analysis of the worldwide fmd situation trends … oie global...analysis of the worldwide fmd...
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Analysis of the Worldwide FMD Situation Trends and Regional Differences
Dr. Jef M. Hammond, Donald King, Nick Knowles, Valerie Mioulet and Yanmin Li
Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey, GU24 ONF, United Kingdom.
WRLFMD
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Outline
•Introduction
•Global Incidence/Trends
•Regional Differences
•Way Forward
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FMD
• The most infectious disease known
• A present and continuing severe global threat
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FMD
• The most infectious disease known
• A present and continuing severe global threat
• Devastating economic, social and environmental impacts
– severe productivity losses
– disruptions in a wide range of agricultural, industrial and social
activities
– major threat to food supply/food security
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FMDV
• 7 serotypes O, A, C, Asia1, SAT1, SAT2, and SAT3
• And multiple subtypes
• No single vaccine
• No single test
• Each outbreak/situation is different
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FMDV Global/One Health Issues
• Healtho Animal welfare – mass slaughter of healthy stocko Human welfare – loss of livelihood
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FMDV Global Issues
• Healtho Animal welfare – mass slaughter of healthy stocko Human welfare – loss of livelihood
• Global Tradeo Excludes many poorer nations from tradeo Restrictions on many goods (not just meat)
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FMDV Global Issues
• Healtho Animal welfare – mass slaughter of healthy stocko Human welfare – loss of livelihood
• Global Tradeo Excludes many poorer nations from tradeo Restrictions on many goods (not just meat)
• Cost of Prevention and Outbreakso Surveillanceo Direct and Indirect (compensation, trade and tourism)
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Susceptible species
• FMD affects more than 70 animal species
• Cattle, Buffalo, Pigs, Sheep and Goats
– Feral pigs, wild boar & deer
Most commonly spread- live animals or products
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FMD in cattle
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FMD in cattle
UK 2007
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• European Community Reference Laboratories for FMD– Support and diagnosis for EU Member States
• OIE Reference Laboratory for FMD – support of safeguarding and promoting international trade
• World Reference Laboratory for FMD designated by FAO– WRLFMD
– Global surveillance and threat recognition
– Reference Laboratory Network of OIE/FAO FMD Labs
FMD Reference Laboratories at Pirbright
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World Reference Laboratory for FMD- WRLFMD®
• 24/7 Diagnostic Service
• Global surveillance
• Strain characterisation
• Vaccine matching (Bulgaria, South Korea, Egypt)
• Extensive library of isolates
• Test improvement & Development, validation,
• Quality assurance
• Reagent supply
• Training
• Advice & Reports
FAO, OIE, EU and National Responsibilities
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Enhanced Surveillance: OIE/FAO Lab network
• WRLFMD: Pirbright, UK
• RRLSEA: Pakchong, Thailand
• LVRI: Lanzhou, China
• FGI ARRIAH: Vladimir, Russia
• PDFMD: Mukteswar, India
• RRLSSA: Gabarone, Botswana
• FMD-Laboratory: Embakasi, Kenya
• PANAFTOSA: Rio de Janeiro, Brazil
• SENASA: Argentina
• ARC-OVI: Onderstepoort, RSA
• PIADC: Plum Island, USA
• CODA-CERVA-VAR: Ukkel, Belgium
Approximately ~2400
samples tested during 2011
OIE/FAO FMD Reference Laboratory Network
Annual Report 2011
Editor: Dr Jef Hammond, IAH, Pirbright, UK.
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• FMD is endemic in most of Southern Asia, Africa and
parts of South America.
• Most of Europe, North and Central America, Australia,
New Zealand and Japan are free
FMD Distribution
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Conjectured Status of FMD
Intermediate, sporadic
Endemic
Free
Free. Virus present in game parks
Free with vaccination
Countries with multiples zones:
FMD-free, free with vaccination or not free
WRLFMD®
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Divides the Globe into 7 pools each with
• Multiple serotypes but topotypes mainly confined to
that pool
• Each pool may need tailored vaccines and strategies
Visualization of Regional Virus Pools as an Aid to Global Control
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Pool 2O, A, Asia 1
Pool 1O, A, Asia 1
Pool 3O, A, Asia 1
The conjectured status of FMD showing approximate
distribution of regional virus pools.
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Pool 5O, A, SAT 1, 2
Pool 6SAT 1, 2, 3
Pool 4A, O, SAT 1, 2, 3
The conjectured status of FMD showing approximate
distribution of regional virus pools.
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Pool 7O, A
The conjectured status of FMD showing approximate
distribution of regional virus pools.
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O - 80%
8.5%7% 2% 2.5%
O
A
SAT 1
SAT 2
Asia 1
Serotypes C and SAT 3 were not detected.
Asia 1 only in India
Serotyping results for 2010
The network labs received >2,300 samples in 2010 from 38 countries
80% were serotype O.
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O60%
A24%
SAT 11%
SAT 21%
SAT 32%
ASIA 112%
.
The network labs received >2,400 samples in 2011 from 34 countries
60% were serotype O
Increased Asia 1 activity
Serotype C was not detected
.
