animal use data breakout session - canadian council on …€¦ · · 2014-06-17animal use data...

The Canadian Council on Animal Care:

Animal Use Data

Gilly Griffin

Director of Standards

June 12, 2014, Ottawa, Ontario

www.ccac.ca

Overview

Purpose of the animal use data

Changes for 2013

Required elements

Publication of the 2011 data

Institutions use of the data

CCAC Mandate

The CCAC oversees the ethical use and care of

animals used in science (research, teaching and

testing) on behalf of the Canadian public

Purpose of the Animal Use Data

Public accountability

Changes in numbers and species

Identifies areas of animal welfare concern

CIHR/NSERC Requirement for Metrics

“The Committee suggests that CCAC comes up

with metrics for the data it has collected to date that

is more “usable” and that can create impact.”

Types of Animal Use (2011)

Purpose of Animal Use (2011)

Category of Invasiveness (2011)

33.7%

33.2%

29.2%

3.9%

Sortable File for 2011

Animal Use Data

Publish compiled data

Compare internationally

Analyze data:

trends in types of animals

areas where most pain and distress occur

http://www.ccac.ca/en_/publications/audf





Changes for 2013 data collection

Use of an excel

spreadsheet

Animal Use Data Form

Instructions

document

http://www.ccac.ca/Documents/Publications/Statistics/2011_Animal_Use_Data.xlsx



What happens when we receive the data

Submission

AUDF Received

Approx. 11,000 AUPs from 200

Institutions

Date received noted

Preliminary Review

AUDF Quick Scan

Receipt of AUDF acknowledged

Request for corrections to

incorrect/missing data

AUDF converted to EXCEL if not

already

First Validation

Remove

(zero animals used, embryos,

invertebrates, etc.)

Cats/Dogs (random/purpose

Bred)

CI & PAU

Compare to description and/or

keywords

Species Name

Monkey vs.

Rhesus Macaque

Reuse

Current yr. vs. Previous yr.

Second Validation

Review all issues flagged in first

validation

Flag additional

discrepancies, make final corrections

Institutional Follow-up

Contact Institutions to

deliver/request corrections

Receive corrections to

amend data

STATISTICS

Standard Format

Standard Format – unique protocol number

Unique Protocol Number

Sounds obvious

Permits the CCAC to quickly ask questions about a

particular protocol

Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979

Standard Format – category of invasiveness

Categories of Invasiveness

CI A: mostly invertebrates or live isolates

CI B: little or no discomfort or stress

CI C: minor stress or pain of short duration

CI D: moderate to severe distress or discomfort

CI E: severe pain near, at, or above the pain tolerance

threshold of unanesthetized conscious animals

Category of Invasiveness

Unique

Protocol

Number

CI

Protocol Description

Keywords

Species

Number of

Animals

Used

ABC D Rodent models of

cardiac disease used to

identify or validate

common mediators of

hypertensive cardiac

growth. The heart will

be excised to

examine pathology

Major

survival

surgery;

chemical

exposure

Mice 23


Standard Format – purpose of animal use

Purpose of Animal Use

PAU 0: breeding colonies, herd management and

holding protocols

PAU 1: fundamental studies

PAU 2: medical studies, including veterinary medicine

PAU 3: regulatory testing

PAU 4: development of products

PAU 5: educational purposes

Purpose of Animal Use

Always report the primary purpose

Unique

Protocol

Number

PAU


Keywords

Species

Number

of

Animals

Used

XYZ 1 Anti-diabetic effect of novel

chemical will be studied in

diabetic rats. Fasting blood

glucose and oral glucose

tolerance will be tested and

some animals will be used to

train graduate students on

experimental procedures

Blood

sampling;

biopsy;

oral

gavage

Rats 63

Standard Format – protocol description


Enables the CCAC to determine the intent of the

protocol i.e. fundamental research, teaching etc.

Helps validate the PAU


Standard Format – keywords

Keywords

Enable the CCAC to determine what procedures have

been carried out on the animals.

Help validate the Category of Invasiveness.

List of keywords in the instruction document.

http://www.ccac.ca/Documents/Publications/Statistics/CCAC_Animal_Use_Statistics_2011.pdf

List of Keywords

Protocol Description or Keywords

Ideally we would like both as the focus is different

IF protocol description only, ensure sufficient

information about procedures

IF keywords only, ensure enough information about

type of studies


Standard Format – animal genus and species

Animal Genus and Species

Be as specific as possible:

mice – wild or house

birds – chickens, zebra finches, loons

fish – zebrafish, wild salmon, trout

monkeys – rhesus, cynomolgus

Cats and Dogs

Random or purpose-bred

Public concern

Specify in the animal genus and species column


Sortable File for 2011

Standard Format – animal use numbers

Animal Use Numbers

Used in that same calendar year

If animals used in more than one protocol, include the

number of the protocol

Unique Protocol

Number

Number of

Animals Used

Number of

Animals Re-used

Protocol Number

of First Use

100359 20 10 100423

Standard Format – re-used from previous year

Re-used From Previous Year

Unique

Protocol

Number

Animal

Species

Number of

Animals

Used

Number of Animals

Re-used From a

Previous Year

2000349 macaque 5 5 - these animals

have been in the

facility for the past

five years, and are

used for...

CCAC does not require this information


Help Us to Help You

Information on animal use at the local level

Comparison with other institutions

Areas where assistance is needed

Contact

For questions related to the

submission of your AUDF,

please contact:

Wendy Clarence,

Research Assistant, CCAC

[email protected]

Tel. (613) 238 - 4031 ext. 228