4th Annual UCLA Children’s

Discovery & Innovation

Institute Symposium

Thursday, May 25, 2017

11:15 AM - 5:30 PM

Tamkin Auditorium, B130

Ronald Reagan UCLA Medical Center

This symposium is supported in part by a Catalyst Award from the UCLA Clinical and Translational Science Institute (CTSI) under NIH/National Center for Advancing Translational Science (NCATS) Grant Number UL1TR000124.

# Name Poster Title

Theme I - Brain and Behavior

1 Danilo Bernardo MD

Interictal Scalp Fast Ripples: An Epileptogenic EEG Biomarker

2 Mike Favazza, MD

Learning Curves in Point of Care Lung Ultrasound Education

3 Antonia Melas DO

Non-Superiority of a Simulator Curriculum in Improving Pediatric Resident PIV Line Placement Skills

4 Elena Minakova MD, MS

Melanotan-II Reverses Autistic Features in the Inflammatory Mouse Model of Autism

5 Divya Nadkarni MD

Subcutaneous IFN-γ-1b for Friedreich’s Ataxia: Present Data from the Phase III STEADFAST Trial

6 Denise Purdie MD

Impact of Mindful Awareness Practices in Pediatric Residency Training

7 Israel Temple MD, FAAP

The Impact of Invasive Intracranial Pressure Monitor Use on Outcomes in Children with Hepatic Encephalopathy

8 Heather Vickers MD

Emotional Health of Children with Sickle Cell Disease

Theme II - Cancer and Regeneration

9 Vanessa Bundy MD, PhD

The Opposing Roles of Let-7c and Mir-125-b2 In Human Hematopoietic Stem Cell Maintenance and Proliferation

10 James Ch’ng, MD

EBV Infection-Induced Alteration of Cellular Metabolism and its Role in Oncogenesis

11 Brian Friend MD

Developing a Hematopoietic Stem Cell Transplantation – Comorbidity Index for Adolescents and Young Adults

12 Steven Jonas MD, PhD

Multifaceted Silicon Nanostructures for Substrate-Mediated Intracellular Delivery to Enable High Throughput Gene-Modification

13 Laurel Truscott MD

Evaluation of Engraftment and Therapeutic Ablation of Gene-modified Human Hematopoietic Stem Cells Using ImmunoPET

Theme III - Infection, Inflammation and Immunity

14 Asmaa Abu-Maziad MD

Proteomic Analysis of Renal Tissue in Lupus Nephritis Using Nano-scale Liquid Chromatography Tandem Mass Spectrometry

15 Amira Baker MD

Morbidity and Mortality in a Cohort of Peruvian HIV-infected Children Before and After Implementation of National HIV Guidelines

16 Marjorie Guerra MD

Immune Memory After Intestinal Transplantation – What Can We Learn from T cell Immunophenotypes Over Time?

17 Debra Lugo MD

Phenotypic Analysis of the 2014 Epidemic Enterovirus D68 Strain from North America in Respiratory Epithelial Cells

18 Mike Martinez MD

The Effects of Cell Saver-Derived RBC Transfusions on Inflammation in Pediatric Cardiac Surgery Patients

# Name Poster Title

Theme III - Infection, Inflammation and Immunity (continued)

19 Leidy Johana Tovar Padua MD

Unidentified Hepatitis C During Pregnancy in Porto Alegre, Brazil; A Missed Opportunity for Identification, Prevention And Treatment

20 Amanda Pope MD

A Pilot Study of IgG4 Staining: An Unreliable Marker of Disease Activity

21 Priya Soni MD

Using ddPCR to Assess Persistence of HIV DNA Reservoirs in Perinatally Infected Infants Treated with cART Before or After 12 Months of Age

22 Emily Whang MD

Study of the Mechanisms Involved in the Resistance to Colitis by VIP Inhibition

Theme IV– Neonatal Health and Development

23 Juanita Lewis MD

Evaluation of Mobile App-Based Asynchronous Educational Curriculum Intervention for Pediatric Residents in the Neonatal Intensive Care Unit

24 Joanna Parga MD

Creation of a Maternal Womb Sound Library for Future Use in Premature Infants in the Neonatal Intensive Care Unit

25 Lina Patel MD

Early Onset Sepsis: The Route of Antibiotic Administration and its Effect on Quality Metrics

Theme V - Nutrition, Metabolism and Growth

26 Claire Baldauf MD

Neuron Rescue for Intra-Uterine Growth Restriction with Novel Peptide: Humanin

27 Neetu Bali MD, MPH

Findings of Wireless Motility Capsule Studies in Patients with Systemic Sclerosis

