anticoagulants 2011

Upload: abryda-ania-aity

Post on 11-Feb-2018

221 views

Category:

Documents


0 download

TRANSCRIPT

  • 7/23/2019 Anticoagulants 2011

    1/53

    Lm~ @HQINB@D]L@HQ^

    IF^I @jeubi~m S`u

    Bnqbeum 5300

    E(Sbliqi~

  • 7/23/2019 Anticoagulants 2011

    2/53

    Lm~ @HQINB@D]L@HQ^

    U`ssml~ ~}u lgjb~q`~m mq l`nb`d}l`qibh

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~`hqinb`d}l`hq~

    Lm~ aiffumhq~ qu`iqmjmhq~

    `hqinb`d}l`hq~

    Lm~ `hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    3/53

    Lm~ @HQINB@D]L@HQ^

    U`ssml~ ~}u lgjb~q`~m mq l`nb`d}l`qibh Dhu`liq~ ~}u lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Lm~ aiffumhq~ qu`iqmjmhq~ `hqinb`d}l`hq~ Lm~ hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    4/53

    1

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Sghbjhm sgy~iblbdip}m nbjslmwm, mh n`~n`am, f`i~`hq ihqmuvmhiu amhbjeum}~m~ subqihm~ sl`~j`qip}m~ 'f`nqm}u~ am l` nb`d}l`qibh) mq`eb}qi~~`hq l` fbuj`qibh a}h n`illbq `fih a`uuqmu lgjbuu`dim(

    Ihquq~ am l` nb`d}l`qibh ? Suvmhiu lm~ ~`idhmjmhq~ ~sbhq`h~,

    @uuqmu lm~ gjbuu`dim~ mh n`~ am l~ibh~ v`~n}l`ium~(

    Sghbjhm~ ihqmuvmh`hq a`h~ lgjb~q`~m mq l` nb`d}l`qibh ? l` v`~bnbh~quinqibh v` aijih}mu lm n`lieum a} v`i~~m`} l~,

    l$ gjb~q`~m suij`ium : `ag~ibh am~ sl p}mqqm~ `} v`i~~m`} l~ mq mhqummllm~ '`dud`qibh sl`p}mqq`ium),

    l$ gjb~q`~m ~mnbha`ium : nbuum~sbha l` nb`d}l`qibh, lm n`illbq `qqium mq ~qij}lm l` nubi~~`hnm am fieubel`~qm~ mq am nmll}lm~ am

    j}~nlm li~~m `} ~mih am l` s`ubi v`~n}l`ium mq mhq`jm lm subnm~~}~ amus`u`qibh p}i u~}lqmu` fih`lmjmhq mh l` ai~~bl}qibh a} n`illbq 'fieuihbly~m)(

  • 7/23/2019 Anticoagulants 2011

    5/53

    =

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Gjb~q`~m suij`ium

    Gjb~q`~m ~mnbha`ium

    b} nb`d}l`qibh

    A~`dud`qibh a} n`illbq s`u fieuihbly~m

  • 7/23/2019 Anticoagulants 2011

    6/53

    6

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Gjb~q`~m ~mnbha`ium 'b} nb`d}l`qibh) : fbuj`qibh a}h u~m`} fieuill`ium a`h~lmp}ml ~bhq mjsui~bhh~ lm~ SP, lm~ DU mq lm~ DE(

    *8 Fbuj`qibh a}h qgubje}~ 'b} n`illbq ~`hd}ih)(

    Lmh~mjelm m~q j`ihqmh} dunm am~ fil`jmhq~ am fieuihm( L` fbuj`qibh am l` fieuihm u~}lqm a}hm n`~n`am am u`nqibh~ mhzyj`qip}m~

    f`i~`hq ihqmuvmhiu am~ f`nqm}u~ am l` nb`d}l`qibh sl`~j`qip}m~ abuidihmgs`qip}m mq sl`p}mqq`ium( Lq`sm fih`lm m~q l` qu`h~fbuj`qibh a} fieuihbdhm

    ~bl}elm mh fieuihm ih~bl}elm, ~b}~ l`nqibh am l` qgubjeihm(

    Fieuihbdhm Fieuihm

    Subqgubjeihm Qubjeihm

    F`nqm}u~sl`p}mqq`ium~ + N`

    5+

  • 7/23/2019 Anticoagulants 2011

    7/53

    4

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    @nqiv`qibh mhabdhm

    'nbhq`nq `vmn lm nbll`dhm)

    @nqiv`qibh mwbdhm

    'elm~~}um)

    Vbimnbjj}hm

    Lm~ aiffumhq~ f`nqm}u~ am l`

    nb`d}l`qibh ?

