Academy of Scientifc Research and Technology

أكاديمية البحث العلمى والتكنولوجيا

Application Form

Ancient Ingredients with Modern Evidence

A Proposal on

Innovative Development of Egyptian Medicinal and Aromatic Plants and their Extracts

A new Approach for Medicinal Plants Sector Growth

BY Consortium Managed by

Faculty of Pharmacy Cairo University

Application Form: ASRT Initiatives 2015

حملة قىمية لحسن استغالل ودعم تسىيق النباتات الطبية والعطرية - 5

Title oftheinitiative

(project):

Arabic/English

Ancient Ingredients with Modern Evidence

Innovative Development of Egyptian Medicinal and Aromatic Plants and

their Extracts

حبث ػظش٠تشوببث لذ٠ت ببربب

اظش٠ت خالطبحب اؼطش٠ت اطب١ت حط٠ش بخىش ببحبث

Name of Applicant:

Arabic/English

Faculty of Pharmacy Cairo University

صبؼت امبشة -و١ت اظ١ذت

Affiliation of the

applicant: Governmental University

Name and contact

information of

Industrial

partner/End user

Dr. Amr Mohamed Helal (Industrial partner)

Mobil 01002100429 - Email dr.amrhelal@hotmail.com

Dr. Heba Labib

Mobil 01001607845 - Email hlabib@nu.edu.eg

Requested Budget

(LE):3500000

ASRT

Share:

74.5%

Industry/Private/

other partners

Sector Share:

1,200,000

Total:LE 4700000

Duration of the

project (months): 2 years

Type of the project:

(Please check one

only)

Manufacturin

g of

Functional

prototype □

Process

development/

Scaling Up □

Semi-industrial

Production/

Commercializatio

n□

Experimental

field □

Approvals

Principal

Investigator

Name:Prof. Dr. Essam

Abd El Hamid Abd El

Sattar

Signature:

Date:19.2.2015

Host Institution

Name:Faculty of Pharmacy Cairo University

Signature:

Date:19.2.2015

Seal:

Date of Submission 11.2.2015

Part A:Short CV of the applicant (One page maximum)

1. Basic Information

Full Name in Arabic:

Full name in English:

Essam Abdel-Sattar

Date of Birth: October 5, 1955

National ID: 25510051300974

Last University Degree

PH.D. Pharmaceutical Sciences

Faculty: Pharmacy, Cairo Univ,

Country: Egypt

PH.D. Graduation Date

1991

Title: Professor Field of specialization: Pharmacognosy

Affiliation: Faculty of Pharmacy, Cairo University, 11562 Cairo, Country:

Egypt

Current Position Professor

Contact Information:

Mobile Phone: 01065847211 Fax: 25321900 E-mail: abdelsattar@yahoo.com

2. Scientific Achievements

h index

14

Citations

277

Total no. of Int. publications in Scopus

48

Last three recent relevant publications

Authors (underline your name), year, title, Journal, vol. and pages

1

Hossam M. Abdallah, Abdel-Moneim M. Osman, Hussein Almehdar, Essam Abdel-Sattar*.

(2013). AcylatedPregnane glycosides from Carallumaqaudrangula. Phytochemistry: 88: 54-

60.

2 Essam Abdel-Sattar, Ashraf B. Abdel-Naim, Hossam M. Abdallah, Alaa Khedr (2012).

Chemical

and Biological Assessment of African Olive Leaf Extract. Research Journal of

Pharmaceutical,

Biological and Chemical Sciences 3: 155-172.

3 Essam Abdel-Sattar, Hossam M. Abdallah, Ashraf B. Abdel-Naim, Alaa Khedr (2011).

Mechanisms of the antihyperglycemic activity of Carallumatuberculata in streptozotocin-

induced diabetic rats (accepted to Food and chemical Toxicology).

Field editor for Journal of Functional Foods in Health and Disease (FFHD).

Granted projects: 18 (four are running)

Conferences: 27

Research of interests

- Isolation and purification of different natural compounds from their plant sources, viz.

sesquiterpene lactones, pregnane glycosides, saponin glycosides diterpenes, iridoids, etc.

- Search for Biologically active natural products through biologically guided fractionation (viz.

anticancer, antiviral, antimalarial, etc…)

- Quality control of herbal drugs.

