annexures...annexure - 6 : habitat-wise checklist of plant species recorded in and around the...

ANNEXURES

ANNEXURE LIST

Sr. No. Annexure No. Details 1 Annexure - 1 TOR 2 Annexure – 2 Land Documents 3 Annexure - 3 NABET Certificate & NABL Certificate 4 Annexure - 4 Undertaking for small scale industry with MAH

conditions 5 Annexure – 5 Undertaking of other conditions 6 Annexure – 6 Habitat-wise checklist of Plant Species 7 Annexure – 7 Baseline monitoring results of Air, Water Noise

& Soil 8 Annexure – 8 Adequacy report & certificate 9 Annexure – 9 Primary Meteorological Data (December 2018

to February 2019) 10 Annexure – 10 SOP 11 Annexure – 11 Check List For Safety Inspection 12 Annexure – 12 Peacock conservation plan 13 Annexure – 13 Manufacturing Process including reaction

chemistry, process flow-diagram & mass balance

14 Annexure – 14 EC to NOC Application Acknowledgement 15 Annexure – 15 MSDS of all Products & Raw Materials

ANNEXURE - 1 TERMS OF REFERENCE (TOR)

ANNEXURE - 2 LAND DOCUMENTS

ANNEXURE - 3 NABET & NABL CERTIFICATE

Annexure - 6 : Habitat-wise checklist of Plant Species recorded in and around the M/s. ALIVE AROMATICS

Sr.No Species Name Local Name Habit Family

Habitat

Agriculture/ Road Side

Hedge

Seasonal Wetland/ Dry river

bed

Open land/Revenue

land

1 Abutilon indicum (L.) Sw. subsp. indicum Kanski Under Shrub Malvaceae √ √ 2 Acacia leucophloea (Roxb.) Willd. Harmo Bavar Tree Mimosaceae √

3 Acacia nilotica (L.) Del. subsp. indica(Bth.) Brenan Deshi Baval, Bavar Tree Mimosaceae √ √

4 Acalypha indica L. Dadario, Dadro Herb Euphorbiaceae √ √

5 Achyranthes aspera L. var. argentea Hook. f. Andhedi, Anghedo Herb Amaranthaceae √ √

6 Achyranthes aspera L. var. porphyristachya Hk. f. Andhedi Herb Amaranthaceae √

7 Aerva persica (Burm.f.) Merrill Gorakh Ganjo Herb Amaranthaceae √ 8 Ailanthus excelsa Roxb. MotoArduso Rukhdo, Tree Simaroubaceae √ √ 9 Albizia lebbeck (L.) Bth. Karo Sirish Tree Mimosaceae √ √

10 Alternanthera pungens H. B. & K. Kantaro Bhangaro Herb Amaranthaceae √ 11 Alternanthera sessilis (L.) DC. Jar Bhaji, Jar Bhangaro Herb Amaranthaceae √ √

12 Alysicarpus monilifer (L.) DC. var. monilifer Nano Sanervo Herb Fabaceae √

13 Amaranthus spinosus L. Jangali tandaljo Herb Amaranthaceae √ √ 14 Ammannia baccifera L. Rato Jal Agio, Lal Agio Herb Lythraceae √ 15 Argemone mexicana L. Darudi Herb Papaverceae √ 16 Azadirachta indica A. Juss. Limbdo, Neem Tree Meliaceae √ √ 17 Balanites aegyptiaca (L.) Del. Hingor, Ingoriyo Small Tree Balanitaceae √ √ √ 18 Bergia ammannioides Roxb. ex Roth Jal Ukharad Herb Elatinaceae √ 19 Blumea sp. - Herb Asteraceae √ 20 Boerhavia elegans Choisy Udha Satodo, Punnarva Herb Nyctaginaceae √ 21 Borreria articularis (L.f.) F.N. Will. - Herb Rubiaceae √


Habitat


Hedge


bed

Open land/Revenue

land

22 Bougainvillea spectabilis Wild. - Straggling Shrub Nyctaginaceae √ √ 23 Butea monosperma (Lam.) Taub. Kesudo, Khakharo Tree Fabaceae √ 24 Caesalpinia crista L. Kakach, Kakchiya Straggling Shrub Fabaceae √ 25 Calotropis procera (Ait.) R. Br. Akado Shrub Asclepiadaceae √ √ 26 Capparis decidua (Forsk.) Edgew. Ker, Kerdo Under Shrub Capparaceae √ √ 27 Capparis sepiaria L. Kanther Straggling Shrub Capparaceae √ √ 28 Carica papaya L. Papaya, Papayu Tree Caricaceae √ 29 Cassia auriculataL. Avar, Aval Shrub Caesalpiniaceae √ 30 Cassia occidentalis L. Sundaro, Kasundro Herb Caesalpiniaceae √ 31 Cassia siamea Lam. Kasid Tree Caesalpiniaceae √ 32 Cassia tora L. Kunwario Herb Caesalpiniaceae √ √ 33 Celosia argentea L. Lampadi, Lampdi Herb Amaranthaceae √ 34 Cenchrus biflorus auct. Dhaman Grass Poaceae √ 35 Chloris barbata Sw. Siyar Puchh Grass Poaceae √ 36 Chrozophora prostrata Dalz. Betho Okharad Herb Euphorbiaceae √ 37 Citrus limon (L.) Burm. Limbu Small Tree Rutaceae √ √ 38 Clerodendrum inerme (L.) Gaertn. Vad Mendhi Herb Verbenaceae √ 39 Clerodendrum multiflorum (Burm.f.) O. Arni Small Tree Verbenaceae √ 40 Coccinia grandis (L.) Voigt Tindora Climber Cucurbitaceae √ √ 41 Cocculus hirsutus (L.) Diels Vevdi Straggling Shrub Menispermaceae √ 42 Coldenia procumbens L. Okharad Herb Boraginaceae √

43 Convolvulus microphyllus (Roth) Sieb. ex Spr. Khetrau Sankhavali Herb Convolvulaceae √ √

44 Corchorus aestuans L. Kag Shing Herb Tiliaceae √ √ 45 Cordia dichotoma Forst. Mota Gunda Tree Ehretiaceae √ √ 46 Cordia gharaf (Forsk.) E.&.A. Gundi Tree Ehretiaceae √ √


Habitat


Hedge


bed

Open land/Revenue

land

47 Cucumis prophetarum L. Kantalo Indranan Climber Cucurbitaceae √ √ 48 Cuscuta reflexa Roxb. Amarvel Parasite Cuscutaceae √ 49 Cynodon dactylon (L.) Pers. Dhrab Grass Poaceae √ √ 50 Cyperus rotundus L. subsp. rotundus Chiyo Sedge Cyperaceae √ √ √

51 Dactyloctenium aegypticum (L.) P. Beauv. - Grass Poaceae √

52 Datura metel L. Dhaturo Under Shrub Solanaceae √ √ 53 Delonix regia (Boj.) Raf. Gulmohor Tree Caesalpiniaceae √ √ 54 Dendrocalamus strictus Nees Narvans, Manvel-Vans Grass Poaceae 55 Derris indica (Lam.) Bennet Karanj Tree Fabaceae √ √ 56 Desmostachya bipinnata (L.) Stapf Dabha, Dabhado Grass Poaceae √ √ 57 Digera muricata (L.) Mart. Kanjaro, Kanejro Herb Amaranthaceae √ √ 58 Diospyros cordifolia Roxb. Makrodu, Makrodi Small Tree Ebenaceae √ 59 Dipteracanthus prostratus Hassk. - Herb Acanthaceae √ 60 Echinochloa colonum (L.) Link Samo Grass Poaceae √ √ 61 Echinops echinatus Roxb. Utkanto Under Shrub Asteraceae √ √ 62 Eclipta prostrata (L.) L. Mant. Jal Bhangro Herb Asteraceae √ √ 63 Enicostema axillare (Lamk.) Roynal Mamejavo Herb Gentianaceae √ √ 64 Eucalyptus globulus Labill. Nilgiri Tree Myrtaceae √ √ 65 Euphorbia hirta L. Dudhali Herb Euphorbiaceae √ √ 66 Euphorbia nivulia Buch.- Ham. Thuar, Thor Shrub Euphorbiaceae √ √ 67 Euphorbia thymifolia L. Dudheli Herb Euphorbiaceae √

68 Evolvulus alsinoides (L.) L. var. alsinoides Kari Sankhavail Herb Convolvulaceae √ √

69 Ficus benghalensis L. Vad Tree Moraceae √ √ 70 Ficus religiosa L. Piparo Tree Moraceae √ √


Habitat


Hedge


bed

Open land/Revenue

land

71 Glinus lotoides L. Okharad Herb Molluginaceae √ 72 Gomphrena celosioides Mart - Herb Amaranthaceae √

73 Gossypium herbaceum auct. Non L. var. acerifolium(Guill. & Perr.) Chevalier Kapas Shrub Malvaceae √

74 Grangea maderaspatana (L.) Poir. - Herb Asteraceae √ 75 Heliotropium ovalifolium Forsk. - Herb Boraginaceae √ 76 Hibiscus rosa-sinensis L. Jasund Shrub Malvaceae √ 77 Holoptelea integrifolia (Roxb.) Planch. Kanaji Tree Ulmaceae √ √ 78 Indigofera linnaei Ali. - Herb Fabaceae √ 79 Ipomoea fistulosa Mart. - Straggling Shrub Convolvulaceae √ √ √ 80 Jatropha gossypifolia L. Ratanjyot Shrub Euphorbiaceae √ 81 Justicia procumbens L. Bodi Andhedi Herb Acanthaceae √ 82 Lindernaria sp. - Herb Scrophulariaceae √ 83 Kirganelia reticulata (Poir.) Baill. Kamboi Shrub Euphorbiaceae √ √ 84 Lantana camara auct. Non L. Indradhanu Under Shrub Verbenaceae √ √ 85 Launaea procumbens (Roxb.) Ram. & Raj. Moti Bhoyan Patri Herb Asteraceae √ √ √ 86 Leucaena latisiliqua (L.) Wt. & Arn. Liso Bavar Tree Mimosaceae √ 87 Lycopersicon lycopersicum (L.) Karst. Tamata, Tamatu Herb Solanaceae √ √ 88 Manilkara sp. - Tree Sapotaceae √ 89 Maerua oblongifolia (Foeak.) A. Rich. Hemkand Woody Twiner Capparaceae √ √ 90 Mangifera indica L. Keri Tree Anacardiaceae √ 91 Momordica charantia L. Karela Climber Cucurbitaceae √ 92 Morus alba L. Setur Tree Moraceae √ 93 Murraya koenigii (L.) Spr. Mitho Limado Small Tree Rutaceae √ 94 Nerium indicum Mill. Lal Karen Shrub Apocynaceae √ 95 Nymphaea nouchali Burm. f. Poyana Aquatic Herb Nympheaceae √


Habitat


Hedge


bed

Open land/Revenue

land

96 Ocimum sanctum L. Tulsi Herb Lamiaceae √ 97 Paspalum sp. - Grass Poaceae √ 98 Parthenium hysterophorus L. Congress Grass Herb Asteraceae √ √ √

