annexure i list of products to be manufactured...

Prism Industries Ltd.

Annexure I

LIST OF PRODUCTS TO BE MANUFACTURED

Sr. No. Name Of Product

Existing Quantity

(MT/Month)

Proposed Quantity

(MT/Month)

Total Proposed Quantity

(MT/Month)

1. Purification Of Spent Potassium Acetate Solution 40 - 40 0

2. Acetone Thiosemi Carbazole 2.5

+43.5 50 3. 2 Mercapto 5-Methoxy Benzimidazole 4

4. Nimesulide 0

5. Sildenafil Citrate. 0

6. Quinine Sulphate/ Derivatives 2

+18.0 20 7. Lumefantrine 0

8. Calcium Sennoside 0

9. Phenyl Epherine HCL 0

10. Pentaprozole 0

11. Hyoscine Butyl Bromide/Derivatives 0

+ 4 4

12. Colchicoside & Thiocolchicoside 0

13. 10-Deacetyl Baccatin-III (10-Dab-III) 0

14. Yohimbine Hydrochloride 0

15. Camptothecin 0

16. Reserpine 0

17. Digoxin 0

18. Artemether 0

19. Α,Β - Arteether 0

20 Artesunate 0

21 Methylcobalamine 0

22 Nicorandil 0

23 R & D Products 0 + 10 10 TOTAL 48.5 +35.5 84.0


Annexure II

1. ACETONE THIO SEMI CARBAZONE (Existing & Proposed Product)

BRIEF PROCESS

Ammonium Thiocyanate Solution and Acetone are added to a mixture of Hydrazine Hydrate

and hydrochloric Acid. The reaction mixture is refluxed at 115 deg.C. and crystallised, filtered

and dried.

CHEMICAL REACTION

NH2NH2H2O + HCl NH2NH2HCl

HYDRAZINE HYDRATE HYDRAZINE HYDROCHLORIDE

H2O+H2O

NH2NH2HCl + NH4SCNNH NH2

H2N

S

+ NH4Cl

HYDRAZINEHYDROCHLORIDE

AMMONIUMTHIOCYANATE THIOSEMICARBAZONE

NH NH2H2N

S

+ CH3COCH3N

NHNH2

SH3C

H3C+ H2O

THIOSEMICARBAZONE ACETONE ACETONE THIOSEMICARBAZONE


FLOW CHART

GLR

C.F

Acetone

Water

HCL (30%)

Hydrazine Hydrate (80%)

Ammonium Thiocynate

Water effluent

ATSC

MASS BALANCE: Sr. No.

Name of Input Material

Input Qty.(Kgs) Output Material Output

Qty.(Kgs.)1 Hydrazine Hydrate 500 ATSC 500 2 Acetone 50 Water effluent 250 3 HCl 30% 75 Recovered Solvent 47 4 Water 125 Distillation residue 3 5 Ammonium

thiocyanate 50

800 800


2. 2-MERCAPTO-5-METHOXY BENZIMIDAZOLE (Existing & Proposed Product)

BRIEF PROCESS 1,2-Dinitro Benzene is reduced in Alcohol as solvent and Potassium Xanthate salt of the

Alcohol is prepared in situ by adding Caustic flakes and Carbon Disulfide. The reaction mixture

is refluxed, excess liquid is distilled out and the residue is hydrolysed and acidified to precipite

the product. The product is then purified if required, filtered and dried.

CHEMICAL REACTION

2 NaHS Na2S + SO2

4-METHOXY-2-NITROANILINE

4-METHOXY-2-AMINOANILINE

+ CS2

NH2NO2

OCH3

NH2

NH2

OCH3

NH2

NH2

OCH3

NH

N SH

+ H2S

2-MERCAPTO-5-METHOXYBENZIMIDAZOLE

+

H3CO


FLOW CHART

S S Reactor(Reduction)

Filteration

4 Methoxy 2- Nitro Aniline

DM Water

Reducing Agent (50%)

Caustic flakes

Carbon disulphide

S S Reactor

C.F

Carbon

Ethyl Acetate

Dilute HCl

ML

MASS BALANCE

Sr. No. Name of Input Material Input Qty.(Kgs) Output Material Output

Qty.(Kgs.) 1 4 Methoxy 2 Nitro Aniline 400.00 2 Reducing Agent 50.00 2M 5MB 500.00 3 Caustic flakes 50.00 Spent Carbon 4.00 4 DM Water 200.00 Water Effluent 300.00 5 Carbon 02.00 Recovered Ethyl

acetate 190.00

6 Ethyl Acetate 200.00 Recovered CS2 92.0 7 Finite HCl 050.00 8 Carbon di-sulphide (CS2) 100.00 1052.00 1052.00


3. NIMESULIDE (Proposed Product)

BRIEF PROCESS

Ortho Nitrochloro Benzene, Caustic Potash, Phenol will be reacted and oily layer charged for

reduction with methanol. The mass will be condensed with dimethyl aniline, methane sulfonyl

chloride, The mass will be treated with diluted Sulphuric Acid then, it will be treated with Ethyl

Acetate and activated charcoal. The methanol will be recovered and the solid mass will be dried

and packed as Nimesulide.


FLOW CHART


MASS BALANCE

Sr.No. Name of Input Material Input Qty. (Kgs) Output Material Out Put

Qty (Kgs.)

1 Ortho Nitrochloro Benzene 358 Nimesulide 1100 2 Caustic Potash 150 Recovered phenol 150 3 Phenol 158 Recovered methanol 2354 4 Methanol 2480 Recovered Ethyl Acetate 1614 5 Dimethyl Anilin 202 Solid Waste 70 6 Methane Sulfonyl Chloride 124 Distillation residue 30 7 Sulphuric Acid 150 Spent Carbon 28 8 Ethyl Acetate 1700 9 Activated Charcoal 24 TOTAL 5346 5346


4. SILDENAFIL CITRATE (Proposed Product)

Brief Process:

Di-ketoester and hydrazine will be reacted to give the pyrazole ring. The regioselective N-

methylation of the pyrozole and hydrolysis gives a carboxylic acid which is then reacted with

HNO3 and H2S04 to give a nitrated product. This is then followed by a carboxamide formation

and the reduction of the nitro group. The compound (4) is then acylated under basic condition

and this produces the pyrazolopyrimidinone (6). (6) is then chlorosulphonylated selectively on

the 5’-position of the phenyl ring. This can then couple with an amine to give Sildenafil.

This Sildenafil is then dissolved in water, heat the reaction mixture and start addition of Citric

Acid activated charcoal. Filter the material and after filtration start the crystallization at room

temperature. Centrifuge the material. Wash the centrifuge with acetone. Unload and dry the

material. Pack the material in a fibre drum containing inner virgin food grade transperant bag

and outer black polyethene bag.


