anemia classification
DESCRIPTION
anemia classificationTRANSCRIPT
-Definition -ClassificationANEMIA
By: Tassaya Kanyook ID:52112158
ANEMIA IS NEVER NORMALMen: HGB < 13.5 or HCT < 41%Women: HGB < 12.0 or HCT < 36%
WHAT IS ANEMIA?
Definition of AnemiaAnemia is a decrease in the RBC count,
Hgb and/or HCT values as compared to normal reference range for age and sex
(Also determined by alteration in plasma volume)
CLASSIFICATION OF ANEMIAS
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CLASSIFICATION OF ANEMIAS
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CLASSIFICATION OF ANEMIAS
Hb levels decreased MCV normal Acute blood loss Anemia of chronic disease Aplastic anemia Hemolytic anemia
size of erythrocytes is larger than normal
Megaloblastic anemia – Vitamin B12, Folate deficiency.
size of erythrocytes is smaller than normal
Heme synthesis defect Iron deficiency anemia Anemia of chronic disease
Thalassemia Sideroblastic anemia
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NORMOCYTIC NORMOCHROMIC ANEMIA
It includesAplastic anemia due to BM failure
Blood loss anemia Hemolytic anemia
Is a condition in which the size & Hgb content of RBCs is normal but the number of RBCs is decreased.
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MICROCYTIC- HYPOCHROMIC ANEMIA
Many RBCs smaller than nucleus of normal lymphocytes
Increased central pallor.Includes
Iron deficiency anemia Thalassemia Anemia of chronic disease Sideroblastic anemia Lead poisoning
Is a condition in which the total body iron content is decreased below a normal level
This results in a reduced red blood cell and hemoglobin production
IRON DEFICIENCY ANEMIA (IDA)
Inherited decrease in alpha or beta globin chain synthesis needed for Hgb A; quantitative defect All have microcytic/hypochromic RBCs and target cells
Genetic mutations classified by: ↓ beta chains = beta thalassemia…Greek/Italian ↓ alpha chains = alpha thalassemia…Asian
THALASSEMIAS
Target cells/Codocytes
Beta
Alpha
MACROCYTIC NORMOCYTIC ANEMIAS
Wright’s stained blood smear
A. MEGALOBLASTIC ANEMIAVitamin B12 deficiencyFolate deficiencyAbnormal metabolism of folate and vit B12
B. Non megaloblastic anemia Liver diseaseAlcoholismPost splenoctomyNeonatal macrocytosisStress erythropoiesis
Macrocytosis due to a deficiency of vitamin B12 or folic acid that causes impaired nuclear maturation
MEGALOBLASTIC ANEMIA
RBC maturation in microcytic anemias…IDA
Normoblastic RBC maturation normocytic red cells
Megaloblastic RBC maturation macrocytic red cells
http://themedicalpost.net/2010/07/18/the-general-concept-of-anaemias/http://accessmedicine.com/search/searchAMResult.aspx?
rootterm=anemias&searchType=1&rootID=64&searchStr=anemia&modifier=yes&subID=180
http://en.wikipedia.org/wiki/Thalassemiahttp://www.medicinenet.com/anemia/article.htm
REFERENCES