99 Peltophorum pterocarpum (DC.) Backer ex Heyne Tamrafali Tree Caesalpiniaceae

√ √

100 Pennisetum typhoides A. Rich. Bajri, Bajaro Grass Poaceae √ 101 Pergularia daemia (Forsk.) Chiov. Chamar Dudheli Twiner Asclepiadaceae √ √ √ 102 Phyla nodiflora (L.) Greene Rat Velio Herb Verbenaceae √ 103 Polyalthia longifolia (Sonn.) Thw. Asopalav Tree Annonaceae √ √ 104 Polygonum glabrum Willd. - Herb Polygonaceae √ 105 Portulaca sp Luni Herb Portulacaceae √ 106 Prosopis cineraria (L.) Druce Khijado, Hangar Tree Mimosaceae √ √ √ 107 Prosopis juliflora (Sw.) DC. Gando Bavar Shrub Mimosaceae √ √ √ 108 Punica granatum L. Dadam Small Tree Punicaceae √ 109 Pupalia lappacea (L.) Juss. Zapti Under Shrub Amaranthaceae √ √ √ 110 Rhynchosia minima (L.) DC. var. minima - Twiner Fabaceae √ √ 111 Ricinus communis L. Divela, Arenda Shrub Euphorbiaceae √ 112 Saccharum spontaneum L. Dabh, Kans Grass Poaceae √ √ 113 Salvadora oleoides Decne. Piludi Shrub Salvadoraceae √ √ √ 114 Salvadora persica L. Piludi-Khari Shrub Salvadoraceae √ √ 115 Sida ovata Forsk. - Herb Malvaceae √ 116 Solanum surattense Burm. f. Bhoyan Ringani Herb Solanaceae √ √ 117 Sorghum bicolor (L.) Moench. Juwar, Jawar Grass Poaceae √ 118 Syzygium cumini (L.) Skells Jambu Tree Myrtaceae √ 119 Tamarindus indica L. Ambali, Emali Tree Caesalpiniaceae √ √ 120 Tamarix sp. - Shrub Tamaricaceae √


Habitat


Hedge


bed

Open land/Revenue

land

121 Tephrosia purpurea (L.) Pers. Sarpankho Herb Fabaceae √ √ √ 122 Terminalia catappa L. Badam Tree Combertaceae √ 123 Thespesia populnea (L.) Sol. ex Corr. Paras Pimpro Small Tree Malvaceae √ 124 Tinospora cordifolia (Willd.) Miers Garo Climber Menispermaceae √ 125 Tribulus terrestris L. Gokharu Herb Zygophyllaceae √ √ 126 Trichodesma amplexicaule Roth Undha Fuli Herb Boraginaceae √ 127 Tridax procumbensi L. Pardeshi Bhangro Herb Asteraceae √

TOTAL PLANT SPECIES RECORDED IN EACH HABITAT 76 51 70

ANNEXURE – 10 : STANDARD OPERATING PROCEDURE (SOP)

A. SOP for reactor:

Select a vessel which has the capacity, pressure rating, corrosion resistance and design features that are suitable for its intended use.

Operate the vessel within a suitable safety devices and controllers Establish training procedures to ensure that any person handling the equipment

knows how to use it properly. Maintain the equipment in good condition, and test periodically per the vendor’s

instructions to ensure that the vessel is remains structurally sound. Complete a hazard assessment before initiating the experiment, including:

o Assessment of any intermediates, side-products and products that may form and their behavior within the vessel, including their corrosive nature and their tendency to violently decompose at elevated temperature and pressure.

o Determination of maximum temperature and pressure limits expected, taking into account the energetics of the reaction being conducted and any pathways that might cause the reaction to run out of control.

Maintain adequate ventilation. This can be achieved by installing the reactor within a fume hood, attaching tubing to the rupture disk that extends to an appropriate exhaust such as the interior of a fume hood, or by ensuring that the lab area as a whole has adequate ventilation and that the reactor is installed near an exhaust fan (in the case of larger reactors).

Run preliminary experiments using small quantities of reactants when starting work with new or unfamiliar materials.

Use appropriate PPE, including safety glasses, chemical resistant gloves, a lab coat, and also a face shield for operations that present particular hazards.

Keep a log of usage for each vessel. Information on the log should include temperature, pressure, reagents/solvents used, and any inspections and tests it has undergone

B. Loading and Unloading

1. Prior to loading/unloading

Visually check all hoses for leaks and wet spots. Verify that sufficient volume is available in the storage tank or truck. Secure the tank vehicle with wheel chocks and interlocks. Verify that the vehicle’s parking brakes are set. Verify proper alignment of valves and proper functioning of the pumping

system. Establish adequate bonding/grounding prior to connecting to the fuel transfer

point.


2. During loading/unloading

Driver must stay with the vehicle at all times during loading/unloading

activities. Facility manager or designee should observe the delivery driver during

loading/unloading. Periodically inspect all systems, hoses and connections. When loading, keep internal and external valves on the receiving tank open

along with the pressure relief valves. When making a connection, shut off the vehicle engine. When transferring

class 3 materials, shut off the vehicle engine unless it is used to operate a pump.

Maintain communication with the pumping and receiving stations. Monitor the liquid level in the receiving tank to prevent overflow. Monitor flow meters to determine rate of flow. When topping off the tank, reduce flow rate to prevent overflow.

3. Loading and Unloading

Driver must stay with the vehicle at all times during loading/unloading activities.

Facility manager or designee should observe the delivery driver during loading/unloading.

Periodically inspect all systems, hoses and connections. When loading, keep internal and external valves on the receiving tank open

along with the pressure relief valves. When making a connection, shut off the vehicle engine. Maintain communication with the pumping and receiving stations. Monitor the liquid level in the receiving tank to prevent overflow. Monitor flow meters to determine rate of flow. When topping off the tank, reduce flow rate to prevent overflow.

4. After loading/unloading

Make sure the transfer operation is completed. Close all tank and loading valves before disconnecting. Securely close all vehicle internal, external, and dome cover valves before

disconnecting. Secure all hatches. Disconnect grounding/bonding wires. Make sure the hoses are drained to remove the remaining oil before moving

them away from the connection. Use a drip pan. Cap the end of the hose and other connecting devices before moving them to

prevent uncontrolled leakage.


Remove wheel chocks and interlocks. Inspect the lowermost drain and all outlets on tank truck prior to departure. If

necessary, tighten, adjust, or replace caps, valves, or other equipment to prevent leaking while in transit.

C. Spills/Leaks

Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or

vermiculite. Do not use combustible materials such as sawdust. Do not get water inside containers. Approach spill from upwind (if outdoors). Use water spray to cool and disperse vapors, protect personnel, and dilute spills

to form nonflammable mixtures. Control runoff and isolate discharged material for proper disposal (if outdoors).

D. Handling of Chemicals

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material (i.e., if in a metal

container). For safety reasons, transfer from glass to glass container using proper techniques (often purged with nitrogen).

Never add water to this product. Avoid shock and friction. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be

dangerous. Keep container tightly closed. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty

containers to heat, sparks or open flames. Keep away from heat, sparks and flame. Use only with adequate ventilation or respiratory protection.

E. Storage of Chemicals/Raw Materials/Products

Keep storage area clean and free from leakages and spillages. Keep storage area dry condition all time. Keep away from heat, sparks & flame. Keep away from sources of ignition. Keep away from acids and moisture. Do not store in direct sunlight or strong incandescent light.


Storage under a nitrogen blanket has been recommended OR inside a glove box (under inert atmosphere).

Isolate from oxidizing materials and acids.

ANNEXURE – 11 : CHECK LIST FOR SAFETY INSPECTION

This checklist shall be completed by the Plant Manager:

Field Visit Review Questions Yes No N.A.

1.0 HOUSEKEEPING 1.1 Is the overall condition of the area neat / items not out where

they present a hazard?

1.2 Are cabinet tops free of stored items? 1.3 Are heavier items are stored at bottoms of shelves or at "thigh

height" where they can be more easily lifted?

1.4 Are emergency exits are free from obstruction? 1.5 Are floors are free from slip/trip hazards? 1.6 Are cabinets/shelves are secure/anchored to prevent

tipping or falling materials?

2.0 ELECTRICAL SAFETY 2.1 Are electrical plugs, outlets, and cords are in good

condition and are not missing covers, taped or broken?

2.2 If "power strips" are used, they are not overloaded or "daisy-chained?" (e.g., a power strip plugged into another power strip)

3.0 FIRE SAFETY 3.1 Fire exits and escape routes are clear/free from any obstruction.

3.2 Has a fire mock drill been conducted (documented) this calendar year? If so, what was the date?

3.3 All portable fire extinguishers have been inspected (accessible and fully charged) and inspection documented?

4.0 ERGONOMICS/MATERIAL HANDLING 4.1 Are obvious ergonomic hazards (awkward postures) observed?

4.2 Dollies/carts are available for handling/moving heavy loads? 5.0 EMERGENCY PREPAREDNESS 5.1 Does the receptionist have a list of currently trained first

responders? Is an adequate number of trained responder in first aid/CPR

5.2 An adequately stocked first-aid kit is available in a prominent location?

5.3 Is an office "evacuation" map prominently posted and includes emergency phone numbers?

ANNEXURE – 11 : CHECK LIST FOR SAFETY INSPECTION

Field Visit Review Questions Yes No N.A.

5.4 Emergency Exit signs functioning properly?

5.5 Are office Emergency and Contingency plans available/posted

Overview and approval

Date of Inspection: Office:

Plant Manager:

Office Head Signature:

Other observations Photos / Additional comments (including positive observations):

FINDINGS ACTION PLAN

Findings Corrective Action Responsible Target date

of 4

ANNEXURE- 12

of 4

o Introduction:

o Apperance:

o Classification:

1 Kingdom 2 Phylum 3 Class 4 Order 5 Family 6 Genus 7 Species 8 Local Name

of 4

o Study Approach :

Pavo

cristatus

o Sightings and Habitat Use:

o Threats in the Study Area:

o Conservation Measures:

of 4

Detailed Action Plan Sr. No

Type of Activity Activites Carried Out During Five Years

Amount to be spent in 5

years

Name of Villages where Activities Will

be Carried Out 1 Plantation

2 Conducting Awareness

Programmes

Total: 50,000/-

All above activities will be carried out with the consultation of local forest department and Gram Panchayat of respective villages.

o Aspects:

1. Plantation:

2. Awareness Programmes:

MANUFACTURING PROCESS DETAILS – M/S. ALIVE AROMATICS

1

01) 2-Cyclohexylidene-2-phenylacetonitrile: Brief Process: Charge Benzyl Cyanide, Cyclohexanone and Methyl Cyclohexane at Room Temperature in to

the reactor. Sodium Hydroxide flaks will be charged slowly into the reactor. Heat up to reflux temperature for 8-10 hrs. After the completion of reaction, neutralize by acetic acid and layer separation will be done. Organic layer will be distilled out & recover the Methyl Cyclohexane. Collect the crude. Crude will be distilled under high vacuum distillation to get pure fraction of product.

Chemical Reaction:

NO

N+ + H2O

Benzyl cyanide

M.Wt –117

Cyclohexanone

M.Wt –98 2-cyclohexylidene-2-phenylacetonitrileM.Wt -197

WaterM.Wt -18

Total : 117 + 98 = 215 Total : 197 + 18 = 215

Material Balance:

Input Quantity (Kg)

Out Put Quantity ( Kg)

Remarks

Benzyl Cyanide 351 Product 571 -- Cyclohexanone 294 Recovered Methyl

Cyclohexane 47 Reused in next

batch

Methyl Cyclohexane

50 Aqueous layer to ETP 96 To ETP

Sodium Hydroxide 20 Vapour Loss 3 Acetic Acid 22 Process Residue

(organic) 20 Disposed to CHWIF

Total 737 Total 737

ANNEXURE - 13


2

Process Flow Diagram :

INPUT OUTPUT

Benzyl Cyanide Cyclohexanone MethylCyclohexane Sodium Hydroxide

Acetic Acid Aq.Layer To ETP

Recover Methyl Cyclohexanone ResidueFinal Product

Reaction

Neutralization /Washing

Distillation

INPUT OUTPUT

Benzyl CyanideCyclohexanoneMethylCyclohexaneSodium Hydroxide

Acetic Acid q.Layer To ETP

Recover Methyl Cyclohexanonesidue

Final Product

Reaction

Neutralization /Washing

Distillation

Aq

e

utraliza

RecResFin

Process Residue-organic Final Product

ANNEXURE - 13


3

02) 4-methyl-2-(2-methylpropyl)oxan-4-ol:

Brief Process:

Product can be synthesized the method of simple cyclization reaction between Isoprenol and Isovaleraldehyde in the presence of diluted Formic acid as catalyst.

