DIVISION OF GERIATRIC MEDICINE DIVISION DE GÉRIATRIE HOWARD BERGMAN, M.D DIRECTOR EXECUTIVE COMMITTEE YVES BACHER, M.D. HOWARD CHERTKOW, M.D. RUBY FRIEDMAN M.D. ALLEN HUANG, M.D. CHRISTINA WOLFSON, Ph.D.

ANNUAL REPORT

2002 - 2003

DIVISION OF GERIATRIC MEDICINE www.med.mcgill.ca/geriatrics

DEPARTMENT OF MEDICINE

McGILL UNIVERSITY

Howard Bergman, MD

September 2003

INTRODUCTION The McGill University Division of Geriatric Medicine of the Department of Medicine is comprised of faculty from the Divisions of Geriatric Medicine of the Jewish General Hospital (JGH), the McGill University Health Centre (MUHC), and from the affiliated division at St. Mary's Hospital. Faculty from the Department of Family Medicine play a key role in the Division. There are links with the Division of Geriatric Psychiatry of the Department of Psychiatry. Faculty from Epidemiology, molecular and cell biology and Neurology with an active and significant interest in aging research and who have been involved in research with division members are integrated in the division. Investigators from other departments continue to show interest and have requested joining the Division. There is ongoing and close collaboration for clinical work, teaching and research with nursing, physiotherapy, occupational therapy and social work. In the past several years, we have collaborated with the Division of orthopedic surgery in the organization of successful CME events. There is significant collaboration with our colleagues from the Université de Montréal as well as other Quebec and Canadian Universities in areas of research and program development. International collaboration has also considerably developed. The Division Executive now includes Drs. Allen Huang (MUHC Division Director), Yves Bacher (McGill Geriatric Medicine Residency Program Director), Howard Chertkow, Ruby Friedman and Christina Wolfson, reflecting our academic objectives.

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1. RESEARCH AND PUBLICATIONS 1.1 Research activity Please see Appendix I for the list of research projects, Appendix II for publications, book chapters and abstracts, Appendix III for lectures, Appendix IV for honors and awards, Appendix VI for graduate students, Appendix IX for the Annual Research Day Program. Research in neurobiology and dementia, informatics, health services, pharmacoepidemiology, nutrition, bone and rehabilitation continue to represent the existing strengths of the Division with programs that cross hospital, department and university lines and in some cases integrate bench to bedside to population. There is increasing collaboration with colleagues from Quebec, Canada and internationally. In the past year, members of our Division lead major research programs with funding from the Canadian Institutes on Health Research (CIHR), the FRSQ, the Canadian Foundation for innovation (CFI) and Valorisation Recherche Québec (VRQ). These major research teams bring together investigators from Quebec, Canada and internationally. Dr. Allen Huang, with Robyn Tamblyn’s group, projet IRIS-Quebec & Cyber-Santé; Dr. Howard Chertkow and other colleagues from our McGill Division and colleagues from the Université de Montréal on Cognitive Impairment in the Elderly. Howard Chertkow is also leading a Canadian effort to create a Network of Centres of Excellence (NCE) on dementia; Drs Howard Bergman and François Béland, co-directors of Solidage: McGill/Université de Montréal Research Group on Integrated Services for the Elderly on The Challenge of Understanding and Meeting the Needs of the Frail Elderly in the Canadian Health Care System. Other members of our Division actively involved include: Johanne Monette, Christina Wolfson, and Wendy Chiu. Johanne Monette continues to develop a Collaborative Research Network in Long-Term Care. Dr. Howard Bergman with Christina Wolfson and François Béland received major funding from the Max Bell Foundation, the FRSQ and other Canadian groups for the Canadian Initiative on Frailty and Aging. Dr. José Morais, along with several other investigators from Quebec received major funding from CIHR for a 5 year Longitudinal Study on Nutrition and Healthy Aging. Because of these strengths, the Division has played an important role in the FRSQ Quebec Research Network on Aging (Réseau Québécois de recherche sur le vieillissement). Howard Bergman was named Director, José Morais is on the executive and other members are present in all sub-themes. Dr. José Morais has an FRSQ chercheur-clinicien award. Gustavo Duque completed his PhD in Experimental Medicine (Aging bone metabolism). The Hutchison award for 2003 was given to Dr. Gustavo Duque for his research in bone. He has joined the Bloomfield Center for Research in Aging at the LDI.

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1.2 Research Day Under the responsibility of Tina Wolfson, this year our McGill Division held its 8th Annual Research Day. A round table discussion on the Canadian Longitudinal Study in Aging was held with Dr. Wolfson and with Susan Kirkland, an epidemiologist from Dalhousie. Oral and poster presentations, essentially all from students, residents, fellows and post-docs, were presented. Two $750 prizes were awarded by a jury of faculty members to: Ryan Ward (Investigating the Role of Telomerase in Chemotherapeutic Resistance) and Christine Whatmough (A 150 PET study of word meaning in AD) for best oral presentations in basic science research and clinical health research respectively. Two $300 prizes were awarded to: Anis Larbi (Effects of cyclodextrine on t cell rafts composition with aging) and Mark Oremus (Physician Efficacy Requirements for Prescribing Drug Treatments for AD) for the best poster presentations in basic science research and clinical health research respectively. Approximately 80 people attended the Research Day and an abstract book was distributed (Appendix IX). 1.3 Students/Fellows Research Club - MAGIC (Montreal Aging and Geriatric

Interactive Club) This year the Research Club again was organized on a more targeted fashion with two visiting professors invited for the McGill Geriatric Medicine Grand Rounds series. 1.4 Travel grant For the 7th year, the Division’s Executive distributed several travel grants to several residents and postgraduate students. 2. EDUCATION 2.1 Joint Education/Training Committee Undergraduate medical students: After over six years of teaching Geriatrics in ICMB, the Faculty Curriculum Committee asked our Division to organize a clerkship in Geriatric Medicine for all medical students (third and fourth year). Geriatric Medicine faculty is also involved in teaching two modules in I.T.P. as well as the integrated course in the first year. Dr. Gustavo Duque, with the collaboration of Dr. Susan Gold and the support of his committee including Drs Catherine Ferrier, Paul Heilpern, and Rob Bailey, are leading the Clerkship Curriculum with innovative web-based methods for teaching and evaluation. This has been and continues to be a tremendous challenge for our Division which taught 12 medical students every month. The student evaluations have been on average very good to excellent. This is a testimony to the hard work and dedication of all the teachers in our Division. We plan to look at the Curriculum of Aging in first and second year as well.

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Medical residents: All medical residents as well as neurology residents have a one-month rotation in Geriatric Medicine in their first year. Dr. Wendy Chiu is responsible for this program. Family medicine residents: All family medicine residents as well do one month of Geriatric Medicine. Geriatric Medicine Specialty Training Program: Dr. Yves Bacher is the Program Director. There is presently one trainee in the program. We are expecting another to begin in January 2004 and another in July 2004. Health care for the Elderly Training Program: In the past eight years we have trained 15 fellows. Dr. Najmi Nazerali is the Director, and Dr. Sylvia Windholz is the Associate Director of this program. In the past year, there were two trainees. 2.2 Post-graduate Courses Dr. Gustavo Duque teaches courses in biology of aging. Dr. Christina Wolfson gives a course on epidemiology of aging in the Department of Epidemiology and Biostatistics while Dr. Nancy Mayo gives a course in methodology to graduate physiotherapy and occupational therapy students. Division members have given lectures in courses in other faculties and universities. 2.3 Education Activities with other McGill Schools and Departments Dr. José Morais organized our participation in a series of lectures for the McGill School of PT and OT. 2.4 Rounds a) McGill University Geriatric Medicine Grand Rounds In October 1994 the Division inaugurated the McGill University Geriatric Medicine Grand Rounds. We have now completed our 9th year. Please see the full program in Appendix VIII. Seven speakers including four local speakers and three visiting professors were part of this year's program. The visiting professors spent two days at McGill giving the Geriatric Medicine Grand Rounds, a Medical Grand Round in one of the three teaching hospitals, as well as meetings with McGill scientists, graduate students and post-doc and residents interested in a particular field. b) McGill University Interdisciplinary Rounds This past year, the Interdisciplinary Rounds in their present form were suspended. A committee of representatives from the hospitals, rehab institutes, CLSC's and long-term care institutions, chaired by Caryn Nash, has decided with the agreement of the executive to hold one or two interdisciplinary, half day or full day, seminar. The first was held on September 19, 2003. (Appendix X)

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c) Hospital Division Rounds The hospital Divisions organize rounds as well. The MUHC has weekly joint rounds with local and visiting speakers and the JGH has regular Journal Club. Both Divisions hold regular presentations by residents. St. Mary’s holds rounds and journal clubs as well. The Jewish General Hospital/McGill Memory Clinic holds Research Rounds. 2.5 Continuing Medical Education With the help and encouragement of Dr. Michael D. Rosengarten of McGill Continuing Medical Education, Geriatric Medicine now has a section on the Continuing Medical Education website (http://www.med.mcgill.ca/~cme/html/cmevidOd.html) where lectures in particular from the Geriatric Medicine Grand Rounds series, as well as other lectures given by members of our division or others on geriatric topics can be viewed directly. Members of the Division actively participated in various activities of continuing medical education including the Thursday evening lecture series. In March 2004, Paul Lysy with Yves Bacher and Susan Vaitekunas are organizing the very successful McGill Geriatric two-day CME course (held every two years). 3. CLINICAL ACTIVITIES The organization of clinical activities is under the responsibility of each of the hospital Divisions of geriatric medicine at the MUHC (Montreal General and RVH sites), Jewish General Hospital, and St. Mary’s. There has been some sharing of resources in the past and this will likely continue to grow. As well, there have been agreements on the development of tertiary care activities. Finally, recruitment is done as a joint activity of the University and each of the hospital Divisions. It is worth noting that the McGill University Division of Geriatric Medicine through its hospital Divisions assumes an extremely important clinical load and is perhaps one of the most complete Divisions in the country in terms of its breath and scope. In the McGill hospitals (MUHC, JGH, St. Mary’s) there are a total of over 100 acute geriatric beds and the Divisions assume the responsibility for approximately 150 long-term care beds situated within the hospitals. All the Divisions run active consultation services in the Emergence Room as well as on the medical, surgical and psychiatric wards. In the last year there were close to 4000 consultations done in the emergency room and on the wards. As well, there are outpatient geriatric clinics in each of the sites, as well as a Geriatric Day Hospital at the MUHC/RVH site. There is a tertiary care Memory Clinic at the JGH and a tertiary care incontinence clinic at the MUHC/MGH site. Each of the sites are actively involved in other community outreach programs with the CLSC home care services and community intermediate resources. Geriatricians and other members of the multidisciplinary team participate actively in program planning and management for services of the elderly in each of the hospitals as well as with the CLSCs, the Regional Board and the Ministry.

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4. INTERNATIONAL ACTIVITIES The work on the international scene has continued to develop considerably in the past year. Members of the Division continue to be invited as speakers, often in major plenary sessions, in many and varied international scientific meetings and forums. This has led to international collaboration in research endeavors in Europe, United States, Latin America and Israel. Members of the Division have been named to boards of international peer-reviewed journals. Our education program continues to develop, particularly in Latin America, thanks to the efforts of Gustavo Duque and Sylvia Windhoz. A fellow from Switzerland is training in our Geriatric Medicine Specialty Training Program. We are expecting another fellow from Colombia for this same program. As well, we expect a geriatrician from Argentina to begin a one-year clinical/research fellowship.