  • 7/23/2019 Anticoagulants 2011

    8/53

    7

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Lbu~p}m l` nin`qui~`qibh m~q qmujihm, lm n`illbq ~m a~`dudm s`ufieuihbly~m 'adu`a`qibh am l` fieuihm)( Lm~ nmll}lm~ mhabqgli`lm~ ihq`nqm~lieumhq lm qS@ '`nqiv`qm}u qi~~}l`ium a} sl`~jihbdhm) p}i v` `nqivmu l`

    vbim am l` fieuihbly~m(

    qS@

    Sl`~jihbdhm Sl`~jihm

    FieuihmU~ia}~ am

    fieuihm

  • 7/23/2019 Anticoagulants 2011

    9/53

    9

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Mwslbu`qibh am lgjb~q`~m suij`ium Qmjs~ am ~`idhmjmhq H}ju`qibh am~ sl`p}mqqm~ Ab~`dm a} f`nqm}u am vbh Tillmeu`ha

    Mwslbu`qibh am lgjb~q`~m ~mnbha`ium Qmjs~ am nsg`lihm `nqiv '@SQQ, Qmjs~ am nsg`lihm k`blih) Q`}w am subqgubjeihm 'QS, Qmjs~ am P}ink, IHU)

    Qmjs~ am qgubjeihm qmjs~ am umsqil`~m Ab~`dm am~ f`nqm}u~ am nb`d}l`qibh

    S`qgblbdim~ am lgjb~q`~m suij`ium qgubjebnyqbshim

    Qgubjebs`qgim

    J`l`aim am vbh Tillmeu`ha

    S`qgblbdim~ am lgjb~q`~m ~mnbha`ium Gjbsgilim~

    Afiniq mh viq`jihm K

    Ih~}ffi~`hnm gs`qb*nmll}l`ium

    @hqinbus~ `hqi*f`nqm}u~

  • 7/23/2019 Anticoagulants 2011

    10/53

    Lm~ @HQINB@D]L@HQ^

    U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~`hqinb`d}l`hq~ Lm~ aiffumhq~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Lm~ hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    11/53

    00

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Ihain`qibh~ ?

    Qu`iqmjmhq am l` sg`~m `id} ? lbu~ a}hm qgubjeb~m vmihm}~m b} `uquimllms`qgblbdip}m

    Sgleiqm, mjeblim s}ljbh`ium Mjeblim `uquimllm 'fieuill`qibh `}uin}l`ium)

    Qgubjebsgleiqm nueu`lm

    Mh subsgyl`wim suij`ium ?

    Subsgyl`wim sui*bsu`qbium am l` ngiu}udim buqgbsaip}m @liqmjmhq sublbhd `vmn @QNA qgubjeb*mjeblip}m~

    V`lvm n`uai`p}m jn`hip}m

    Mh subsgyl`wim ~mnbha`ium ?

    @hbj`lim~ nbh~qiq}qibhhmllm~ am l` nb`d}l`qibh @QNA qgubjeb*mjeblip}m~

  • 7/23/2019 Anticoagulants 2011

    12/53

    05

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Nbhqum*ihain`qibh~ ?

    ^`idhmjmhq~ mh nb}u~

    ]lnum d`~qub*a}bah`l hbh nin`qui~

    @hbj`lim~ am l` nb`d}l`qibh ui~p}m gjbuu`dip}m 'gjbsgilim, mqn() Ih~}ffi~`hnm gs`qip}m mq uh`lm ~vum~

    Sb~q*ngiu}udim ui~p}m 'mw? hm}ubngiu}udim)

    S`qimhq ihn`s`elm am dumu nbuumnqmjmhq lm qu`iqmjmhq 'ajmhnm, qub}elm~

    s~yngi`quip}m~) Ui~p}m am ng}qm 'smu~bhhm~ dm~, j`lvby`hq~, jbeiliq ua}iqm +++)

    Ihqmu`nqibh~ jain`jmhqm}~m~ '@VK +++)

  • 7/23/2019 Anticoagulants 2011

    13/53

  • 7/23/2019 Anticoagulants 2011

    14/53

  • 7/23/2019 Anticoagulants 2011

    15/53

    0=

    Lm~ gs`uihm~

    5 qysm~ ags`uihm ?

    Lm~ gs`uihm~ hbh fu`nqibhhm~ ?

    Gs`uihm ~baip}m *8 gs`uihm ~q`ha`ua s`u vbim IV

    Gs`uihm n`lnip}m : N@LNIS@UIHM

    *8 gs`uihm ~q`ha`ua s`u vbim ^N

    Lm~ gs`uihm~ am e`~ sbia~ jbln}l`ium~ 'GESJ) ? vbim ^N

    Mhbw`s`uihm ~baip}m : LBVMHBW

    A`lqs`uihm ~baip}m : FU@DJIHM

    Qihz`s`uihm ~baip}m : IHHBGMS H`aubs`uihm n`lnip}m : FU@WIS@UIHM, FU@WBAI

    A`h`s`ubam : BUD@U@H

  • 7/23/2019 Anticoagulants 2011

    16/53

    06

    Lm~ gs`uihm~

    Jn`hi~jm a`nqibh ?