Reviewers for several international journals

Previous or running projects with STDF

a. Running (ID no. & type of grant, role of applicant)

b. Previous (ID no., type, role of applicant and deliverables to be attached)

CO PI

1. Basic Information

Full Name in Arabic:

عمرو محمد هالل

Full name in English: Amr M. Helal

Date of Birth: 20.2.1961

National ID 26102200102555

Last University Degree

PH.D Phytochemistry

Faculty, University, Country Cairo

University, Egypt

Graduation Date 1983

PH.D. 1996

Title: Dr. Field of specialization: Pharmacognosy and Phytochemistry

Affiliation: Health Tech for Integrated Health Solutions

Current Position: CEO

Contact Information:

Mobile Phone: 01002100429 Fax: 33477755 E-mail:

amr@itm.com.eg

2. Scientific Achievements

h index

4

Citations

62

Total no. of Int. publications in Scopus

7

Last three recent relevant publications

Authors (underline your name), year, title, Journal, vol. and pages

1

Ammar, H. O., Al-Okbi, S. Y., Mostafa, D. M., and Helal, A. M. (2012). Rice bran oil:

Preparation and evaluation of novel liquisolid and semisolid formulations. International

Journal of Pharmaceutical compounding, 16(6), 516-523 (USA).

2 Al-Okbi, S. Y., Mohamed, D. A., Hamed, I. M., Agoor, F. S., Ramadan, A. A. M., El-Saed,

S., Helal, A. M. (2013). Comparative Study on Egyptian Rice Bran Extracted by Solvents and

Supercritical CO2. Advances in Food Sciences, 35(1), 23-29. (Germany).

3 Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP

Rice Bran Extract compensates mitochondrial dysfunction in a cellular model of early

Alzheimer's disease J Alz Dis 2015, 1;43(3):927-38.

If applicable, state other salient scientific achievements such as patents (granted only) and

scientific prizes A- Winner of Green Apple Award, UK, Best Environmental Practice, Gold Winner, Africa 2005

for Environmental control of Black smog (Rice straw composting / AWARDS).

B- Innova award at 2011 from Heliopolis University (Rice Waste Management)

C- COMESA Gold Innovation AWARD 2013 (SME Catigory)

Part B: R&DProposal

The proposalshould provide a clear and concise definition of the R&D proposal, innovation or

invention, description of the target product, which will be developed through this fund and its

advantages in comparison with other existing technologies in the same field. Economic

feasibility and potential market of the product supported with verified statistics (with citation)

must be presented. The proposalshould not exceed 10pages(including all parts of the

proposal, i.e. part A, B, C and D) and can be written either in English or Arabic. The proposal

must include the following:

B.1. English Summary:

The Egyptian Folk medicine is a heritage of knowledge and experiences accumulated during

thousands of years from the Pharonic, Greek, Roman to the Arab era. These Egyptian medicinal and

aromatic plants (MAP) are used in a wide range for alleviation and/or treatment of many diseases as

well as national and international use as healthy ingredients. What enriched this field is the diversity in

the Egyptian climate from Sinai Mountains to Western Desert Oasis in Siwa, and from Nile Delta and

valley to Upper Egypt.

However our problem analysis clearly defines that the Egyptian exports market share of this

sectordid not exceed 3.2% in 2013 compared to China possessing more than 35 % of the sector market

share(1). Unfortunately, trade of Egyptian MAP, in the local market or for export; rely heavily on small

and medium producers who do not follow the appropriate standards (Good Agricultural Practices –

GAP or Good Manufacturing Practices - GMP) during the cultivation, harvesting, post harvest and

industrial processing. Thisresults into a low quality produce which does not match the exporting

standards, and hence cripples the export volume and value.This alarming scenario was exposed through

the report of Industrial Modernization Centre about herbs and spices sector in Egypt (2), published a

decade ago.

The problem is even intense in the medicinal plants extracts segment. The Egyptian

Pharmaceutical companies are importinggreat part of their requirements instead of producing them

locally. For instance, in 2013, Egypt imported Licorice extract for US$ 723000 (3) despite the

abundance of raw material in Egypt.

Due to the above we concluded that the supply chain of MAP needs serious reform. Starting with

production, farmers don’t observe good agricultural practices, especially in their usage of pesticides.