Members of the Division are actively involved in American Geriatric Society International Special Interest Group. 5. WEBSITE Thanks to the work of Shek Fung with the help of Allen Huang, Gustavo Duque and Carol Novosellor, our website (http://www.med.mcgill.ca/geriatrics/) is now up and running as well as a work in development. It should become a central point of communication for those interested in finding out about what our Division does or communicating our monthly Calendar of Events and for announcing various rounds, etc., as well as an instrument for the teaching of medical students and residents. 6. CONCLUSION There is no doubt that the McGill Division of Geriatric Medicine has developed considerably in the area of education as well as research and publications. In fact, if one looks at the depth and variety of the education activities, in particular now with the clerkship, and if one looks at the importance of the research programs in terms of the amount of peer-reviewed and industry funding, as well as publications, our Division is making important contributions to the field of Geriatric Medicine and Aging. It is a testimony to the work of the members of our faculty who continue to maintain the very important clinical load (see section 3). There are several important challenges in the upcoming year. Teaching The clerkship continues to be a major challenge for the coming year. Clinical The consolidation of the merged divisions at the RVH/MGH still requires a significant amount of energy and collaboration. Recruitment is still a priority for our Division. As we consolidate our Divisions at the MUHC, as well as at the JGH and St.Mary’s, we can think of effective cross-appointments at the clinical level.

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Research We will need to continue to recruit and train new investigators and be involved in strategic research programs in development at the FRSQ and CIHR. Acknowledgements Geriatric Medicine continues to receive constant support from the Chair of Medicine, David Goltzman and the Dean of Medicine, Abe Fuks. I would like to express my special appreciation to Dr. Robert Levine of the Kaufmann Foundation and Ms. Anita David of the Gustav Levinschi Foundation who continue to be a source of counsel and advice for our Division. They have constantly supported innovative clinical work and research in our hospital Division. I would like to express my appreciation to Carol Novoseller who is instrumental in the organization of the McGill Geriatric Medicine Grand Rounds and who assures the administration base for our Division, to Elizabeth Iacono, Enza Volpe and Renée Kaminski for secretarial and organization support in all our division activities. We welcome Ayana Roberts who is the coordinator for our teaching program.

Respectfully submitted,

Howard Bergman, MD

The Dr. Joseph Kaufmann Professor of Geriatric Medicine

Director

Division of Geriatric Medicine, McGill University HB/ei

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APPENDIX I

RESEARCH

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

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RESEARCH 2001-2006 The challenge of meeting and understanding the needs of frail older persons in the

Canadian health care system. Béland F, Bergman H (PI); co-investigators: Wolfson C, Monette J, Lebel P, et al. Canadian Institutes of Health Research/ Interdisciplinary Health Research Team (CIHR/IHRT) $709,783 per year.

2003-2006 The Canadian Initiative on Frailty and Aging. Bergman H, Béland F (PI); co-

investigators: Wolfson C, Hogan D, Macknight C, Patterson C, Hébert R, Feightner J, Fernie G, Paccaud F, Michel J-P. The Max Bell Foundation. $400,000.

2001-2006 Multi-level evaluation in the early diagnosis of Alzheimer’s disease. Chertkow H

(PI); co-investigators: Bergman H, Kabani NJ, Wolfson C. Canadian Institutes of Health Research. $565,830.

1999- A randomized, double-blind, placebo-controlled trial to evaluate the safety and

efficacy of vitamin E and Donezepil Hcl (Aricept) to delay clinical progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD). H Chertkow, H Bergman, S Vaitekunas, S Windholz, S Gold, G Inglis, H Schipper, Y Bacher

1999- Effects of Estradiol versus placebo in elderly men with Mild Cognitive Impairment.

H Chertkow, B Sherwin, H Bergman, S Vaitekunas, S Windholz, S Gold, G Inglis, H Schipper, Y Bacher

2001- A randomized double blind placebo-controlled trial to evaluate the efficacy and

safety of galantamine (GAL-INT-18) in subjects with mild cognitive impairment (MCI) at risk for development of clinically probable Alzheimer’s disease. H Bergman, H Chertkow, S Vaitekunas, S Windholz, S Gold, G Inglis, H Schipper, Y Bacher.

2000-2003 Cognitive Neuroscience Studies of Language in Alzheimer’s Disease. Chertkow, H.

(P.I.), Arnold,D. CIHR (Canadian Institutes of Health Research) operating grant of $120,000/year

1999-2002 Selective impairments of the ability to abstract form and meaning. Baum, S. [P.I.] ,

Chertkow, H. & Pell,M. FCAR (Fonds pour la formation de chercheurs et l'aide à la recherche) grant (00-ER-2089) of $42,150./year

2001-2004 Consortium, Cognition et Vieillissement: Consortium pour la recherche sur

l’identification précoce et le traitement des troubles de la cognition reliés aux maladies neurodégénératives lors du vieillissement – total grant of $1,656,000 to Dr. Yves Joanette & Dr. Howard Chertkow (P.I.’s). This grant supports 30 investigators working in aging and cognition.

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2002-2007 Collaborative health informatics research training program. Francis Lau, PI. Allen Huang, Co-Investigator. Canadian Institutes of Health Research. $1,500,000

2001-2004 Cyber-Santé Robyn Tamblyn, PI. Allen Huang, Co-PI. Nancy Mayo, co-investigator.

Valorisation-Recherche Québec. $5,000,000 2001-2003 MOXXI-COMPETE. Robyn Tamblyn, PI. Allen Huang, Co-Investigator. Health

Canada: Canadian Health Infostructure Partnerships Program. $4,950,000 2001-2005 The Integrated Health Research Network for Quebec. Robyn Tamblyn, PI. Allen

Huang, Co-Investigator. Canadian Foundation for Innovation. $28,255,117 2001-2005 Role of caspases in human neuronal cell death and in Alzheimer's disease. PI:

Andréa LeBlanc. CIHR $109,525 per year. 2001-2005 Role of prion protein against Bax mediated apoptosis, PI: Andréa LeBlanc. CIHR

$69, 254 per year. 2001-2003 Intracellular amyloid � toxicity in neurons. PI: Andrea LeBlanc. Neurochem. Inc.

$126,000 CDN/year. 2002-2007 Role of prion protein in neuronal survival. Principal investigator: Andréa LeBlanc.

NIH Operating grant. $200,000 US per year. 2002-2006 Isolation and identification of 17-ß-estradiol induced Caspase Inhibitory factor

(CIF). Principal Investigator: Andrea LeBlanc, NIH Operating grant. requested $118,950 US per year.

2002-2007 Multi-User Equipment and Maintenance Grant for the Electron Microscopy Center.

Co-applicant: Andrea LeBlanc, Principle Investigator: John Bergeron, Dept. Anatomy and Cell Biology ($134,206.00/year).

2003 Le développement d’un cours de formation à distance en gériatrie sur WEBCT.

Louise Mallet. Merck Frost- $15,000.00 2003 Canal Savoir. Soins pharmaceutiques - développement d’une vidéo de 3 heures.

Rédaction d’un scénario pour le développement d’un vidéo de 3 heures sur les soins pharmaceutiques. Louise Mallet. $15,000.00

2000-05 Quebec Integrated Health Research Network (CFI, Quebec Gov’t, Private sources).

R Tamblyn (alphabetical order: M-D Beaulieu, A Barkun, R Blais, J Brisson, A Clarke, R Cote, M Goldberg, P Larochelle, N Mayo, D Menzies, D Roy, J Sampalis, J-F Yale). CFI. $11,598,844, $11,598,844, $ 5,799,422

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2000-04 Canadian Stroke Network. A Hakim (alphabetical order: V Hachinsky, B Kolb, A Laupacis, N Mayo, P Morley, S Phillips, F Silver, H Robertson, S Weiss, K Young) NCE. $14.1 million

2001-02 The short-term effects of ambient air pollution on clinical signs and symptoms for

congestive heart failure: A pilot study. M Goldberg (alphabetical order): R Burnett, K Flegel, N Giannetti, N Mayo, R Tamblyn, R Vincent. CIHR. $81,303

2000-04 Manual Dexterity and Walking Competency Post-Stroke: A Randomized Controlled

Trial. N Mayo, R Côté, C Richards, S Wood-Dauphinee, M Verrier. CSN. $72,000 (per yr)

2000-04 Understanding Health Related Quality of Life Post-Stroke. Wood-Dauphinee, N

Mayo, Cheung, Garland, Jutai, Bayleyr. CSN. $240,000 (per yr) 2000-04 Predicting the Brain’s Capacity to Reorganize Post-stroke. N Mayo, R Côté, B Kolb,

F Malouin, G Bray. CSN. $82,000 (per yr) 2000-03 Coûts reliés aux séjours en hébergement: Étude de cohorte. Johanne Monette, M.D,

M.Sc. (PI) and François Béland, Ph.D. (PI). Funded by the Ministère de la santé et des Services sociaux. (30 000$) and the Canadian Institute of Health Research (20,733$).

2001-03 Optimisation de la qualité de la prescription des antibiotiques en centre

d’hébergement et de soins de longue durée. Johanne Monette, M.D, M.Sc. (PI). Funded by the Canadian Institute of Health Research (CIHR): 64 747$ for first year. Total : 107 943$

2001-03 Étude comparative du rapport coût-efficacité des nouveaux antidépresseurs dans la

population de personnes âgées du Québec. Yola Moride, PhD (PI). Johanne Monette, MD, co-investigator. Funded by the Fonds de la Recherche en Santé du Québec (Quebec health research funding agency): 73,897$

2003-05 Programme d’interventions visant l’optimisation de la prescription des

neuroleptiques en milieu d’hébergement : Johanne Monette M.D., M.Sc. (PI), Nathalie Champoux M.D., M.Sc. (PI). Funded by the Comité Aviseur pour la Recherche Clinique (CAREC), Institut Universitaire de Gériatrie de Montréal : 34 992$.

2003 Insulin sensitivity of protein metabolism in elderly persons with Type 2 diabetes.

José A. Morais, Principal Investigator. Canadian Diabetes Association. $75,000/yr

2003 Gluconeogenesis and insulin sensitivity in Type 2 diabetes Mellitus. Réjeanne Gougeon, Principal Investigator. José A. Morais, Co-investigator. CIHR. $116,552/yr

2003 The effect of improved oral prostheses on the nutritional state of edentulous elderly

individuals. Jocelyne Feine/José A. Morais, Principal Applicants. CIHR. 313,194/yr

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2003 Nutrition as a determinant of successful aging. The Quebec Longitudinal study.

Hélène Payette, Principal Investigator José A. Morais, Co-investigator. CIHR. $753,300/yr

2003 Mechanisms of insulin resistance of protein metabolism in human obesity. Errol B.

Marliss, Principal Investigator; José A. Morais, Co-investigator. CIHR. $160,753/yr 2003 Facteurs associés avec la résistance à l’insuline chez la personne âgée fragile. José

A. Morais, Principal Investigator. FRSQ – Réseau on Aging. $61,967/yr 2000-03 Investigation of heme oxygenase-1 as a systemic biological marker of sporadic

Alzheimer disease. Schipper H. Canadian Institutes of Health Research (CIHR) ($251,676)

2001-2002 Antioxidant and antiapoptotic effects of erythropoietin. Schipper H. Co-PI: Wilson

Miller, MD, PhD. Ortho Biotech ($65,000) 2001-2002 Consortium Cognition et Vieillissement: Traitement des Troubles Cognitifs dans les

Maladies Neurodegénératif. Schipper H. Co-PI : Hemant Paudel, PhD. Valorisation-Recherche Québec (VRQ) ($40,000)

2002-2003 Consortium Cognition et Vieillissement: Traitement des Troubles Cognitifs dans les

Maladies Neurodegénératif. Schipper H. Co-PI : Hemant Paudel, PhD Valorisation-Recherche Québec (VRQ) ($60,000)

2002-2003 Brain erythropoietin expression in Alzheimer disease and mild cognitive

impairment. Schipper H. Co-PI: Wilson Miller, MD, PhD. Ortho Biotech ($30,000) 2000- The Living Will Evaluation Research Project: M Dworkind, S Windholz, J Erban 2001- The Prognosis of Major and Minor Depression in Elderly Medical Inpatients: J

McCusker, M Cole, F Primeau, S Windholz (principal investigator, SMBD Jewish General Hospital site)

2000- Public Foster homes for the elderly: a descriptive study. Clarfield AM, Windholz S,

Nash C 2000- Enteral feeding in end-stage dementia: a comparison of religious and national

differences. Clarfield AM, Windholz S, Monette J, Bergman H, Lajeunesse Y, Boire-Lavigne AM, Gordon M, Marr S, Gore B, Caine Y, Ben-Israel Y

2003-2004 The use of medications in the Alzheimer's disease population - Caregiver

perspective. Wolfson C (PI). Co-investigators: Oremus M, Bergman H, Vandal A. Consortium of Canadian Centres for Clinical Cognitive Research (C5R). $7,600.