Stir at 90-95°C temperature for 8-10 hrs. till complete the reaction . End of the reaction, reaction mass will be washed by 5% Sodium Carbonate solution to get

pH Neutral. Layer separation will be done and crude product subject to high vacuum distillation to

achieve pure product.

Chemical Reaction:

+

M.Wt –86.13Iosprenol

M.Wt –86.13

FlorelolM.Wt- 172.26

Isovaleraldehdye

Total : 86.13+86.13 = 172.26 Total :172.26

CH3

CH3

OCH3

CH2

OH

Formic acid

OCH3

CH3

CH3 OH

Material Balance:

Input Quantity (Kg) Out put Quantity ( Kg) Remarks Isovalderaldehyde 258.39 Product 504 - Isoprenol 258.39 Aq. To ETP 85 To ETP 10% Formic Acid 25 Process Residue

(organic) 12.78 Disposed to

CHWIF 5% Na2CO3 60 Total 601.78 Total 601.78

ANNEXURE - 13


4


Process Residue -organic Final Product

ANNEXURE - 13


5

03) Allyl amyl Glycolate:

Brief Process:

Charge Iso Amyl Alcohol and Sodium Hydroxide at room temperature. Then Heat to 100-110 °C. After addition of Mono Choro Acetic Acid, maintain temperature for 4 -5 hrs. at 100-110 °C

till reaction complete. Adjust pH Neutral using Acetic Acid. Layer separation and collect crude product of Iso Amyl Oxy Acetate. Esterification reaction will be done at 80 °C temperature for 5 hrs. between Iso Amyl Oxy

Acetate and Allyl Alcohol in the presence of Ethyl Acetate as a solvent and pTSA as catalyst to get crude Allyl Amyl Glycolate which will be high vacuum distilled to pure Allyl Amyl Glycolate.

Chemical Reaction:

ANNEXURE - 13


6

Material Balance:

Input Quantity (Kg)

Out put Quantity ( Kg)

Remarks

Iso Amyl Alcohol 264 Product 546 - Sodium Hydroxide 120 Process Residue

(organic) 12 Disposed to

CHWIF Mono Chloro Acetic Acid 283 Dist. loss 2 - Acetic acid 40 Aq. to ETP 153 To ETP Allyl Alcohol 174 Sodium Chloride 175 Goes to ETP with

wastewater Ethyl Acetate 30 Recovered Ethyl

Acetate 28 Reused in next

batch PTSA 5 Total 916 Total 916

ANNEXURE - 13


7


Process Residue –organic Final Product

Aq. Layer to ETP + NaCl

ANNEXURE - 13


8

04) Allyl Cyclohexy Glycolate:

Brief Process:

Charge Cyclohexanol and Sodium Hydroxide at Room Temperature. Heat to 140-145 °C. After addition of Monochoro Acetic Acid, maintain temperature for 4 hrs. at 140-145 °C till

reaction complete. Adjust pH Neutral using Acetic acid. Layer separate and collect crude product of Cyclohexyl Oxy Acetate. Etherification reaction at 80 °C temperature for 5 hrs. between Cyclohexyl Oxy Acetate and

Allyl Alcohol in the presence of Ethyl Acetate as a solvent and pTSA as catalyst to get crude Allyl Cyclohexy Glycolate which will be high vacuum distilled to pure Allyl Cyclohexy Glycolate.

Chemical Reaction:

M.Wt –100.18

sodium Salt

M.Wt- 122.14Cyclohexanol

++ NaOH

Sodium HydroxideM.Wt -40

M.Wt- 18

H2O

Cl-CH2-

NaCl+

+

Mono Chloro Acetic AcidM.Wt -94.49

Cyclohexyl Oxy Acetic Acid

M.Wt- 158.19Sodium Chloride

M.Wt- 58.44

CH2=CHCH2-O

Allyl Alcohol H2OProduct WaterM.Wt -58.08M.Wt -198.25 M.Wt -18.015

+

+

Stage-1

Stage-2

Stage-3

OH ONa

ONa O

O

OH

O

O

OH

O

O

O

CH2

sodium Salt

M.Wt- 122.14

Cyclohexyl Oxy Acetic Acid

M.Wt- 158.19

ANNEXURE - 13


9

Material Balance:

Input Quantity (Kg)


Remarks

Cyclohexanol 300 Product 582 - Sodium Hydroxide 120 Recover Ethyl Acetate 28 Reused In next

batch Mono Chloro Acetic Acid 283 Dist. Loss 5 - Ethyl Acetate 30 Aq. Layer send to ETP 163 To ETP Allyl Alcohol 174 Process Residue

(organic) 09 Disposed to

CHWIF PTSA 5 Sodium Chloride 175 Goes to ETP with

wastewater Acetic acid 50 Total 962 Total 962

ANNEXURE - 13


10


10

Process Residue -organic Final Product

Aq. Layer to ETP + NaCl

ANNEXURE - 13


11

05) Ethyl (2,4-dimethyl-1,3-dioxolan-2-yl)acetate:

Brief process: Product can be prepared by refluxing mixture of Propylene Glycol and Ethyl

Acetoacetate in presence of acid catalyst and pTSA for 6-8 hrs. After completion of reaction, layer separation will be done. Unload the crude mass. Crude mass subject to high vacuum distillation gives pure product.

Chemical Reaction:

+ + H2O

WaterM.Wt -18

CH3 O CH3

CH2CH2

CH3

OHOH CH3 O

CH3O

O

CH3O

Ethylacetoacetate

M.Wt –130

Propyleneglycol

M.Wt –76

Product

M.Wt- 188

Material Balance:

Input Quantity ( Kg)

Out Put Quantity (Kg)

Remarks

Ethyl Aceto Acetate 390 Product 554 -

Propylene Glycol 228 Aqueous layer to ETP

56 To ETP

PTSA 2 Process residue (organic)

10 Disposed to CHWIF

Total 620 Total 620

ANNEXURE - 13


12


INPUT OUTPUT

Propylene Glycol Ethyl Aceto Acetate pTSA

Aq.Layer To ETP

Process Residue-Organic Final Product

Reaction

Layer Separation

Distillation

INPUT OUTPUT

Propylene GlycolEthyl Aceto AcetatepTSA

Reaction

Layer Separation

Distillation nal Productocess Residue-Organic

.Layer To ETP

stillatio

Aq.

ProFin

r Separa

12ANNEXURE - 13


13

06) Ethyl (2-methyl-1, 3-dioxolan-2-yl)acetate

Brief process: Product can be prepared by refluxing mixture of Ethylene Glycol and Ethyl Acetoacetate in

presence of acid catalyst and pTSA for 8-10 hrs. After completion of reaction, layer separation and to get crude, which will be purified by

high vacuum distillations.

Chemical Reaction:

+ + H2O

Water

M.Wt -18

CH3 O CH3

CH2CH2

OHOH CH3 O

CH3O

O

O

Ethylacetoacetate

M.Wt –130Ethyleneglycol

M.Wt –62

Final ProductM.Wt- 174

Total : 130 + 62 = 192 Total : 174 + 18 = 192

Material Balance:

Input Quantity (Kg)


Remarks

Ethyl Acetoacetate 390 Product 513 - Ethylene Glycol 186 Aqueous layer to

ETP 56 To ETP

PTSA 2 Process Residue (organic)

9 Disposed to CHWIF

Total 578 Total 578

ANNEXURE - 13


14


INPUT OUTPUT

Ethylene GlycolEthyl Aceto AcetatepTSA

Aq.Layer To ETP

Process Residue –Organic Final Product

Reaction

Layer Separation

Distillation

INPUT OUTPUT

Ethylene GlycolEthyl Aceto AcetatepTSA

.Layer To ETP

ocess Residue –Organic

Reaction

Layer Separation

Distillation nal Productstillatio

Aq.

ProFin

r Separa

ANNEXURE - 13


15

07) Aldehyde C14:

Brief Process:

Charge Acrylic Acid, N-Octanol and PTSA Catalyst at Room temperature. Heat up to 140-145°C for 6-8 hrs. Check the GC & progress of process. If reaction completed Layer separation will be done. Aq. layer will be sent to ETP for further treatment. Collect the organic layer and distilled out the product to get pure final product.

Chemical Reaction:

+

M.Wt –72.06N-Octanol

M.Wt –130.23Aldehyde -C14M.Wt- 184.27

Acrylic Acid

Total : 72.06+130.23 = 202.29 Total:184.27+18= 202.29

Cat.CH3 OH

OO

CH3

M.Wt-18.02

+CH2 O

OH

H2O

Material Balance:

Input Quantity (Kg)

Out put Quantity (Kg)

Remarks

Acrylic Acid 216 Product 540 - N-Octanol 390 Distil. Loss 3 - pTSA 2 Process Residue


Aqueous layer Sent to ETP

56 To ETP

Total 608 Total 608

ANNEXURE - 13


16


INPUT OUTPUT

Acrylic Acid n-Octanol pTSA

Aq.Layer To ETP


Reaction

Layer Separation

Distillation stillatio

Aq.

ProFin

er Sepa

ANNEXURE - 13


17

08) Aldehyde C18

Brief Process:

Charge Acrylic Acid, N-Hexanol and PTSA catalyst at Room temperature. Heat up to 140-145°C for 6-8 hrs. Check the GC & progress for process. If reaction completes than Layer separation will be done. Aq. layer will be sent to ETP for further treatment. Collect the organic layer and distilled out the product to get pure final product.

Chemical Reaction:

+

M.Wt –72.06N-Hexanol

M.Wt –102.18Aldehyde -C18M.Wt- 156.22

Acrylic Acid

Total : 72.06+102.18= 174.24 Total:156.22+18= 174.24

Cat.

OO

CH3

M.Wt-18.02

+CH2 O

OH

H2O

OHCH3

Material Balance:

Input Quantity (Kg)


REMARKS

Acrylic Acid 216 Product 462 - N-Hexanol 306 Dis. loss 2 pTSA 1.0 Process Residue


Aq. Layer Sent to ETP

55 To ETP

Total 523 Total 523

ANNEXURE - 13


18


INPUT OUTPUT

Acrylic Acid n-Hexenol pTSA

Aq.Layer To ETP


Reaction

Layer Separation

Distillation stillatio

Aq.

ProFin

r SeparaLa

ANNEXURE - 13


19

09) Alpha Ionone:

Brief Process:

Pseudo ionone undergoes cyclization reaction in presence of mild Phosphoric Acid & water at 110-115 °C for 12 hrs. to form alpha Ionone crude.

Then crude will be subjected to distillation. It will give Alpha Ionone, final product.

Chemical Reaction:

M.Wt- 192.30Alpha IononeM.Wt- 192.30

CH3CH3

CH3

CH3

O

Peusdo Ionone

H3PO4

CH3

CH3 CH3

CH3

O

Cycliz.n

Material Balance:

Input Quantity (Kg)


Remarks

Pseudo Ionone 576 Alpha Ionone 561 - H3PO4 5 Dist. Loss 3 Water 50 Aq. Layer sent to

ETP 55 To ETP

Process Residue (organic)


Total 631 Total 631

ANNEXURE - 13


20


INPUT OUTPUT

Peusdo Ionone Phosporic acid

Water Aq.Layer To ETP


Reaction

Washing

Distillation

INPUT OUTPUT

Peusdo IononePhosporic acid

Water .Layer To ETP

ocess Residue –Organicnal Product

Reaction

Washing

Distillationstillatio

Aq.

ProFin

Washing

ANNEXURE - 13


21

10) Cyclohexyl Salicylate:

Brief Process:

Charge Salicylic Acid followed by Cyclohexanol & Toluene in the reactor equipped with mechanical stirrer, condenser and receiver.