    Fiw`qibh am lgs`uihm ~}u l`hqiqgubjeihm nm p}i `}djmhqm ~bh `nqibh ihgieiquinm ~}ul` qgubjeihm mq lm f`nqm}u W`( Il mh u~}lqm }hm `nqiviq `hqinb`d}l`hqm s}i~~`hqm(

  • 7/23/2019 Anticoagulants 2011

    17/53

  • 7/23/2019 Anticoagulants 2011

    18/53

  • 7/23/2019 Anticoagulants 2011

    19/53

    09

    Lm~ gs`uihm~

    Sb~blbdim~ mq ~}uvmill`hnm ?

    Lm~ gs`uihm~ hbh fu`nqibhhm~ ?

    Gs`uihm ~baip}m

    Al`i mq a}um a`nqibh ? al`i *8 pp}m~ jih}qm~, a}um *8 > gm}um~

    Sb~blbdim~ ? ebl}~ am =3 73]I"kd mh IVA s}i~ smuf}~ibh IV mh ~muihd}m lmnquip}m am 05 07]I"kd"g mh fbhnqibh am~ ihain`qibh~ mh n}u`qif( Sm} }qili~m mh suvmhqif(

    ^}uvmill`hnm ? 0mu sulvmjmhq 6g `su~ lih~q`}u`qibh a} qu`iqmjmhq s}i~ qb}qm~ lm~ 1*6g `su~ng`p}m jbaifin`qibh am sb~blbdim + ~}uvmill`hnm a} q`}w am SP(

    Beomnqif a} qu`iqmjmhq ? QN@ mhqum =3 mq 43~mn b} 0,= 5,= fbi~ lm qjbih mq gs`uihjim 3,>

    3,4]I"jL(

    N@LNIS@UIHM

    Al`i mq a}um a`nqibh ? al`i *8 0 5 gm}um~, a}um *8 7 05 gm}um~

    Sb~blbdim~ ?

    Mh n}u`qif *8 5 > iho ^N"o, =33]I"kd"o '> iho ~i vbl80,5jL)Mh suvmhqif *8 5 > iho ^N"o, 0=3]I"kd"o

    ^}uvmill`hnm ? 0mu sulvmjmhq 1 b} 6g `su~ lih~q`}u`qibh a} qu`iqmjmhq ~i > b} 5 iho"o,~m}lmjmhq mh n}u`qif+ ~}uvmill`hnm a} q`}w am SP(

    Beomnqif a} qu`iqmjmhq ? QN@ mhqum =3 mq 43~mn b} 0,= 5,= fbi~ lm qjbih(

  • 7/23/2019 Anticoagulants 2011

    20/53

    53

    Lm~ gs`uihm~

    Ihain`qibh~ ?

    Lm~ GESJ ?

    Qu`iqmjmhq n}u`qif

    * QVS nbh~qiq}m~ l` sg`~m `id}

    * MS nbh~qiq}m~ l` sg`~m `id}* IAJ ~`h~ bham P mq `hdbu ih~q`elm l` sg`~m `id}

    * IAJ `id} `vmn an`l`dm a} ~mdjmhq ^Q mq qu`iqmjmhq qgubjeblyqip}m

    Qu`iqmjmhq suvmhqif

    * Suvmhqibh am l` j`l`aim qgubjeb*mjeblip}m vmihm}~m ?* mh ngiu}udim

    * mh jamnihm 's`qimhq `liq)

    * ngmz lm~ s`qimhq~ `qqmihq~ am n`hnmu~

    * Suvmhqibh am l` nb`d}l`qibh a`h~ lm~ niun}iq~ am NMN mq as}u`qibh mwqu`*uh`lm(

  • 7/23/2019 Anticoagulants 2011

    21/53

    50

    Lm~ gs`uihm~

    Sb~blbdim~ am~ GESJ mh qu`iqmjmhq n}u`qif ?

    @@^ : `niam `nqyl~`linylip}m

  • 7/23/2019 Anticoagulants 2011

    22/53

    55

    Lm~ gs`uihm~

    Sb~blbdim~ am~ GESJ mh qu`iqmjmhq suvmhqif ?

  • 7/23/2019 Anticoagulants 2011

    23/53

    5>

    Lm~ gs`uihm~

    Suihnism a} qu`iqmjmhq mq ~}uvmill`hnm am~ GESJ mh qu`iqmjmhq

    n}u`qif ?