Chemical Reaction


Production Capacity:

Sr. No. Name of Input Material Input Qty. (Kg)

Output Material Output Qty. (Kg)

1 2-pentanone 0.26 Sidenafilnitrate 1 2 Di- Ethyl Oxalate 0.51 Recovered Methanol resuse 1.5 3 Sodium Methoxide

Solution 0.64 Recovered Ethyl Acetate Reuse 8.79

4 Hydrazine Hydrate 0.2 Recovered Toluene Reuse 3.17 5 Hydrochloric Acid 0.51 Recovered Methylene Di chloride

Reuse 6.53

6 Di Methyl Sulphate 0.39 Recovered Acetone Reuse 0.2 7 Ethyle Di chloride 2.23 Recovered Ethylene Di chloride

Reuse 2.14

8 Nitric Acid 0.31 Process ML for Reuse (Recovery) 10.47 9 Water 5.25 Distillation Residue 0.08 10 Methanol 1.56 Effluent ETP 5.25 11 Ammonia Gas 0.13 Spent Carbon 0.1 12 Ethyl Acetate 8.97 Inorganic Residue 0.07 13 NCR Cat 1.03 14 2- Ethoxy Benzoic Acid 2.56 15 Thionyl Chloride 1.15 16 Di Methyl Formamide 0.08 17 Caustic Soda Flakes 0.1 18 Toluene 3.21 19 Chloro Sulfonic Acid 1.67 20 Methylene Di Chloride 6.67 21 N- Methyl Piperazine 0.18 22 Citric Acid 0.36 23 Activated Charcol 0.05 24 Acetone 0.26 25 Soda Ash 0.1 26 Sulphuric Acid 0.92 Total 39.3 Total 39.3


Flow Charts

S.S Reactor

2- pentanoneDiethyl oxalate

Hydrazine sulphateDi methyl sulphateSodium methoxide

1- Methyl - 3, n- propyl pyrazole -5- carboxylic acid Ethyl Ester

STAGE - I

STAGE - II

S.S ReactorStage - I compund

Sulphuric acid Nitric Acid

GLR

1- Methyl -4- nitro - 3, n- propyl pyrazole -5- carboxylic acid Ethyl Ester

STAGE - II

S.S ReactorStage - II compund Liquid Ammonia

1- Methyl -4- nitro - 3,n- propyl pyrazole -5- carboxamide


S.S ReactorEthyl AcetateIron powder

STAGE - IV

STAGE - V

Leaf filter

S.S Reactor

Stage - III compund

Filterate

4-Amino -1- methyl - 3,n- propyl pyrazole -5- carboxamide

GLR 1000 Lts.2 - Ethoxy benzoic acid

Thionyl chloride

2- Ethoxy benzoyl chloride


S.S Reactor2000 Lts

Potassium Carbonate

STAGE - VI & VII

STAGE - VIII

S.S Reactor1000 Lts

Centrifuge/ Spray drier

Stage - IV Ethyl Acetate Layer

Filterate

5- (2-ethoxyphenyl) -1- methyl - 3,N- propyl-1,6-dihydro-7H- pyrazolo -[4,3,d]-

pyrimidine - 7-one

GLR & S.S Reactor 1500

Lts.

Chloro sulphonic acidMethylene chloride

Stage V compund

Caustic Soda Flakes

Toluene

Stage VII compund

N- Methyl piperazine Soda ash

S.S Tray drier

5- (5- chloro sulfonyl-2-ethoxy phenyl) -1- methyl - 3,N- propyl-1,6-dihydro-7H- pyrazolo -[4,3,d]- pyrimidine - 7-one

(Sildenafil Base)

Centrifuge/ Spray drier


S.S ReactorCitric Acid

STAGE - IX

Leaf Filter

Centrifuge / Spray Drier

Sildenafil Base

GLR Reactor

Water

Acetone

DRIER

SILDENAFIL CITRATE


5. QUININE SULPHATE / DERIVATES (Existing & Proposed Product)

BRIEF PROCESS

First Chinchona Bark is pulverised in pulveriser then it is taken into Ribbon blender with

Hydrated Lime, Caustic Flakes and Water. Then The Mixer of bark + Hydrated Lime + Water +

Caustic Flakes are charged into Extractor with toluene for extraction process. Then this

extracted toluene is passed through H2SO4 98% and then the extracted acid is neutralised to get

crude Quinine. It is then purified to get pure Quinine Sulphate by purification process.

In this process after extraction of bark, there is no organic or chemical compound in the

extracted bark because we do vacuum distillation to recover toluene from bark. The waste Bark

(Extracted Bark) contains 1800 Kg Calorific Value. So it can be used in the boiler as a fuel.

FLOW CHARTS

Pulveriser Bark Blender Extractor Receiver

PH Treatment

Q. Sulphate(Crude)

Q. Sulphate(Purification)

CF

DryingPacking

Water Holding tank

Water

H.Lime C.Flakes Toluene H2SO4

C.Lye


MASS BALANCE

Sr. No. Name of Input Material Input

Qty.(Kgs) Output Material Output Qty.(Kgs.)

1 Cinchona Bark 100 Quinine 502 Toluene 2000 Recovered solvent 19703 Hydrated Lime 100 Spent carbon+ impurity 34 Activated Carbon 2 ML of crude Quinine 3435 Sulphuric Acid 9 Distillation Residue 326 Caustic Soda Lye 200 Other Alkoide (Derivatives) 5

Saw dust 8 TOTAL 2411 2411


5.1. HCL QUININE

STAGE 1: QUININE SULPHATE

BRIEF PROCESS First Chinchona Bark is pulverised in pulveriser then it is taken into Ribbon blender with








FLOW CHARTS


PH Treatment

Q. Sulphate(Crude)


CF

DryingPacking

Water Holding tank

Water


C.Lye


MASS BALANCE

STAGE 2: HCL QUININE

BRIEF PROCESS

ML of Quinine Sulphate is taken into SS reactor and reacted with Barium Chloride. It is

purified with Activated carbon and then concentrated and filtered by sparkler filter and taken

into another SS reactor where it is cooled, filtered, dried and packed.

FLOW CHART

ML OF QUININE SULPHATE BARIUM CHLORIDE ACTIVATED CAROBN

HCL QUININE ML REUSE IN BLENDER





SS REACTOR

SS

FILTERATION


MASS BALANCE

Sr.No Name of Input Material Input Qty.(Kgs) Output Material Out Put

Qty (Kgs.)