Serotyping results for 2011
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.
From > 300 samples in 2011 from 13 countries
43% were serotype O
No Serotype C (not reported since 2004)
Serotyping results for 2012- so far!
O-43%A- 18%
Asia 1- 25% SAT 2- 14%
O
A
Asia 1
SAT 2
WRLFMD
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Trends- Serotyping results for 2010-2012
0
10
20
30
40
50
60
70
80
O A C Asia 1 SAT 1 SAT 2 SAT 3
2010
2011
2012
O
Asia1
A
SAT 2
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Submissions
to WRLFMD 2011
Country samples O A C SAT 1 SAT 2 SAT 3 Asia 1 NVDAFGHANISTANa 292 109 22 - - - - 7 92BAHRAIN 19 2 1 - - - - 4 12BOTSWANA 5 - - - - 5 - - -BULGARIA 47 17 - - - - - - 30CAMBODIAb 4 2 - - - - - - -DR CONGO 20 4 7 - - - - - 9DP ROK (North Korea) 31 1 - - - - - - 30ESTONIA 1 - - - - - - - 1ETHIOPIA 28 14 - - - - - - 14HONG KONG 9 9 - - - - - - -IRAN 91 13 24 - - - - 7 9IRAQ 17 6 1 - - - - - 10ISRAEL 26 21 - - - - - - 5KENYA 22 9 - - 4 - - - 9KUWAIT 2 2 - - - - - - -LAOS 4 4 - - - - - - -LIBYA 52 2 - - - - - - 50MALAYSIAc 52 2 6 - - - - - 6MONGOLIA 4 1 - - - - - - 3PAKISTANd 130 50 1 - - - - 48 33PARAGUAY 1 1 - - - - - - -SOUTH AFRICA 24 - - - - - - - 24SOUTH KOREA 17 9 - - - - - - 8SRI LANKA 2 2 - - - - - - -THAILAND 17 6 11 - - - - - -TURKEYe 68 11 37 - - - - 3 18
UNITED KINGDOM 5 - - - - - - - 5VIETNAM 47 41 1 - - - - - 5ZAMBIA 2 - - - - - - - 2ZIMBABWE 2 - - - - 2 - - -TOTAL 1041 338 111 - 4 7 - 69 375
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Country samples O A C SAT 1 SAT 2 SAT 3 Asia 1 NVDAFGHANISTANa 292 109 22 - - - - 7 92BAHRAIN 19 2 1 - - - - 4 12BOTSWANA 5 - - - - 5 - - -BULGARIA 47 17 - - - - - - 30CAMBODIAb 4 2 - - - - - - -DR CONGO 20 4 7 - - - - - 9DP ROK (North Korea) 31 1 - - - - - - 30ESTONIA 1 - - - - - - - 1ETHIOPIA 28 14 - - - - - - 14HONG KONG 9 9 - - - - - - -IRAN 91 13 24 - - - - 7 9IRAQ 17 6 1 - - - - - 10ISRAEL 26 21 - - - - - - 5KENYA 22 9 - - 4 - - - 9KUWAIT 2 2 - - - - - - -LAOS 4 4 - - - - - - -LIBYA 52 2 - - - - - - 50MALAYSIAc 52 2 6 - - - - - 6MONGOLIA 4 1 - - - - - - 3PAKISTANd 130 50 1 - - - - 48 33PARAGUAY 1 1 - - - - - - -SOUTH AFRICA 24 - - - - - - - 24SOUTH KOREA 17 9 - - - - - - 8SRI LANKA 2 2 - - - - - - -THAILAND 17 6 11 - - - - - -TURKEYe 68 11 37 - - - - 3 18
UNITED KINGDOM 5 - - - - - - - 5VIETNAM 47 41 1 - - - - - 5ZAMBIA 2 - - - - - - - 2ZIMBABWE 2 - - - - 2 - - -TOTAL 1041 338 111 - 4 7 - 69 375
No Asia 1 in 2010
69 in 2011 ***
Afghanistan, Bahrain
Pakistan, Iran &
Turkey
all had outbreaks of
Asia 1
Submissions
to WRLFMD 2011
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FMD Outbreaks 2012SAT 2 in North Africa and Middle East
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Monufia North Sinai
Port Said
Sharqia
Matrouh
Minya
Qalyubia
South Sinai
Suez
Luxor
New Valley
Qena
Red Sea
Sohag
Alexandria
Aswan
Asyut
Beheira
Beni Suef
Cairo
Dakahlia Damietta
Faiyum
Gharbia
Giza
Ismailia
Kafr el-Sheikh
200 km
100 mi
© Daniel Dalet / d-maps.com
EGY/2/2012
O
ASAT 2FMDV-GD
NVD
EGY/4/2011
EGY/8/2011
EGY/2/2011
EGY/5/2011
EGY/2/2010
EGY/3/2010
EGY/1/2011
EGY/15/2012
EGY/3/2012
EGY/14/2012
EGY/1/2010
EGY/10/2012
EGY/1/2012
EGY/3/2011
EGY/6/2012
EGY/4/2012
EGY/5/2012
EGY/7/2012
EGY/8/2012
EGY/6/2011
EGY/7/2011
EGY/11/2012
EGY/13/2012
EGY/12/2012
EGY/9/2011
EGY/10/2011
EGY/9/2012
FMD Outbreaks 2012SAT 2 in North Africa and Middle East
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Egypt- Recent FMD Outbreaks
Egypt now has at least 3 serotypes of FMDV
and a number of topotypes
1. O/ME-SA/Egy-72 (2006-2009)
2. A/Africa/G-VII (Ken-05) (2006 & 2009)
3. O/ME-SA/PanAsia 2 (Egy-09) (2009 & 2011
4. A/Asia/Iran-05 (Bar-08) (2010-2011)
