time course of hypoxia/sugen-induced pah
Post on 05-Aug-2015
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Additional data demonstrating time course of PAH development in most relevant preclinical model
Hypoxia + SU5416
- rat develops thickening of arterioles AND occlusion of endothelial lumen (as human PAH)
We previously validated model with sildenafil, bosentan, riociguat
RAT PULMONARY ARTERIAL HYPERTENSION
0
20
40
60
80
100
120
Vehicle_x000d_Sildenafil 60 mg/kgRiociguat 10 mg/kg
Syst
olic
Pulm
onar
y Ar
teria
l Pr
essu
re (m
m H
g)
0.0000.1000.2000.3000.4000.5000.6000.700
Vehicle_x000d_Sildenafil 60 mg/kgRiociguat 10 mg/kg
Fulto
n's I
ndex
RV/
(LV+
S)
- Rats administered DMSO/normoxia or SU5416/hypoxia- Serial measurements at Days 2, 4, 8, 15, 22, and 29- Pulmonary arterial pressures and RV hypertrophy obtained
RAT PULMONARY ARTERIAL HYPERTENSION
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