1 Quinine Sulphate 50 Quinine HCL 172 Activated Carbon 0.5 ML of Quinine HCL 33.53 Barium Chloride 1 Spent Carbon/Solid waste 1

TOTAL 51.5 51.5


5.2. Di-HCL QUININE

STAGE 1: QUININE SULPHATE

BRIEF PROCESS First Chinchona Bark is pulverised in pulveriser then it is taken into Ribbon blender with








FLOW CHARTS


PH Treatment

Q. Sulphate(Crude)


CF

DryingPacking

Water Holding tank

Water


C.Lye


MASS BALANCE

STAGE 2: HCL QUININE

BRIEF PROCESS

ML of Quinine Sulphate is taken into SS reactor and reacted with Barium Chloride. It is

purified with Activated carbon and then concentrated and filtered by sparkler filter and taken

into another SS reactor where it is cooled, filtered, dried and packed.

FLOW CHART

ML OF QUININE SULPHATE BARIUM CHLORIDE ACTIVATED CARBON

HCL QUININE ML REUSE IN BLENDER





SS REACTOR

SS

FILTERATION


MASS BALANCE

Sr.No Name of Input Material Input Qty.(Kgs) Output Material Out Put

Qty (Kgs.)

1 Quinine Sulphate 50 Quinine HCL 172 Activated Carbon 0.5 ML of Quinine HCL 33.53 Barium Chloride 1 Spent Carbon/Solid waste 1

TOTAL 51.5 51.5

STAGE 3: DI-HCL QUININE

BRIEF PROCESS

Quinine HCL is taken into SS reactor and dissolved in Acetone. It is then purified by Activated

carbon and taken into another SS reactor where PH treatment is done by Anhydrous HCL to get

Quinine Di-HCL.

FLOW CHART

QUININE HCL ACTIVATED CARBON ACETONE

Anhydrous HCL

DI-HCL QUININE ML ACETONE FOR DISTIL.

MASS BALANCE

SR.No. Name of Input Material Input Qty.(Kgs) Output Material Out Put

Qty (Kgs.)

1 Quinine HCL 17 Quinine DI-HCL 15 2 Activated Carbon 0.5 Recovered Solvent 66 3 Acetone 67.5 Spent Carbon 1 4 Anhydrous HCL 1 Distillation Residue 4

TOTAL 86 86

SS REACTOR

GLR


6. LUMEFANTRINE (Proposed Product)

BRIEF PROCESS

First 2 D-N-Butyl-l-(2,7 Dichloro) 9H Fluorenyl Ethano is charged in SS reactor with Methanol and Caustic Sode Lye resulting in dissolution of the intermediate. Then Para ChloroBenzadehyde is charged. Continue stirring till the T C is ok. Then it is filtered. Dry and pack.

CHEMICAL REACTION

C lC l

C H

O H

C H 2 NC H 3

C H 3

2-D-N-Butyl-I-(2,7 Dichloro) 9H Fluorenyl Ethanol

M.W = 406

P-Chloro benzaldehyde M.W. = 140.5

C lC l

C H

O H

C H 2 NC H 3

C H 3

C H O

C l

Lumefantrine M.W = 528.95

C H O

C l


FLOW CHART

Reactor

Reactor

Centrifuge/ Spray Drier

Drying

Lumefantrine

Methanol

NaOH

Para chloro Benzaldehyde

Methanol ML of Methanolfor Distillation

2D-N-Butyl-I(2,7 Dichloro) 9H Fluoreny Ethanol

MASS BALANCE

Sr. No.

Name of Input Material Input Qty.(Kgs) Output Material Output

Qty.(Kgs.)

1 2D-N-Butyl-I(2,7 Dichloro) 9H Fluoreny Ethanol 500 Lumefantrine 550

2 Caustic Soda Flakes 50 Recovered PCB 963 Para Chloro Benzeldehyde 100 Recovered n-hexane 964 N-Hexane 100 Recovered acetone 4805 Acetone 500 Recovered methanol 19206 Methanol 2000 Distillation residue 108

TOTAL 3250 3250


7. CALCIUM SENNOSIDE (Proposed Product)

BRIEF PROCESS

First senna leaves are pulverized and then it is mixed in ribbon blender with caustic soda flakes then this mix powder is taken into extractor for extraction by methanol. After extraction the methanol is distilled for reuse of next batch into SS reactor the concentrated solution (syrup form) of methanol is reacted with calcium chloride to make crude calcium sennoside which is then purified by carbon treatment then filter, dry, packed.

FLOW CHART

PULVERISER BLENDED EXTRACTOR SS REACTOR

PACKING DRYING FILTERATION PURIFICATION

DISTILLATION

ACTIVATED CARBON

METHANOLCAUSTIC SODA FLAKESSENNA LEAVES

REUSE

MASS BALANCE



1 Senna Leaves 100 Calcium Sennoside 582 Methanol 800 Recovered Methanol 7803 Calcium Chloride 13 Agricultural waste 514 Caustic Soda Flakes 10 Distillation Residue 305 Activated Carbon 3 Spent Carbon 7

TOTAL 926 926


8. PHENYL EPHERINE HCL (Proposed Product)

Brief Process

First charge Aluminium Chloride Metahydroxy Acetophenone in GLR then bromisnation is done by adding bromine & Ethyl Acetate at 0-5°c then filter it. Then go for Hydrogenation with methanol in Hydrogenator. Filter the material then and charge it in SS reactor with propyl alcohol at room temperature, then L+ Tarteric acid will be charged and filtered. Crude will be taken for dissolution .Then propyl alcohol and HCL will be added and stirred for 30 min. methanol will be distilled of completely then acetone will be charged and filtered. It will be then dried.

Chemical Reaction

O CH3

OH

AlCl3

OH

O

Br

+Br2

OH

O

Br

C6H5CH2NH-CH3 +(DPA/HCl 20.0%)

OH

O=C CH2 N CH2 C6H5 HCl

CH3

Stage 1 (P/A)

Bromometa Hydroxyl Acetophenone M.W = 215.04

Meta Hydroxy Acetophenone M.W = 136.15

Stage 1 (P/B)

3- Hydroxy – n- Methylbenzyal amino Acetophenone Hydrochloride

Stage-I (P/A + P/B) M.W = 291.77


Stage‐ 2

C

OH

H

OH

CH2 NH.HCl

CH3

+ C6H5CH3

O=C CH2 N CH2 C6H5 HCl

CH3

OH

C

OH

H

OH

CH2 NH. CH3

HO HN CH3

H OH

HCL

Methanol

M.W = 203.66 pH 9.0 to 9.5

M.W = 291.77

.

DL- Phenylepherine Base M.W = 203.66

Phenylepherine Hydrochloride M.W = 203.67


Production Capacity:

Sr. No.