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2002-2004 Study Protocol for a Canadian Longitudinal Study of Aging. PI: Wolfson C. Co-PIs: Dr. S. Kirkland (Dalhousie U), Dr. P. Raina (McMaster U). 20 Co-investigators. 170 Collaborators. Canadian Institutes of Health Research. $400,000.

2001-2003 Unmet needs for community-based services for the elderly aged 75 years and over:

12 month follow-up. PI: Wolfson C. Co-investigators: L. Levesque, H. Bergman, F. Béland, L. Trahan, J. Podoba. Canadian Institutes of Health Research. $80,000.

2001-2003 Epidemiologic Approaches to the Study of Dementia in the Elderly..

Co-PI’s: C. Wolfson & Dr. G. Ferland. Co-investigators: Drs. H. Bergman, M.J. Kergoat, Y. Moride, G. Galbaud DuFort, J. Monette, M. Giguère. FRSQ. Equipe Prioritaire. $70,000.

2000-2002 Understanding Cognitive Decline: Patterns & Prognosis. Co-PI’s: M.J. Kergoat & C.

Wolfson Co-investigators: H. Chertkow; H. Bergman, B. Shatenstein, B. Ska. Canadian Institutes of Health Research. $171,208.

2003-2004 Constitution d’une batterie d’évaluation et statut post-réadaptation des personnes

âgées admises en unités de réadaptation fonctionnelle intensive et en hôpitaux de jour. Demers, L (PI). Co-Investigators: C. Wolfson, J. Desrosiers, B. Ska. Fonds de la recherche en Santé du Québec. $82,810.

2003-2004 Efficacité de la réadaptation gériatrique offerte en milieu hospitalier: étude pilote

pour constituer la batterie d'évaluation. Demers, L (PI). Co-Investigator: C. Wolfson. Canadian Institutes of Health Research. $ 50,000.

2002-2004 Development and validation of an elder abuse suspicion index for physician use.

Yaffe MJ (PI). Co-investigators: C. Wolfson, M. Lithwick, E. Podnieks, S. Straka. Canadian Institutes of Health Research. $204,879.

1995-2003 Les personnes âgées en perte d'autonomie. PI: Dr. R. Hebert. Steering Committee

on Cognition in the elderly: Dr. C. Wolfson, Dr. H. Bergman, Dr. H. Chertkow, Dr. Y. Joannette. Fonds de la recherche en Santé du Québec. Geriatric Reseau (Network). $200,000

1999-2002 Proton magnetic resonance spectroscopy of multiple sclerosis. D. Arnold (PI).Co-

investigators: GB Pike, C. Wolfson. Medical Research Council of Canada. $319,390. 2001-2002 Conception d’un modèle d’évaluation des effets de la réadaptation en milieu

hospitalier. L. Demers (PI). Co-investigators: C. Wolfson, B. Ska, J. Desrosier. FRSQ/Réseau provincial de recherche en adaptation-réadaptation. $14,995.

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APPENDIX II

PUBLICATIONS

Peer Reviewed Papers, Book Chapters, Abstracts

2002

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

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PUBLICATIONS 2002 Papers Peer Reviewed

Béland F, Birch S, Stoddart G : Unemployment and health : contextual-level influences on the production of health in populations. Social Science & Medicine; 2002;55(11):2033-2052.

Bergman H, Béland F, Perrault A. The global challenge of understanding and meeting the needs of the frail older population. (Editorial) Aging clinical and experimental research. Special Issue on Systems of Care (Guest Editors: Bergman H and Beland F). 2002: 14 (4) 223-25

Bergman H, Béland F : Commentary on : The future of health care in Canada. International Journal of Integrated Care 2002; 2 (March)

Levinoff, E. J. , & Chertkow, H. (2002). The biological and cognitive effects of Estrogen on the aging brain. Geriatrics and Aging, 5, 41-44.

Murtha, S., Cismaru, R., Waechter, R., & Chertkow, H. (2002). Increased variability accompanies frontal lobe damage in dementia. Journal of the International Neuropsychological Society, 8, 360-372.

Chertkow, H. (2002). Mild Cognitive Impairment. The Canadian Alzheimer Disease Review, June 2002, 15-20.

Chertkow, H. (2002). Mild Cognitive Impairment. Current Opinion in Neurology, 15, 401-407.

Kabani N., Sled J.G. and Chertkow, H. (2002) Magnetization Transfer Ratio in Mild Cognitive Impairment and Dementia of Alzheimer's Type. NeuroImage15, 604-610.

Saumier, D. & Chertkow, H. (2002). Semantic Memory. Current Neurology and Neuroscience Reports.2(6), 516-522.

Duque G, Chang G. Age-related bone loss: old term new facts. Gerontology 48:2:62-71,2002

Duque G, El Abdaimi K, Macoritto M, Miller, M. M. Kremer R. Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochem Biophys Res Commun.; 299(3):446-54, 2002.

Dudkiewicz M, Gold S, Monette J, LeCruguel JP, Bergman H. The Clock Drawing Test for the Identification of Responders to Donepezil. Geriatrics Today 2002: 5: 17-20

Yan Zhang, Richard McLaughlin, Cynthia Goodyer, and Andréa LeBlanc. Selective Cytotoxicity of Intracellular Amyloid β Peptide1-42 through p53 and Bax in Cultured Primary Human Neurons. J. Cell Biol. 2002, 156 (3), 519-529. Featured in News.

Megan Blacker, Mark C. Noe, Thomas J. Carty, Cynthia G. Goodyer, Andrea C. LeBlanc. TACE inhibitor prevents regulated secretion of amyloid precursor protein without altering amyloid ß peptide production in human neurons. J. Neurochem. 83(6) 2002, 1349-1357.

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Bergeron J, Pelletier S, Mallet L. L’effet des oestrogènes durant la ménopause sur le risque et l’âge d’apparition de la maladie d’Alzheimer. Pharmactuel 2002;35 :158-60.

Génois MC, Paquette A, Mallet L. Effet du risédronate sur le risque de fracture de la hanche chez les femmes âgées. Pharmactuel 2002; 35 : 119-121

Carli F, Mayo NE, Klubien K, Schricker T, Trudel J, Belliveau P, Epidural analgesia enhances functional exercise capacity and health-related quality of life after colonic surgery. Results of a randomized trial. Anesthesiology, Sept 2002, 97(3):540-9

Mayo NE, Wood-Dauphinee S, Côté R, Durkin L, Carlton J. Activity, Participation, and Quality of Life Six Months Post-Stroke. Arch Phy Med Rehab, August 2002, Vol 83, No.8, pp. 1035 – 1042. MacDonald N, Ayoub D, Farley J, Foucault C, Lesage P, Mayo NE. A Quebec survey of issues in cancer pain management. J Pain Symptom Manage Jan 2002, 23(1):239-247 Moride Y, Galbaud du Fort G, Monette J, Ducruet T, Boivin JF, Champoux N, Crott R. Patterns of antidepressant use in the Quebec ambulatory elderly population: association with selected physician characteristics. Journal of the American Geiratric Society 2002;50(8):1365-71. Hutton B., Feine J., Morais J.A. Is there an association between edentulism and nutritional state? J Can Dental Assoc 2002;68:176-181.

Sahlas DJ, Liberman A, Schipper HM. Role of heme oxygenase-1 in the biogenesis of corpora amylacea. Biogerontology 3:223—231, 2002

Schipper HM, Small L, Wang X, Brawer JR. The role of porphyrin sequestration in the biogenesis of iron-laden astrocytic inclusions in primary culture. Dev Neurosci 24:169-176, 2002 Perrault A, Wolfson C, Egan M, Rockwood K, Hogan D. (2002). Prognostic Factors for Functional Independence in Older Adults with Mild Dementia: Results from the Canadian Study of Health and Aging. Alzheimer’s Disease and Associated Disorders, 16(4):239-247. Wolfson C, The Canadian Study of Health and Aging Working Group. (2002). Patterns and Health Effects of Caregiving for People with Dementia: The Impact of Changing Cognitive and Residential Status. The Gerontologist, 42:643-652. Wolfson C, Talbot P (2002). Bacterial infection as a cause of multiple sclerosis. An invited commentary. The Lancet, 360:352-353.

Wolfson C, Wolfson DB. (2002) Survival with dementia, from onset: shorter than previously reported. Research and Practice in Alzheimer’s Disease. Vol 6:114-120.

17

Demers L, Monette M, Descent M, Jutai J, Wolfson C (2002). The Psychosocial Impact of Assistive Devices (PIADS): Translation and Preliminary Psychometric Evaluation of a Canadian-French Version. Quality of Life Research, 11(6):583-592. Wolfson C, Oremus M, Shukla V, Momoli F, Demers L, Perrault A, Moride Y. (2002). Donepezil and Rivastigmine in the Treatment of Alzheimer’s Disease: A Best Evidence Synthesis of the Evidence for Efficacy and Cost-Effectiveness. Clinical Therapeutics, 24(6):862-866. Moore F. G.A. and Wolfson C. (2002). Human Herpes Virus 6 and Multiple Sclerosis. Acta Neurologica Scandinavica, 106 (2):63-83. Marrie RA, Wolfson C. (2002). Multiple Sclerosis and Epstein-Barr Virus: A Review. Canadian Journal of Infectious Diseases, 13(2):111-118. Wolfson C, Perrault A, Moride Y, Esdaile J.M, Abenhaim L, Momoli F. (2002). A case-control analysis of nonsteroidal anti-inflammatory drugs and Alzheimer's disease: are NSAIDs protective? Neuroepidemiology, 21:81-86. Rockwood K, Macknight C, Kirkland S, Hogan D, Merry H, Verrault R, Wolfson C, McDowell I. (2002). Use of lipid lowering agents, indication bias and the risk of dementia in community-dwelling elderly people. Archives of Neurology, 59:223-227. Demers L., Monette M., Lapierre Y., Douglas A., Wolfson C. (2002). Reliability, validity, and applicability of the Quebec User Evaluation of Satisfaction with assistive Technology (QUEST 2.0) for adults with Multiple Sclerosis. Disability and Rehabilitation 24:21-30.