Postharvest processing is another concern especially that it doesn’t observe the necessary hygiene

practices required for food production. Finally, the export process itself has a huge space for

improvement, whether in applying quality measures in final processing and packaging, or in

establishing a collective brand or in terms of the value added and the final product form.

In this proposal, we try to tackle the aforementioned problem using two parallel alternatives, study

their feasibilities and compare their outcomes.

The First Alternative relies on acting upon the existing value chain and applying grass root reforms

along the chain to remedy the incompetence of that fragmented industry. The reform involves multiple

stages starting with awareness and capacity building to small farmers and processors, assisting small

exporters in the field in improving their processing and packaging techniques, and enforcing quality

control measures. At the same time, we will work on the scientific standardization of the targeted

products and avail a list of recommendations to regulators to ensure an end of process QC by the

authorities. Meanwhile, a “Seal of Quality” image and branding story is being built. The quality image

of “Seal of Quality” will be used for international industry branding (the outside image) and the success

stories associated with that Seal of Quality will be communicated to the inside beneficiaries as a

motivation to embrace higher quality standards.

The Second Alternative will take a disruptive approach; maximizing the value of existing products.

Instead of exporting bulk MAP (Low Value), we will develop the export chain of MAP extracts (High

Value).

The Main Objective of the proposal is toimprove and developMAP sectorthat will reflect on

the export value of this industry

The Specific Objectivesare to improve the competence of the industry through applying grass

root reforms to the classic MAP supply chain, supported by up-to-date monographs, to develop a

quality-approved plant materials and standardized extracts for a number of plants that is commonly

requested by the market, and to conduct a feasibility studyof the industrial extracts production asan

additional local market and export channel.

The project aims to introduce to the sector the concepts of Exporting VALUE instead of VOLUME,

and "Forward Integration"to improve the competitiveness of Egyptian Herbs and aromatic plants

industry toward a better market share in the Export markets.

This project shall witness the establishment of a unique multidisciplinary team composed of

Private Sector; Health Tech for Integrated Health Solutions(HT), Nile’s Gift(NG),Research

Institutes; Faculty of Pharmacy Cairo University(FOPCU), Faculty of Agriculture Ain Shams

University(ASU), Faculty of Engineering Menia University(FEMU), Agriculture Research Center

(ARC) as well as NGO; Fayoum Agro Organic & Development Association (FAODA).

Also the participation of Bibliotheca Alexandrina represented by its consulting firm

Alexandrina for Technical Consultingin the consortium is a great edge in the direction of developing

draft for Egyptian MAP encyclopedia. The consortium members are cooperating together since more

than five years in different projects. The equipment purchased, the expertise generated, as well as the

international networking developed through these national and international projects are assets to the

project.

B.2. Arabic Summary: An understandable translation of the English summary.

خشاد اؼبسف اخبشاث ف اطب اشؼب اظش اخ حشاوج خالي آالف اس١ ا افغض اؼ اذل١ك

اؼظش افشػ عخ اؼظش اغذ٠ذ لذ سبػذ ف اوخشبف ضػت اسؼت اببحبث اطب١ت اؼطش٠ت اخ حسخخذ ف

. صذ٠ش ببزوش أ صد بػ الئ الخبس اؼذ٠ذ ز اببحبث حخف١ف/ أػالس اؼذ٠ذ األشاع، أ وأغز٠ت طغ١ت

ػ ذاس اؼب حع اخشبت ف ااد األساض اضذ٠ذة ف س١بء اظغشاء اغشب١ت ، طؼ١ذ ظش لذ أرش زا

اضبي ببؼذ٠ذ اببحبث اخ بصاج حغظ بمبي اسغ عي اؼب.