    0 'ihhbgms mq fu`wbai) b} 5 'lbvmhbw, fu`wis`uihm, fu`djihm) ihomnqibh~ ^N"o

    Jm~}um am l`nqiviq `hqi*W` >*1g `su~ l` >jm ihomnqibh 'beomnqif ? 3,=*0]I"jL)

    A}um a} qu`iqmjmhq ? 03 ob}u~ j`wij}j s}i~ ~i sb~~ielm, uml`i~ s`u lm~ @VK

    Suihnism a} qu`iqmjmhq mq ~}uvmill`hnm am~ GESJ mh qu`iqmjmhq

    suvmhqif ?

    0 ihomnqibh ^N"o

    Ab~m~ `a`sqmu `} ui~p}m

    S`~ am ~}uvmill`hnm a} QN@ mq am l`nqiviq `hqi*W`

    S`~ a`a`sq`qibh sb~blbdip}m

    ^}uvmill`hnm am~ SP 5 fbi~"~mj`ihm

    A}um a} qu`iqmjmhq ~mlbh lm ui~p}m

  • 7/23/2019 Anticoagulants 2011

    24/53

    51

    Lm~ gs`uihm~

    Lm a`h`s`ubam : BUD@U@H

    ^m}lm GESJ ihaip}m mh n`~ a@QNA am QIG

    Qu`iqmjmhq suvmhqifam~ j`hifm~q`qibh~ qgubjebmjeblip}m~ ? mh ^N

    < 93kd ? 4=3]I 5 b} > fbi~"o '> fbi~ ~i QIG ~`h~ qgubjeb~m) 8 93kd ? 05=3]I 5 b} > fbi~"o '> fbi~ ~i QIG ~`h~ qgubjeb~m)

    Mh subsu`qbium, l` amuhium ihomnqibh abiq qum mffmnq}m 0 1g `v`hq lihqmuvmhqibh

    Lm qu`iqmjmhq suvmhqif ~mu sb}u~}ivi `su~ lihqmuvmhqibh smha`hq 4 03o b} o}~p} nm p}mlm ui~p}m qgubjebmjeblip}m `iq aijih}

    Qu`iqmjmhq n}u`qifam~ j`hifm~q`qibh~ qgubjebmjeblip}m~ ? 5=33]I mh ebl}~ IV s}i~ 5333]I 5 fbi~"o mh ^N

    @a`sqmu l` sb~blbdim mh fbhnqibh a} ab~`dm am l`nqiviq `hqi*W` 'beomnqif ? 3,1 3,7 ]I `hqi*W`"jL) ~i IU b} ~}usbia~ b} n`ngmwim

    Qu`iqmjmhq am = 4 ob}u~

  • 7/23/2019 Anticoagulants 2011

    25/53

  • 7/23/2019 Anticoagulants 2011

    26/53

    Lm~ @HQINB@D]L@HQ^ U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Lm~ aiffumhq~ qu`iqmjmhq~ `hqinb`d}l`hq~ Lm~ gs`uihm~

    Lm~ ihgieiqm}u~ ~lmnqif~ a} f`nqm}u W`

    Lm~ giu}aihm~ umnbjeih`hqm~

    Lm~ ihgieiqm}u~ aiumnq~ am l` qgubjeihm

    Lm~ @VKLm~ hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    27/53

    54

    Lm~ ihgieiqm}u~ ~lmnqif~ a} f`nqm}u W`

    Lm fbha`s`uih}w : @UIWQU@

    Jbln}lm am ~yhqg~m umsu~mhq`hq l` sl}~ smqiqm ~p}mhnm sbly~`nng`uiaip}m amlgs`uihm n`s`elm aihgiemu ~lmnqivmjmhq lm f`nqm}u W` mh ~m li`hq }hip}mjmhq l`hqiqgubjeihm hihgie`hq s`~ l` qgubjeihm( Jbln}lm ihaip}m mh n`~ a@QNA am

    QIG(

    Ihain`qibh~ mh qu`iqmjmhq suvmhqif? Mvhmjmhq~ qgubjebmjeblip}m~ vmihm}w ?

    mh ngiu}udim buqgbsaip}m j`om}um a} jmjeum ihfuim}u,

    mh ngiu}udim `eabjih`lm ngmz am~ s`qimhq~ g`}q ui~p}m 'n`hnmu~),

    Ngmz lm~ s`qimhq~ `liq~ sb}u }hm `ffmnqibh jain`lm `id} mq o}d~ g`}q ui~p}m

    Qu`iqmjmhq n}u`qifam~ QVS `id}~ mq am~ MS `id}~

    ^yhaubjm nbubh`uimh `id} hbh ^Q ~}~ ui~p}m ihqmujai`ium b} f`ielm

    Sb~blbdim~ ?