18

PUBLICATIONS 2002 Book Chapters, Reviews

Zunzunegui MV, Pinzon SA, Béland F, Pantelides EA, Albala C, Prats O : Chapitre 7 : - Estado de salud, capacidad functional y necesidades. In : Mas Vale Por Veijo. TA Englery et MB Pelaez (éd.). Banco Interamericano de Desarrollo, Organizacion Panamerican de Salud, Washington, DC, 2002 Whatmough, C., & Chertkow, H. (2002). Category specific recognition impairments in Alzheimer’s disease. In E. Forde and G. Humphreys (Eds.), Category specificity in brain and mind, pp. 181-210. Clarfield AM, Bergman H, Kane R. Fragmentation of Care for the Frail Elderly – Experience from three countries: Israel, Canada and the United States. The Changing Face of Health Systems. The Israel National Institute for Health Policy and Health Services Research. 2002; 151-166. Adapted from JAGS. 2001: 49: 1714-1721 Huang, A.R., Mallet, L. Traitment de l’herpes zoster. In Manuel de soins pharmaceutiques de gériatrie. Eds. Mallet, L., Grenier, L, Guimond, J., Barbeau, G. Presses de l’Université Laval, May 2003. Younes Bounhar, Omar Tounekti, Andrea C. LeBlanc, Monitoring the involvement of caspases in neuronal cell death. Neuromethods: Apoptosis Techniques and Protocols, second edition, edited by Andrea LeBlanc, Series Editor, G. Baker and A. Boulton, Humana Press, 2002, 35-60 Yan Zhang and Andrea C. LeBlanc, Microinjections as a method to study the specific role of pro-apoptotic proteins in neurons. Neuromethods: Apoptosis Techniques and Protocols, second edition, edited by Andrea LeBlanc, Series Editor, G. Baker and A. Boulton, Humana Press, 2002, 83-106 Finch E., Brooks D., Stratford P., Mayo N. Physical Rehabilitation Outcome Measures. 2nd Edition. Canadian Physiotherapy Association 2002. Elspeth Finch, Dina Brooks, Paul Stafford, Nancy Mayo. Physical Rehabilitation Outcome Measures (PROM) II. Marcel Dekker Publishers.2002 Feine J.S., Carlsson G.E., Morais J.A. et al. McGill Consensus statement on overdentures. Mandibular two-important overdentures as first choice standard of care for edentulous patients. J Prosthetic Dentistry. P 123-124, Aug 2002. Najmi Nazerali. Revision of chapters on “Les Anticonvulsivants” and “Les Medicaments AntiParkinsoniens” in Mallet L, Grenier L, Guimond J, Barbeau G. editeurs. Manuel de soins pharmaceutiques en gériatre. Les presses de l'université Laval. Aout 2003.

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Mawal Y, Berlin D, Kravitz S, Schipper HM. Heme oxygenase-1 and Alzheimer disease. In Abraham NG, Alam J, Nath KA (eds): Heme Oxygenase in Biology and Medicine, Kluwer Academic/Plenum Publishers, New York, pp. 145-155, 2002 Miller WH, Schipper HM, Lee JS, Singer J, Waxman S. Mechanisms of action of arsenic trioxide. Cancer Res 62: 3893-3903, 2002

20

PUBLICATIONS: 2002 Abstracts

Béland F, Bergman H : The SIPA Demonstration and Evaluation Project : The Agony and the Ecstasy of Integrated Care. 10th Canadian Conference on Health Economics, «Change and Stability in the Canadian Health Care System», Halifaz, Nova Scotia, 22-25 mai, page 64, 2002 Morales C, Béland F, Bergman H, Contandriopoulos AP : The SIPA Demonstration and Evaluation Project : Impact on Costs and Utilisation. 10th Canadian Conference on Health Economics, «Change and Stability in the Canadian Health Care System», Halifaz, Nova Scotia, 22-25 mai, page 64, 2002 Johri M, Bergman H, Béland F: Policy Comparisons : International Experiments in Integrated Care for the Elderly 10th Canadian Conference on Health Economics, «Change and Stability in the Canadian Health Care System», Halifax, Nova Scotia, 22-25 mai, page 65, 2002 Chertkow, H., Fung, D., Whatmough, C., Verret, L., & Paus, T. (2002). Converging PET/fMRI/TMS evidence that the left posterior temporal region is critical for semantic memory and picture naming. Neurology, 58 (Suppl 3), A270-271. Chertkow, H. ,Whatmough, C., Verret, L., Hanratty, K. & Whitehead, V. An 15O PET study of word meaning in AD. The 8th International Conference on Alzheimer’s Disease and Related Disorders. Stockholm: July 2002. Chertkow, H. Five year follow-up of Mild Cognitive Impairment – predictors of progression. The 8th International Conference on Alzheimer’s Disease and Related Disorders. Stockholm: July 2002. Babineau, V., Kabani, N., Kar, A., Sled, J., Dorr, A., & Chertkow, H. Callosal changes in dementia of Alzheimer's type and mild cognitive impairment. (2002). Geriatrics Today: Journal of the Canadian Geriatrics Society, Vol 5,(3), 125 P2. Kravitz S, Mawal Y, Sahlas DJ, Liberman A, Chertkow HM, Bergman H, Schipper HM. Heme oxygenase-1 suppressor activity in Alzheimer plasma. 127th Meeting American Neurological Association, New York City, October 13-16, 2002. Ann Neurol 52 (Suppl1): S31, 2002 Kravitz S, Schipper HM. HO-1 in central and peripheral Alzheimer tissues. 2nd International Conference on Heme Oxygenase (Catania, Italy, June 6-9, 2002). Exp Biol Med 228: 635 Berlin D, Mawal Y, Liberman A, Schipper HM. Partial characterization of a heme oxygenase-1 suppressor in Alzheimer plasma. 127th Meeting American Neurological Association, New York City, October 13-16, 2002. Ann Neurol 52 (Suppl1): S30, 2002 Lagnaoui R, Moride Y, Wolfson C, Ducruet T, Begaud B, Moore M. “The Risk of Cognitive Impairment in Elderly Community-Dwelling Women after Benzodiazepine Use”.

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Pharmacoepidemiology and Drug Safety, 2002, 11: S80. Poster at the 18th International Conference on Pharmacoepidemiology, 19-21 August, 2002, Edinburgh, Scotland. Oremus M, Wolfson C. Physician prescribing practices for Alzheimer’s disease drug treatments: What do we know? Poster presented at the 18th International Conference on Pharmacoepidemiology (International Society for Pharmacoepidemiology), Edinburgh, Scotland, UK, August 18-21, 2002. Demers L, Ska B, Desrosiers J, Alix C, Wolfson C. Les effets de la réadaptation gériatrique: quoi mesurer? 31st Annual Scientific and Educational Meeting of the Canadian Association on Gerontology. Aging and Society: Taking Charge of the Future. Montreal, October 24-26, 2002. Abstract 267 p. 127. Demers L, Alix C, Ska B, Desrosiers J, Wolfson C. Vers la conception d'un cadre conceptuel pour l'évaluation des effets de la réadaptation gériatrique. Conférence présentée dans le cadre de la Matinée des chercheurs boursiers de la 44e réunion annuelle du Club de recherche clinique du Québec. St-Sauveur, Canada, 20 septembre 2002. Médecine Sciences, 18 (suppl no 2), p8:#5. Demers L, Monette M, Lapierre Y, Arnold D, Wolfson C. Reliability, validity, and application of the Quebec User Evaluation of Satisfaction with assistive Technology (QUEST 2.0) for adults with multiple sclerosis. Disability and Rehabilitation 2002, 24(1-3), 21-30. Oremus M, Wolfson C. Physician prescribing practices for Alzheimer's disease drug treatments: What do we know? Pharmacoepidemiology and Drug Safety 2002:11(Suppl. 1):S2.

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APPENDIX III

INVITED LECTURES

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY Division members Cross appointed members Adjunct members

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INVITED LECTURES BÉLAND François Évaluation et implantation du SIPA. Workshop «Integrated services delivery networks for frail elderly : A Canadian Overview». 31e réunion scientifique et éducative annuelle de l’Association canadienne de gérontologie, Montréal, 24-26 octobre 2002. Assurance dépendance versus assurance maladie versus allocation sociale – dépendance, réflexion québécoise. VIIe Congrès international Francophone de Gérontologie, Bruxelles, 23-25 septembre 2002. SIPA: Implementation and Evaluation the Agony and Ecstasy of Integrated Care. Deutsches Zentrum für Altersfragen, 10 juillet 2002. Évaluation et implantation du SIPA. Troisième séminaire Franco-québécois sur la santé et le vieillissement, Toulouse, France, 25-28 juin 2002. The SIPA Demonstration and Evaluation Project : The Agony and the Ecstasy of Integrated Care. 10th Canadian Conference on Health Economics, «Change and Stability in the Canadian Health Care System», Halifaz, Nova Scotia, 22-25 mai 2002. The SIPA Demonstration and Evaluation Project : Impact on Costs and Utilisation. 10th Canadian Conference on Health Economics, «Change and Stability in the Canadian Health Care System», Halifaz, Nova Scotia, 22-25 mai 2002 Policy Comparisons : International Experiments in Integrated Care for the Elderly 10th Canadian Conference on Health Economics, «Change and Stability in the Canadian Health Care System», Halifaz, Nova Scotia, 22-25 mai 2002. A Model for Delivery of Integrated Care ti frail elderly persons : SIPA. Valencia Forum. Spain, 1– 4 avril 2002. BERGMAN Howard International SIPA: Implementation and Evaluation-the Agony and the Ecstasy of Integrated Care. Best Practices and Developments in Integrated Care Conference. International Journal of Integrated Care. Strasbourg, France (2002) The Assessment of Dementia. Jornadas Peruano-Canadienses de Geriatría. Lima, Peru (2002) The Global Challenge of Understanding and Meeting the Needs of the Frail Elderly Population. Jornadas Peruano-Canadienses de Geriatría. Lima, Peru (2002)

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Understanding Mild Cognitive Impairment. Jornadas Peruano-Canadienses de Geriatría. Lima, Peru (2002) Treatment and Prevention of Dementia. Jornadas Peruano-Canadienses de Geriatría. Lima, Peru (2002) Système de services intégrés pour personnes âgées en perte d’autonomie. SIPA projet de démonstration – Reflexion Canadienne. VII Congrès International Francophone de Gérontologie. Bruxelles, Belgium (2002) Système de services intégrés pour personnes âgées en perte d’autonomie. SIPA projet de démonstration - Résultats d’une étude randomisée. VII Congrès International Francophone de Gérontologie. Bruxelles, Belgium (2002) The Challenge of Understanding and Meeting the Needs of Frail Older Persons. International Japanese Conference. Japan (2002) Health Care Reform: The experience in Quebec of the Challenge of Meeting the Needs of the Population. 1st International Conference: “Problems of Population Health”. Chelyabinsk, Russia (2003) From Experimentation to Policy to Implementation: the Agony and the Ecstasy of Integrated Care. 1st International Conference: “Problems of Population Health”. Chelyabinsk, Russia (2003) Mild Cognitive Impairment: Research and Clinical Implications in the Understanding of Alzheimer’s Disease. Sociedad Argentina de Gerontología y Geriatría. III CONGRESO PANAMERICANO. Argentina (2003) National The Integration of Care for the Frail Elderly: The Agony & the Ectasy. 3rd Annual Continuing Care Conference. Health Association of BC. Vancouver, BC (2002) The Role and Value of Primary Care Practice. Inst study of Canada 7th Annual Conference: Diagnostics and Solution: Is the Can. Model of Health Care Sustainable? Montreal, Quebec (2002) The Agony and Ectasy of Integrated Care. 16th Annual Refresher Day in Geriatric Medicine. Integrating Practices: The Changing Mosaic of Care. London, Ontario (2002) Advances in the Understanding of Alzheimer’s Disease: Awaiting the breakthrough-settling for less? 16th Annual Refresher Day in Geriatric Medicine. Integrating Practices: The Changing Mosaic of Care. London, Ontario (2002)

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The Management of Dementia: Mild, Moderate, Severe. 16th Annual Refresher Day in Geriatric Medicine. Integrating Practices: The Changing Mosaic of Care. London, Ontario (2002) The Agony and Ecstasy of Integrated Care for Frail Older Persons. 19th Annual McMaster Summer Institute on Gerontology. Hamilton, Ontario (2002) Mild Cognitive Impairment and Prediction of Alzheimer’s Disease. McMaster University. Hamilton, Ontario (2002) Care for Older Persons in Quebec. The Ontario Association of Community Care Access Centre 2002 Conference. Toronto, Ontario (2002) Integrated Models of Care for the Frail Elderly. The Ontario Hospital Association Convention & Exhibition 2002. Toronto, Ontario (2002) Le Défi de l’intégration: de l’expérimentation à l’implantation. L’exemple de SIPA. PERFORM. Les Grands Sommets des Dirigeants de la Santé. Réseaux Intégrés de Services. Montréal, Québec (2003) BROWN-JOHNSON Anita Led Workshop on Management of Behavioural Disturbance in the In-Patient Setting. McGill Geriatrics Retreat CHERTKOW Howard Research Reports. AGI presents 12th Annual Education Conference, Montreal: May 30, 2002. New developments in Visual Agnosia. McGill Neurology Conference, Montreal General Hospital. Montreal: September 20, 2002. Mild Cognitive Impairment – A multi-centre approach to assessment. ACG Symosium - The Challenge of Mild Cognitive Disorders: the VRQ Consortium on Cognition and Aging Approach. Montreal: October 25, 2002. Cognitive neuroscience approaches to studying semantic memory. Universita Cattolica del Sacro Cuore. Rome: November 2002. MCI/CIND/MRI/Neuroimaging for practitioners. Update in the dementia syndrome CME 2003. Vancouver: January 2003.