28 Maria Domingo MD

Effectiveness of E-learning Tool During Pediatric Nephrology Training

29 Roja Fallah MD

Iodine Nutrition of U.S. Weaning Infants

30 Manal Habib MD

Humanin is a Novel Endogenous Defender of Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells

31 Marciana Laster MD

Racial-Ethnic Disparities in Bone and Mineral Metabolism in the Pediatric Dialysis Population

32 Tammy Peng MD

Retrospective Review of Clinical Outcomes Post Physician-Supervised Negative Oral Baked Egg Challenge

Theme VI - Cardiovascular

33 Diana Drogalis-Kim DO

Clinical, Immunologic, and Pathologic Features of AMR Positive Pediatric Heart Transplant Patients: A Single Center Review

34 Viviana Fajardo MD

Hyperglycemia for Promoting Cardiac Regeneration

35 Roberto Gallotti MD

Mechanisms and Predictors of Recurrent Tachycardia After Catheter Ablation for D-Transposition of the Great Arteries After the Mustard or Senning Operation

36 Sanjay Sinha MD

Use of the SAPIEN S3 Valve for Percutaneous Transcatheter Pulmonary Valve Replacement: A Multi-Institutional Experience

37 Venessa Wong MD

Arrhythmias After Heart Surgery in Children

“Advances in translational child health research”

2:30 - 3:10 NIH K12 Funded Child Health Research Center

Development Scholars

Moderator: Martín G. Martín, MD, MPP Professor, Pediatrics

Associate Vice Chair for Translational Research, UCLA CDI Institute

2:30 - 2:40

Claire Baldauf MD Fellow, Neonatology

“Neuron rescue for intra-uterine growth restriction with novel peptide: Humanin ”

2:40 - 2:50

Alison Chu, MD Assistant Professor, Nephrology

“Immunologic mechanisms of placental insufficiency ”

2:50 - 3:00

Joanna Gell, MD Clinical Instructor, Pediatric Hematology/Oncology

“Interrogating the role of PRDM14 in human germ cell development and germ cell tumorigenesis ”

3:00 - 3:10

Mark Hanudel, MD, MS Assistant Professor, Nephrology

“Erythropoietin increases bone and circulating FGF23 levels ”

UCLA Speaker for Research Theme Topic: Infection, Inflammation & Immunity

Moderator: Anna-Barbara Moscicki, MD

3:15 - 3:50

Manish J. Butte, MD, PhD Associate Professor of Pediatrics Chief, Pediatric Allergy/Immunology/Rheumatology

“Diagnosis and treatment for rare, genetic immune diseases ”

11:15 - 12:15 Check-in, Poster Viewing and Box Lunch

12:20 - 12:30

Welcoming Remarks & Introduction Sherin U. Devaskar, MD Executive Chair, Department of Pediatrics UCLA Children’s Discovery and Innovation Institute

UCLA Speaker for CDI Research Theme Theme: Infection, Inflammation & Immunity

Moderator: Anna-Barbara Moscicki, MD Professor, Pediatrics

Associate Vice Chair for Clinical Research, UCLA CDI Institute

1:30 - 2:05

Jonathan Braun, MD, PhD Professor of Medicine Chair, Pathology & Laboratory Medicine

“Extraterrestrial travel, the dark side of vitamins, and the microbiome”

2:05 - 2:30 Coffee Break & Poster Viewing

4:00 - 5:30 Poster Viewing & Judging of Pediatric Fellows Posters

B-level area

Sherin U. Devaskar, MD Distinguished Professor and Executive Chair Department of Pediatrics

Executive Director, UCLA Children’s Discovery and Innovation Institute

Physician-in-Chief, Mattel Children's Hospital UCLA

Assistant Vice Chancellor of Children's Health, UCLA Health

Jonathan Braun, MD, PhD

Professor of Medicine Chair, Pathology & Laboratory Medicine

For more information about the CDI Institute,

visit www.uclahealth.org/cdi or contact:

Candace J. Wilkinson, PhD, Scientific Officer, UCLA CDI Institute

cwilkinson@mednet.ucla.edu 310-794-4336

Manish J. Butte, MD, PhD

Associate Professor of Pediatrics Chief, Pediatric Allergy, Immunology, Rheumatology

12:30-1:30 Keynote Speaker

Patrick C. Seed MD, PhD, MS

Professor of Pediatrics

Associate Chief Research Officer of Basic Science

Northwestern University, Feinberg School of Medicine

“The Early Life Microbiome: Laying the Foundation for Lifelong Health and Disease”