angiopoietin-1 prevents hypertension and target organ damage through its interaction with...
TRANSCRIPT
Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2
receptor
by Jung-Sun Lee, Sun-Hwa Song, Jeong-Min Kim, In-Soon Shin, Koung Li Kim, Yeon-Lim Suh, Hak-Zoo Kim, Gou Young Koh, Jonghoe Byun, Eun-Seok Jeon,
Wonhee Suh, and Duk-Kyung Kim
Cardiovasc ResVolume 78(3):572-580
June 1, 2008
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]
COMP-Ang-1 gene transfer prevents the blood pressure (BP) elevation in spontaneously hypertensive rats (SHRs).
Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]
COMP-Ang-1 gene transfer reduces myocardial damage in SHRs. (A) Representative images of H&E-stained heart.
Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]
COMP-Ang-1 gene transfer reduces renal damage in SHRs. (A) Representative images of H&E-stained kidney.
Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]
COMP-Ang-1 gene transfer attenuates the microvascular rarefaction and tissue ischaemia in the heart and kidney of SHRs. The microvasculature of the heart (A) [arrowheads in (A) indicate the
absence of capillaries], (B) and kidney (C) was visualized and quantified by immunohistochemical staining with CD31 IgG on frozen sections or RECA IgG on paraffin
sections, respectively.
Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]
COMP-Ang-1 protein induces beneficial effects in SHRs via Tie2 receptors on endothelium.
Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]
COMP-Ang-1 enhances nitric oxide production by activating endothelial nitric oxide synthase (eNOS).
Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]