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DUQUE Gustavo Senile Osteoporosis: Diagnosis and treatment. Military Geriatric Hospital. Lima, Peru Treatment of senile osteoporosis in the frail elderly. Congres Francophone de Gerontologie. Brussels, Belgium. Treatment of osteoporosis in the old and the old old in long term care: What to do and what not to do? American Medical Association Symposium. Orlando. FL. Treatment of osteoporosis in the old and the old-old. Meeting of the Canadian Geriatrics Society, Montreal, QC HUANG Allen McGill Thursday Evening Lecture Series, March 13, 2003: “The dangers of drugs” Royal Victoria Hospital Internal Medicine Residents Rounds Sept 23,2002: “Falls & Gait Disorders in the Elderly” “Drug therapy in the elderly” WebCT presentation for the Practice of Medicine rotation in Geriatric Medicine, July 2002. INGLIS Gary Mild cognitive impairment and Alzheimer disease. The 18th Annual medical conference on ageing, Saint-George Hospital and University of Balamand. Beirut 7-10 november 2002. LEBLANC Andrea Neuronal Cell Death and Survival in Alzheimer’s disease. McGill University Division of Geriatric Medicine Grand Rounds, Montreal, Qc. April 9, 2002. MALLET Louise Les médicaments potentiellement non appropriés en gériatrie : 27 février 2003. Conférence donnée aux médecins de médecine familiale. Laval Le traitement de l’ostéoporose. Vision Santé. 26 octobre 2002. Conférence donnée aux pharmaciens communautaires. Montréal.

Le traitement de l’herpès zoster. 30 octobre 2002. Conférence donnée aux pharmaciens en CHSLD. C. H. Chauveau. Québec. Olanzapine : déficit du métabolisme du glucose. 30 octobre 2002. Conférence donnée aux pharmaciens en CHSLD. C. H. Chauveau. Québec.

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Soins pharmaceutiques en gériatrie : Formation continue de l’APES. 12 novembre 2002- Baie Comeau MONETTE Johanne Programme d’interventions communautaires qui visent à optimisr la thérapie pharmacologique des personnes âgées fragiles Mieux vieillir à petite dose.” Hotel Sheraton. Laval, November 23, 2002 Coûts reliés aux séjours en hébergement : étude de cohorte : création d’une matrice. Université McGill, Groupe Solidage, December 5, 2002 Mesure des signes extrapyramidaux parmi les personnes âgées hébergées : étude de validation”. Summer seminars of the Centre of Clinical epidemiology and Community Studies. Jewish General Hospital. 2002 MORAIS José Symposium entitled: Implant Overdentures as Minimum Standards of Care for Edentulous Patient’s. McGill University, Montreal, Nutrition and Edentulism. May 24, 2002. McGill University, Geriatric Medicine Grounds, Osler Amphitheater, Montreal General Hospital; From Tea and Toast to Folic Acid: Homocysteine: a risk factor for cognitive impairment. February 18, 2003. Montreal General Hospital, Medical Grand Rounds, Osler Amphitheatre. Homocysteine: a risk factor for cognitive impairment. March 25, 2003. SCHIPPER Hyman Glial aging, oxidative stress and Parkinson's disease. Anatomy 504-541B, McGill University, Feb. 21, 2002. Introduction. Free Radical Biomedicine (NEUR 550), McGill University, January 6, 2003 Antioxidant enzymes. Free Radical Biomedicine (NEUR 550), McGill University, January 20, 2003 Aging. Free Radical Biomedicine (NEUR 550), McGill University, February 17, 2003 Redox Neurology I (An Overview). Free Radical Biomedicine (NEUR 550), McGill University, March 3, 2003 Redox Neurology II (A Model). Free Radical Biomedicine (NEUR 550), McGill University, March 3, 2003.

28

Epilogue. Free Radical Biomedicine (NEUR 550), McGill University, April 7, 2003 Approaches to biomarker discovery in Alzheimer’s Disease (H. Yu, S. Kravitz, H.M. Schipper). Diploma in Clinical Research (516-619) Div. of Experimental Medicine, McGill University, May 3, 2003 Heme oxygenase-1 suppressor activity in Alzheimer plasma (S. Kravitz, Y. Mawal, D.J. Sahlas, A. Liberman, H.M. Chertkow, H. Bergman, H.M. Schipper). FRSQ and McGill Division of Geriatric Medicine 7th Annual Research Day, Montreal, April 26, 2002. Is HO-1 mRNA in Alzheimer mononuclear cells chemically unstable? (D. Berlin, Y. Mawal, H. Chertkow, H. Bergman, H.M. Schipper). FRSQ and McGill Division of Geriatric Medicine 7th Annual Research Day, Montreal, April 26, 2002. Principles of Redox Neurology. McGill Neurology Conference, Jewish General Hospital, May 24, 2002. Heme oxygenase-1 expression in the human eye (M.B. Mydlarski, J. Deschenes, H.M. Schipper). 25th Annual McGill Ophthalmology Clinical and Scientific Research Day. May 23-24, 2002 Age-related expression of HO-1 and GFAP in the human eye (M.B. Mydlarski, J. Deschenes, H.M. Schipper). 26th Annual McGill Ophthalmology Clinical and Scientific Research Day. May 29-30, 2002 Provincial/National/International Hemochromatosis as a factor in Alzheimer disease: Live Discussion. Alzheimer Research Forum, www.alzforum.org/members/forums/journal.milward/index.html, January 22, 2002. Heme oxygenase-1: Role in brain aging and neurodegeneration. Centre for Neuroscience Studies Seminar Series, Queens University, Kingston, Ontario, March 13, 2002. Principles of redox neurology. Neurology Rounds, Queens University, Kingston, Ontario, March 14, 2002. HO-1 in central and peripheral Alzheimer tissues. Invited Symposium Speaker, 2nd International Conference on Heme Oxygenase (Catania, Italy, June 6-9, 2002; represented by S. Kravitz, student). Schipper Lab 2002. Journée scientifique du Consortium Cognition et Vieillissement, Centre de recherche institut universitaire de gériatrie de Montréal, May 28, 2002. Alzheimer Disease: Quest for diagnostic and surrogate biomarkers. Caprion Pharmaceuticals, Inc. Montrael, June 7, 2002.

29

VAITEKUNAS Susan Use of Cholinesterase Inhibitors in Dementia – presented to Herzl Family Practice Residents, April 18, 2002 Falls in the Elderly - Herzl CME , Oct. 29, 2002 Workshop on “Falls in the Elderly” McGill University Family Practice Uptake, Nov. 27, 2003 WINDHOLZ Sylvia Core Lecture for Family Medicine Residents. SMBD Jewish General Hospital:. Ethical issues. Informed Decision Making May 29, 2002 Demencia, una visión actualizada, un enfoque multidisciplinario: 12 hours course on dementia. Escuela Internacional de Gerontologia, A Coruña, Galicia, Spain. July 3 and 4, 2003 Medications in the Elderly: Lecture to 3rd year Occupational Therapy Students, School of Physical and Occupational Therapy, McGill University, March 13, 2003 End-of-Life Issues: Thursday Evening Lecture Series. (McGill CME) Montreal, March 13, 2003 WOLFSON Christina Statistics Careers Day, Concordia University. “A career in statistics? You bet!”. Montreal, November 21st, 2002. Gertrude H. Sergievsky Center. “Multiple Sclerosis and Viruses: Is the epidemiological evidence convincing.” Columbia University, New York, USA, May 28, 2002.

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APPENDIX IV

AWARDS/NOMINATIONS

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

31

AWARDS/NOMINATIONS 2002 - 2003

BROWN-JOHNSON Anita Director, Secondary Care Division, MUHC Department of Family Medicine (April 2002–present) CHERTKOW Howard Appointed Scientific Officer, CIHR Biological and Clinical Aspects of Aging Committee (2002) DUQUE Gustavo McCall Hutchinson Award, Web-based self-learning system as a complement of learning for first year medical students ($27,000) LEBLANC Andrea William Dawson Scholar Award, McGill University, 2003 – 2008 National Institutes of Health, Division of Research Grants, Member of Molecular, Cellular and Developmental Neuroscience, member Feb 2003-June 2006 MAYO Nancy Chercheur-boursier, Senior. FRSQ. $182,58. (1998-2002) MONETTE Johanne Bourse de chercheur clinicien (Career award), Fonds de la Recherche en Santé du Québec (Medical Research Council of the Province of Quebec): first year: 22 906 $, second year: 24,132$, third year: 25 357 $ (2000-03) MORAIS José McGill, Assistant Professor – University Based FRSQ - Chercheur-clinicien Junior II level

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SCHIPPER Hyman Fonds de la Recherche en Santé du Québec (FRSQ). Chercheur Boursier Senior (Salary award: $252,423) "Mechanisms of pathological brain iron deposition in Parkinson disease" (1999-2003) Prize for best scientific presentation. FRSQ/McGill Division of Geriatrics Annual Research Day, Montreal, April 26, 2002: Is HO-1 mRNA in Alzheimer mononuclear cells chemically unstable? (D. Berlin, Y. Mawal, H. Chertkow, H. Bergman, H.M. Schipper) (2002) Challenge 2002 Summer Student Award, Human Resources Development Canada (2002) Prize for best clinical presentation. 25th Annual McGill Ophthalmology Clinical and Scientific Research Day. May 23-24, 2002. Heme oxygenase-1 expression in the human eye. (M.B. Mydlarski, J. Deschenes, H.M. Schipper). (2002) WOLFSON Christina Promoted to Full Professor, Department of Epidemiology and Biostatistics, and Department of Medicine, McGill University. (June 2002) “Student Advocate Award” for outstanding advocacy on behalf of students. Department of Epidemiology and Biostatistics, McGill University. (May 2002)

33

APPENDIX V

COMMITTEE WORK

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

34

COMMITTEE 2002 - 2003

BÉLAND François Congrès et colloques Membre du Comité scientifique du 26e Congrès de l’Association canadienne de gérontologie, Montréal, Octobre 2002. Membre de Conseils, comités et de groupes de travail : Conseil de la santé et du bien-être, 2002- Membre du comité de préparation sur l’Avis sur le financement privé des services médicaux et hospitaliers, 2003. Conseil consultatif de l’Institut canadien de recherche sur la santé des hommes et des femmes, 2000 – Conseil d’administration du Centre hospitalier Jacques-Viger, 1999 – Conseil consultatif de gérontologie, ministère des Anciens combattants, 1997 – Comité consultatif sur la politique sociale de la Direction générale de la politique, de la planification et de l’information du ministère de la Santé et du Bien-être social du Canada, Ottawa, 1992 – Conseiller Ministère de la Santé et des Services sociaux, Ontario, consultation sur la politique des soins de longue durée, mai 2002. Rédacteur • Rédacteur en chef. Ruptures : Santé publique, 2001-. • Membre du comité scientifique international de la Revista de Gerontologia, 1991 – . • Membre du comité scientifique international de Health & Social Care in the Community,

