an autonomic application development & management environment
TRANSCRIPT
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IFT Nano TechnologyChicago
Sponsor: USDA/CSREES
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IFT Nano TechnologyChicago
Electronic Applications
High sensitivity and selectivityNear Real Time DetectionField use
Low costBuilt upon existing semiconductor infrastructure
PortableBuilt-in intelligenceCommunication
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IFT Nano TechnologyChicago
Detector Sensor
Electronic Amplifier
Micro processor
Communication Link
Cell Phone Internet Satellite Computers
National Data Base
Pathogen Biomarker Capture & Amplification
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IFT Nano TechnologyChicago
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IFT Nano TechnologyChicago
Pathogen Detection System Level View
PathogenRecognition
SignalGeneration
Detector
System Output
DetectCapture
Pathogen
BiomolecularSignal
Detector
Digital Output
Charge
ElectronicBio-signal
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IFT Nano TechnologyChicago
Expertise Required for Nano
Detector Designs
System level designMolecular BiologyNano ElectronicsSurface and organic ChemistryDeep submicron electronics
Detector (Sensor) integrated with system elementsDetector sensing property
Electronic chargeCapture mechanism must produce sensing property upon capture and detection
Background noise reductionSensing property must transmit signal to sensorSensor device must detect signal
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IFT Nano TechnologyChicago
Complexity of surface modification for molecular recognition
• Self-assembled monolayer• Covalent linkage• Spacing of capture probes• Molecular orientation
Complexity of biological sample and reaction conditions• The complexity of biological materials • The complexity of reaction conditions• Limited sensing surface area and sample volume
Complexity of electrical properties of bio-molecules
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IFT Nano TechnologyChicago
Nano-FET Nano-FET
Nano-FETNano-FET
Ideal Detection Real Detection
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IFT Nano TechnologyChicago
Nano
Transistor
NanoWireGold Pads
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IFT Nano TechnologyChicago
Universal Nano-FET Biosensor
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IFT Nano TechnologyChicago
0 50 100 150 200 250-20
0
20
40
60
80
100
120
-Z Im
ag (M
Ω)
Z Real (MΩ )
PNA TE Buffer 1E-18 Moles A20 1E-17 Moles A20 1E-16 Moles A20 1E-15 Moles A20 D I W ater W ash TE Buffer W ash
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IFT Nano TechnologyChicago
Au AuNano FET
Al Al
VSSAmplifier ComputerDigitizer
Off Chip Communications
Silicon Substrate
Self-assembled monolayerCapture Molecule
Target Molecule
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IFT Nano TechnologyChicago
Oligonucleotide Bac338-A20 detection Staph. 16S rRNA detection
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IFT Nano TechnologyChicago
1.Developed nano electronic system with early results showing high sensitivity and selectivity
2.Integrating nano electronics with deep submicron electronics
3.Goal is to provide complete electronic system soon