ف % 3.2أب ال حخؼذ صذ 2013ف اببحبث اطب١ت اؼطش٠ت اظبدساث اظش٠تببث ػ ف حغ١ إعظبئ ب١

اسخخذا حم١بث بذائ١ت ف زا امطبع أب اخ حؼق ا زا خ١ضت صد ػذد اغذداث سق اخظذ٠ش

٠م فشص اخظذ٠ش أب ز اغبط١ اخس٠ك، بػ١بث ب بؼذ اغظبد، اضغ اخضف١ف اخؼبئت، ا اخغ١ف

ب١ب ػ اضبب ا٢خش ش بذاب ز اظ١ اذ لبج بخط٠ش ؼب١٠ش اضدة حم١بث اؼبضت فمب ؼب١٠ش اذ١ت، ،

ف سق اخظذ٠ش. % ( 35اسخطبػج أ حسخغر ػ عظت وب١شة )عا

ساث و ظ بن احضب ػب 10حغذ٠ذ اظبػت لذ أشبس ا زا اس١بس٠ ز أوزش صذ٠ش ببزوش أ حمش٠ش شوض

خظذ٠ش اببحبث اطب١ت اؼطش٠ت بظسة خب "غ١ش راث ػالت حضبس٠ت" بسخ صد خذ د صد ل١ت ضبفت،

اد اخب اؼشب١ت أ سخخظبحب، زه اػخذث ششوبث اذاء اؼبت ف ظش ػ اسخ١شاد ؼظ اعخ١بصبحب ا

أط١ب زا امطبع ببش أطبظ غ١ش لبدس ػ ابفست.

زه، فإ زا امطبع ٠غخبس طش٠مت بخىشة خغب ػ حه اؼلبث، زه وب زا امخشط بببدسة ٠خمذ بب ف سبس٠

ػ دساست صذ مبست خشصبحب. خاص١٠

سؼ ؼ حط٠ش ف اشاع اخخفت اضغ اخضف١ف ا حس٠ك اببحبث اطب١ت خالطبحب ف المسار األول:ف

اسق اغ اخظذ٠ش ضب اغظي ػ خش بفس ٠غ ػالت اضدة ، وب ٠خ زا اسبس ببخ١ت ابشش٠ت

اخذس٠ب.

اسخفبدة زا امطبع خالي اخشو١ض ػ ص٠بدة ام١ت اضبفت خش اظش حط٠ش : سؼ خغم١ك أػ المسار الثانى

سست إخبس خالطبث ؼذد اببحبث خغي اخظذ٠ش اى خش خذ اضدة ا حظذ٠ش خالطبث حغ ػالت

اضدة.

بحبث اطب١ت اؼطش٠ت.حط٠ش لطبع اإلخبس اخظذ٠ش ب الهدف األوسع من االقتراح:

: ص٠بدة امذسة اخبفس١ت مطبع اخظذ٠ش اببحبث اطب١ت اؼطش٠ت خالي إػبدة ١ىت حؼذ٠ شاع والهدف المحدد

ؼذد ب، Monographsإخبس حظ١غ ػذد اببحبث خالطبحبفمب ؼب١٠ش اضدة اؼب١ت ػ حط١ف شصؼ

حظ١ شؼبس ؼخذ ضدة اخش اظش اببحبث اطب١ت اؼطش٠ت اظش٠ت حش٠ض غ١ب د١ب.سؼ وزه ا

أ ز اببدسة حذف ا حمذ٠ ف صذ٠ذ بضشسة اخغي اخظذ٠ش اى ا حظذ٠ش خالطبث راث ل١ت

B.3. Product Description:

On a pilot scale we will be applying modern postharvest techniques (collection, drying, packing

standardization and marketing support)for at least 15 plants and 7 extractsthe feasibility study of the

industrial extracts production will be reported as one of the main products of the project to address

the international importer and potential investor in this sector as well as the Sector stakeholders.

A number of Egyptian MAPare selected based on cultivation on large scale and big international

demands. These plants are currently exported as non-standardized, non-branded crude drugs and not

necessarily follow the required quality standards.These are: Chamomile, Basil, Marjoram, Spearmint,

Peppermint, Lemongrass, Calendula, Fennel, Caraway, Anise, Rosemary, Salvia, Nigella, Fenugreek,

Coriander, Cumin, Hibiscus, Parsley and Thyme. A number of products should be produced and

developed as an outcome of this fund as follow:

Product

Problem

Impact

1- A Cultivation, Harvest, Post-Harvest Pilot Project with Process Manual.

a. Will solve the lack of quality standards.

This product will provide the sector with a demonstration pilot for GAP, GMP to improve

the quality of the MAP production to meet the export standards. Sufficient documentation

for this pilot will be done, and will act as an industry guideline, and can be employed

towards international branding.

2- Egypt MAP monographs Version 1

a. Lack of knowledge problem.

b. Absence of creative marketing tools.