Name of Input Material Input Qty. (Kg)


1 Metahydroxy Acetophenone 0.426 Phenyl Epherine HCL 12 Ethyl Acetate 1.447 Recovered Solvent 16.83 Aluminium Chloride 0.009 4 Bromine 0.223 Inorganic Waste 0.4595 Toluene 2.736 Solvent Residue 1

6 Sodium Bi Carbonate 2% Solution

0.052Spent Carbon 0.2

7 N-Methyl Benzylamine 0.355 8 IPA HCL 20% 0.526 9 Methanol 6.44

10 PD/C 10% 0.122 11 Activated Carbon 0.073 12 Liquid Ammonia 0.571 13 IPA 1.857 14 L (+) Tarteric Acid 0.428 15 Acetic Anhydride 1.342 16 Sulphuric Acid 0.385 17 IPA HCL 20% 0.8 18 Acetone 1.667

Total 19.459 Total 19.459


Flow Charts

GLR

Aluminium Chloride + Metahydroxy Acetophenone + Bromine

Toluene + Sodium Bi Carbonate

N-Methyl Benzyamine + IPA HCL + Ethyl Acetate


Hydrogenator Methanol + Carbon (10%)

Filter

IPA + Liquid Ammonia + Anhydride (+) Tarteric Acid

SS ReactorLiquid Ammonia

SS Reactor

H2SO4



GLR


Drying

Pulvolizer

Packing

Methanol + IPA HCL


9. PENTAPROZOLE (Proposed Product)

Brief Process:

Stage:1 Pentaprozole Sulfide 2-Chloromethyl-3, 4-dimethoxy pyridine hydrochloride and 5- Difluorornethoxy-2-

mercaptobenzidimide will be suspended in methanol and DM water. To the resulting reaction

mixture aqueous sodium hydroxide solution will be added. The resulting reaction mixture will

be then maintained for some time and concentrated. The concentrated mass will be isolated in

centrifuge to get Pentaprozole sulphide.

Stage:2 Pentaprnzole.Base Wet Pentaprozole sulfide will be then suspended in methylene dichloride and product will be

extracted in methylene dichloride. The product layer will be cooled and a mixture of Sodium

chloride and sodium hypochlorite will be added to it. After completion of reaction pH of

organic mass will be adjusted with acetic acid and the organic layer will be treated with sodium

sulphate. The organic layer will be further concentrated and IPE will be added to it. The

reaction mass will be isolated in centrifuge to get Pentaprozole Base and will be further dried in

Vacuum Tray Dryer.

Stage:3 Pentaprnzole.Base Pure

Pentaprozole base will be suspended in methylene dichloride. Reaction mass will be stirred for

a while and IPE will be charged into it and maintained for some time. The reaction mass will be

then isolated in centrifuge to get Pentaprozole Base Pure and will be further dried in Vacuum

Tray Dryer for 8-10 Hours.


N

OCH3

OCH3

Cl

.HCl

N

HNHS

Methanol Water

Sodium Hydroxide flakes

N

OCH3

OCH3N

HNS

OCF2H OCF2H

Chemical Reaction

Stage-I Pantaprozole Sulfide Stage-II Pantaprozole Base

N

OCH3

OCH3N

HNS

OCF2HN

HNS

O OCF2H

N

OCH3OCH3

Stage-III Pantaprozole Base Pure

N

HNS

O OCF2H

N

OCH3OCH3

N

HNS

O OCF2H

N

OCH3OCH3

2-Chloromethyl-3,4-dimethoxypyriedine

hydrochloride

5- Difluorornethoxy-2-mercaptobenzimidazole

Pantaprozole Sulfide

Methylene Chloride, Sodium hypochlorite, Triethyl Benzyl Ammonium chloride, Sodium sulphate.

Pantaprozole Sulfide Isopropyl Ether, Water

Sodium Thiosulphate, Acetic acid, Sodium Hydroxide flakes and Pentaprazol base

Pantaprozole Base Pantaprozole Base Pure

Isopropyl Ether

Methylene Chloride


Mass Balance:

Sr. No.

Name of Input Material Input Qty. (Kg)


1 5 Difloro Methoxy 2 Mercapto Benzimidazole 0.52 Pentaprozole 1 2 3 -4Dimethoxy 2 Chloromethyl Pyridine HCl 0.57 Recovered Solvent 23.26 3 Sodium Hydroxide 0.46 Solid Waste 0.24 ISO Propylether 1.25 Solvent residue 15 MDC 7.85 Water Effluent 1.5 6 Ethyl Acetate 10.97 7 Naocl. (4% solution) 0.21 8 Methanol 3.63 9 RO Water 1.5 Total 26.96 Total 26.96


Flow Charts

Preparation of sodium hydroxide solution

RO Water

Sodium Hydroxide Flakes

R-701

Reaction

Methanol

RO Water

2-Chloromethyl 1-3,4-dimethoxypridine

hydrochloride

5- Difloromethoxy -2 mercapto benzimidazole

R-707/ R-702

Start heating and maintain temp.for 8 hrs. at temp

40 - 45 oC

Send sample to QC for Unreacted 2-Chloromethyl

1-3,4-dimethoxypridine hydrochloride (Limit NMT

2.0%)

R-707/ R-702

Distill out Methanol completely under

vacuum

Send sample of Distilled Methanol for purity by GC (Limit:

NLT 98.0%)

R-707/ R-702Change RO Water and cool the reaction mixture for 5hrs.

25-35 oC

Unload the Wet Cake. Send the sample to QC for complete

analysis

CF - 702


Preparation of mixture of sodium hydroxide and sodium hypochlorite solution

RO Water

Sodium Hydroxide Flakes R-715

Reaction

Methylene Chloride

RO Water

Triethyl benzyl ammonium Chloride

Charge mixture of sodium hydroxide and sodium

hypochlorite

R-705/ R-709

R-705/ R-709

R-705/ R-709

Charge Methylene chloride

Send the sample to QC for complete analysis

Sodium Hydpochloride Flakes

Pantaprozole sulphide

Stirring, settling & speration

Collect organic layer

Send sample to QC lab for pantaprozole sulphide

content (Limit: NMT 3.0%)

RO Water + Sodium hydroxide and sodium

hypochlorite

RO Water

Adjust pH with Acetic Acid 9.0-9.5

Stirring, settling & speration

Collect organic layer

R-705/ R-709Sodium Sulphate

Methylene Chloride

NF -701

CF - 703

R - 710Isopropyl ester

Distilled out Methylene Chloride

DCVD-402

PNT - II


Stage: PNT

R-704

Methylene Chloride

Charge Isopropyl ether to maintain the temp. of

reaction mixture. Temp 20-30oC

Send the sample to QC for complete analysis

Pantaprozole sulphide

Cool the reaction mass temp. 20-35 oC

Heat the reaction mixture about 40 oC to get Clear

solution

SPF - 703

R-711

CF - 704

VTD - 701

PANTAPRAZOLE BASE PURE


10. HYOSCINE BUTYL BROMIDE (Proposed Product)

BRIEF PROCESS

Dbosia extract is first converted into Hysoscine syrup by dissolving it in MDC & extracted in

chloroform at a particular Ph adjustment. Thus prepared Hyoscine syrup is further reacted with

N-Butyl Bromide in presence of Acetonitrile to produce Hyoscine Butyl Bromide which is

concentrated, cooled, crystallized & filtered. The filtered mass is again re-crystallized in

Methanol to give Hyoscine Butyl Bromide in pure form which is filtered, dried, pulverized &

packed.