1995– Arbitre pour revues scientifiques et congrès • Sociologie et sociétés, 1986, 2002. • Social Science & Medicine, 1988, 1992, 1993, 1994, 1995, 1998, 2000, 2002. • Cahiers québécois de démographie, 1999, 2003 BERGMAN Howard Executive Committee, McGill Division of Geriatric Medicine 1991-present Education Committee, McGill Division of Geriatric Medicine 1994-present Policy Committee, Jewish General Hospital Department of Medicine 1990-present

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Journals Editorial Board Revue de Gériatrie (publiée en France), membre, Comité Scientifique 1996-present Geriatrics & Aging 1998-present International Journal of Integrated Care (IJIC) 2001-present Geriatrics Today 2001-present Ad hoc Reviews Canadian Family Physician 1988-present Canadian Journal on Aging 1990-present Canadian Medical Association Journal (CMAJ) 1992-present Journal of the American Geriatrics Society 1993-present Age and Ageing 1998-present Grant reviews Committees • Merit Review Panel, Canadian Health Services Research Foundation 1998-present • FRSQ Comité pour l’évaluation des demandes de subventions 2000-present

à la recherche évaluative, épidémiologique et opérationnelle Ad hoc reviews • National Health Research and Development Programs (NHRDP), 1990-present

Health and Welfare Canada • Medical Research Council, Canada 1992-present • Fonds de la Recherche en Santé du Québec (FRSQ) 1991-present Conference Organizer, Health Challenge 2002 Annual Workshop: Managing Health Beyond Borders: Integrated Care for Integrated Health, McGill University 2002 BROWN-JOHNSON Anita • Member of MUHC Department of Family Medicine Executive Committee (April

2002 – present) • MUHC Division of Geriatrics Executive Committee • MUHC Transition Care Task Force: (October 2002 – present)

Mandated by the Chief Operating Officer, Victor Simon, to review the distribution of transition care patients within MUHC Adult Sites, and endeavour to regroup those patients occupying acute care beds. The Task Force met over a period of four months and submitted its recommendations to the MUHC Utilization Management Committee and MUHC Operations Committee in February 2003. Subsequently, a subgroup was formed to facilitate implementation of the recommendations.

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• Physician Representative on MUHC Transition/Long-Term Care Quality Management Committee: (March 2000 – present)

This committee analysed indications and utilization of physical and chemical restraints in transition care patients with behavioural disturbance, and instituted appropriate monitoring of same, respecting the guidelines of the Collège des Medécins du Québec.

Established standards for systematic determination of patients’ level of care in consultation with patients and/or families on Transition Care Service (MGH & RVH sites).

Participated in subgroup working to develop a new multidisciplinary Kardex. Established standards for family meetings to be held within three weeks of admission

to Transition Care Unit (RVH & MGH Sites). Family Meeting Satisfaction Survey completed over one year duration at MGH site

resulted in 96.7% satisfaction rating.

• Member of MUHC Interdisciplinary Workgroup on Management of Behavioural Disturbance (Sept 2002 – present)

• MUHC Physician Representative on Joint MUHC-Grace Dart Extended Care

(GDECC) Board-Appointed Committee: (October 2001 – December 2002) This committee was mandated to determine the needs of long-term care patients presently and in the future, once the new MUHC facility is built, and to propose solutions to adequately meet their needs. Over a period of 15 months, this committee completed its analysis and submitted a report with recommendations to both MUHC and GDECC Boards of Directors in December 2002.

• MGH Physician Representative on MUHC Joint Committee on Patient Care: (April

2002 – present) This committee was mandated to review and advise on matters relating to patient care of an interdisciplinary nature. During the course of the past year, we have been reviewing and revising the delegation of professional acts at MUHC, and developing standards for documentation and monitoring of same.

• Member of Division of Geriatrics Committee on Morbidity & Mortality – MGH Site

(Spring 2002 – present)

• MUHC – GDECC Committee on Shared Medical Manpower (Spring 2002 – present)

• Participated in MUHC Division of Geriatrics Retreat to develop Balanced Scorecard. (February 2003)

• MUHC Co-Lead for Long-Stay Patient Workgroup, mandated to analyze clinical

efficiency for MUHC Operational Review. (Fall 2001 - 2002)

37

• MUHC Division of Geriatrics Long-Term Care Declaration and Discharge Planning Policy Development Committee (January 2000 – December 2001)

• Co-Chair, MUHC Division of Geriatrics Transition Care Services Task Force:

(November 2000 – June 2001) Developed MUHC Division of Geriatric Medicine Transitional Care Position Paper.

CHERTKOW Howard 2000 Jewish General Hospital Academic Advisory Committee 1998 Medical advisor, Québec division of the Alzheimer’s Society of Canada. 1999 Member, Executive Committee, Lady Davis Institute, S.M.B.D.-Jewish General Hospital 2001 Coordinator, Québec Consortium for Alzheimer’s disease and Related Neurodegenerative

Disorders. 2001 Member, FRSQ (Fonds de la recherche en santé du Québec) Committee for awarding

chercheur-boursier clinicien salary grants. 2002 Action Editor, Brain and Cognition. 2003 Leader, FRSQ site visit for ‘GRENEC’ group grant, Université de Montreal. DUQUE Gustavo Education Committee, Division of Geriatric Medicine, McGill University FISHER Gillian Examiner for Family Medicine OSCE exam in May 2003 Attendance at course for Medical Examiners dealing with complaints in the hospital setting. GOLD Susan Coordinator, Undergraduate Medical Education, McGill University HEILPERN Paul Chair, Mortality and Morbidity Committee, Division of Geriatric Medicine, Jewish General Hospital HUANG Allen 2003 Member Alternate Level of Care Task Force MUHC 2002- Chair Division of Geriatric Medicine administrative committee MUHC 2002- Member Utilization Management Committee MUHC 2002- Member Expected Date of Discharge ad hoc Sub-committee MUHC 2002 Member Acute Rehabilitation Unit ad hoc workgroup MUHC 2002 Member Emergency Room Bed management committee MUHC

38

2001- Member Clinical Information System Selection and Implementation Team MUHC-CHUM

2000- Chair Hutchison Scholarship Fund MGH 2000- Chair Levinschi Foundation Fund Committee MGH 1999- Co-chair Geriatrics Quality Management Committee MUHC 1997- Co-chair 8 Medical Service Management Committee RVH 1997- Member Transition Care Work Group MUHC 1997- Member Medical Pavilion Management Committee RVH 1995- Member Division of Geriatric Medicine Executive Committee McGill 2000- Member & examiner Geriatric Medicine Specialty Examination committee. Royal College of Physicians and Surgeons of Canada LEBLANC Andrea Member of Graduate Student Committee of the Neuroscience Department., McGill U.1996-2003 Ad Hoc Reviewer, National Prion Research Program 1, United States army medical research and material command (USAMRMC), Department of Defense. September 2002 to December 2002, Meeting in Washington Dec. 4-6, 2002. Advisory Committee: Student Degree Department Supervisor Year Tara Moriarty Ph.D. Anatomy and Cell Biol. Chantal Autexier 2000- Julie Pilotte Ph.D. Experimental Medecine Stephane Richard 2000-2002 Lisa Mandrusiak M.Sc. Endocrinology Mark Trifiro 2002-2003 Sophie Gaudreault Ph.D. GPNS Judes Poirier 2002- Examiner Student Degree University Supervisor Year Committee Jordanna Bermack Ph.D. McGill G. Dubonnel 2002 Candidacy Exam GPNS chair Heather Pim M.Sc. McGill G. Dubonnel 2002 M.Sc. Seminar GPNS chair Steve Szabo Ph.D. McGill P. Briere 2002 Ph.D. Seminar GPNS chair Steve Szabo Ph.D. McGill P. Briere 2002 Ph.D. Defense GPNS chair Wenhua Zheng Ph.D. McGill Remi Quirion 2002 Ph.D. Defense/Examiner Tara Moriarty Ph.D. McGill C. Autexier 2002 CandidacyExam/Examiner Younes Bounhar M.Sc. McGill A. LeBlanc 2002 Thesis Internal Examiner Elise Levinoff M.Sc. McGill H. Chertkow 2002 M.Sc. Seminar GPNS chair Matthier Fortier M.Sc. McGill F. Miller 2002 M.Sc. Seminar GPNS chair Ian McKenzie Ph.D. McGill F. Miller 2002 Candidacy Exam GPNS chair Mandanna Modirrousta M.Sc. McGill B. Jones 2002 Candidacy Exam GPNS chair

39

MALLET Louise Traduction de résumés de l'anglais au français pour le journal Annals of Pharmacotherapy. Réviseur scientifique: Annals of Pharmacotherapy Réviseur scientifique : Canadian Society of Hospital Pharmacists Responsible de la chronique pharmacothérapie pour le journal PharmActuel- journal des pharmaciens des établissements de santé du Québec MAYO Nancy Journals Present Co-Editor Clinical Research, Physiotherapy Canada Present Reviewer, Stroke; Archives of Physical Medicine and Rehabilitation,

Current Administrative Responsibilities 2000-present Member, Planning and Priorities Committee, Canadian Stroke Network 2000-present Theme Co-Leader, Canadian Stroke Network 1999-present Co-Theme Leader: Health Outcomes Axis, MUHC Research Institute 1994-present Co-Director, Health Services and Outcomes Research Group. Department

of Medicine & Department of Epidemiology and Biostatistics Current Committees 1999-present MUHC Research Institute, Executive Advisory Panel (Elected) MONETTE Johanne Professional and Learned Societies Committee Membership 1987-present The Quebec Medical Association 1991-present Quebec Association of Geriatricians 1991-present The Royal College of Physicians and Surgeons of Canada 1992-present Quebec Geriatric Society 1992-present Canadian Society of Geriatric Medicine 1992-present American Geriatrics Society MORAIS José FRSQ – Member of the Review board for the evaluation of post-graduate application – professional diplomas.

40

FRSQ – Member of the Executive Committee of the Provincial Reseau for Aging Research Member Examination Jury for the Certicate of specialist in Geriatric Medicine, College des médecins du Québec, March 19-20, 2002 (written); September 5-6, 2002 (oral) Member FRSQ; Réseau – Nutrition and Healthy Aging Member of the Committee for searching new director of the Réseau on Aging and Research – FRSQ CIHR – Review of 1 application for Institute of Aging Journal of Age and Aging - Review of 1 manuscript Canadian Diabetes Association – External reviewer of 3 applications NAZERALI Najmi Member of Scientific Committee for McGill Annual Family Medicine Refresher Course (Nov 27-29, 2002) SCHIPPER Hyman McGill 1993- Health Sciences Library Advisory Committee. Conducted survey to assist the Health

Sciences Library in the acquisition of 1994-5 monographs and textbooks. 2001- Appointment, Promotion and Tenure Committee, Dept. of Neurology and Neurosurgery 2002 Tomlinson Fellowship Committee Other 2002 Scientific Advisory Board, Celmed Biosciences, Inc. (Montreal) 2003 Biology of Aging Working Group-Canadian Longitudinal Study of Aging Other Scholarly Activities 2002 Submitted report to Brown University School of Medicine (Dr. A. Kane) in support of a

candidate's promotion to Full Professor of Neuropathology

41

2003 Contributed to biography of Dr. Eugenia Wang published in SCIENCE ONLINE by I. Chen: “The Accidental Biologist”. Sci. SAGE KE 2003, nf8 (30 April 2003) http://sageke.sciencemag.org/cgi/content/full/sageke;2003/17/nf8

VAITEKUNAS Susan Medical Records Committee Organization JGH Division of Geriatrics Journal Club Co-chair Accreditation Committee JGH Division of Geriatric Medicine WINDHOLZ Sylvia National: 1997-present Health Care for the Elderly Committee (Quebec Representative) College

of Family Physicians of Canada. 1996-present Peer reviewer for the Canadian Family Physician Journal 2002-present Editorial Board member and peer reviewer for Geriatrics Today: Journal

of the Canadian Geriatrics Society Provincial: 2001-May 2003 President, Société Québécoise de Gériatrie. 1997-present Member, Executive Committee, Société Québécoise de Gériatrie. 2001-2002 Comité Gériatrie et Soutien au Réseau, Ministère de la Santé et des

Services Sociaux McGill University: 1996-present Education Committee, McGill University, Division of Geriatric Medicine. Sir Mortimer B. Davis - Jewish General Hospital 1991-present Clinical Ethics Committee 1998-present Clinical Ethics Subcommittee: developing the SMBD Jewish General

Hospital Living Will Project. 2001-present Critical Intervention Committee

42

1995-present Committee for the Assessment of Medical Acts (CAMA) 1999-present Network Integration Committee 1995-present Management Committee, Division of Geriatric Medicine: Other committee work: 2000-2002 Services Committee, Cummings Jewish Centre for Seniors 1997-2002 Member, Board of Directors, Cummings Jewish Centre for Seniors 1999-Sept 2002 Member representing McGill University, Board of Directors, CLSC René

Cassin WOLFSON Christina Journals - Ad hoc Reviews Journal of Clinical Epidemiology Canadian Medical Association Journal Canadian Journal of Neurological Sciences Stroke Epidemiology Canadian Journal of Aging Annals of Epidemiology Lancet Journal of Geriatric Psychiatry and Neurology Other Committees President. FRSQ Comité d’évaluation du Centre de recherche de l’Institut universitaire de gériatrie de Sherbrooke. 2001.