Add Catalyst, pTSA in reaction mixture. Stir it for 1 hr. Then start heating Step by step. Heat the reaction mass up to reflux for 10

hrs. Withdraw the sample from reactor to check in process GC analysis. After completion of reaction, add Na2CO3 to make pH neutral. Layer separation will be done. Take toluene layer & Toluene distilled out High vacuum distillation to collect final product.

Chemical Reaction:

M.Wt- 138.11

Total : 138.11+100.15=238.26 Total:220.26+18=238.26

+

Cyclohexyl Salicylate

M.Wt- 220.26

CH3 O

OH

OH

pTSA

CH3 O

O

Salicylic acid CyclohexanolM.Wt- 100.15

+ H2O

Water

M.Wt- 18

Material Balance:

Input Quantity (Kg)


Remarks

Salicylic Acid 414 Cyclohexyl Salicylate 645 - Cyclohexanol 300 Recover Toluene 48 Reused in next

batch PTSA 5.0 Dist. Loss 9.0 - Toluene 50 Aq. Layer sent to ETP 64 To ETP Sodium Carbonate 5.0 Process Residue (organic) 8.0 Disposed to

CHWIF Total 774 Total 774

ANNEXURE - 13


22


INPUT OUTPUT

Salicylic Acid Cyclohexanol Toluene pTSA

Aq. To ETP Sodium Carbonate

Recover Toluene Process Residue-Organic Final Product

Neutralization / Washing

Reaction

Distillation

N t li ti

till ti

Aq.

FinaProcReco

ANNEXURE - 13


23

11) 1-3, 3-Dimethylcyclohexyl) ethoxy) carbonyl) methyl Propionate:

Stage-1

Brief Process:

Dimethy Cyclohexyl Ethanol reacts with Mono Chloro Acetic Acid in the presence of acid catalyst, pTSA & Toluene as carrier solvent at reflux temperature for 6-8 hrs.

Confirm the progress of reaction by checking GC. If reaction completes than layer separated out. Aq. layer send to ETP. Organic layer distilled out Toluene under reduced pressure to collect crude stage -1

Product.

Chemical Reaction:

M.Wt- 156.27

Total : 156.27+94.48=250.75 Total:232.75+18=250.75

+

Cyclohexyl chloro acetateM.Wt- 232.75

Cat

MCAAM.Wt- 94.48

+ H2O

WaterM.Wt- 18

CH3 CH3

OH

CH3

1-(3,3-dimethylcyclohexyl)ethanol

Cl-CH2-COOH

CH3 CH3

OCH3

OCl

Material Balance:



Remarks

Dimethyl Cyclohexyl Ethanol

468.81 Dimethyl Cyclohexyl chloro acetate-Stage 1 product

698.25 Stage -1 product used

for stage-2 Mono Chloro Acetic Acid

283.44 Recover Toluene 45 Reused in next batch

pTSA 5.0 Aq. Layer sent to ETP 59 To ETP Toluene 50.0 Dist. Loss 5.0 -

Total 807.25 Total 807.25

Dimethyl

ANNEXURE - 13


24

Stage-2

Brief Process:

Dimethyl Cyclohexyl Chloro Acetate reacts with Sodium Propionate at 100-110 °C temperature & maintain for 4-5 hrs.

Filter the reaction mass and separate the sodium chloride. Separate organic product layer and get pure product by high vacuum fraction distillation.

Chemical Reaction:

Total : 232.75+96.06=328.81 Total:270.36+58.44=328.81

+

ProductM.Wt- 270.36

CH3 CH3

OCH3

OO

CH3

O

CH3 CH3

OCH3

OCl

Cyclohexyl chloro acetateM.Wt- 232.75

CH3O

NaO

Sodium PropionateM.Wt- 96.06 M.Wt- 58.44

+ NaCl

Material Balance:



Remarks

Dimethyl Cyclohexyl Chloro Acetate

698 1-3, 3-Dimethylcyclohexyl) ethoxy) carbonyl) methyl Propionate

751 -

Sodium Propionate 288 Process waste (inorganic) 175 Disposed off to TSDF

Process Residue (organic) 50 Disposed to CHWIF

Dist. Loss 10 -

Total 986 Total 986

ANNEXURE - 13


25


Process waste-Inorganic

Process residue-Organic Final Product

ANNEXURE - 13


26

12 ) Ethyl trimethyl cyclopentene butenol:

Stage -1

Brief Process: Reaction between Campholenic Aldehyde and Butyraldehyde in the presence of Sodium

Hydroxide at 40-45 °C temperature. Stir the reaction mass at same temperature for 4-6 hrs. After reaction complete wash with diluted Sulphuric Acid to get stage-1 product. This will be sent for further process.

Chemical Reaction:

O

CH3 CH3CH3

CH3

O

+ CH3CH3

CH3

CH3

O+ H2O

Stage-1 Product

NaOH

Campholenic Aldehyde ButyraldehydeM.Wt – 152 M.Wt – 72

M.Wt -206

M.Wt - 18

Total : 152 + 72 = 224 Total : 206 + 18 = 224

Material Balance



Campholenic Aldehyde 456 Stage-1 Product 618 Butyraldehyde 216 Aq. layer sent to ETP 89 Sodium Hydroxide 25

Sulphuric Acid (30%) 10

Total 707 Total 707

ANNEXURE - 13


27

Stage -2 Brief Process: Above mentioned Stage -1 product react with alkaline sodium Borohydride solution in

Methanol & sodium hydroxide solution (50 %). Heat to reaction mass up to reflux temperatures for 4-5 hrs. & check GC for progress of

process After completion of process, neutralize with Acetic Acid (50%) and then layer separation will

be done. Then after high vacuum distillation will be done to get pure final product. Chemical Reaction:

+ CH3CH3

CH3

CH3

OH+ NaBH2

Stage-1 Product M.Wt -206

M.Wt - 36

CH3CH3

CH3

CH3

O

NaBH4Sod.BorohydrideM.Wt – 38

M.Wt -208Final Product

Total : 206 + 38 = 244 Total : 208 + 36 = 244

Material Balance:



Remarks

Stage-1 product 618 Ethyl trimethyl cyclopentene butenol

610 -

Sodium hydroxide (50%)

20 Recovered Methanol 95 Distilled & Reused in next batch

Methanol 100 Aq. layer sent to ETP 198 To ETP Sodium Borohydride 37 Vapour loss 10 - Acetic Acid (50%) 52 Process Residue


Water 100 Total 927 Total 927

ANNEXURE - 13


28


INPUT OUTPUT

Campholenic Aldehyde Butyraldehdye Sodium Hydroxide

Dil. Sulphuric Acid Aq.Layer To ETP

Caustic Lye Methanol Sodium Boro hydride

Recover Methanol

Acetic Acid

Water

Aq. Layer to ETP.

Final Product Process Residue-Organic

Organic Layer

Washing / Neutralization

Distillation

Distillation

Reaction


INPUT OUTPUT

Campholenic AldehydeButyraldehdyeSodium Hydroxide

Dil. Sulphuric Acid Layer To ETP

Caustic LyeMethanolSodium Boro hydride

over Methanol

Acetic Acid

Water

Aq. Layer to ETP.

Organic Layer


Distillation

Distillation

Reaction


cess Residue-Organical Product

Aq.Washing

ganic Lay

stillation FinaProc

Aq. L

stillatio

Washing /

Reco

ANNEXURE - 13


29

13) 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopentyl)-2-buten-1-ol.:

Stage 1: Brief Process:

Reaction between Campholenic Aldehyde and Proipionaldehyde in the presence of Sodium

Hydroxide at 40-45 °C temperature for 5 hrs. After reaction complete, wash with diluted Sulphuric Acid to get stage-1 product. This will be sent for further process.

Chemical Reaction:

O

CH3 CH3CH3 CH3

O

+ CH3CH3

CH3

CH3

O+ H2O

Stage-1 Product

NaOH

Campholenic Aldehyde ProionaldehydeM.Wt – 152

M.Wt -192

M.Wt - 18

M.Wt – 58

Material Balance:



Remark

Campholenic Aldehyde 456 Stage-1 product

576 -

Propionaldehyde 174 Aq. layer sent to ETP

89 To ETP

Sodium Hydroxide 25

Sulphuric Acid (30%) 10

Total 665 Total 665

ANNEXURE - 13


30

Stage -2: Brief Process: Above mentioned satge-1 product will be treated with alkaline sodium Borohydride solution

in methanol for 5-6 hrs. After completion of process recover the excess of methanol and neutralize with Acetic Acid

and unload the crude. Purified by high Vacuum distillation to get pure final product.

Chemical Reaction:

+ CH3CH3

CH3

CH3

OH+ NaBH2

Stage-1 Product M.Wt -192

M.Wt - 36

CH3CH3

CH3

CH3

O


M.Wt -194Final Product

Material Balance:

Input Quantity (Kg)


Remark

Stage-1 product

576 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopentyl)-2-buten-1-ol.

578 -


20 Recovered Methanol 85 Distilled & reused in next batch

Methanol 90 Aq. layer sent to ETP 185 To ETP Sodium Borohydride 30 Vapour loss 5.0 - Acetic Acid (50%) 52 Process Residue

(Organic) 5.0 Disposed to CHWIF

Water 90

Total 858 Total 858

ANNEXURE - 13


31


INPUT OUTPUT

Campholenic Aldehyde Propionaldehdyde Sodium Hydroxide

Dil. Sulphuric Acid Aq.Layer To ETP

Caustic Lye Methanol Sodium Boro hydride

Recover Methanol

Acetic Acid

Water

Aq. Layer to ETP.


Organic Layer


Distillation

Distillation

Reaction


INPUT OUTPUT

Campholenic AldehydePropionaldehdydeSodium Hydroxide

Dil. Sulphuric Acid Layer To ETP

Caustic LyeMethanolSodium Boro hydride

over Methanol

Acetic Acid

Water

Aq. Layer to ETP.

Organic Layer


Distillation

Distillation

Reaction


cess Residue-Organical Product

Aq.Washing

ganic Lay

stillation FinaProc

Aq. L

stillatio

Washing /

Reco

ANNEXURE - 13


32

14) 3,3 -dimethyl-5-(2,2,3-trimethyl-3-cyclopenen-1-yl)-4-penten-2-ol:

Stage -1 Brief process: Stage-1 product will be prepared by adding mixture of Campholenic Aldehyde and Methyl

Ethyl Ketone and sodium hydroxide. Heat slightly at 40°C temperature for 5 hrs. After completion of reaction, the reaction mass will be neutralized with Acetic Acid. Organic layer separate out & unload the organic layer as stage – 1 product.

Chemical Reaction:

O

CH3 CH3CH3 + CH3

CH3

CH3

CH3

O

CH3+ H2O

Stage-1 Product

NaOH

Campholenic Aldehyde Methyl Ethyl KetonM.Wt – 152

M.Wt - 18

CH3CH3

O

M.Wt – 72M.Wt – 206

Total : 152 + 72 = 224 Total : 206 + 18 = 224

Material Balance:

Input Quantity (Kg)


Remarks

Campholenic Aldehyde 456 Stage-1 product 618 MEK 216 Aqueous layer to

ETP 102 To ETP

Sodium Hydroxide 23

Acetic acid (50%) 25

Total 720 Total 720

ANNEXURE - 13


33

Stage-2 : Brief Process: Stage-2 product will be prepared by adding a mixture Toluene and Sodium Hydroxide under

cold condition. Stir for 3 hrs. till complete isomerisation done. Check GC for progress of process. After completion of reaction, add Methyl Bromide slowly at 20-25 °C temperature over a

period of 1 hr. Then maintain temperature for 4 hrs. at reflux temperature and collect Aziotrop water. After completion of reaction, filter the reaction mass, separate out the Sodium bromide as a

byproduct from the reaction mass. Recover the excess of toluene and collect the crude of stage-2 product.