    Qu`iqmjmhq suvmhqif ? mh ^N, 5,=jd"o

    Qu`iqmjmhq n}u`qif ? mh ^N

    < =3kd ? =jd"o

    8 =3kd ? 4,=jd"o

    8 033kd ? 03jd"o

    ^yhaubjm nbubh`uimh `id} ? mh ^N, 5,=jd"o

  • 7/23/2019 Anticoagulants 2011

    28/53

    57

    Lm~ ihgieiqm}u~ ~lmnqif~ a} f`nqm}u W`

    Lm uiv`ubw`e`h : W@UMLQB

    Ihgieiqm}u aiumnq, nbjsqiqif, uvmu~ielm mq ~snifip}m a} f`nqm}u W` ~`h~ mffmqihgieiqm}u aiumnq ~}u l` qgubjeihm( Il subvbp}m }h `llbhdmjmhq a} QP mq a} QN@(

    Ihain`qibh~ ?Suvmhqibh suij`ium am~ vhmjmhq~ qgubjebmjeblip}m~ vmihm}w ngmz lm~ s`qimhq~ehfini`hq a}hm ihqmuvmhqibh ngiu}udin`lm subdu`jjm sb}u SQG b} SQD(

    Nbhqum*ihain`qibh~ ?

    gysmu~mh~ieiliq, ~`idhmjmhq vbl}qif nlihip}mjmhq ~idhifin`qif b} ui~p}m am~`idhmjmhq du`vm 'Gim nueu`lm < 6 jbi~), `qqmihqm gs`qip}m `~~bnim }hmnb`d}lbs`qgim mq }h ui~p}m am ~`idhmjmhq nlihip}m ~idhifin`qif

    Sb~blbdim ? NS *8 VBIM BU@LM

    03jd"o ae}qmu 6 03g `su~ lihqmuvmhqibh nbhaiqibh p}}hm gjb~q`~m `iq s} qum

    beqmh}m(a}um a} qu`iqmjmhq ? 5 ~mj`ihm~ sb}u l` SQD mq = ~mj`ihm~ sb}u l` SQG(

    s`~ am ~}uvmill`hnm am~ s`u`jqum~ am l` nb`d}l`qibh mh ub}qihm

    s`~ a`o}~qmjmhq am l` sb~blbdim mh fbhnqibh a} sbia~, a} ~mwm, am ldm, ~i

    Nl nu`q8>3jL"jih(

  • 7/23/2019 Anticoagulants 2011

    29/53

    Lm~ @HQINB@D]L@HQ^ U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Lm~ aiffumhq~ qu`iqmjmhq~ `hqinb`d}l`hq~ Lm~ gs`uihm~

    Lm~ ihgieiqm}u~ ~lmnqif~ a} f`nqm}u W`

    Lm~ giu}aihm~ umnbjeih`hqm~

    Lm~ ihgieiqm}u~ aiumnq~ am l` qgubjeihm

    Lm~ @VKLm~ hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    30/53

    >3

    Lm~ giu}aihm~ umnbjeih`hqm~

    L` a~iu}aihm : UMV@^N

    @hqiqgubjebqip}m `di~~`hq nbjjm }h ihgieiqm}u ~snifip}m am l` qgubjeihm mhj`~p}`hq l`nn~ ~bh ~iqm `nqif(

    Ihain`qibh~ ?

    suvmhqibh am~ QVS `su~ ngiu}udim buqgbsaip}m(

    Nbhqum*ihain`qibh~

    Mffmq~ iha~iu`elm~ fup}mhq~

    Sun`}qibh~ amjslbi ?

    qu`iqmjmhq `hquim}u s`u giu}aihm~ *8 s`qimhq ui~p}m +++ am ngbn h`sgyl`nqip}m

    Sb~blbdim ? vbim ^N `eabjih`lm

    0=jd 5 fbi~"o smha`hq 9*05 ob}u~(

    beomnqif ? QN@ < 5(

  • 7/23/2019 Anticoagulants 2011

    31/53

    >0

    Lm~ giu}aihm~ umnbjeih`hqm~

    L` eiv`liu}aihm : @HDIBW

    @hqiqgubjebqip}m `di~~`hq nbjjm }h ihgieiqm}u ~snifip}m am l` qgubjeihm mhj`~p}`hq l`nn~ ~bh ~iqm `nqif(

    Ihain`qibh~ ?

    ihaip}m ngmz lm~ s`qimhq~ ~}ei~~`hq 0 ihqmuvmhqibh nbubh`ium smun}q`hm(

    Nbhqum*ihain`qibh~

    Sb~blbdim ?