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APPENDIX VI

TEACHING ACTIVITIES

GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

44

TEACHING ACTIVITIES BERGMAN Howard CME/McGill 2002 MCI/Early Dementia: Diagnosis. Geriatric Medicine for Practitioners, McGill

University, Continuing Medical Education 2002 Incentives and the Configuration of Services in the Canadian Health Care System.

Health Challenge 2002 Annual Workshop, McGill University McGill Geriatric Medicine Grand Rounds 2002 SIPA - Implementation and Evaluation; The Agony and the Ecstasy of Integrated Care Other Universities (Post Graduate) Fragmentation ou Intégration: l’Organisation des Services pour Personnes Âgées Vulnérables. Evolution vers des systemes integres. Master’s Course. Département d’administration de la santé, Université de Montréal. (2002) Fragmentation ou Intégration: l’Organisation des Services pour Personnes Âgées Vulnérables. Diplôme Universitaire de Qualite en Sante. Promotion 2000-2002. Universite de Paris. Paris, France (2002) Supervisor 1999-present Co-thesis director, PhD student, Université de Marseille 2002-2003 Co-thesis director, PhD student, Unviersité de Paris 2002-present Co-thesis director, PhD student, McGill University BROWN-JOHNSON Anita PostGraduates • Supervised University of Montréal Fellow in Geriatric Pharmacy during rotation in

Transition/Long-Term Care at MGH site. (September 2002) • Served as consultant in design and data analysis of a study completed by a Masters of Health

Administration student at Université de Montréal investigating reasons for transfers of patients from GDECC to emergency rooms at the MUHC, and exploring potential role of telehealth medicine in reducing number of transfers.

45

Courses Taught • Geriatric Clerkship – Transition Care Course: (October 2002 – present)

Interactive workgroup format, one afternoon per month, for 2nd year medical students. • Clinical Tutor in Geriatrics for McGill University “Introduction to Clinical Medicine”

(ICMB) course, MGH. (Spring 2002) Family Medicine Preceptor for 2nd year medical students in McGill University “Introduction to Clinical Sciences Course” in private practice. (Spring 2001 – 2002) CHERTKOW Howard Graduate Students 2000-03 Elise Levinoff, M.A. Student, Dept. of Neurosciences, McGill University (supervisor). Postdoctoral Fellows 1998 Christine Whatmough, Ph.D., Psychology (Université de Montréal) 2000 Daniel Saumier, Ph.D. Psychology (Université de Montréal) 2002 Ahn Duong, Ph.D. Bio-Medical Sciences, Option - Speech Pathology (Université de

Montreal) 2002-03 Dr. Michèle Houde . M.D. (Université deLaval): post-graduate Pschiatry fellow . DUQUE Gustavo Curriculum development: Design and organization of the Clerkship in Geriatric Medicine for third year medical students Undergraduate Associate Director, undergraduate medical students. Division of Geriatric Medicine. Physiology of bone. Graduate students.McGill University Teaching Scholar- Faculty Development, McGill University Macy Scholar in Medical Education – Harvard University, Boston, MA. Tutor, small group sessions, Division of Endocrinology, Department of Medicine, McGill University.

46

Seminars on aging, aging bone. Faculty of Graduate studies and Research, Division of Experimental Medicine Back to basics: bone metabolism. Seminars for last year medical students

Postgraduate Core Internal Medicine Residents, Jewish General Hospital. Hip fractures: prevention and management in the elderly. Core Internal Medicine Residents, Jewish General Hospital. Anticoagulation in elderly. Rounds 2003 Anabolic treatment for senile osteoporosis: From mice to human. Department of

Medicine Grand Rounds. Jewish General Hospital, McGill University 2003 Anabolic treatment for senile osteoporosis: Division of Geriatrics Rounds. McGill

University Health Centre FISHER Gillian Examiner for Family Medicine OSCE exam in May 2003 Attendance at course for Medical Examiners dealing with complaints in the hospital setting. HUANG Allen Undergraduate Clinical Teaching 2002-present Practice of Medicine Clinical Clerkship rotation in Geriatric Medicine Clerkship

medical students. McGill University 1991-present Introduction to Clinical Sciences & Professional skills. Pre-clinical clerkship

medical students. McGill University Postgraduate Clinical Teaching 1989-present Geriatric Medicine rotation Internal Medicine, Emergency Medicine McGill

University GRADUATE STUDENTS (SUPERVISED) 2003-present 18 students across Canada. MSc, PhD. CIHR Health Informatics PhD/Postdoc Strategic Training Program. U Victoria, McGill U & pan-Canadian partnerships

47

LEBLANC Andrea Graduate Students and Postdoctoral Fellows Younes Bounhar, M.Sc. student May 1999-2003 Yan Zhang Ph.D. student September 1999- (Alzheimer Society of Canada doctoral awardee) Omar Tounekti, Post-doctoral fellow October 2000-November 2002 Emily Vereker, Post-Doctoral fellow, May 2001-May, 2002 Huishan Guo, M.Sc. student, October 2001- Xavier Roucou, PDF January 2002- Malcolm Gains, Ph.D. student March 2002- Guy Klaiman, M.Sc. student November 2002- Lina Musallam, Ph.D. Post-doctoral fellow January 2003- (Alzheimer Society of Canada/CIHR PDF 003-2005- ranked 1st). Undergraduate students Heather Ternan April 2002- Present (FRSQ summer scholarship 2002) Alex Goldberg May 2002-August 2002 MALLET Louise Graduate Students and Postdoctoral Fellows Directeur de la résidence spécialisée en pharmacie gériatrie : Novembre 2002-Octobre 2003. Résidente : Louise Papillon-Ferland Lectures at the Faculté de Pharmacie- Université de Montréal PHM 3541 : Pharmacothérapie 2: 4 crédits: 1er cycle (15 heures) PHM 6100: Pathophysiologie et pharmacothérapie avancée: 2 ième cycle (3 heures) PHM 6504 : Pharmacothérapie gériatrique (3 crédits)) Responsable du cours et prestation de cours. Heures de cours dispensés : 20 heures de cours PHM 2444 : Antibiotiques et infectiologie. Le traitement de la tuberculose. 2 heures. PHM 2282: Problèmes pharmaceutiques 1er cycle (2 crédits) Supervision d'une étudiante pour la rédaction d’un article : Traitement de la dépression chez les patients souffrant de la maladie de Parkinson.

48

MAYO Nancy Carolina Moriello. In people with stroke, is strength an independent variable of endurance or is its effects mediated by other consequences of the neurological damage. 2003 MONETTE Johanne Thesis committee member for Nadine Larente, MD, candidate for a PhD in Ethics, Université de Montréal, ““Informed consent regarding resuscitation orders and other types of advance directives. Realisation of an educational to best inform the elderly population and their families on the salient issues related to advance directives”. MORAIS José Undergraduate Gastro-enterology, Endocrinology, Metabolism and Nutrition. February 6, 2003, 1 hr Lecture on Nutritional Assessment, February 7, 2003 Back to Basics, April 18, 2002, April 15, 2003, 3 hr Introduction to the patient (Unit 9A) Course 3524-161H. Participation in small group sessions on lecture on Spirituality in Medicine, November 20, 2002, 2 hr Physical and Occupational Therapy Department. Lifespan Course: Physical and social aspects of aging, November 28, 2002. Research Training Supervisor Stéphanie Chevalier – end of December 2002 Manal Subki – end of May 2002 Member on Thesis Committee: Sylvia Santos External Reviewer PhD Thesis Committee of Heather Lambert, Department of Physical and Occupational Therapy, McGill University, Fall 2002. Clinical Teaching Instructor in the clerkship in Geriatric Medicine Practise of Medicine – POM. Four months/year, started July 2002. Internal Medicine Residence Lecture. Royal Victoria Hospital, “Delirium: a diagnosis for internists” July 22, 2002.

49

Lecture on Geriatric Nutrition for Internal Medicine Residents rotating in Geriatric Medicine, 1 hour/month ended in July 2002. NAZERALI Najmi Graduate Students and Postdoctoral Fellows Program Director Health Care of Elderly Training Program ( 3rd Year Family Medicine) SCHIPPER Hyman Post-doctoral Wei Song, M.D., Ph.D. (2002- ) (Co-supervisor: Dr. Hemant Paudel) Dr. Song is investigating the effects of HO-1 up-regulation on downstream signal transduction pathways in cultured astroglia. Haixiang Su, Ph.D (2002- ) Responsible for establishing antioxidant enzyme and oxidative damage assays in our institute’s Biomedical Redox Laboratory Graduate Dan Berlin (2000-2002) (M.Sc. program, Dept. of Neurology & Neurosurgery, McGill University) Dan studied the relationship between hfe (hemochromatosis) gene mutations and the natural history of Alzheimer disease and Mild Cognitive Impairment (MCI). Thesis title: “The role of hfe gene mutations in sporadic Alzheimer disease” Steven Kravitz (2000- ) (M.Sc. program, Dept. of Neurology & Neurosurgery, McGill University) Steven is characterizing a novel heme oxygenase-1 suppressor (HOS) activity in plasma derived from Alzheimer subjects and patients with other neurological and medical disorders. Michael Assaraf (2002- ) (M.Sc. program, Dept. of Neurology & Neurosurgery, McGill University) Michael is investigating the potentially neuroprotective role of erythropoietin in Alzheimer disease and Mild Cognitive Impairment (MCI).

