apoptosis
DESCRIPTION
general pathology , apoptosis...TRANSCRIPT
Apoptosis
Types
Cell Injury
?
Cell
Death
NECROSIS
APOPTOSIS
Apoptosis
Coordinated Programmed
cell death
Coordinated Programmed
Cell Death
Apoptosis
* Falling off
* Dropping off
Features of Apoptosis
Involvement of single/group of cells.
Shrinkage of cell
Formation of Apoptotic bodies
No Acute Inflammatory reaction
Phagocytosis
Molecular Mechanism
Simplyfy
Mechanism of Apoptosis
Cascade of molecular events
culminating In to activation of
caspases.
Initiation
Death Signals
Death receptors : Type 1 TNF receptor
EXTRINSIC (DEATH
RECEPTOR) PATHWAY
Bcl 2 , Bcl x
Anti-Apoptotic Proteins
Bak, Bax, Bim
Pro Apoptotic Proteins
Cytochrome C Apaf-1
Caspase 9
INTRINSIC (Mitochondrial)
PATHWAY
Execution Phase
Caspase 8 and 9 :
Initiator Caspase
Caspase 3 and 6 :
Executioner Caspase
Apoptotic Bodies and
Phagocytosis at the end…
p53 gene
Programmed Cell Deatha step ,
towards “Life”
Cell Death : Necrosis / Apoptosis
Features of ApoptosisInitiation (2 Pathways) & Execution
p53Anti Apoptotic genesBcl 2 , Bcl x
Pro Apoptotic genes
Bak Bax Bim
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