This product will be a state of the art reference and marketing tool. To start with, it will

cover the selectedMAP, forming the nucleus of Egypt MAP Encyclopedia.

3- Standardized selected MAP extracts

a. Low value of exported raw material

b. Lack of local supply against MAP extract demands

This product will help changing the export trends from low value raw material to higher

value products. It will also increase the competitiveness of Egyptian pharmaceutical

industry through supplying it with high quality low cost ingredients.

4- Feasibility study with ROI indicators for the industrial extracts production.

a. Absence of clear vision on the potential industry growth.

The feasibility study will validate the Industrial Extracts as a profitable business.

5- An accredited Egyptian Medicinal and Aromatic Plants "Quality Excellency Seal".

a. Negative perception of Egyptian MAP quality in international market

This product will be a new accreditation produced by the project to be provided to

producers according to an NGO – Governmental Agreement to reflect Quality Excellency.

6- Branded Quality Excellency Seal on the national and internationallevels.

a. Lack of marketing tools

b. Absence of Egyptian produce competitive advantage

This is a new competitive advantage for quality producers to empower their production as

the best quality produce recognized by the Egyptian Government.

B.4. State-of-the-Art MAP market needs scientific evidence of authentication, proper and hygiene collection,

drying and packing processes for plants, proof of bioactives in both the crude drugs as well as

their extracts with validated methods of analysis, marketing and branding tools to promote the

sector. All these criteria and others are burdens for the development of this sector in Egypt. To

solve such problems a state of art technologies needs to be implemented to improve the

development process such as:

- State of art solar drying that improve the processing speed, product quality and hygiene

environment.

- State of the art Innovative extraction techniques such as ultrasonic extraction and

subcritical water extraction.

- The DNA profiling in monograph is an authentication tool to preserve the Egyptian MAP

products identity.

- Innovative analysis tools will be adopted to develop the state of art Fingerprint for the

plants and extracts.

- Using the state of art branding and Marketing tools and approaches to promote the

Egyptian MAP Export industry such as branding quality seals, Excellency accreditation,

etc.

In this regards, it has to be stated that, to the best of our knowledge, this might be the first time where a

number of funded projects (STDF- RDI- EU) will join their state of art results, equipment as well as

developed networking to serve the project tasks.(See Table below)

Ser. Applicant /

Funding body Project name

Project’s team / State-of-the-Art

experience

1 ITM (2014-15)

RDI/ EURO 100000 Innovation in Rice Bran extraction

Health tech Applicant - (ITM spin

off company) experienced in

extraction and Marketing.

2 FOPCU/ 2010-2012

RDI/ Euro 192,000 Rice Bran Nutraceuticals FOPCU –Partner 1 experienced in

extraction, standardization and

fingerprinting. 3 FOPCU (2014-16)

STDF/LE 900,000

High value pharmaceutical materials from

food processing waste

4 FEMU (2014-2016)

STDF/ LE 1.2 M

Innovative Green Extraction Technology

for Medicinal Plants

FEMU –partner 2 experienced in

chemical engineering, green

extraction technology.

5 ARC (AEnRI)

STDF/ LE 1.35 M

Design and manufacture of mobile grapes

dryer

ARC- Partner 3, Agro- machinery

and solar drying.

6 NG / 2014

ILO/ LE 200,000 Solar dryer

Nile gift- partner 4 MAP drying,

Marketing, and Branding.

7 FAODA

EU

Agro Ecology Practices and Marketing for

Fayoum Small Growers project. FAODA – Partner 5 Agro-

development implementation. 8

FAODA World

Bank

Enhance incomes for rural girls through

training them on Eco heritage hand craft

and marketing

9

BGED

MCIT /Bibliotheca

Alexandrina

2000,000 EGP

This project aims to document plants,

animals and history of 6 botanical gardens

beside the history of El-Zahraa stud. found

in Cairo under the authority of Ministry of

Agriculture

Alexandrina consulting- partner 6

(spin off Bibliotheca Alexandrina)

experienced in Documentation and

monographing,marketing and

branding development.

B.5. Objectives: State briefly and concisely your project’s main and specific objectives.

