apoptosis signaling pathway - bio cusa · apoptosis pro-apoptotic genes dna damge pro-apoptotic...
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CUSABIO TECHNOLOGY LLCPostal Address: 6161 Savoy Dr. Suite 1018 Houston, TX 77036, USA
Tel : 301-363-4651（Available 9 a.m. to 5 p.m. EST from Monday to Friday）Email: [email protected] Web: www.cusabio.com
Protein
Gene
chemical molecule
Other signal path diagram
phosphorylation+P
dephosphorylation-P
Direct promotion
ubiquitination+u
Direct inhibition
combination
dissociation
complex
CAMLG Antibody CSB-PA004475LA01HU
S1PR3 Antibody CSB-PA859932LA01HU
KRT18 Antibody CSB-PA10629A0Rb
WISP1 Antibody CSB-PA026119LA01HU
TMBIM1 Antibody CSB-PA853376LA01HU
ACTL6A Antibody CSB-PA001236ESR2HU
CDK2 Antibody CSB-PA005061LA01HU
EIF3F Antibody CSB-PA007535ESR2HU
NFKB1 Antibody CSB-PA10354A0Rb
AKT1 Antibody CSB-PA15905A0RB
120kD
90kD
50kD
35kD
25kD
20kD
Contr
ol IgG
PDLIM
1
Input
APOPTOSIS SIGNALING PATHWAY
120kD
90kD
50kD
35kD
25kD
20kD
Contr
ol IgG
EIF3F
Input
Lane 1 2 3 4 5 6 7 8
120kDa
85kDa
50kDa
35kDa
25kDa
20kDa
120kDa
85kDa
50kDa
35kDa
25kDa
20kDa
Lane 1 2 3 4 5 6 7 8
NUPR1 Antibody CSB-PA527662LA01HU
FATE1 Antibody CSB-PA839274LA01HU
DRAM1 Antibody CSB-PA836675LA01HU
XPO1 Antibody CSB-PA026221LA01HU
PLK1 Antibody CSB-PA018193LA01HU
EIF3M Antibody CSB-PA745333DSR1HU
TIA1 Antibody CSB-PA023527DSR1HU
AIMP1 Antibody CSB-PA618638DSR1HU
HDAC1 Antibody CSB-PA17869A0Rb
SMARCA2 Antibody CSB-PA021799LA01HU
120kDa
85kDa
50kDa
35kDa
25kDa
20kDa
Lane 1 2 3 4 5
120kDa
85kDa
50kDa
35kDa
25kDa
20kDa
Lane 1 2 3 4 5 6
120kD
90kD
50kD
35kD
25kD
20kD
Contr
ol IgG
TIA1
Input
120kD
90kD
50kD
35kD
25kD
20kD
Contr
ol IgG
AIM
P1
Input
SMARCA2IgG
Survival factorsCytotoxic T lymphocytes (CTLs)Natural killer (NK) cells
IL-3
NGF
TNF signaling
pathway
TNFα
Fas-L
TRAIL
IL-3
R
Trk
A
TN
F-R
1
Pe
rforin
Fa
s
TR
AIL
-R
Ras
Raf
+P
MEK1/2
+P
ERK1/2
MAPK signaling
pathway
PIP3
Degradation
PI3KPI3K-Akt signaling pathway
PDK1
+P
Akt/PKB
+P
IKK
+P
NF-κB signaling pathway
IκBαNF-κB
Sphingosine
Lisosomotropic detergents
H O2 2
NIK
+P
TRADD
RIP1
TRAF2
AIP
Lysosome
Cathepsin
ASK1+P
JNK
+P+P +P
Bid
BadBcl-2
Mcl-1
Bim
Bcl-XL
Bax/Bak-induced mitochondrial outer membrance permeabilization(MOMP)
jBid
NOXA
PUMA
ENDO-G
AIF
CytC
Apaf-1
TRADD
FADD DAXX
ASK1FLIP
eiF2α
ATF4
e
CHOP
2+Ca
FADD
ER
ER stress
TRAF2 Ire1α
PERKIP3R
Calpain
CASP12
Calcium signaling pathway
tBidgtBid
CASP2
PIDDCASP8
CASP10
Bid
Bim
Bax
Bak
Mitochondrion
Pro-caspase 9
Apoptosome
DIABLO
ARTS
HTRA2
CASP9
IAP/XIAP
CASP7
CASP3
CASP6
GZMB
CAD ICAD
PARP
Fodrin
Lamin
Actin
Mcl-1
α-tubulin
Pro-survval genes
Pro-survval genes
Bcl-2
FAP1 LAP/XIAP
Gadd45 A1 FLIP
TRAF1/2 Bcl-XL
+P
DNA Fragmentation
Apoptosis
Pro-apoptotic
genes
DNA Damge
Pro-apoptotic genes
c-jun AP1
p53 Fas Fas-L
Bim HRK
p53 ATM
Bak Bax PIDD
Bid Apaf-1 p53AIPI
Fas TRAILR2
PUMA NOXA
DNA fragmentation
Low synthesis of poly
(ADP-ribose)
Disruption of
microtubule function
Bim-mediated mitochondrial
apoptotic events
Cell shrinkage and membrane blebbing
Loss of integrity of the nuclear membrane
Apoptosis