Chemical Reaction:

+

NaBr

Stage-1 Product

M.Wt - 103

M.Wt – 206

CH3CH3

CH3

CH3

O

CH3 CH3Br

M.wt-95

Methyl bromide

CH3CH3

CH3

CH3

O

CH3CH3

+ NaOH

Stage-2 Product

M.Wt -220

++ H2O

M.Wt - 18

M.wt-40

Total : 206 + 95 + 40 = 341 Total : 220 + 103 + 18 = 341

ANNEXURE - 13


34

Material Balance:

Input Quantity (Kg)


Remarks

Stage-1 product 618 Stage-2 product 660 Toluene 100 Recovered Toluene 90 Distilled & reused

in next batch Sodium Hydroxide 120 Process waste

(Inorganic) 309

Disposed to TSDF

Methyl Bromide 285 Vapour loss 10 - Aziotrp Water re use

in Acetic Acid solution 54 Reused to

prepare Acetic acid solution

Total 1123 1123

Stage-3 Brief Process: Above mentioned stage-2 product will be treated with alkaline sodium Borohydride solution

in methanol media. Stir the reaction mass at reflux temperature for 4-5 hrs. Check GC & progress of process till completely conversation of products. After completion of process recover the excess of methanol and neutralize with Acetic Acid

and unload the crude. Distilled the product through high vacuum distillation to get pure final product.

Chemical Reaction:

++ NaBH2

Stage-1 Product

M.Wt - 36


Final Product

CH3CH3

CH3

CH3

O

CH3

CH3CH3

CH3

CH3

OH

CH3

M.Wt -222M.Wt -220

ANNEXURE - 13


35

Material Balance:



Remarks

Stage -2 product 660 3,3 -dimethyl-5-(2,2,3-trimethyl-3-cyclopenen-1-yl)-4-penten-2-ol

655 -


45 Recovered Methanol 90 Distilled & reused in next batch

Methanol 100 Aq. Layer sent to ETP 205 To ETP Sodium Borohydride

114 Vapour loss 10 -

Acetic Acid (50%) 52 Process Residue (organic)


Total 971 Total 971

ANNEXURE - 13


36


Aq. To ETP

Final Product Process Residue -Organic


ANNEXURE - 13


37

15) 3-methyl-5-(2,2,3-trimethyl-3-cyclopentenyl)pent-4-en-2-ol: Stage-1: Brief Process: Stage-1 product will be prepared by adding mixture of Campholenic Aldehyde and Methyl

Ethyl Ketone and Sodium Hydroxide solution under cold condition at 40-45 °C temperature for 8 hrs.

After completion of reaction, the reaction mass will be neutralized with Acetic Acid solution. Separate the layer and unload the organic layer.

Chemical Reaction:

O

CH3 CH3CH3 + CH3

CH3

CH3

CH3

O

CH3+ H2O

Stage-1 Product

NaOH

Campholenic Aldehyde Methyl Ethyl KetonM.Wt – 152

M.Wt - 18

CH3CH3

O

M.Wt – 72M.Wt – 206

Total : 152 + 72 = 224 Total : 206 + 18 = 224

Material Balance:

Input Quantity (Kg)


Remarks

Campholenic Aldehyde

456 Stage-1 product

618 -

Methyl Ethyl Ketone 216 Aq. layer to ETP 100 To ETP Sodium Hydroxide 22

Acetic acid ( 50% ) 24

Total 718 Total 718

ANNEXURE - 13


38

Stage-2

Brief Process:

Above mentioned satge-1 product will be treated with alkaline solution. Heat up to reflux temperature for 2-3 hrs. for Isomerisation conversation by checking GC. Reaction mass will be cooled down to 25-30 °C. Methanol will be charged & Sodium Borohydride will be added slowly in to the reaction mass. Stir at reflux temperature 5-8 hrs. After completion of process, recover Methanol and neutralized with acetic acid and unload

the crude. Chemical Reaction:

Stage- 2 Product

M.Wt – 206

CH3CH3

CH3

CH3

CH3

OH

Product

M.Wt – 208

CH3CH3

CH3

CH3

O

CH3 + NaBH4

M.Wt – 38+ NaBH2

M.Wt – 36

Total : 206 + 38 = 244 Total : 208 + 36 = 244

Material Balance:

Input Quantity (Kg)


Remarks

Stage-1 618 3-methyl-5-(2,2,3-trimethyl-3-cyclopentenyl)pent-4-en-2-ol

612 -

NaBH4 114 Aq. layer to ETP 188 To ETP

Methanol 100 Recover methanol 90 Distilled & reused in next batch

Sodium Hydroxide solution 50 %

40 Distillation loss 10 -

Acetic acid (50%) 40 Process Residue (organic)


Total 912 Total 912

ANNEXURE - 13


39



ANNEXURE - 13


40

16) 1-methyl-2-[(1, 2, 2-trimethyl bicyclo (3.1.0)hex-3-yl)methyl ]cyclopropane methanol:

Brief Process:

Charge Sandel Core and Dibromo Methane at 145-150 °C temperature in Reaction vessel in the presence of Zinc metal.

Maintain the temperature for 5-6 hrs. till reaction is completed. Zinc Bromide will be filtered from filtration. Separate the liquid and solid phase, liquid phase will be distilled under high vacuum distillation to

get pure final product.

Chemical Reaction:

M.Wt - 194.31Product

M.Wt- 222.37Sandel core

Total : 194.31+347.66+130.78 = 672.75 Total:222.37+450.38=672.75

M.Wt-225.19

++ 2 CH3-Br2

Dibromo methaneM.Wt -173.83

CH3

CH3 CH3

OH

CH3CH3

CH3 CH3

CH3

OH 2 ZnBr2

2 Zn

Material Balance:

Input Quantity (Kg)


Remarks

Sandel core 97.15 1-methyl-2-[(1, 2, 2-trimethyl bicyclo (3.1.0)hex-3-yl)methyl ]cyclopropane methanol

96.0 -

Dibromo methane 86.91 Process waste (Inorganic)

105.76 Disposed to TSDF

Zinc metal 21.7 Dist. Loss 1.0 - Process residue (organic) 3.0 Disposed to CHWIF Total 205.76 Total 205.76

ANNEXURE - 13


41


Process waste -Inorganic


ANNEXURE - 13


42

17) Alpha Damascone:

Stage-1

Brief Process:

Take Magnesium metal in to the reactor. Charge Tetra Hydro Furan at Room temperature. Heat to get reflux temperature for 4-5 hrs. till completely dissolve metal in Tetra Hydro Furan. Slowly addition of Allyl Chloride to control exothermic by applying cooling system. Stir for further 4 hrs. at reflux to get Grignard reagents. Cool the solutions. Addition of Cyclocitral will be done in to Grignard solution slowly and reflux for 4-

5 hrs. and reaction ongoing check by GC. After Reaction complete distil out Tetra Hydro Furan & wash by Acetic acid & second wash by water. Layer separation done & organic layer (stage-1) will be used in next stage.

Chemical Reaction:

M.Wt –152.23Stage - 1M.Wt- 194.32

CycloCitral

+

Allyl ChlorideM.Wt -76.52

CH3CH3 CH3

CH3

ClCH2

+ Mg

Magnesium

M.Wt -24.33

THF

OH

CH2

CH3

CH3 CH3

+ Mg (OH)2

M.Wt -58.31

Total : 152.23 + 76.52 + 24.31 = 253.06 Total : 194.75 + 58.31 = 253.06

Material Balance:

Input Quantity (Kg)


Remarks

Cyclocitral 456 Stage -1 Product 582 - Allyl chloride 229 Recover tetra

Hydrofuran 145 Distilled & reused in

next batch Magnesium Metal

73 Dist. Loss 6 -

Tetra Hydro furan 150 Aq. Layer to ETP 290 To ETP Acetic acid 45 Water 70 Total 1023 Total 1023

24.31 194.75

ANNEXURE - 13


43

Stage-2

Brief Process:

Reaction of Stage-1 Product with Chromium Trioxide in presence of catalyst and dil. Sulphuric Acid at 60-70 °C temperatures for 6 hrs.

Reaction completes on checking by GC. Cool to Room temperature and organic layer separate out and Product will be distilled to get pure

Alpha Damascone.

Chemical Reaction:

M.Wt- 194.32

+CH3

CH3 CH3

O

CH3

OH

CH2

CH3

CH3 CH3

CrO3

Alpha DamasconeM.Wt- 192.3

Cromium trioxide

+ CrO + H2O

M.Wt- 68 M.Wt- 36M.Wt- 100

2 2 2

Total: 194.32*2 +100 = 488.64 Total: 192.3*2 +68+18*2 = 488.64

Material Balance:

Input Quantity (Kg)


Remarks

Stage-1 582 Alpha Damascone

562 -

Chromiun Trioxide 150 Process Residue (organic)


Sulphuric Acid 98% 2.0 Dist. Loss 4 - Aq. Layer to ETP 158 To ETP

Total 734 Total 734

ANNEXURE - 13


44



ANNEXURE - 13


45

18) ALLYL ISO THIO CYANATE

Brief Process:

Sodium Thiocynate and Iso Proply Alcohol will be charged in to a reactor. It will be stirred well and heated up to 35°C temperature to get clear solution. Allyl chloride will be added slowly at temperature 35° to 45°C. Temperature will be maintained at 45°C to 55°C for 4 hrs. Cooled up to room temperature. Total batch will be filtered to separate solid and liquid phase. Liquid phase will be distilled & IPA will be recovered (recover IPA to reuse in next batch)

and collect pure Allyl Iso Thiocynate.

Chemical Reaction:

M.Wt –76Allyl isothiocyanate

M.Wt- 99

Allyl chloride

Total : 76+81 = 157Total:99+58=157

M.Wt-58

++ NaSCSodium thiocynate

M.Wt -81

NaCl

CH2

CH3

CH2

N S

Material Balance:

Input Quantity (Kg)


Remarks

Allyl chloride 228 ALLYL ISO THIO CYANATE

290 -

Sodium thiocynate

243 Recover IPA 45 Distilled & reused in next batch

Iso Propyl alcohol 50 Dist. Loss 5 - Process residue


Process waste (inorganic)

174 Disposed to TSDF

Total 521 Total 521

ANNEXURE - 13


46




ANNEXURE - 13


47

19) Safranal:

Step -1 : Brief process:

Stage -1 can be prepared by Cyclization of adding a mixture of Citral, Zinc chloride and toluene heat to 110 c for 8-10 hrs.Maintain this temperature.

After completion of reaction, the reaction mass will be quenched into chilled water. Separate the layer.Remaining organic layer will be washed with Sodium Carbonate solution

till pH is Neutral to send ETP for Primary Treatments. Distilled out toluene, Collect the crude, which will be carrying forwarded to next stage

without purification/ Distillation.

Chemical Reaction:

CH3CH3

CH3

O

Citral

M.Wt –152

O

CH3

CH3 CH3

Stage-1

M.Wt- 152

ZnCl2

Toluene

Material Balance:

Input Quantity (Kg)


Remarks

Citral 100 Stage-1 product 99 - Zinc chloride 1 Recover Toluene 33 Distilled & reused

in next batch Toluene 35 Vapour Loss 3 -

Sodium bicarbonate 5 % solution

25 Aq. Layer To ETP 51 To ETP

Water 25

Total 186 Total 186

ANNEXURE - 13


48

Step -2: Brief Process: Safranal can be prepared by adding N-Bromo succinamide into mixture of TMCC, NaOH and

Ethyl aaceate as a solvent under 10-15°Ctemperature. After heat slowly 75-80°C for 1.0 -2.0 hrs. After completion of reaction, check GC. If reaction complete cool the solution to Room temperature. Filter the reaction mass. removed desired side product Collect Ml. Organic layer will be washed with sodium bicarbonate solution till pH is Neutral. Recover the excess of Ethyl Acetate and collect the crude. After High vacuum distillation collect pure product of Safranal.