CHEMICAL REACTION

C17H21NO4 + HBr C17H22NO4.Br

Hyoscyamine Hysoscine Hydrobromide

ACN C17H22NO4.Br + C4H9Br C21H30BrNO4 .Br + HBr Hysoscine Hydrobromide N-Butyl Hyoscine Butyl Bromide Bromide


HYOCINE BUTYL BROMIDE PROCESS CHART

O

O

O

NOH

DUBOSIA LEAVES

CH3OH

N-Butyl Bromide

OH

O

O

NH3C

O

CH3

Br

Hyocine Butyl Bromide(440,40 g/mol)


PROCESS FLOW CHART

S.S.EXTRACTION VESSEL

DUBOSIAEXTRACT

EXTRACTION

S.S.REACTIONVESSEL

COOLING/CHILLING

FILTRATION

GLASS UNIT

COOLING/CHILLING

FILTRATION

GLASS UNIT

COOLING/CHILLING

FILTRATION

DRYING

PACKING PULVERIZING

M.D.C. METHANOL

ACETONITRILE

N-BUTYL

BROMIDE

PH

ADJUST-

MENT

RECYCLE

FOR RECYCLEFOR RECYCLE

HYOSCINE

BUTYL BROMIDE

M.D.C.


MASS BALANCE



1 Dubosia Leaves 75 Hyoscine Butyl Bromide 502 Hydrobromic Acid 60 ML of Hyoscine Butyl Bromide 5903 N-Butyl Bromide 119 Recovered acetonitrile 554 Acetronitrile 58 Recovered chloroform 43855 Liquid Ammonia 40 Recovered MDC 64806 Dil Hydrochloric Acid 125 Recovered methanol 11957 Chloroform 4467 Distillation residue 68 MDC 6600 Saw dust 909 Methanol 1217

TOTAL 12761 12761


10.1. CIMETROPIUM BROMIDE

STAGE 1: HYOSINE BUTYL BROMIDE

BRIEF PROCESS

Dbosia extract is first converted into Hysoscine syrup by dissolving it in MDC & extracted in

chloroform at a particular Ph adjustment. Thus prepared Hyoscine syrup is further reacted with

N-Butyl Bromide in presence of Acetonitrile to produce Hyoscine Butyl Bromide which is

concentrated, cooled, crystallized & filtered. The filtered mass is again re-crystallized in

Methanol to give Hyoscine Butyl Bromide in pure form which is filtered, dried, pulverized &

packed.

CHEMICAL REACTION

C17H21NO4 + HBr C17H22NO4.Br

Hyoscyamine Hysoscine Hydrobromide

ACN C17H22NO4.Br + C4H9Br C21H30BrNO4 .Br + HBr Hysoscine Hydrobromide N-Butyl Hyoscine Butyl Bromide Bromide


HYOCINE BUTYL BROMIDE PROCESS CHART

O

O

O

NOH

DUBOSIA LEAVES

CH3OH

N-Butyl Bromide

OH

O

O

NH3C

O

CH3

Br

Hyocine Butyl Bromide(440,40 g/mol)


PROCESS FLOW CHART

S.S.EXTRACTION VESSEL

DUBOSIAEXTRACT

EXTRACTION

S.S.REACTIONVESSEL

COOLING/CHILLING

FILTRATION

GLASS UNIT

COOLING/CHILLING

FILTRATION

GLASS UNIT

COOLING/CHILLING

FILTRATION

DRYING

PACKING PULVERIZING

M.D.C. METHANOL

ACETONITRILE

N-BUTYL

BROMIDE

PH

ADJUST-

MENT

RECYCLE

FOR RECYCLEFOR RECYCLE

HYOSCINE

BUTYL BROMIDE

M.D.C.


MASS BALANCE

STAGE 2: CIMETROPIUM BROMIDE

BRIEF PROCESS

First take Acetone in GLR with Hyosine Butyl Bromide. Then PH treatment is done by

Hydrobromic Acid. After PH, filter it and further the slurry is taken into glass assembly and

catalyst A is added & heated to 75°C to 80 °C for 24hr then cool to 0°C. Finally it is filtered,

dried and packed.

FLOW CHART

Hyosine Butyl Bromide

Acetone Hydrobromic Acid (48%)

Catalyst A



1 Dubosia Leaves 75 Hyoscine Butyl Bromide 502 Hydrobromic Acid 60 ML of Hyoscine Butyl Bromide 5903 N-Butyl Bromide 119 Recovered acetonitrile 554 Acetronitrile 58 Recovered chloroform 43855 Liquid Ammonia 40 Recovered MDC 64806 Dil Hydrochloric Acid 125 Recovered methanol 11957 Chloroform 4467 Distillation residue 68 MDC 6600 Saw dust 909 Methanol 1217

TOTAL 12761 12761

G.L.R

FILTERATION

G.A.A

Centrifuge

Packing Dryer


MASS BALANCE

Sr.No. Name of Input Material Input Qty.(Kgs) Output Material

Out Put Qty

(Kgs.)1 Hyosine Butyl Bromide 50 Cimetropium bromide 402 Acetone 400 Solvent Recovery 3903 Hydrobromic Acid 10 Distillation Residue 364 Catalyst A 6

TOTAL 466 466


11. COLCHICOSIDE & THIOCOLCHICOSIDE (Proposed Product)

BRIEF PROCESS: First Glorisa superba hjuseeds powder is charged with methanol in the extractor then the

extracted methanol taken into another SS reactor for distillation. The concentrated solution is

mixed with alumina in SS reactor. Then it is filtered. The wet cake form will be Colchicoside

and mother liquor of the cake is charged with acetic acid and chloroform in extractor. Then it is

taken into glass assembly for distillation process and finally filtered, dried and packed.

