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Health & Wellness withEnzymes, Intra-cellular

Antioxidants & Nrf2 Technology

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WHAT IS FREEDOM ?1. The state of being free or at liberty rather than in confinement or under

physical restraint.

2. Exemption from external control, interference, regulation, etc.

3. The power to determine your own actions without restraint.

4. The power to determine your political or national independence.

5. The power to determine your personal liberty, as opposed to bondage or slavery.

In Science: the Freedom to influence your own state of medical health.

In Business: the Freedom to influence your own financial health.

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Presentation Topic: Health & Wellness with Enzymes, Intra-cellular Antioxidants & Nrf2 Technology

My Name: Brent McLean - Publisher of Master Reference InfoWebs:

“The Food Industry Digest” & “The Food Ingredient Digest”

--- I have used, studied and professionally marketed Antioxidants over 35 years.

--- I eat fruits/vegetables with antioxidants and take antioxidants as supplements every day.

--- I take a supplement that regulates the human body’s production of intra-cellular antioxidants and “reduces oxidative stress 40-70% in 30 days” (all mammals).

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Dr. Joe McCord•A world renowned scientist nominated for four "Nobel Prize“ in Medicine

Awards; one of the most prominent and distinguished Doctors of our time.

•He is a past recipient of the prestigious "Elliott Cresson Gold Medal”, the highest award given by The Franklin (Benjamin) Institute.

•The "Discovery Award" from the Society for Free Radical Biology and Medicine (SFRBM).

•A "Lifetime Achievement Award" from the Oxygen Society.

•He holds an Honorary Doctorate from the University of Buenos Aires.

•Served as Honorary President of the International Society of Antioxidants in Nutrition and Health (ISANH).

•Chairman of the Third International Conference on Super Oxide Dismutases at the Louis

Pasteur Institute in France.

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Dr. Joe McCord

• B.S. Degree in from Rhodes College (graduated 1966). • Ph.D. in Biochemistry from Duke University (graduated 1970), where he also conducted postdoctoral research.

• Dr. McCord has held Biochemistry Faculty Positions at Duke University Medical Center, University of South Alabama, and the University of Colorado Denver.

• He most recently served as a professor in the Department of Biochemistry, Biophysics, and Molecular Genetics at the University of Colorado Denver.

• Dr. McCord recently retired as Chief Science Officer of LifeVantage, our company that makes and distributes Protandim, TrueScience Anti-aging Cream and Canine Protandim.

• Protandim is a Nrf2 ACTIVATOR not just an Antioxidant• SYNERGY….1800% more effective• Clinically Proven to Reduce Oxidative Stress by 40-70%

and Slow the Aging Process

What is:

1 to 1 Ratio

1 Million to 1 Ratio

VS

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What is this Magic Supplement Called Protandim?

•LifeVantage has 6 Protandim patents = No Competitors products.

•Protandim is only available thru the LifeVantage direct sales network so the product details are properly communicated. It is not sold in any large commercial chain stores .

•Protandim is safe: made from 5 natural herbs, and approved for human consumption by the BSCG (Banned Substances Control Group) that regulates professional sports teams.

•Protandim is being studied at over 24 major Universities around the world, including Harvard Medical School.

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What does Protandim do?

• Protandim is only Supplement (producing Antioxidants) that stimulates Antioxidant activity inside the human (any mammals) cell’s nucleus and inside the cell’s mitochondria.

• Protandim reduces oxidative stress 40-70% in 30 days (Aging in all mammals).• Protandim stimulates intracellular antioxidant activity (Antioxidant stabilizing Free

Radicals) at an accelerated rate:

--- Protandim antioxidant activity is a 1 to 1 million + ratio

1 antioxidant: stabilizes 1 million + free radicals (ratio) each second, every second

for 13 consecutive days before losing AO activity.

--- All Other Antioxidants function at a 1:1 ratio

1 antioxidant : stabilizes 1 free radical and AO activity is over.

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The National Football League (NFL)

National Collegiate Athletic Association (NCAA)

United States Anti-Doping Association (USADA)

Major League Baseball (MLB)

and all Olympic Athletes.

All batches are tested in order for a product to be certified by the “Banned Substances Control

Group” (BSCG); and no certified products have ever been involved with a positive Drug test!