Chemical Reaction:

+

O

CH3

CH3 CH3

O

CH3

CH3 CH3

TMCC

M.Wt- 152

NBS

M.Wt –178Safranal

M.Wt- 150

M.Wt- 103

NaBrN OO

Br

+ + NaOH

M.Wt –40

Total:152+178+40=370 Total:150+103+18+99=370

+ H2O

M.Wt- 18

+

M.Wt- 99

NH

OO

ANNEXURE - 13


49

Material Balance:



Remarks

Stage-1 product 99 Safranal 95 -

Ethyl Acetate 50 Recovered Ethyl Acetate

45 Distilled & reused in next batch

N-Bromo Succinamide

116 Process waste (inorganic)

67 Disposed to TSDF

Sodium Hydroxide 26 Process waste (inorganic)

64 Disposed to TSDF

Sodium bicarbonate 5% Solution

38 Process Residue (organic)

3.0 Disposed to CHWIF

Vapour loss 5.0 -

Aq. Layer to ETP 50 To ETP

Total 329 Total 329

ANNEXURE - 13


50




ANNEXURE - 13


51

20) Ethyl Safranate:

Brief Process:

Charge Mesityl Oxide and Ethyl Aceto Acetate and Toluene in to reactor. Zinc was added, heat up to reflux temperature for 4-5 hrs. Reaction complies by checking GC. After reaction completes, filter the reaction mass and collect Zinc Hydroxide from the mass. Distilled out Toluene from the mass and crude subject to high vacuum distillation to get

pure product of Ethyl Safranate.

Chemical Reaction:

+

ProductM.Wt- 194.27Mesityl Oxide

M.Wt- 98.15Ethyl aceto acetateM.Wt- 130.14

CH3

CH3 CH3

O

CH3

O

O CH3

O

CH3

CH3 CH3

O

CH3O

+

+

Zn

M.Wt- 65.4

Zn (OH)2

M.Wt- 99.42

Material Balance:



Remarks

Mesityl Oxide 294 Ethyl Safranate 562

Ethyl Acetoacetate 390 Process waste (inorganic)

297 Inorganic residue to TSDF

Zinc dust 195 Process Residue (organic)


Toluene 90 Recovered Toluene 81 Distilled & reused in next batch

Distillation Loss 9 -

Total 969 Total 969

ANNEXURE - 13


52




ANNEXURE - 13


53

21) Melon heptenal:

Brief process:

Melon Heptenal will be prepared by Darzen’s Glysidic Ester Condensation between Methyl Heptanone and Ethyl Chloro Acetate in presence of base catalyst like Sodium Hydroxide at lower temperature 35-45 °C for 15 hrs.

Check GC for progress of process. Reaction completes & filter the reaction mass. Remove by product of Sodium Chloride by filtration. Distill Methanol from filtrate to collect crude of product. Heat to 160-165 °C. Decarboxylation process for 2-2.5 hrs. and produced crude Melon Heptenal. Crude Melon

Heptenal will be subject to high vacuum distillation to give pure fraction of Melon Heptenal.

Chemical Reaction:

+

Methyl heptanone

+

CH3CH3

CH3

O

Cl-CH2-COO-C2H5

Ethyl chloro acetateM.Wt- 122

NaOH

Sodium Hydroxide

M.Wt- 40

Decarboxylation CH3

O

CH3CH3

Glycidic Ester Melon heptenal

M,Wt - 126

M.Wt -212 M, Wt - 140

+ CH3-CH2-CH2-CHO

ButyraldehdyeM, Wt - 72

H2O NaCl+M, Wt - 18 M, Wt - 58

CH3 CH3

CH3

O

O

O

CH3

ANNEXURE - 13


54

Material Balance:

Input Quantity (Kg)


Remarks

Methyl Heptanone 252 Melon Heptenal 267 - Ethyl chloro acetate 245 Aq. Layer To ETP 36 To ETP Sodium Hydroxide 80 Process waste

(inorganic) 116 Disposed to TSDF

Distillation Loss 5 - Process Residue


Process waste (inorganic)

144 Disposed to TSDF

Total 576 Total 576


ANNEXURE - 13


55




ANNEXURE - 13


56

22) Aldehyde C11 Undecylenic:

Brief Process:

In a dry and clean distillation reactor charge crude Aldehyde C-11. Heat slowly and apply vacuum to collect intermediate Fraction and final pure fraction.

Chemical Reaction:

Aldehyde -C11 PureM.Wt- 168

CH2=CH-(CH2)7-CH2-COHCH2=CH-(CH2)7-CH2-COHDist.

Aldehyde -C11 CrudeM.Wt- 168

Material Balance:

Input Quantity (Kg)


Remarks

Aldehyde C11 Crude 150 Aldehyde C11 Undecylenic

120 -

Process Residue (organic)


Int. Cut To be Dist.

15 Reused in next batch

Total 150 Total 150



ANNEXURE - 13


57

23) Alpha Campholenic Aldehyde:

Brief Process: Alpha- Pinene undergoes epoxidation with Hydrogen peroxide at 70-75 C temperature for staring 1-2 hrs gives Crude A-Pinene epoxide crude which subjected to as such carry forward to next stage. A-Pinene epoxide react with acid catalyst rearrangement at 90-95 °C temperature for 12 hrs. to give Alpha-Campholenic Aldehdye crude which subjected to distillation gives Alpha-Campholenic Aldehyde.

Chemical Reaction:

CH3

CH3

CH3

+ H2O2

M.Wt- 136.23M.Wt- 34

CH3

CH3

CH3

O

M.Wt- 152.23

CH3

CH3 CH3O

M.Wt- 152.23

Alpha PineHydrogen Peroxide

Alpha Pine Epoxide

Alpha Campholenic Aldehyde

+ H2O

M.Wt- 18

Catalyst

ANNEXURE - 13


58

Material Balance:

Input Quantity (Kg)


Remarks

Alpha pine 200 Alpha Campholenic Aldehyde

215 -

PTC Catalyst 8.1 Aq. Layer to ETP 89 To ETP Phenyl phosphonic acid 1.6 Dis. Loss 2.2 - Hydrogen Peroxide 50% 50 Process Residue

(organic) 6.0 Disposed to

CHWIF Acid Catalyst 2.5 5% Sodium Carbonate 50.0 Total 312.2 Total 312.2

ANNEXURE - 13


59



ANNEXURE - 13

NET Payment Receipt

Address : Survey no. 518, Survey no. 518, Village: Amrajina Muwada, Amrajina Muwada, Gandhinagar Pin : 382305

Bank Details

Transaction No

Application: 162197(ECC)-dd/MM/yyyy

HMP-035828

QHMP7800313856

PCB ID: 72880-Alive Aromatics

Payment Id 228145

Payment Date 26/07/2019

Date : 30/07/2019

Paid Amount 15000

Status Success

Remarks PGS10001-Success

Type

Referance No

MIS Date

162197 (Environment Clearance)

EC -ECC-CCA

27/07/2019

ANNEXURE - 14 EC TO NOC ACKNOWLEDGEMENT RECEIPT

–

—

50% and 100

ANNEXURE - 15 MSDS OF PRODUCTS & RAW MATERIALS

THE JOHN D. WALSH CO., INC.

US-SDS 1 of 4 2/8/2017


US-SDS 2 of 4 2/8/2017



.08 hPa (0.08 hPa)

US-SDS 3 of 4 2/8/2017


Disclaimer: The information in this MSDS was obtained from current and reliable sources.However the data is provided without any warranty, expressed or implied, regarding its correctnessor accuracy. It is the user’s responsibility both to determine safe conditions for use of this product

and to assume liability for loss, injury, damage, or, expense resulting from improper use of thisproduct

US-SDS 4 of 4 2/8/2017


1. Product and Company Identification

Catalog Numbers: 4C6F-0

Product Name

Trade Name: Fructone

Synonyms: Ethyl 2-methyl-1,3-dioxolane-2-acetate; Ethyl acetoacetate 3-ethylene acetal

Manufacturer & Distributor

Company Name: Reagent World, Inc.

Address: 2048 E. Francis Street

City: Ontario

State: California

Postal Code: 91761

Country: USA

Business/Emergency

Phone: 909-947-7779

Fax: 909-947-9595

URL: http://www.ReagentWorld.com

2. Hazards Identification

Emergency Overview: Irritating to eyes, respiratory system and skin.

Potential Health Effects

Eye: Causes eye irritation

Skin: Causes skin irritation. May be harmful if absorbed through the skin.

Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.

Inhalation: Causes respiratory tract irritation. May be harmful if inhaled.

Chronic: -

3. Composition/Information on Ingredients

Chemical Name: Fructone

Molecular Formula: C8H14O4

Molecular Weight: 174.19

Content: 80+%

CAS Number: 6413-10-1

EINECS NO. [EC No]: 229-114-0

4. First Aid Measures

Eye: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes

Ingestion: Get medical aid. Wash mouth out with water.

Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

5. Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.

Extinguishing: Use water spray, dry chemical, carbon dioxide, or chemical foam.

6. Accidental Release Measures

General Information: Use proper personal protective equipment as listed in Section 8.

Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Do not let this chemical enter the environment

7. Handling and Storage

Handling: Refer to section 8

Storage: 1.Keep in a cool,dry place 2.Keep container tightly closed

8. Exposure Controls/Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower facility.

Personal Protective Equipment

Eyes: Wear chemical safety goggles.

Skin: Wear appropriate protective gloves.

Clothing: Wear appropriate protective clothing.

Repirators: Wear NIOSH/MSHA - approved respirator

9. Physical and Chemical Properties

Physical State: Liquid

Color: Colourless

Odor: -

Boiling Point: 90-95

Melting Point : -

Vapor Pressure : -

Specific Gravity : -

PH: -

Solubility in Water : -

Flash Point: -

Autoignition Temperature : -

Decomposition Temperature : -

10. Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.

Conditions to Avoid: Incompatible materials.

Incompatibilities with Other: Strong oxidizing agents, strong reducing agents, strong bases

Material Safety Data Sheet

ReagentWorld™ is a trademark of Reagent World, Inc.Copyright © 2005-2011 Reagent World, Inc. All Rights Reserved. [Legal Information]Unauthorized use of any and all materials (content) contained herein is strictly prohibited.Material included herein may not be copied or recopied, reproduced or otherwise redistributed.

Hazardous Decomposition Products : Carbon monoxide, carbon dioxide.

Polymerization : Has not been reported.

11. Toxicological Information

RTECS#: JH6762500

Toxicity Data[LD50/LC50]: -

Carcinogenicity: -

Other: -

12. Ecological Information

Ecotoxicity: -

Other: Do not empty into drains.

13. Disposal Considerations

Disposal considerations: Contact a licensed professional waste disposal service to dispose of this material in a manner consistent with federal, state and local environmental regulations

14. Transport Information

Shipping Name: -

Hazard Class: -

UN Number: -

Packing Group: -

15. Regulatory Information

European/International Regulations: -

European Labeling in Accordance with EC Directives

Hazard Symbols: 1.Xi

R-Phrases: 1.Irritating to eyes. 2.Irritating to respiratory system. 3.Irritating to skin.

S-Phrases: 1.Do not breathe gas/fumes/vapour/spray. 2.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 3.Wear suitable protective clothing. 4.Wear suitable gloves. 5.Wear eye/face protection.

WGK(Water Danger/Protection): 1

US Federal TSCA: CAS# 6413-10-1 is listed on the TSCA Inventory

16. Other Information

Other information: The above information is believed to be accurate but does not suppose to be all inclusive and shall be used only as a guide. Reagent World makes no warranty of merchantability or any other warranty, express or implied, with respect to such information. Users should make their own investigations to determine the accountability of the information for their purposes in particular. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential of exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.


Potential for bioaccumulation (500 BCF


Disclaimer: ______________________________________________________________________________________ 150 River Road, Suite G3B, Montville, NJ 07045. Ph. # (973) 335-2500; Fax # (973) 335-2552.