FLOW CHART

S. S. Extractor

Dryer

S.S.DistilllationVessel

Nutch Filter

S.S. Mixer

S.S.Reactor

Glass AssemblyLiquid-LiquidExtractor

Packing Pulverizer

S.S. Column

S.S. DistillationVessel

Nutch Filter

Dryer

Glorisa superba seedpowder +

Methanol

Activated

Alumina

Syrup + (1) Chloroform

(2) Methanol

Syrup +

Methanol +

Acetone mixture

Acetone

Glass-LinedRector

Colchicoside +

Mercaption +

Acetic Acid

Chloroform

+

Reaction Mass

MASS BALANCE



1 Gloriosa Superba Seed 100 Colchicoside 502 Methanol 550 Recovered methanol 5433 Activated Alumina 10 Recovered chloroform 1474 Chloroform 150 Recovered acetic acid 105 Mercaption 2 Recovered acetone 1956 Acetic Acid 10 Solid Waste of Alumina 157 Acetone 200 Distillation Residue 22

Agricultural waste 40 TOTAL 1022 1022


12. 10-DEACETYL BACCATIN-III (10- DAB-III)

BRIEF PROCESS

Taxus Baccata Powder is extracted with Dichloromethane. The extract is concentrated.

Methanol is added to the concentrated mass and stirred. The slurry is centrifuged and the

aqueous solution is collected. It is extracted with Dichloromethane. The Dichloromethane

extract is concentrated. It is dissolved in a mixture of Dichloromethane: Methanol (20:1) and

charged into a Silica Gel Column. It is eluted with the same solvent mixture. The fraction

containing 10-DAB is collected separately and concentrated. Acetonitrile is added to the

concentrated mass. It is stirred and cooled. The slurry is filtered and dried at 50°C under

vacuum to get pure 10-DAB-III.


PROCESS CHART

O

O

OH

NHO

OO

OH

HO

OH

OO

OO

OH

Texus Baccata

Dichloromethane-Methanol (Extraction)

HO

OH OH

OOH

OH

O

O

OO

10-Deacetylbaccatin III (10-DAB) (Molecular Weight 544.59 g/mol)


FLOW CHART

S.S. EXTRACTOR

S.S.DISTILLATION UNIT

CENTRIFUGE/ SPRAY DRIER

LIQUID - LIQUIDEXTRACTOR

S.S.DISTILLATION UNIT

SILICA GELCOLUMN

WATER

DICHLOROMETHANE

TAXUS BACCATA POWDER

METHANOL

DICHLORORMETHANE

DICHLORORMETHANE-METHANOL MIXTURE

DICHLORORMETHANE-METHANOL MIXTURE

GLASS DISTILLATION

FILTER

DRYER

PULVERIZER

PACKING

ACETONITRILE


S.S. EXTRACTION VESSEL


DISTILL-ATION

RECOVEREDSOLVENT

GLASS

COLUMN

SOLVENT

CONCENTRATION

COOLING/CHILLING

FILTRATIONDRYING

PACKING

TEXAUS BACCATA EXTRACT

RECOVERED SOLVENT

SOLVENT

RECOVERED SOLVENT

CRUDE 10 - DAB

MASS BALANCE



1 Taxus Baccata Powder 100 10-DAB 252 Methanol 400 Recovered methanol 3903 Dichloromethane 200 Recovered Dichloromethane 1904 Acetonitrile 250 Recovered Acetonitrile 240

Distillation residue 45Agricultural waste 60

TOTAL 950 950


13. YOHIMBINE HYDROCHLORIDE

BRIEF PROCESS

Yohimbine extract is charged in extractor and treated with methanol. The product containing methanol layer is concentrated and to it conc. HCl acid is added in required quantity. Upon adjusting its pH with liq. Ammonia ppt. of Yohimbine, HCl will come out which is filtered, dried, micronized & packed as Yohimbine HCl.

CHEMICAL REACTION

C21H26N2O3 + HCl C21H26N2O3.HCl

YOHIMBINE YOHIMBINE HYDROCHLORIDE


PROCESS FLOW CHART

S.S. EXTRACTIONVESSEL

DISTILLATION

GLASS UNIT

COOLING/CHILLING

FILTRATION

DRYING

MICRONIZINGPACKING YOHIMBINE

YOHIMBINE

EXTRACT METHANOL

RECYCLED METHANOL

LIQ. AMMONIA

CONC. HCl

HYDROCHLORIDE

MASS BALANCE



1 Yohimbine Extract 85 Yohimbine Hydrochloride 502 Methanol 4000 Recovered Methanol 39203 Conc. HCl 100 Drying Loss 2104 Liquid Ammonia 25 Distillation residue 30

Total 4210 4210


14. CAMPTOTHECIN

BRIEF PROCESS

Extract of Mapia Potedia is purified by dissolving it in Methanol & Acetone and passing through a column packed with silica gel & alumina oxide. The clear liquid is chilled. Upon crystallization the mass is filtered in vacuum water & wet cake is dried, purified & packed in liner bag.

CHEMICAL REACTION

Extract of Camptothecin Mappia Potedia

NOTE : No chemical reaction only Mass Transfer operation has been done.

By packed Column

Purificatio


PROCESS FLOW CHART



DISTILL-ATION

RECOVEREDSOLVENT

GLASS

COLUMN

CONCENTRATION

COOLING

FILTRATIONDRYING

PACKING

RECOVERED SOLVENT

RECOVERED SOLVENT

CAMPTOTHECIN

MAPPIA POTEDIAEXTRACT METHANOL

ACETONE

PACKING

MATERIAL

MASS BALANCE

Sr. No.

Name of Input Material

Input Qty.(Kgs) Output Material Output

Qty.(Kgs.)

1 Extract Of Mappia Potedia 50 Camptothecin (Min.96%) 30

2 Methanol 400 Recovered methanol 3903 Acetone 160 Recovered acetone 150

4 Silica Gel 10Solid Waste Of Silica Gel & Alumina Oxide 23

5 Alumina Oxide 3 Distillation residue 30 Total 623 623


15. RESERPINE

BRIEF PROCESS

Rauwolfia Extract is dissolved in Methanol & Chloroform and the solution is passed through silica gel + alumina oxide column. Pure product containing solvent layer is taken or crystallization, filtration. Recovered ML is taken for solvent recovery where as filter cake obtained is dried, pulverized & packed in bags.