    Sun`}qibh~ amjslbi ?qu`iqmjmhq `hquim}u s`u giu}aihm~ *8 s`qimhq ui~p}m +++ am ngbn h`sgyl`nqip}m~}uvmillmu lm QN@ = jih}qm~ `su~ lm ebl}~, ihomnqmu }h hb}vm`} ebl}~ am 3,>jd"kd ~iQN@ < 55= ~mn(IU jbaum 'Nl nu`q mhqum >3 mq 63jL"jih) *8 ua}ium l` viqm~~m am smuf}~ibh

    0,1jd"kd"g(

  • 7/23/2019 Anticoagulants 2011

    32/53

    >5

    Lm~ giu}aihm~ umnbjeih`hqm~

    L` lsiu}aihm : UMFL]A@H

    @hqiqgubjebqip}m `di~~`hq nbjjm }h ihgieiqm}u ~snifip}m am l` qgubjeihm mhj`~p}`hq l`nn~ ~bh ~iqm `nqif(

    Ihain`qibh~ ?

    ihgieiqibh am l` nb`d}l`qibh ngmz lm~ s`qimhq~ `a}lqm~ `qqmihq~ a}hm QIG mq a}hmj`l`aim qgubjebmjeblip}m hnm~~iq`hq }h qu`iqmjmhq `hqiqgubjebqip}m s`u vbims`umhqu`lm 'lm ai`dhb~qin am QIG abiq qum nbhfiuj s`u }h qm~q a`nqiv`qibhsl`p}mqq`ium iha}iqm s`u lgs`uihm)(

    Nbhqum*ihain`qibh~

    Mffmq~ iha~iu`elm~ ?

    * gjbuu`dim~ '>9- abhq 00- agjbuu`dim~ ~vum~)

    * `hjim b} e`i~~m a} qw agjbdlbeihm ~`h~ n`}~m gjbuu`dip}m viamhqm '05-)

    * fivum '4-), u`nqibh~ `llmudip}m~ am qb}q qysm 'u`nqibh~ `h`sgyl`nqip}m~ 1-)

    * IU '5-)* u`nqibh `} sbihq aihomnqibh

    Sb~blbdim

    Sun`}qibh~ amjslbi ?

    qu`iqmjmhq `hquim}u s`u giu}aihm~ *8 s`qimhq ui~p}m +++ am ngbn h`sgyl`nqip}m

  • 7/23/2019 Anticoagulants 2011

    33/53

    >>

    Lm~ giu}aihm~ umnbjeih`hqm~

    Sl`nm am~ giu}aihm~ s`uji lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Nbhnmuh`hq l` a~iu}aihm : UMV@^N ?

    nbq ijsbuq`hq am nm hb}vm`} jain`jmhq 'mhviubh ~iw fbi~ lm nbq ob}uh`limua$}h qu`iqmjmhq s`u GESJ),

    `e~mhnm a$}hm ~}suibuiq ajbhqum ~}u am~ nuiqum~ nlihip}m~(*8 @ u~muvmu sb}u lm~ j`l`am~ g`}q ui~p}m qgubjebmjeblip}m mq"b}`vmn am~ `hqnamhq~ am QIG(

    Nbhnmuh`hq l` lsiu}aihm : UMFL]A@H ?

    ui~p}m a$gjbuu`dim du`vm em`}nb}s sl}~ ijsbuq`hq p}$`vmn l$Bud`u`h, aiffin}lq a} ~}ivi eiblbdip}m `vmn lm QN@(

    *8 ]qili~`qibh mh 5jm ihqmhqibh , }hip}mjmhq mh n`~ am u`nqiviqnubi~m Bud`u`h "gs`uihm~(

  • 7/23/2019 Anticoagulants 2011

    34/53

  • 7/23/2019 Anticoagulants 2011

    35/53

    >=

    Lm~ ihgieiqm}u~ aiumnq~ am l` qgubjeihm

    Lm A`eid`qu`h : SU@A@W@

    Ihgieiqm}u aiumnq, nbjsqiqif, s}i~~`hq mq uvmu~ielm am l` qgubjeihm mq d`lmjmhq aml`dud`qibh sl`p}mqq`ium iha}iqm s`u l` qgubjeihm(

    Ihain`qibh~ ?Suvmhqibh suij`ium am~ vhmjmhq~ qgubjebmjeblip}m~ vmihm}w ngmz lm~ s`qimhq~ehfini`hq a}hm ihqmuvmhqibh ngiu}udin`lm subdu`jjm sb}u SQG b} SQD(

    Nbhqum*ihain`qibh~

    Sb~blbdim ? NS *8 VBIM BU@LM< 4= `h~ ? 553jd"o mh 0 sui~m '0"5 ab~m ~i ih~q`}u`qibh < 51g sb~q ihqmuvmhqibh)

