clinical Trials” “Evidence base” “Cochrane” “Humans” “Evidence based medicine”
What is the evidence for the use of Metoclopramide in the management of nausea and vomiting in palliative care?
Records identified
(n = 91)
Records excluded (n = 90)
Full-text articles excluded, with reasons
n = 1 multimodal treatment
Search criteria and search terms used Nausea” OR “Vomiting” AND “Lorazepam” NOT “chemotherapy”
What is the evidence for the use of Lorazepam in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - Olanzapine
Reviewers: Dr Paula Powell, Tracy Hindley
Records identified
(n = 36)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 36)
Records excluded (n = 30)
Full-text articles assessed for eligibility
(n = 6)Full-text articles excluded,
with reasons (n = 3)
Studies included in final literature review
(n = 3)
Search criteria and search terms used Nausea” OR “Vomiting” AND “Olanzapine” NOT “chemotherapy”
What is the evidence for the use of Olanzapine in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - Ondansetron
Reviewers: Dr Laura McGlynn and Dr Richard Latten
Records identified
(n = 232 )
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 230)
Records excluded (n = )
Duplicates = 2Chemotherapy = 205
Not relevant = 12Not Ondansetron = 2
Children = 10Post operative = 1
Full-text articles assessed for eligibility
(n = 0 )Full-text articles excluded,
with reasons (n = 0 )
Studies included in final literature review
(n = 0)
Search criteria and search terms used “nausea” OR “vomiting” AND “Ondansetron” Filters: Humans, English, Adults, Evidence
base, Clinical Trials
MEDLINEWhat is the evidence for the use of Ondansetron in the management of nausea and vomiting in palliative care?
Systematic Review Summary Form - Prochlorperazine
Reviewers: Dr Paula Powell, Tracy Hindley (RN)
Records identified
(n = 135)
S C R E E N I N G
I N C L U D E D
E LI G IB IL IT Y
I D E N TI FI C A TI O N
Records screened (n = 135)
Records excluded (n = 119)
Full-text articles assessed for eligibility
(n = 16)Full-text articles excluded,
with reasons (n = 11)
n=2 unable to obtain
Studies included in final literature review
(n = 3)
Search criteria and search terms used Nausea” OR “Vomiting” AND “Prochlorperazine” NOT “chemotherapy”
What is the evidence for the use of Prochlorperazine in the management of nausea and vomiting in palliative care?