Protandim is Certified & Approved for use in Amateur and Professional Sports:

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Athletes will increase their GLUTATHIONE levels 300% and gain:

Rapid increase in energy Increases stamina Increase endurance Lessens muscle fatigue Lessens exhaustion Quickens recovery time Strengthens immune system

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Athletes will increase their GLUTATHIONE levels 300% and gain:

Protects your body from injury

Reduces muscle stress

Decreases inflammation

Feeds muscle tissues

Maintains muscle growth

Improves athletic performance

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Amino AcidsEssential &

Non-essential

Atoms

Molecules

Enzymes(Small Proteins/Peptides)

Proteins

RNA & DNA

Protandim Regulates Enzymes: 1. Superoxidase Dismutase2. Catalyse3. Glutathione

The Building Blocks of LifeNrf2 activators work inside the human cell with your DNA to up and down regulate the 500 survival genes that control and direct the other 25,000 human genes (with coding sequences made of: G, A, T, C) activities, including your immune system.

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Protandim5 Natural Herbs

Activates Nrf2 pathway

CatalyseOne C enzyme converts hydrogen peroxide to

Hydrogen and Oxygen 1 C enzyme = millions H2O2

ratio per second

Nrf2 MessengerUp and down regulates

survival genes thru enzymatic activity

Nrf2 activates these three enzyme Super Factories:

Superoxidase Dismutase Mfg’er Antioxidants

1 SOD enzyme neutralizes millions free radicals each

second, every second for 13 day period

Glutathione Electron donor neutralizes

peroxide (H2O2) waste products from 8 families of

hydro-peroxide waste.

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Kinase enzymes transmit signals and regulate complex processes in cells.

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“Protandim’s” Key Points:

“Protandim” is an all natural supplement for mammals that stimulates Nrf2 messengers to regulate 500 lead survival genes, and stimulates 3 enzymes to produce Antioxidants.

It is made from 5 synergistically combined natural herbs.

Protandim is “Patent Protected” by 6 patents; there are no competitors.

“Protandim” is only Antioxidant known to work inside the human cell structure and stimulate the Nrf2 messengers and open their pathways.

Nrf2 activators increase the activity of 500 survival genes in the human body, which regulate Antioxidant enzyme activity and the other 25K human genes.

The survival genes activity increases production of the Antioxidant enzymes: Super-Oxidase Dismutase (SOD), Catalyse and the tri-peptide Glutathione. They produce free radical scavengers at a one-million-to-one ratio (1: 1,000,000), where typical Antioxidants work on a one-to-one basis ( 1:1).

What Causes Oxidative Stress?

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ROS = Reactive Oxygen Species

Tissue damage leads to increased production of ROS. Major source of ROS is mitochondrial (Krebs Energy Cycle starts here) & microsomal transport chains inside the cell.

Free Radicals (unpaired electrons) are Formed By: 1. Addition of single electron from non-radical molecule. 2. Loss of single electron from non-radical molecule. 3. Separation of covalent bond of non-radical molecule so each part retains one of the electrons.

The electron imbalance causes the free radical to search for another electron to pair with to become stable again.

This includes: Hydroxyls (*OH); Superoxideradical (*O2-); Nitric Oxide Radical (NO*) ; Non-radicals Hydrogen Peroxide (H2O2); and singlet Oxygen (3).

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“Protandim” Reduces Oxidative Stress in Humans: • The human body produces 13 sextillion free radicals per day in an average 24 hour day. You

need every antioxidant you can get to help this situation including eating fruits/vegetables, supplements and your body producing its’ own antioxidants inside the cells.

• “Protandim” reduced human oxidative stress on average by 40% to 70% in 30 days. This is true for all mammals, so products are available for equines(horses) and canines(dogs).

• One way to measure Oxidative Stress is T-bars, which is a numerical measure of peroxidase.

• There are 8 families of Glutathione peroxidases that use glutathione as an electron donor and are active with both H2O2 and organic hydro-peroxide (H2O2 + H2O) substrates.

• Free radicals are associated with many diseases known to modern medicine. Free radicals and reactive oxygen species are one in the same, and are being studied at many major universities around the world as they are associated with 200 modern diseases.

• In compliance with FDA rules, please note LifeVantage Representatives do not claim “Protandim” cures or treats any disease. Go to: pubmed.com to get the latest information on peer reviewed studies from the US National Institute of Health. Search terms: Nrf2, antioxidants, “Protandim”, and enzymes SOD, Glutathione and Catalyse.