CHEMICAL REACTION

Rauwolfia Purification Reserpine + Recovered + Silica Gel, Alumina Oxide

Extract With Column Solvent alongwith Impurities


PROCESS FLOW CHART


S.S. EXTRACTION VESSEL(LLE)

GLASS

COLUMN

CONCENTRATION

Distillation & Reco.Of Methanol

RALUWOLFIAEXTRACT

Methanol

Chloroform

PACKING MATERIAL

Crystallization

FILTRATIONDRYING

PACKING RESERPINE

RECSOLVENT

MASS BALANCE



1 Rauwolfia Extract 60 Reserpine 302 Methanol 480 Recovered methanol 4653 Chloroform 100 Recovered chloroform 904 Silica Gel 22 Silica Gel/ Alumina Oxide Impurities 625 Alumina Oxide 10 Distillation residue 25 TOTAL 672 672


16. DIGOXIN

BRIEF PROCESS

The extract of Digitalis lanata is hydrolysed with mild alkali and thereafter Digoxin is obtained by fractional with boiling chloroform. Finally extracted product is concentrated and cooled/ chilled in order to crystallize the product which is again re-crystallized, filtered, dried, micronized & packed as a “Digoxin”.

CHEMICAL REACTION

CHLOROFORM

Extract of Digitalis Lanata + Sodium Bicarbonate Digoxin

Note : No chemical reaction only Mass Transfer operation has been done.


PROCESS FLOW CHART


LIQUID LIQUIDEXTRACTION

DRYING

PULVERIZING

PACKING

DISTILLATION

CHLOROFORMGLASS UNIT

COOLING / CHILLING

FILTRATION

RECRYSTALLIZATION

FILTRATION

DIGITALIS LANTA EXTRACT

SODIUM BICARBONATE

SOLUTION RECOVERED CHLOROFORM

DIGOXIN

MASS BALANCE



1 Extract Of Digitalis Lanata 70 Digoxin 502 Chloroform 5000 Recovered Chloroform 49403 Sodium Bicarbonate Solution 30 Distillation residue 110

TOTAL 5100 5100


17. ARTEMETHER

BRIEF PROCESS

First charge Toluene with Di-hydro Artemisinin in GLR and charge Sodium Methoxide and catalyst at RT. Check TLC, then take this reaction mass to SS reactor and filter it through sparkler filter and take the Toluene in another SS reactor for distillation. Filter it. Dry and pulverize and pack.

CHEMICAL REACTION:

O

O H

H

OO

O

CH3

H

CH3

CH3

Artemisinin (282.332 g/mol)

CH3OH Catalyst

O

O

O H

H

OO

H

H

Dihydroartemisin

284.35 g/mol

Sodium Meth oxide Catalyst

O

O

O

H

O O

H

H

Arthemether (298.374 g/mol )


FLOW CHART

G.L. REACTOR

PULVERIZER

PACKING

S.S.REACTOR

DRYER

S.S.REACTOR

CENTRIFUGE

DISTILLATIONTOLUENE FILTRATION

DISTILLATION

ARTEMETHER

TOLUENESODIUM METHOXIDE

DIHYDRO ARTEMISININCATALYST

TOLUENECRUDE ARTEMETHER

ACTIVATED CHARCOAL

MASS BALANCE

Sr. No. Name of Input Material Input Qty.(Kgs) Output Material Output

Qty.(Kgs.) 1 Di-Hydro Artemisinin 100 Artemether 1002 Toluene 500 Recovered Solvent 4803 Sodium Methoxide 25 Spent Carbon 74 Catalyst 10 Distillation residue 535 Activated Charcoal 5

Total 640 640


18. α, β – ARTEETHER

BRIEF PROCESS

First charge Toluene with Di-hydro Artemisinin in GLR and charge Sodium Ethoxide and catalyst at RT. Check TLC, then start distillation of Toluene. Filter it and take crude Artemether into SS reactor with Toluene and filter it. Take another SS reactor and distil Toluene up to certain limit and then filter. Dry and Pack.

CHEMICAL REACTION

O

O H

H

OO

O

C H 3

H

C H 3

C H 3

Artemisinin

282.332 g/mol

CH3OH Catalyst

O

O

O H

H

OO

H

H

Dihydroartemisin

284.35 g/mol

Sodium Ethoxide Catalyst

O

O

O

H

O O

H

H

Alpha Beta Arteether

312.41 g/mol

FLOW CHART


G.L. REACTOR

PACKED INPLASTIC

CONTAINER

CENTRIFUGE

DISTILLED INROTARY VACCUM

EVAPORATOR

S.S.REACTOR

S.S.REACTOR

DISTILLATIONTOLUENE

FILTERDISTILLATION

TOLUENEDIHYDRO ARTEMISININ

CATALYSTSODIUM ETHOXIDE

TOLUENECRUDE ARTEETHER

ACTIVATED CHARCOAL

Alpha, Beta- ARTEETHER

MASS BALANCE



1 Di-Hydro Artemisinin 100 Α, Β - Arteether 982 Toluene 500 Recovered toluene 4803 Sodium Ethoxide 33 Spent Carbon & Catalyst 424 Catalyst 12 Distillation residue 495 Activated Charcoal 24

TOTAL 669 669


19. ARTESUNATE

BRIEF PROCESS

First take Acetone with Di-hydro Artemisinin in GLR and charge Succinic acid with catalyst. Take it into SS reactor and filter it. Dry, pulverize and pack.

CHEMICAL REACTION

O

O H

H

OO

O

C H 3

H

C H 3

C H 3

Artemisinin

282.332 g/mol

CH3OH Catalyst

O

O

O H

H

OO

H

H

Dihydroartemisin : 284.35 g/mol

Succinic Acid Catalyst

O

O

O O

HC H 3

H

O

H C H 3

H

C H 3

H

O

O

O H

Artesunate

384.421 g/mol


FLOW CHART

G.L. REACTOR

DRYER

PULVERIZER

S.S.REACTOR

S.S.REACTOR

S.S.REACTOR

CRYSTALLIZER

FILTRATION

ACETONEDIHYDRO ARTEMISININ

SUCCINIC ACIDCATALYST

CRUDE ARTESUNATEACTIVATED CHARCOAL

WATER

FINAL PRODUCT PACKING IN FIBERDRUM

CENTRIFUGE

CENTRIFUGE

ARTESUNATE

MASS BALANCE

SR. NO. Name of Input Material Input


1 Di-Hydro Artemisinin 100 Artesunate 922 Acetone 150 Recovered acetone 1443 Succinic Acid 31 Spent Carbon & Catalyst 484 Catalyst 11 Distillation residue 285 Activated Charcoal 20

TOTAL 312 312


20. METHYLCOBALAMINE

BRIEF PROCESS

STAGE – I:

Cyanocobalamine is dissolved in water and reacted with Sodium Borohydride to get Hydroxy Cobalamine

STAGE – II:

Hydroxy Cobalamine is reacted with Dimethyl Sulphate in the presence of methanol, to form Methylcobalamine. It is extracted with organic mixture.