CHEMTEX USA, INC. Provides the information contained herein in a good faith but makes no representation as to its comprehensiveness or accuracy. Certain data contain in this document is taken from literature and or referred from other sources available in the web. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose and take the responsibility for observing existing laws and regulations.



contact lenses if present and easy to do – continue rinsing

US-SDS 1 of 4 11/14/2016


US-SDS 2 of 4 11/14/2016



US-SDS 3 of 4 11/14/2016


Disclaimer: The information in this MSDS was obtained from current and reliable sources.However the data is provided without any warranty, expressed or implied, regarding its correctnessor accuracy. It is the user’s responsibility both to determine safe conditions for use of this product

and to assume liability for loss, injury, damage, or, expense resulting from improper use of thisproduct

US-SDS 4 of 4 11/14/2016


Product: Acetic Acid, Glacial Revision Date: 11/27/2012 1/7

Acetic Acid MSDS Effective Date: November 27, 2012 24 Hour Emergency Contact: ChemTel: (800)255-3924 www.pioneerforensics.com

Safety Ratings



Ethyl Acetate Safety Data Sheet according to the federal final rule of hazard communication revised on 2012 (HazCom 2012)

Jubilant Life Sciences Limited Page 1 of 8

CH3 O

O

CH3

SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier

PRODUCT NAME : Ethyl Acetate CAS RN : 141-78-6 EC# : 205-500-4 SYNONYMS : Ethyl acetic ester, Ethyl ester, Ethyl ethanoate, Acetoxyethane . SYSTEMATIC NAME : Acetic acid ethyl ester, Ethyl acetate MOLECULAR FORMULA : C4H8O2

STRUCTURAL FORMULA:

1.2. Relevant identified uses of the substance or mixture and uses advised against 1.2.1. Relevant identified uses

It is used in production of pharmaceuticals and foods, for contact lenses, Photographic films & plates, synthetic flavoring, chemical intermediate, perfumes, in leather processing industry, printing industry, absorbents and adsorbents, adhesives and binding agents, cosmetics, coloring agents etc.

Uses advised against: None 1.3. Details of the supplier of the safety data sheet Jubilant Life Sciences India

FACTORY & REGISTERED OFFICE: Jubilant Life Sciences Ltd., Bhartiagram, Gajraula, District: Amroha, Uttar Pradesh-244223, India

HEAD OFFICE: Jubilant Life Sciences Ltd., Plot 1-A, Sector 16-A,Institutional Area, Noida, Uttar Pradesh, 201301 - India

T:FACTORY & REGISTERED OFFICE : T +91-5924-252353 to 252360 Contact Department-Safety: Ext. 7424 HEAD OFFICE: T +91-120-4361000

[email protected]

1.4. Emergency telephone number

Emergency number : +91-9997022412; +91-9359674864

SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mixture GHS-US classification Flammable Liquids: Category 2 Specific Target Organ Toxicity:Category 3 (Single exposure) 2.2. Label Elements Hazard Pictogram: GHS 02 and GHS 07

Signal Word:Danger! HAZARD AND PRECAUTIONARY STATEMENTS:

HAZARD STATEMENTS • H225:Highly flammable liquid and vapour • H335: May cause respiratory irritation. • H336: May cause drowsiness or dizziness

PRECAUTIONARY STATEMENTS

• P233: Keep container tightly closed. • P240: Ground/bond container and receiving equipment. • P241: Use explosion-proof electrical/ventilating/lighting/.../ equipment.



• P242: Use only non-sparking tools. • P243: Take precautionary measures against static discharge. • P280: Wear protective gloves/protective clothing/eye protection/face protection. • P261: Avoid breathing dust/fume/gas/mist/vapours/spray. • P271: Use only outdoors or in a well-ventilated area. • P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. • P370+P378: In case of fire: Use ... for extinction. • P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. • P312: Call a POISON CENTER or doctor/physician if you feel unwell. • P403+P233: Store in a well-ventilated place. Keep container tightly closed. • P403+P235: Store in a well-ventilated place. Keep cool. • P405: Store locked up. • P501: Dispose of contents/container to local/regional/national/international regulations.

SECTION 3: Composition/information on ingredients

SECTION 4: First aid measures 4.1. Description of first aid measures Key symptoms Acute effects

• Inhalation results in drowsiness, cough, nausea and headache. Skin exposure can lead to dry skin. Eye exposure can lead to redness and possible irritation.

Chronic effects:

• After skin contact: Degreasing effect on the skin possibly followed by secondary inflammation. After long-term exposure to the chemical: Sensitization with allergic manifestations have been reported.

FIRST AID: Eyes: If in eyes rinse cautiously with water for at least 15 minutes. Remove contact lenses if easy to do continue rinsing. Seek medical attention. Skin: Immediately take off all contaminated clothing. Wash thoroughly with water for at least 15 minutes. Wash contaminated clothes before reuse. Seek immediate medical attention. Inhalation: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a physician if you feel unwell. Ingestion: If swallowed call a poison center if you feel unwell. Rinse mouth. Do NOT induce vomiting by use of emetics.Seek medical attention.

SECTION 5 : FIRE-FIGHTING MEASURES Extinguishing media

• Appropriate extinguishing media: Dry chemical powder, carbon dioxide, and alcohol resistant foam. Avoid using water. In very large fires one may use water spray, fog or alcohol-resistant foam by directing streams to the periphery of the fires to prevent spread.

Special Protective Equipment and Precautions for Fire Fighter • Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Keep the containers cool by spraying

water if exposed to heat or fire. Move containers out of hazard area if safe to do so. Unusual fire and explosion hazard Flashback along vapor trail may occur. Closed container exposed to heat may explode. Contact with strong oxidizer may cause fire.

SECTION 6 : ACCIDENTAL RELEASE MEASURES Minor Spills

• Clean up all spills immediately following relevant Standard Operating Procedures. • Avoid breathing vapors and contact with skin and eyes. • Shut off leak source if possible. • Shut off all possible sources of ignition. • Wear protective clothing, boots, impervious gloves and safety glasses. • Wipe up. • Decontaminate all equipment.

Chemical CAS # Purity GHS-US classification

Ethyl Acetate 141-78-6 ~ 99.8% Flammable Liquids: Category 2 Specific Target Organ Toxicity:Category 3 (Single exposure)




Major Spill • Alert Emergency Responders and tell them location and nature of hazard. • Shut off all possible sources of ignition and increase ventilation. • Wear protective clothing, full boots, impervious gloves, safety glasses and Self Contained Breathing Apparatus (SCBA), as may be deemed

appropriate. • Clear area of personnel and move upwind. • Stop leaks if possible. • Prevent, by any means available, spillage from entering drains or water and watercourses. • Collect recoverable product into labeled containers for recycling, recovery or disposal. • Contain spill with sand, earth or vermiculite. • Spread area with lime or absorbent material, and leave for at least 1 hour before washing. • Clean up all tools and equipment. • Inform authorities in event of contamination of any public sewers, drains or water bodies.

SECTION 7: HANDLING AND STORAGE Precautions for safe handling

• Do not breathe vapor or mist. • Wear protective gloves/clothing and eye/face protection. • Wash thoroughly after handling. • Ground and secure containers when dispensing or pouring product. • Avoid contact with incompatible materials. • When handling,DO NOT eat, drink or smoke. • Launder contaminated clothing before re-use. • If on skin or hair, IMMEDIATELY remove all contaminated clothing and rinse/shower with plenty of water. • Use in a well ventilated place/Use protective clothing commensurate with exposure levels.

Storage • Store in a cool, well ventilated place. • Store away from incompatible materials. • Keep container tightly closed. • Keep securely closed when not in use.

SECTION 8 : EXPOSURE CONTROLS / PERSONAL PROTECTION Control parameters • Exposure Limits Values • NIOSH REL: TWA 400 ppm (1400 mg/m3) • OSHA PEL: TWA 400 ppm (1400 mg/m3) • ACGIH 1997: TLV: 400 ppm; 1440 mg/m3 • IDLH 2000 ppm • OEL-AUSTRALIA: TWA 400 ppm (1400 mg/m3) • OEL-THE PHILIPPINES: TWA 400 ppm (1400mg/m3) • NDS –POLAND: 200 mg/m3 DNELS/ PNEC

PNEC Water (Freshwater) Sediment (Freshwater) Soil Sewage treatment plant 0.26 mg /L.

1.25mg/kg sediment dry wt.

0.24 mg/kg soil dw 650 mg/L

DNEL

Dermal Inhalation Oral

Workers 63 mg/kg bw/day 734 mg/m³ General Population 37 mg/kg bw/day 734 mg/m3 4.5 mg/kg bw/d

Exposure Controls • Provide exhaust ventilation or other engineering controls to keep the relevant airborne concentrations below their respective occupational

exposure limits. Local ventilation is usually preferred. Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protection: • Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous

substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier.

Hands: Wear appropriate protective gloves to prevent skin exposure. Eyes: Safety goggles/ Chemical Safety glasses and Face shield. Clothing: Boots and clothing to prevent contact. Respirator: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.



General Industrial hygiene:

• Immediately change contaminated clothing • Apply skin protective barrier cream • Wash hands and face after working with the substance

SECTION 9 : PHYSICAL AND CHEMICAL PROPERTIES

• Information on basic physical and chemical properties. Sr.No. Parameter Typical value

1 Appearance Clear colourless liquid 2 Odor Ether like fruity odour 3 Odor Threshold 0.96 - 176.9 ppm 4 pH Not available 5 Melting point (-) 84°C 6 Boiling point/ Distillation range

A)Initial B.P at 760 mm Hg B)Dry Point at 760 mm Hg

76.0 °C (Min) 78.5 °C (Max)

7 Flash point (-)4.4°C, closed cup 8 Evaporation rate (n-BuAc=1) 4.2 9 Explosive limits 2.1%-11.5% 10 Vapor pressure 124.79 hPa at 20 °C 11 Vapor density (air=1) Not available 12 Relative density 0.902@ 20 °C 13 Specific gravity at 20/20°C 0.900 -0.903

SECTION 10: STABILITY AND REACTIVITY

• Stability: Stable under normal temperature and pressure. Heat will contribute to instability. • Conditions to avoid: Avoid heat, flame and other sources of ignition. Contact with nitrates, strong oxidizers, strong alkalis, or strong acids

may cause fire and explosions. Will attack some forms of plastic, rubber, and coatings. • Incompatible chemicals: Strong acids, strong oxidizing agents and strong bases. • Hazardous decomposition: Thermal decomposition may produce carbon monoxide, carbon dioxide, acetic acid, and ethyl alcohol. • Hazardous Polymerization: Not reported.

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

• Acute toxicity RTECS#: AH5425000

ACUTE ORAL LD50 (Rat) = 5620 mg/kg ACUTE DERMAL LD50:(Rabbit) = > 20 mL/kg ACUTE INHALATION LC50: = 200000mg/m3

a) Skin irritation/ corrosion Method: Rabbit (New Zealand) : Slightly irritating Reference: Friend, DR, Phillips, SJ, Hills, JR (1991)

b) Serious Eye damage/ irritation

14 Solubility 83g/l at 20°C; 80g/l at 25°C 15 Log Pow (octonol/water) 0.60 16 Auto-ignition temperature 427°C 17

Decomposition temperature Not available

18 Viscosity

0.44 Pas @25 °C

19 Molecular Weight 88.11 20 pKa (@250C) Not available 21 Koc 8.8 22 Flammable material Yes 23 Oxidizer No 24 Corrosive material No 25 Explosive material No




Method: Rabbit (New Zealand) :Not irritating Reference: ECETOC, Brussels (1998)

Summary of irritation: In a briefly reported study carried out to a US Federal Register protocol, rabbits were dermally exposed to ethyl acetate under semi-occlusive conditions for a period of 4 hours. No signs of any irritation were observed during the 72 hour observation period after the exposure. Under the conditions of this study, ethyl acetate was clearly not a skin irritant Ethyl acetate vapor is a weak sensory irritant at high concentrations. Liquid ethyl acetate is mildly irritating to the eye and is not a skin irritant.

c) Respiratory or skin sensitization Skin Method: Guinea Pig Result: Not sensitizing Reference: Murmann P (1988)

Respiratory system: No data available Summary: The skin sensitization has been evaluated in humans using patch tests, although the original publications of these studies are not available. Ethyl acetate was tested at 10% in petrolatum on the skin of 25 volunteers. No sensitization reactions occurred. There is no data available on respiratory sensitising properties. Ethyl acetate does not have any functional groups or structures that are associated with respiratory sensitisation.

d) Germ cell Mutagenicity Method: bacterial reverse mutation assay (e.g. Ames test) (gene mutation) S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 (met. act.: with and without) Result: negative Reference: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. (1992)

Summary: There is clear evidence to indicate that ethyl acetate is not mutagenic in vitro bacterial or yeast test systems with or without metabolic activation and no evidence for mutagenicity results from in vivo assays.

e) Carcinogenicity • Not listed by NTP, IARC and OSHA. • Not present on the EU CMR list. • According to information presently available,ethyl acetate is not found to be carcinogenic.