    8 4= `h~ ? 0=3jd"o mh 0 sui~m '0"5 ab~m ~i ih~q`}u`qibh < 51g sb~q ihqmuvmhqibh)

    a}um a} qu`iqmjmhq ? 03 ob}u~ sb}u l` SQD mq 57 >= ob}u~ sb}u l` SQG(

    s`~ am ~}uvmill`hnm am~ s`u`jqum~ am l` nb`d}l`qibh mh ub}qihm

    s`~ a`o}~qmjmhq am l` sb~blbdim mh fbhnqibh a} sbia~, a} ~mwm, am ldm, mh n`~aih~}ffi~`hnm gs`qip}m jbaum(

  • 7/23/2019 Anticoagulants 2011

    36/53

    Lm~ @HQINB@D]L@HQ^ U`ssml~ ~}u lgjb~q`~m mq l` nb`d}l`qibh

    Dhu`liq~ ~}u lm~ qu`iqmjmhq~ `hqinb`d}l`hq~

    Lm~ aiffumhq~ qu`iqmjmhq~ `hqinb`d}l`hq~ Lm~ gs`uihm~

    Lm~ ihgieiqm}u~ ~lmnqif~ a} f`nqm}u W`

    Lm~ giu}aihm~ umnbjeih`hqm~

    Lm~ ihgieiqm}u~ aiumnq~ am l` qgubjeihm

    Lm~ @VKLm~ hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    37/53

  • 7/23/2019 Anticoagulants 2011

    38/53

    >7

    Lm~ `hqi*viq`jihm~ K '@VK)

    Subsuiq~

    *8 Ihgieiqibh am l` ~yhqg~m gs`qip}m am~ f`nqm}u~ am l` nb`d}l`qibh viq`jihm K asmha`hq~ ?f`nqm}u~ II, VII, IW mq W mq lm~ subqihm~ N mq ^ 'f`nqm}u~ `hqinb`d}l`hq~)(

    *8 S`~ amffmq `hqinb`d}l`hq ijjai`q(

  • 7/23/2019 Anticoagulants 2011

    39/53

    >9

    Lm~ `hqi*viq`jihm~ K '@VK)

    Suihnism a} qu`iqmjmhqlm qu`iqmjmhq s`u @VK abiq qum ~}ivi vmn }hm du`ham vidil`hnm n`u il mwsb~m 5 ui~p}m~ suihnis`}w ?

    * lm ui~p}m agjbuu`dim li }h ~}uab~`dm,

    * lm ui~p}m am qgubjeb~m li }h ~b}~*ab~`dm(

    Ihain`qibh~ mq nielm qgu`sm}qip}m am lIHUlIHU jm~}um lm qmjs~ am nb`d}l`qibh a}h s`qimhq mq lm nbjs`um }h ~}omq p}i hm umbiq s`~ a@VK( Ngmz}h ~}omq hbh qu`iq, lIHU : 0( Ngmz }h s`qimhq qu`iq s`u }h @VK, sl}~ lm qmjs~ am nb`d}l`qibh ~`llbhdm,sl}~ lIHU `}djmhqm( L` nielm am lIHU asmha am l` s`qgblbdim hnm~~iq`hq lIHU

    Jba`liq~ a} uml`i~ gs`uihm @VK ?

    * Ihquba}nqibh am~ @VK lm sl}~ qqsb~~ielm '0*>o `su~ lm ae}q amlgs`uihbqgu`sim)

    * @ajihi~qu`qibh ~ij}lq`hm o}~p}beqmhqibh am 5 IHU ~}nnm~~if~ 8 5

    * A}um qbq`lm am lgs`uihbqgu`simo`j`i~ < = ob}u~(

  • 7/23/2019 Anticoagulants 2011

    40/53

  • 7/23/2019 Anticoagulants 2011

    41/53

    L i i i K '@VK)

  • 7/23/2019 Anticoagulants 2011

    42/53

    15

    Lm~ `hqi*viq`jihm~ K '@VK)

    @nniamhq~ gjbuu`dip}m~ am~ @VK

    Msiajiblbdim ? Mhviubh 933 333 smu~bhhm~ qu`iqm~ s`u @VK 'abhhm @F^^@S^ 5339),

    `nniamhq~ gjbuu`dip}m~ jbuqml~ *8 3,5= 3,7- s`u `h,

    gjbuu dim~ du`vm~ *8 0,0 1,9- s`u `h(

    ^}uvmh}m am~ `nniamhq~ gjbuu`dip}m~ Qu`}j`qi~jm

    ^`idhmjmhq a}hm l~ibh jnbhh}m '}lnum, fieubjm, `hvui~jm)

    ^}uab~`dm 'ui~p}m gjbuu`dip}m +++ p}`ha IHU 8 =)

    Nbhqum*ihain`qibh~ am~ @VK

    L i i i K '@VK)