STAGE – III:

Methylcobalamine is extracted from the organic mixture using water. The aqueous extract is concentrated. Acetone is added to the concentrated extract and stirred. The crystals of Methylcobalamine are filtered.

STAGE – IV:

The wet cake of Methylcobalamine is charged into the dryer and dried at 50°C under vaccum till the water content is not more than 12.0%.

The dried material is pulverized, sieved and packed.

SYNTHESIS SCHEME

1) C63H88CON14O14P + 2H2 + H2O NaBH4 C62H89CON13O15P + CH3NH2

Cyano Cobalamine Hydrogen Water CH3OH Hydroxy Cobalamine Methylamine

2) C62H89CON13O15P + (CH3)2SO4 C63H91CON13O14P + CH3HSO4 + 1/2O2

Hydroxy Cobalamine Dimethyl Sulphate Methyl Cobalamine Methyl Hydrogen Oxygen

Sulphate


FLOW CHART

S.S. REACTOR

S.S. REACTOR

S.S. REACTOR

GLASS LINEDREACTOR

BUCKNER FUNNEL

DRYER

PULVERIZER

SODIUM BOROHYDRIDE

+WATER

CYANO COBALAMINE

DIMETHYL SULPHATE

WATER

WATER

ACETONE

ACETONE

(1) METHANOL (2) ORGANIC MIXTURE

SIEVE

PACKING


MASS BALANCE

SR. NO. Name of Input Material Input


1 Cyano Cobalamine 50 Methylcobalamine 472 Sodium Borohydride 12 Recovered methanol 3853 Dimethyl Sulphate 14 Recovered acetone 1804 Methanol 400 Distillation residue 645 Acetone 200

TOTAL 676 676


21. NICORANDIL

BRIEF PROCESS

Nicotinic Acid is reacted with methanol in the presence of sulphuric acid to get Methylnicotinate. Methylnicotinate is condensed with Monoethanolamine to get amide derivative.The amide derivative is reacted with Sulphuric Acid to get Nicorandil.

FLOW CHART

Methanol Nicotinic Acid Monoethanolamine Sulphuric Acid

MASS BALANCE

SR.No. Name of Input Material Input Qty.(Kgs)

Output Material

Out Put Qty (Kgs.)

1 Nicotinic Acid 25 Nicorandil 302 Methanol 200 Recovered methanol 1923 Monoethanolamine 13 Distillation Residue 194 Sulphuric Acid 3

TOTAL 241 241

Glass Assembly

Glass

Filter

Filter Dryer Packing

Glass


ANNEXURE III

DETAILS OF WATER CONSUMPTION:

Source of water: Borewell

Sr. No. Breakup

Existing Consumption

(KL/Day)

Proposed Consumption

(KL/Day) I Domestic 2.8 3.8 II Gardening -- 20.0 II Industrial 1 Process 1.2 12.0 2 Boiler (make up) 1.4 2.2 3 Cooling (make up) 1 2.0 Total Industrial 3.6 16.2 Total 6.4 40.0

Total water consumption for the proposed activities will be 40 KLD out of which gardening & domestic water consumption will be 23.8 KLD and 16.2 KLD being industrial water consumption. Hence, there will be increase in water consumption by 33.6 KLD.

Details of waste water generation:

Sr. No.

Breakup Existing Generation (KL/Day)

Proposed Generation (KL/Day)

I Domestic 2.8 3.0 II Industrial 1. Process 0.8 12.0 2. Boiler (Blow down) 0.5 1.3 3. Cooling (Bleed off) 0.5 1.2 Total Industrial 1.8 14.5 Total 4.6 17.5

Total waste water generation will be 17.5 KLD, out of which 3 KLD will be domestic effluent, which will be sent to soak pit. 14.5 KLD will be industrial effluent, out of which 12 KLD being process effluent will be incinerated in existing inhouse incinerator and 2.5 KLD being effluent from utilities will be passed through pressure sand filter and Carbon filter and then used for gardening activities.


ANNEXURE IV

Flue gas Emission/stack

Sr. No.

Stack attached to

Stack Height

(m)

Fuel Type Fuel consumptio

n rate

Stack Dia

APCM Probable pollutants

Existing

1. Thermic Fluid

Heater 18 mt. Wood

166 Kgs/Hr.

22 Cyclone

SO2, NOx, PM

2. Boiler Wood 22 SO2, NOx, PM

3. Furnace 13 mt. Wood 15 Cyclone SO2, NOx, PM

4.

Incinerator 30 mt. LDO 100 Lit./Hr. 22 Cyclone SO2, NOx, PM, HCL, CL2, H2S,

CO, HF, HC

Proposed (No new boiler or TFH will be installed)

1 Thermic Fluid Heater

18 mt.

Agrowaste / Process

Agricultural waste 200 Kgs/Hr. 22

Multi-

Cyclone

SO2, NOx, PM

2. Boiler Agrowaste /

Process Agricultural

waste

SO2, NOx,

PM

3. Incinerator 30 mt. LDO 100 Lit./Hr. 22 Cyclone SO2, NOx, PM, HCL, CL2, H2S,

CO, HF, HC

Process gas Emission/stack

Sr.

No.

Stack attached to Stack Height

(m)

APCM Probable pollutants

Existing

1. Reaction vessel 11 mt. Alkali scrubber SO2 & H2S

Proposed

1. Reaction vessel 11 mt. Alkali scrubber SO2 & H2S


ANNEXURE V

Details of hazardous waste generation and disposal:

Existing & Proposed Scenario:

Sr. No.

Waste Details Waste Category

Existing Generation (MT/Year)

Proposed Generation (MT/Year)

Mode of Disposal

1 ETP Sludge 34.3 3.5 MT/Year -- Collection, storage, transportation and disposal to TSDF.

2 Used Oil 5.1 0.2 MT/Year 0.4 MT/Year Collection, storage, transportation and disposal to authorised recycler.

3 Waste / Residue 28.1 -- 152 MT/Year Collection, storage, transportation and disposal to CHWIF / Co-processing.

4 Distillation residue

28.5 -- 405 MT/Year Collection, storage, transportation and disposal to CHWIF / Co-processing.

5 Spent catalyst / Spent Carbon

28.2 1 MT/Year 220 MT/Year Collection, storage, transportation and disposal to authorised recyclers / CHWIF / Co-processing.

6 Bags & containers

33.3 100 No.’s/Year

1000 No.’s /Year

Collection, storage, transportation and disposal to authorised recycler.

7 Process Agricultural Waste

-- -- 326 MT/Yr. Collection, storage, transportation and use as fuel in boiler & TFH / sent for Co-processing.

The hazardous waste shown above is with respect to worst case scenario if the product is

manufactured at its full capacity for the entire year.

annexure i list of products to be manufactured...

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