The competitiveness and hence the export growth, of the medicinal plants and herbal sector are

low due to wrong pre- and post- harvest practices as well as little added values in the value chain of

production

Main Objective To improve and develop MAP cultivation and production that will reflect on the export value of this

industry and provide the market with new tools and product to enrich the industry.

Specific objectives

1- To apply a grass root reforms along the cultivation, Harvest,Post-harvest chain to remedy

the incompetence of the industry.

2- Preserving the Identity of the Egyptian MAPs with DNA fingerprint Identification.

3- Development of an Egyptian monographsfor Selected MAPs widely cultivated and

exported in large volumes.

4- Development of a quality-approved plant materials and standardized extracts for a number

of plants that is commonly requested by the market.

5- Develop a feasibility study with ROI indicators for the industrial extracts production as an

alternative product approach for export markets and investors.

6- Developing an accredited Egyptian MAP"Quality Excellency Seal".

7- Quality Excellency Seal branding nationally and internationally.

B.6. Outcomes and Impact:

This project is a continuation of collaboration of the consortium partners in related activities. The

synergistic cooperation in this project is expected to lead to the following

Outcomes:

1- The existence of Cultivation, Harvest, post Harvest process manual that will solve the lack of

quality standards that will upgrade the production capacity and quality to international export

level witch will have a great positive impact on the national income and export Market share.

2- An Egypt herbs and aromatic plants monographs in accordance with WHO requirementsthat

will be used as an educating tool to the benefit of the sector producers as well as a great

marketing tool to promote Egyptian herbs and Aroma plants.

3- A strategic Feasibility study to identify investment opportunity and a production alternative to

the row plants exporting industry.

4- Creation of a new Egyptian Herbs and aroma plant extracts product with an approved quality

for Export.

5- Identification of accredited Egyptian Medicinal and Aromatic Plants "Quality Excellency Seal"

to be Branded as a Quality Trademark for national producers and international importers.

6- Creation of a new trends in the herbal plant business; value rather than volume; business

consistency rather than random exportation.

7- Establishing a pilot village where the international standards of collection, drying, packing,

labeling are applied.

Impacts:

1- MAP Value chain Process development.

2- Improving the pharmaceutical sector competitiveness by supplying high quality ingredients at

reasonable cost.

3- The empowerment of women (usual labor force in this sector) in the pilot village through

training and awareness will have its socioeconomic impacts.

4- Raised awareness among the Herbs and Aroma producers Where Value is more important than

Volume

The overall impact of this development is increasing the competiveness of the MAP sector with

more jobs creation, exports volume and value as well as lowering to some extent importation of herbal

extracts. The feasibility studies within this project are expected to attract more investors (Local and

foreign) to this field of promising growth and profits.

B.7. Approach and Methodology:

Project implementation:

The project will be based on a pilot implementation that will take place in one of the least

developed areas in Egypt at Fayoum Governoratethat will roll out the cultivation , collection , drying ,

packing , Process mapping and Manual development. Extraction and standardization will take place in

the partner’s facilities (HealthTech, FOPCU and ARC) in a collaboration between owned resources and

other funded resources with over than 6M value equipment and facilities.

Final Monograph will be developed for all the outputs in a joint effort lead by Bibliotheca

Alexandrina in cooperation with FOPCU and ASU.

Approach

Two parallel (classical and non-classical) approaches will be adopted. In the former the classical

way of cultivation and production processed will be innovatively developed, while value added MAP

extracts will be developed in the second approach.

Activities

Ser. Activity Task/(methods) Input/provided by

1 Products selection and

Mapping

- Selecting the MAPs ( Statistical )

- Authentication ( Taxonomy)

- Standardization ( HPLC )

- Advanced monograph editing (

DNA)

Collective experience and facilities that will

do the market studies, Technical and

scientific support, Documentation &

publishing experience.BA- FOPCU – ASU

2 Pilot project

implementation

- Cultivation Selected MAPs (

GAP )

- Harvest Selected MAPs (GAP)

- Post-Harvest ( Solar Drying –

Hygiene Auto- packing )

- Process Documentation and

Manual Development.

Land cultivation and labor management, Women

capacity building, Training, Business

Commercial experience.Utilization of thePartners

assets(Industrial and pilot SolarDryer).Packing

machine purchased by the project. Training

material. workshops

facilities.FAODA – NG – ASU – ARC- AC

3 Pilot MAP extraction

& feasibility study

- Extraction of the selected

plants(subcritical &ultrasonic)

- Analyze the plants bioactive(s).