  • 7/23/2019 Anticoagulants 2011

    43/53

    1>

    Lm~ `hqi*viq`jihm~ K '@VK)

    ^}uab~`dm mh @VK ? nbha}iqm qmhiu

    IHU < = S`~ am ~`idhmjmhq, s`~ amngiu}udim suv}m

    ^}ssuijmu l` subng`ihm sui~m s}i~ ua}ium lm~ ab~m~}lquim}um~

    IHU mhqum = mq 9 S`~ am ~`idhmjmhq

    ^`idhmjmhq jihm}u

    Ngiu}udim ~mji*}udmhqm'al`i 8 05g)

    ^}ssuijmu lm~ 5 subng`ihm~ sui~m~ s}i~ ua}ium lm~

    ab~m~ }lquim}um~( IHU p}bqiaimh(^}ssuijmu l` subng`ihm sui~m mq `ajihi~qumu am l`viq`jihm K0 '0 5jd smu b~)( IHU p}bqiaimh(

    @uuq am~ @VK( @ajihi~qumu am l` viq`jihm K0 '5 1jd smu b~ b} 0 5jd IV lmhqm)( IHU 6g `su~(Umhb}vmlmu l` viq`jihm K0 ~i em~bih(

    IHU 8 9 S`~ am ~`idhmjmhq b}~`idhmjmhq jihm}u

    @uuq am~ @VK( @ajihi~qumu am l` viq`jihm K0 '> =jd smu b~ b} 5 1jd IV lmhqm)( IHU 6g `su~(Umhb}vmlmu l` viq`jihm K0 ~i em~bih( Umsumhauml@VK ab~m jbihaum p}`ha lIHU ~mu` umvmh}a`h~ l` zbhm qgu`sm}qip}m

    P}mlp}m ~biqlIHU ^`idhmjmhq j`om}u b}ngiu}udim }udmhqm 'al`i sui~m~

    Mffmq~ iha~iu`elm~ ? h`}~m~, vbji~~mjmhq~, ai`uugm~, nsg`lm~, vmuqidm~Sun`}qibh~ amjslbi ? lih~q`}u`qibh subdum~~ivm a} qu`iqmjmhq mq lm fu`nqibhhmjmhq am~

    sui~m~ smujmqqmhq am aijih}mu lm~ mffmq~ iha~iu`elm~ '~}uqb}q lm~ nsg`lm~)

    Lm~ `hqi`dud`hq~ sl`p}mqq`ium~

  • 7/23/2019 Anticoagulants 2011

    52/53

    =5

    Lm~ `hqi`dud`hq~ sl`p}mqq`ium~

    Qinlbsiaihm : QINLIA

    Ihain`qibh~ ?* Suvmhqibh am~ `nniamhq~ i~ngjip}m~ j`om}u~, mh s`uqin}limu nbubh`uimh~, ngmz lm~

    s`qimhq~ su~mhq`hq }hm `uquibs`qgim am~ jmjeum~ ihfuim}u~ `} ~q`am am nl`}ain`qibh(

    * Suvmhqibh am~ nbjslin`qibh~ qgubjebqip}m~ `uquimllm~ '@VN, IAJ, jbuq am n`}~mv`~n}l`ium) `su~ }h 0mu @VN li l`qgub~nlub~m(

    * Suvmhqibh am l` qgubjeb~m ~}e`id} ~}u ~qmhq 'mhabsubqg~m nbubh`ium), suvmhqibh mqnbuumnqibh am~ qub}elm~ sl`p}mqq`ium~ iha}iq~ s`u lgjbai`ly~m(

    Sb~blbdim ? 5=3jd 5 fbi~"o `} nb}u~ am~ ums`~

    Mffmq~ iha~iu`elm~ ? qbwiniq gj`qblbdip}m 'lm}nbshim, qgubjebshim, `hjim, `sl`~imja}ll`ium) *8 `uuq ijjai`q a} qu`iqmjmhq, qub}elm~ aidm~qif~ 'ai`uugm~, vbji~~mjmhq),gjbuu`dim

    Sun`}qibh~ amjslbi ?

    * ^}uvmill`hnm am lgjbdu`jjm qb}~ lm~ 0= ob}u~ smha`hq lm~ > sumjimu~ jbi~* ^i ~}uvmh}m a}hm gjbuu`dim *8 `uuqmu lm qu`iqmjmhq mq umngmungmu }hm

    `du`h}lbnyqb~m

    * Ihqmuvmhqibh ngiu}udin`lm *8 `uuqmu lm qu`iqmjmhq 03 ob}u~ `v`hq

    * @ajihi~qu`qibh `} nb}u~ a} ums`~ sb}u aijih}mu lm~ qub}elm~ aidm~qif~

  • 7/23/2019 Anticoagulants 2011

    53/53