50

Sisi Song (2002- ) (M.Sc. program, Dept. of Neurology & Neurosurgery, McGill University) Mr. Song is studying the effects of HO-1 up-regulation on oxidative mitochondrial injury in cultured astroglia. Zuanel Diaz (2002- ) (PhD Program, Div. of Experimental Medicine, McGill University) Co-supervisor: Dr. Wilson Miller. Zuanel is investigating redox mechanisms of arsenic toxicity. Awarded McGill University Max Stern Recruitment Fellowship (2002-2003). Graduate Student Research Committees Oral examiner on Ph.D. Thesis Defense, Dept. of Medicine (Division of Experimental Medicine), McGill University (Candidate: Louis-Bruno Ruest) Graduate Student Advisory Committee, Dept. of Neurology & Neurosurgery, McGill University (Candidate: Katherine Neufield) External examiner on M.Sc. Thesis, Dept. of Neurology & Neurosurgery, McGill University (Candidate: Suh Young Jeong) Graduate Student Advisory Committee, Dept. of Genetics, McGill University (Candidate: Thomas Scanlon) Internal Examiner on PhD thesis, Dept. of Anatomy and Cell Biology, McGill University (Chantale Lacelle, candidate) Undergraduate Research Students Yaron Spitzer Concordia University 2001-2002 Marcus Povitz McGill University Summer 2002 VAITEKUNAS Susan Course facilitator – Learning program on Alzheimer’s disease and other dementias, Module 3 (MainPro C Course for Family Physicians) March 29, 2003 Supervision clinical clerks, family medicine residents, internal medicine residents, geriatric fellows on acute geriatrics ward, ER consult team, in-patient consult team, memory & geriatric clinics

51

Lectures on falls to clerks, residents and fellows WINDHOLZ Sylvia 1996-present Associate Program Director of the Health Care for the Elderly Fellowship

Program. 2002-present Coordinator for the Geriatric Rotation for Family Medicine Residents (Herzl

FMU, SMBD Jewish General Hospital and CLSC Côte des Neiges) 2001-2002 International: Invited professor. SYSTED – Escuela Internacional de

Gerontologia, Spain Teaching to medical students, family medicine residents, internal medicine residents and geriatric fellows rotating through the Division of Geriatric Medicine Workshop for the 3rd year Occupational Therapy students. School of Physical and Occupational Therapy, McGill University, March 13th, 2003 WOLFSON Christina Post Doctoral Fellows Dr. Fraser Moore. Department of Neurology and Neurosurgery. Neurology Resident RV. “The assessment of Quality of Life in Multiple Sclerosis”. 2001-2002. Dr. Eric Marmor. Department of Neurology and Neurosurgery. Neurosurgeon. “The role of surgical resection of brain tumours arising from astrocytes in improving survival”. 2002. PhD Students Mark Oremus, Department of Epidemiology & Biostatistics. Thesis Supervisor. Thesis Title: “Use of medications in the Alzheimer's disease population: Physician and caregiver perspectives”. PhD candidate 2000- Source of funds: : CIHR; Scottish Rite Charitable Foundation. John Podoba, Department of Epidemiology & Biostatistics. Thesis Supervisor. Thesis Title: “Unmet needs in community dwelling elders: impact on use of medical services”. PhD candidate 1999- Source of funds: CIHR. MSc Students Dr. Stephen Vida. Department of Epidemiology & Biostatistics. Thesis Supervisor. Thesis Title: “Delirium as a marker of cognitive decline”. MSc candidate. 2001-2003.

52

Marie-Rose Shoucri. Department of Epidemiology & Biostatistics. Thesis Topic: “Assessment of exposure to infectious agents in case-control studies of multiple-sclerosis”. MSc candidate 2003- Course Taught 2002-2003 Instructor. Principles of Study Design & Analysis II. 3 credits. (39 hours) 2002-2003 Lecturer Half-Day for Neurology Residents. Neurology Academic Introduction to Neuroepidemiology (6 hours).

53

APPENDIX VII

DIVISION OF GERIATRIC MEDICINE JEWISH GENERAL HOSPITAL

CONSULTATION

2002 - 2003

Division member Cross-appointed to the division Adjunct Member

54

CONSULTATION Public and Private Sector

BERGMAN Howard 2002 Canadian Advisory Board on Exelon, Novartis Canada. Geneva, Switzerland 2002 Health Management Advisory Board, Aventis Pharma. Vancouver, BC BROWN-JOHNSON Anita Public Sector Community Outreach Project: Telephone consults with select long-term care facilities regarding management of particularly challenging cases discharged from MUHC Transition Care Service. (Fall 2001 – present) MUHC Physician Representative on the Long-Term Care Network Advisory Group: (June 2001 – present) Through this community outreach activity, we continue to foster the development of closer partnerships with community long-term care facilities, sharing our expertise in the care of the elderly, identifying and working to overcome obstacles to more timely discharge of patients awaiting placement, thereby facilitating continuing care of our most vulnerable elderly patients in the community. Together with my colleagues in Geriatrics, I participated in development of proposal for a clerkship in Geriatric Medicine for Undergraduate Medical Students as it pertains to the educational objectives in Transition/Long-Term Care. Consultant to Length of Stay Committee, MGH. (2001 - 2003) Private Sector Operate private practice in Family Medicine in Notre-Dame-de-Grace, one-half day per week. (January 2000 – present) CHERTKOW Howard 1999- Pfizer 2001- Janssen-Ortho, Astra Zeneka, Neurochem Advisory Boards

55

LEBLANC Andrea Public Sector 1998, 2000, 2002, 2003 Course 501-541B McGill U. Molecular Biology of Aging, Lectures in Methods and technology for the study of Aging, in Molecular Biology of Alzheimer's Disease and in neuronal cell death in neurodegenerative diseases. Two sessions of 2 hours each. 1998-present Course Co-Coordinator with Dr. Phil Barker 531-602A Current Topics in Neurosciences. 1998 Course Instructor 531-602A Molecular Biology of Alzheimer’s disease (2 hours/week for one semester). 2000-2003 Back to Basics, Molecular Biology Coordinator: John Bergeron/David Thomas. Three sessions of 2 hours each. 1998- present: Lecture in Viral Pathogenesis and Host Defense 528-466B April 3 and 7 , 1998. Course Cordinator: John Hiscott. 2 hour lecture and 12 hours correction of papers/exams. 1999, 2000 Course 531-604A Lecture on Prion Diseases in Seminars in cell and Molecular Biology of Neurological Disease. Course Coordinator Heather Durham and Josephine Nalbantoglu. (11/2 hour lecture) 1999, 2000, 2002, 2003 Winter sessions. Elements de neuropathologie cellulaire. Universite de Montreal. Coordinator: Guy Doucet et Nicole LeClair. (1-2 hour lecture 1999-2000, 5 hrs 2002, 6 hours in 2003). 2002. Impact Clinique des Neurosciences. Mort neuronale et maladies neurodégénératives. Universite de Montreal. Coordinator: Laurent Descarries. (3 hour lecture). 2002 Academic Half Day in Dept. Neurol. & Neurosurg. 2 hour lecture on Prion Diseases. 2003 Academic Half Day in Dept Neurol. and Neurosurg. Lecture on Prion and on Alzheimer’s Disease (4 hours). Private Sector Neurochem Inc. Ville St. Laurent WOLFSON Christina Consultant. Société Canadienne de la Sclérose en plaques (Division du Québec). “Programme de soutien pour les conjoints des personnes atteintes de Sclérose en plaques”. 2000-2002. Consultant. Exogenous factors in the etiology of multiple sclerosis in Cuba. Project conducted by Dr. Jose Cabrera. Neurological Service, University Gustavo Aldereguia. Cienfuegos, Cuba. 1998-present.

56

APPENDIX VIII

GERIATRIC MEDICINE GRAND ROUNDS

2003 - 2004

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

57

58

APPENDIX IX

RESEARCH DAY PROGRAM

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

59

8th Annual Research Day

McGill Division of Geriatric Medicine

Friday, June 6, 2003

HOLIDAY INN Montréal-Midtown, 420 Sherbrooke Street West

514-842-6111

PROGRAM

08:00 - 08:30 Continental Breakfast (Foyer Ambassadeur) 08:30 - 08:45 Welcome (Ambassadeur A)

Dr. Howard Bergman 08:45 - 9:45 Round table discussion (Ambassadeur A)

The Canadian Longitudinal Study on Aging (CLSA) A research opportunity for the future

Dr. Howard Bergman (Chair) Dr. Susan Kirkland

(Co-PI, Protocol Development for the CLSA) Dalhousie University Dr. Christina Wolfson

(Co-PI, Protocol Development for the CLSA) McGill University 9:45 - 10:30 Poster session / coffee & tea (Ambassadeur B/Foyer Ambassadeur) 10:45 - 12:30 Paper session (Ambassadeur A) 12:30 - 13:30 Lunch (Gouverneur 1) 13:30 - 15:30 Paper session (Ambassadeur A) 15:130- 15:45 Coffee and refreshments (Foyer Ambassadeur) 15:45 - 16:15 Closure / Prizes (Ambassadeur A)

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Ambassadeur A COMMUNICATIONS ORALES – ORAL PRESENTATIONS

10:30 Neuroleptic malignant syndrome: a case-study and review of the literature

Daren Nicholson

10:45 Evaluation of the Utilization of a Methicillin-Resistant Staphylococcus Aureus decolonization protocol in patient aged 75 and older at the McGill University Heath Centre

Caroline Beauchamp

11:00 p75NTR protects against extracellular amyloid toxicity in human neurons Yan Zhang

11:15 Function of qki, the quaking viable mouse gene product, in myelination and brain development

Daniel Laroque

11:30 Prevalence and correlates of self-rated health in a community-dwelling cohort of seniors 75 years of age and over

Vittorio Addona

11:45 Donepezil improves lexical-semantic and attentional functions in Alzheimer’s disease.

Daniel Saumier

12:00 Investigating the Role of Telomerase in Chemotherapeutic Resistance Ryan Ward

12:15 Pathogenic Tau Protein Mutations and Neurodegenerative Diseases Dong Han

Ambassadeur A COMMUNICATIONS ORALES – ORAL PRESENTATIONS 1:30 Focus Group Analysis “How does Medical School influence medical

students’ attitudes toward the elderly? In search of strategies to encourage interest in a career in Geriatrics”

Rene Leiva

1:45 Frailty amplifies the effects of aging on protein metabolism; role of protein intake

Stéphanie Chevalier

2:00 Interaction of Glycogen Synthase

Kinase-3β with Tau Protein

Zongfei Yuan

2:15 A proteomic approach to biomarker discovery in Alzheimer’s disease Hanling Yu

2:30 La modélisation de l'utilisation de services hospitaliers d'urgence au sein de SIPA

François Truchon

2:45 Limitations and lessons leaned for assessing agreement between self-reported physician utilization and data obtained from the RAMQ medical services database

John Podoba

3:00 Cross-talk between cyclin-dependent protein kinaze 5 and glycogen synthase-3ß within a microtubule-associated tau phosphorylation complex

Tong Li

3:15 An 15O PET study of word meaning. in AD Christine Whatmough

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Ambassadeur B COMMUNICATIONS PAR AFFICHE – POSTER PRESENTATIONS

P1. The Relevance of Caregivers in Economic Evaluations of Alzheimer’s Disease Medications

P2. An Assessment of Non-Response Bias in a Physician Survey of Drug Treatments for Alzheimer’s Disease

P3. Physician Efficacy Requirements for Prescribing Drug Treatments for Alzheimer’s Disease

Mark Oremus

P4. Detection and management of depression among seniors: A multidisciplinary research team project

P5. G-AGE: A multidisciplinary research team to improve emergency department (ed) care of seniors

Jane McCusker

P6. Anthropometric characteristics of hospitalised female elderly Slimane Belbraouet

P7. Effects of cyclodextrine on t cell rafts composition with aging Anis Larbi

P8. Diète et stress oxydatif chez le sujet âgé atteint de diabète de type 2 Marie-Noelle Caron

P9. L'altération de l'activité paraoxonase du pon1 est un indicateur de la réduction dans le potentiel antioxydant des hdl

Leila Jaouad

P10. The McGill University/Jewish General Hospital Memory Clinic: A new approach to the management of patients with cognitive disorders

Kamadore Toure

P11. Médecins de première ligne et les réseaux intégrés pour personnes âgées avec des incapacités: vision médicale comparative entre cliniciens SIPA, leaders de GMF et gestionnaires (protocole de l’étude)

Mathieu De Stampa

P12. Undertaking a Population-Based Prospective Cohort Study on Community Dwelling Elderly: From Subject Recruitment to Follow up

Deborah Weiss

P13. Canadian Longitudinal Study on Aging Protocol Development Sathya Karunananthan

62

APPENDIX X

INTERDISCIPLINARY SEMINAR

2002 - 2003

DIVISION OF GERIATRIC MEDICINE

McGILL UNIVERSITY

Division members Cross appointed members Adjunct members

63

64 .