(HPLC- LC/MS/MS)

- Feasibility studies for the

industrial scale extraction process.

Utilizing Health Tech resources and ARC to

extract the selected plants .FOPCU will analyze

and standardize the outputs of the extraction

process.Alexandrina for Tech. consulting will

utilize its resources to develop a feasibility study

for industrial implementation. HT-FOPCU-

ARC- AC

4 Branding and

Marketing

- Creatingquality Excellency seal

for the Egyptian MAP.

- Branding Quality Seal Locally

and internationally

- International Marketing for the

outputs.

Quality process accreditation system will be the

input of the ARC in this phase.

Utilizing the international Branding experts of

AC and business operation experience of NG

Brand the quality Excellency seal.Utilizing the

International Network of HT will be the main

input for the international marketing task in this

activity.ARC -AC-NG- HT

B.8. Key References:List outstanding, recent and relevant literature cited in the proposal and

source of given statistics.

References

1- List of exporters for the selected product in 2013 - Product : 1211 Medicinal plants

- http://www.trademap.org/Country_SelProduct.aspx.

2- http://www.imc- egypt.org/studies/Full Report/Herbs%20&%20Spices%20

Survey_Part%203_EN.pdf)

3- http://www.trademap.org/Index.aspx

4- Reducing risks and preventing disease:population-wide interventions http://www.who.int/nmh/publications/ncd_report_chapter4.pdf

5- http://apps.who.int/medicinedocs/index/assoc/s14213e/s14213e.pdf

Part C: Gantt chart and Logical Framework Matrix (LFM)

# Task Title S

tart

Date

En

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(Mon

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M1-M

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M3-

M4

M5-M

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M7-M

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M9-M

10

M

11

-M12

M

13

-M14

M

15

-M16

M

17

-M18

M19

-M20

M21

-M22

M

23

-M24

Expected measurable

outcomes of successful

implementation of the task

1 Selecting the

MAPs(Statistical) X List of 15 plant

2 Authentication (

Taxonomy) X X 15 certificate of authenticity

3 Standardization (

HPLC ) X X X 15 HPLC chromatograms

4

Advanced

monograph

editing ( DNA)

X X X

X 15 Monograph

15 DNA Fingerprint

5

Cultivation

Selected MAPs (

GAP )

X X X X X

X X X X

15 planted acers

6 Harvest Selected

MAPs (GAP) X X X X X X X X X X 15 harvested plant.

7

Post-Harvest (

Solar Drying –

Hygiene Auto-

packing )

X X X X X X X X X

15 dried and packed plant.

8

Process

Documentation

and Manual

Development.

X X X X X X X X X X

Production Chain manual .

9

Extraction of the

selected

plants(subcritical

&ultrasonic)

X X X X X X X

7 Extracts at the pilot scale.

10

Analyze the

plants

bioactive(s).

X X X X X X X

7 Certificates for Extracts

ingredients.

11 (HPLC-

LC/MS/MS) X X X X 7 chromatograms

12

Feasibility studies

for the industrial

scale extraction

process.

X X X X

Feasibility study document.

13

Creating quality

Excellency seal

for the Egyptian

MAP.

X X X

Excellency seal Pre-requisites

manual.

Excellency seal design and

model.

14

Branding Quality

Seal Locally and

internationally

X X X X Recognition certificate by

Local and International

agencies.

15

International

Marketing for the

outputs.

X X X X Certificate of attendance for

Marketing exhibitions.

Part: D Budget Distribution

IPR: all issues related to IPR, royalty and revenue/profit must be discussed case by case and

accepted by all parties in the light of governing rules and laws (law no. 82/2002).

Item Cost in LE

ASRT share Others

Incentives and labor 875000

Supplies and Materials 800000

Equipment and parts 650000 1200000 *

Certified analysis and tests 200000

Costs of feasibility study/ business

plan/Startups/ Visibility/

Registration

250000

Exhibitions, national and

international, seminars,

conferences, travel

550000

Overhead 175000

Subtotal 3500000 1200000

Grand Total : LE 4 700 000

Purchases by the partners through other projects and will be supplied to serve this project