Method Result Reference mouse (A/He) male/female (intraperitoneal) 150 mg/kg bw/injection (total dose: 3600 mg/kg bw) and 750 mg/kgbw/injection (total dose: 18000 mg/kg bw) Exposure: 8 w (3 times/week) Mouse Pulmonary Tumour Test according to method of Andervant

Ethyl acetate did not produce an increase in mouse lung tumours compared with controls:

Stoner GD; Shimkin MB; Kniazeff AJ; Weisburger JH; Weisburger EK; Bori GB. (1973)

Summary: The potential for ethyl acetate to induce lung tumors in a mouse pulmonary tumor model was evaluated by Stoner (1973). A/He Mice received intraperitoneal injections of 150mg/kg or 750mg/kg three times weekly for eight weeks. The animals were sacrificed 24 weeks after the 1st injections and the lungs examined for lesions. Ethyl acetate did not produce an increase in mouse lung tumours compared with controls

f) Reproductive toxicity

Method Result Referencemouse (CD-1) male/female two-generation study oral: drinking water 5, 10 and 15% v/v in water (analytical conc.) 0.0 6900, 13800, and 20700 mg/kg/day. (actual ingested (based on water consumption values)) Exposure: Exposure period: 18 weeks Premating exposure period (males): Parental 7 days; F1 74 days Premating exposure period (females): Parental 7 days; F1 74 days (ad libitum)

NOAEL (P): 20700 mg/kg bw/day (actual dose received) (male/female) (No effects observed in parameters studied at all doses. Result for ethanol. Equivalent to 39600mg/kg/day for ethyl acetate on a molar basis.)

George, J., Myers, C., Reel, J. et al. (1985)

Summary: The evidence suggests that the potential for ethyl acetate to cause fertility effects is low. A two generation study on the surrogate substance shows no effects with oral doses up to 13800mg/kg/day for ethanol (equivalent to 26400mg/kg/day ethyl acetate). By inhalation, ethyl acetate itself produced no effects at exposures of 6000ppm (22mg/l). Effects were reported following acute exposures to 16000ppm ethyl acetate.

g) Aspiration hazard. • No data available.



SECTION 12: ECOLOGICAL INFORMATION

Toxicity • Ecotoxicity: • Aquatic LC50 (48h) Leuciscusidusmelanotus (fish, fresh water) = 270-333 mg/L • Aquatic LC50 (96h) oncorhyncusmykiss (fish, fresh water) = 484 mg/L • Aquatic EC50 (24h) Artemia Salina (Crustacea) = 644.8 mg/L • Aquatic EC50 (48h) Daphnia Cucullata (Crustacea) = 164mg/L • Aquatic EC50 (48h) Scenedesmussubspicatus (Algae) = 3300mg/L • Aquatic EC50 (15min) PhotobacteriumPhosphoreum (Bacteria) = 5870mg/L

Chronic Toxicity to Fish Aquatic LOEC (32days) PimephalesPromelas (fish, fresh water) = 9.65mg/L (Embryo Larval test)

(a) Persistence and degradability • It undergoes rapid biodegradation. Substance is biodegradable with low possibility of bioaccumulation.

(b) Bioaccumulative potential(Predicted) • Log Pow = 0.6. this chemical is not likely to bioconcentrate (c) Mobility in soil • Log Koc =8.8(estimated). • Log Koc=8.8(estimated). If released on land, Ethyl acetate will be lost by evaporation and leaching into groundwater. Biodegradation should

also occur. It is very soluble in water and is not expected to absorb significantly to soil. • Because of its high vapor pressure and low adsorption to soil, ethyl acetate would be expected to volatilize rapidly from soil and other

surfaces. • Solubility In Water: 83g/l at 200 C. This product is lighter than water and will float on the surface. The product is poorly absorbed onto soils or

sediments. (d) Environment Fate

• Koc=8.8. If released on land, Ethyl acetate will be lost by evaporation and leaching into groundwater. Biodegradation should also occur. It is

very soluble in water and is not expected to absorb significantly to soil. • Because of its high vapor pressure and low adsorption to soil, ethyl acetate would be expected to volatilize rapidly from soil and other

surfaces. • Solubility In Water: 83g/l at 200 C. This product is lighter than water and will float on the surface. The product is poorly absorbed onto soils or

sediments. • Henry’s Law constant: 1.5 10E-4 atm-m3/mole. From Henry’s Law constant one can calculate a half-life for volatilization from a river 1 m deep

with a 1 m /sec current and 3 m/sec wind of 10.1 hour. Diffusions through the liquid and the vapor phase are an important element in the volatilization process so changes in current and wind will affect the rate.

• Log Pow =0.6. This chemical is not likely to bioconcentrate. • It undergoes rapid biodegradation. Substance is biodegradable with low possibility of bioaccumulation.

SECTION 13: Disposal considerations

Waste treatment methods

• Burn in a chemical incinerator equipped with an afterburner and scrubber. • Exert extra care in igniting, as this material is combustible. • Dispose of this material in accordance with standard practice for disposal of potentially hazardous materials as required by applicable federal,

state or local laws. Note that disposal regulations may also apply to empty containers and equipment rinsates.

SECTION 14: Transport information

• This substance is considered to beHazardous for transport by Air/Rail/Road and Sea and isregulated by IATA/ICAO/ARD/RID/IMO/IMDG.

S.No Agency UN Number Proper Shipping name

Hazard Class Packing Group

Land Transport

ADR/ RID UN 1173

Ethyl acetate 3 Flammable liquid. II

Maritime Transport

IMDG UN 1173


Air Transport IATA UN 1173



Ethyl Acetate Safety Data Shaccording to the fede

Jubilant Life Sciences Limited

Hazard Label

Environmental hazards

• It is expected that this chemical is not a m

SECTION 15: REGULATORY INFO• European Union Information

Classification (as per Regulation (EC) No 12Hazards Class and Category: Flammable LiquiHazard Statements: H225; H319;H336

US information:

• It is listed in EPA TSCA chemi• CERCLA Section 103 ((40CFR• None of the chemicals in this p• None of the chemicals in this p• None of the chemicals in this

under ‘Clean Air Act’ • None of the chemicals in this p

Water Act • NFPA Code: H1; F3; R0 • Transport Emergency Card: TE

CANADA REGULATORY INFORMATION WHMIS Classification: This product has been c

DSL: YesNDSL: No

SECTION 16: OTHER INFORMATION

a) Compilation information of safety dataDate of compilation : March 30Chemical : Ethyl aceCAS # :141-78-6 File Name : 0044Gj GRevision Number : 08 Date of Revision : January Revision Due Date : DecembeSupersedes date : October

b) A key or legend to aberrations and ac

• PBT =Persistent Bioaccumulative a• vPvB= Very Persistent and Very Bio• SCBA= Self Contained Breathing A• NIOSH REL= National Institute for O

Health Adminstration Permissible E• OELTWA= Occupational Exposure • IDLH= Immediately Dangerous to L• UEL= Upper Explosive Limit. • LEL= Lower Explosive Limit. • RTECS= Registry of Toxic Effects o• NTP=National Toxicology Programm• IARC= International Agency for Res• EPA=Environmental Protection Age• TSCA= Toxic Substances Control A• CERCLA= Comprehensive Environ

eet eral final rule of hazard communication revised on 201

Flammable

marine pollutant and is not Harmful to the Aquatic environmen

ORMATION

272/2008): d Cat.2, Eye Irritation Cat.2, STOT single exposure Cat.3

cal inventory. R302.4): 5000 LBS RQ product have an TPQ under SARA Section 302 TPQ product are reported under SARA Section 313

product contain any class1 & class2 ozone depletors, neith

product are listed as Hazardous substances or priority polluta

EC (R)-76

classified in accordance with the hazard criteria of the CPR.

a sheet 0,2012 etate

Ghs08 Div.1sdsEthyl acetate 06, 2016 er, 2017 20,2015

ronyms used in the safety data sheet nd Toxic. oaccumulative. pparatus. Occupational Safety and Health Recommended Exposure Limxposure Limit. Limit Time Weighted Averages. ife or Health.

of Chemical Substances. m. search on Cancer. ency.

Act. mental Response, Compensation, and Liability Act.

2 (HazCom 2012)

Page 7 of 8

nt.

her contain any hazardous air pollutants

ants or Toxic substances list under ‘Clean

mit. OSHA PEL=Occupational Safety and



• SARA= Superfund Amendments and Reauthorization Act. • NFPA= National Fire Protection Association. • WHIMS= Workplace Hazardous Materials Information System. • DSL/NDSL= Domestic/Non-Domestic Substances List. • CSR=Chemical Safety Report. • BCF = Bio Concentration Factor. • DNEL = Derived No Effect Level. • PNEC = Predicted No Effect Concentration. • TLV = Threshhold Limit Value. • ACGIH = American Conference of Governmental Industrial Hygienists. • REACH = Registration, Evaluation .Authorisation and Restriction of Chemicals. • CLP = Classification, Labelling and Packaging. • LD / LC = Lethal Doses / Lethal Concentration. • GHS = Globally Harmonised System. • ADR = Accord europeen relative au transport international de marchandises. • IMDG-Code = International Maritime Code for Dangerous Goods. • EmS = Emergency measures on Sea. • ICAO = International Civil Aviation Organization. • IATA/DGR= International Air Transport Association/Dangerous Goods Regulation.

c) Key Literature reference and sources for data Biographical reference and data sources

• CLP REG (regulation) (EC) no. 1272/2008, last modification by regulation (EC) no. 790/2009 • DIR 67/548/EWG, last modification by DIR 2009/2/EC • REG (EC) no. 1907/2006, last modification by REG (EC) Nr. 453/2009.

SDS US (GHS HazCom 2012)

This information is based on our current knowledge and is intented to describe the product for the purposes of health,safety and environmental requirements only.It should not therefore be construed as guaranteeing any specificproperty of the product.

(End of Safety Data Sheet)


PPE must not be considered a long-term solution to exposure control. PPE usage must be accompanied by employer programs to properly select, maintain, clean, fit and use. Consult a competent industrial hygiene resource to determine hazard potential and/or the PPE manufacturers to ensure adequate protection.


Waste Disposal

Handling & Storage.


oo

DISCLAIMER

The information and recommendations herein are taken from data contained in independent, industry-recognized references and is believed to be accurate and represents the best information currently available to us. Methanol Holdings (Trinidad) Limited makes no representation or warranties, either expressed or implied, including without limitation any warranties of merchantability, fitness for a particular purpose with respect to the information set forth herein or the product to which the information refers. Users should conduct their own investigations to determine the suitability of the information to their particular purpose. Accordingly, Methanol Holdings (Trinidad) Limited will not be responsible for loss or damages resulting from use of or reliance upon this information.

Prepared by: Methanol Holdings (Trinidad) Limited.

Date of Issue: August 2007


In an event of discrepancy between the contents of this SDS and the English version of it, the English version shallprevail.