“Protandim” Research is being conducted by major Universities around the world on many diseases:

Skin Cancer Altitude Sickness Periodontal Disease Photo aging of the skin Heart Disease Renal (kidney) Failure Coronary Artery bypass Osteoarthritis Graft Failure Optic Neuropathy HIV/AIDS- immune diseases & associated lipo-dystrophy Pulmonary Hypertension And more ---

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ROS Investigative Disease Research:

Sepsis Multi-system Organ Failure Adult Respiratory Distress Syndrome (ARDS) Fulminant Hepatic Failure Pancreatitis Cancer Cardiovascular Disease Diabetes Mellitus Alzheimer’s Disease Asthma Cystic Fibrosis Chronic Obstructive Pulmonary Disease (COPD) Rheumatoid Arthritis Systemic Lupus Erythematosus Inflammatory Bowel Disease Ulcerative Colitis Eye Cataracts Age Related Macular Degeneration of Retina

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“Protandim”: To Date we have 16 active studies, with 20 more in the works. These will be peer reviewed studies when completed.

They can be found at: pubmed.gov

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“Protandim” Research at these well known universities:

University of Colorado University of Kentucky Ohio State University Children’s Hospital of Denver University of Florida University of Michigan Massachusetts General Hospital, Harvard Medical School Vanderbilt University Louisiana State University Glamorgan University, Wales Sahlgrenska University Hospital, Goteborg, Sweden

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“Protandim” Research: continued

Nicholls State University Texas Tech University US Veteran’s Affairs Medical Virginia Commonwealth University Jililn University (China) Riken Nanomedical Engineering Laboratory (Japan) University of Toronto / St. Michelle’s Hospital, Canada University Hospital, Brno, Czech Republic Mexican Institute of Social Security, Mexico City VU University Medical Center (The Netherlands)

Linked to over 200 Diseases

This is a very strong study endorsement from a very prominent organization directly involved with human health and wellness.

PubMed.comScholar.Google.com

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For your own research check out:

Google Scholar In the search box type Protandim Youtube In the search box type Protandim PubMed.gov In the search box type Protandim (15)

Protandim (15) Protandim and inflammation (2)

Protandim cardiovascular (6) Protandim (15) Protandim side effe cts (3) Protandim and inflammation (2)

Protandim and high blood pressure (2) P rotandim cancer (6) Protandim heart (3) Protandim oxidative (10)

Protandim skin (3) Protandim glutathione (3) Protandim ingredients (2) Protandim nrf2 (7)

Protandi m oxidative stress (10) Protandim skin cancer (3) Oxidative Stress (122,840) Protandim cardiovascular (6)

Results:

1. BG-12, tBHQ, SFN and Protandim are well-tolerated and strongly induce Nrf2-driven antioxidant enzyme production in oligodendrocytes (nerve cells), with Protandim showing the most potent induction.

2. Nrf2 activators are able to protect oligodendrocytes against ROS-induced cytotoxicity.

Conclusions:

Our findings indicate that several Nrf2 activators are able to significantly increase antioxidant enzyme production in oligodendrocytes.

Interestingly, Protandim, a dietary supplement consisting of herbal ingredients, was the most potent inducer and therefore may be the most suited as a therapeutic strategy.

Importantly, Nrf2-mediated antioxidant enzyme expression in oligodendrocytes resulted in enhanced oligodendrocyte survival during an oxidative attack.

Dr. J. van Horssen received research grants from BiogenIdec 30

Multiple Sclerosis JournalMsj.sagepub.com

TrueScience

Scientific Breakthrough Lowers Oxidative Stress 40-70% in 30 days Peer-Reviewed and Published Science Pubmed.gov 6 U.S. Patents BSCG Approved

LifeVantage TrueScience Anti-Aging Cream

Protandim Technology Reduces Fine Lines & Wrinkles Tones & Moisturizes the Skin Protects Skin from Free Radical Damage Fights Age Spots Tightening of the Skin Moisturizing the Skin Brightening of the Skin **Paraben and Sulfate Free**

Protandim & True Science, the most Scientifically Proven Anti-Aging System in the World

Canine Health • Protandim Technology• Supports brain, heart and eye functions• Supports normal joint function, mobility and

flexibility• Supports cognitive function• NASC Approved

TrueScience

Protandim

Canine Health

* Plus Tax & Shipping for PC and Distributor

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Company Direct Product Pricing:www.lifevantage.comTo order use # 799125

1. Retail Customers: retail pricing listed on website.

2. Preferred Customers (PC): --- They auto ship to buy at wholesale discount prices. --- Sign up PC’s (saves $10 per PC signed) to lower product cost.

3. Distributors: Invest in an Independent Distributorship to expand their business.

LIFEVANTAGE IS A DIRECT SALES COMPANY

Order online at: www.lifevantage.com--- Protandim supplement --- Anti-aging Skin Care Products --- Powdered Beverages with Nrf2

Use Distributor # 799125 to: 1. Direct Purchase2. Set up auto ship discount3. Buy a Distributorship

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