5. A/Africa/G-IV (ISM-12) (2012)
6. SAT2/VII/Alx-12 (2012)
7. SAT2/VII/Ghb-12 (2012)
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Intermediate, sporadic
Endemic FMD -Free
Free. Virus present in game parks
Free with vaccination
Countries with multiples zones:
FMD-free, free with vaccination or not free
Vietnam
O
China
O
Turkey
O, A & Asia 1
Iran
O, A & Asia 1
Chinese Taipei
O
Hong Kong
O
Thailand
A WRLFMD
18 countries
~500 samples
~ 300 positive
South Africa
SAT 2
FMD Outbreaks 2012~ 500 Samples from 18 Countries
Afghanistan
O, A & Asia 1
Kazakhstan
O & A
Russia
O
Zambia
SAT 2
Bahrain
O & SAT 2
Libya
O & SAT 2
Malaysia
O & A
Israel
O
Kuwait
O UAE
O
Egypt
O, A & SAT 2
Ethiopia
O Namibia
SAT 1
Tanzania
SAT 2
PAT
SAT 2
Pakistan
A & Asia 1
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O, A
Pool 7
Pool 5O, A, SAT 1, 2
Pool 4A, O, SAT 1, 2, 3
Pool 1O, A, Asia 1
Pool 2O, A, Asia 1
Pool 3O, A, Asia 1
Pool 6SAT 1, 2, 3
Regional Analysis- 2012
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O, A
Pool 7
Pool 5O, A, SAT 1, 2
Pool 4A, O, SAT 1, 2, 3
Pool 1O, A, Asia 1
Pool 2O, A, Asia 1
Pool 3O, A, Asia 1
Pool 6SAT 1, 2, 3
Pool 3
O, A, Asia 1 & SAT 2
Regional Analysis- 2012
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Serotype O- widespread circulation
– FMDV type O – ME-SA topotype – PanAsia-2 lineage
– FMDV type O – SEA topotype – Mya-98 lineage
Serotype A- widespread circulation
– FMDV type A – ASIA topotype – Iran-05 lineage
– FMDV type A – ASIA topotype – other
Serotype Asia 1 – limited circulation- BUT risk of further spread
– Reports from 6 countries in 2011 and now 2012
– Laboratory vaccine matching failed with Asia 1 Shamir
– Continues to be closely monitored by WRLFMD – Pirbright Vaccine trial carried out for EU
Serotypes SAT – restricted circulation
– Have not established outside of Africa
– But recent spread of SAT 2 into North Africa and Middle East
Serotype C - No reports of serotype C since 2004
Current FMD Threat Analysis: from reported incidence
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Vaccine Recommendations (National & European Antigen Banks)
O Manisa*O PanAsia -2*O BFS or CamposA-Iran-05A24 CruzeiroA22 Iraq
Asia 1 Shamir*
SAT 2 Saudi Arabia (or equivalent - SAT 2 Eritrea)
A Argentina 01A Iran 96A Iran 99A EritreaA Iran 87 or A Saudi Arabia 23/86 (or equivalent)A Malaysia 97 (or Thai equivalent such as A/Sak/97)*O Taiwan 97 (pig-adapted strain or Philippine equivalent)*SAT 1 South AfricaSAT 2 Zimbabwe
A15 Bangkok related strainA KenyaA87 Argentina related strainSAT 1 KenyaSAT 2 KenyaSAT 3 ZimbabweC Noville
Within category: not in order of importance
HIGH
PRIORITY
MEDIUM
PRIORITY
LOW
PRIORITY
Institute for Animal Health-WRLFMD®
* or additional
strain
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Is FMD Control Necessary?
• South Korea- 2010-2011
– >3 million slaughtered- $3billion USD
• Japan 2010
– > 300 outbreaks- 300,000 cattle – $3 billion USD
• Egypt 2012 SAT2
– 1st time since 1950
– > 3000 outbreaks
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Summary• FMD present in many regions
• Significant impact on livelihoods
• Major risk of spread through movement of animals and products
• Vaccination alone is not enough- Education and bio-security
• Improve surveillance
• We can do more together within networks
• The situation is complex
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www.wrlfmd.org
• A major combined effort both National and Global is needed for control
• Accurate & Timely disease information is vital
• The FMD Reference Laboratory Network provides the
Engine Room for the Global Control Initiative
WRLFMD