the laboratory report spring 2011
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The
Laboratory Report Spring 2011
A Publication of the Department of Pathology and Laboratory Medicine
James M. Musser, M.D., Ph.D.
Table of Contents
Dr. Mary Schwartz Receives Lifetime Achievement Award
Dr. Alberto Ayala Receives Koss Medal
Methodist West Houston Pathology Department Opens
San Jacinto Laboratory Obtains New Instruments
Demand Increases at Sugar Land and Willowbrook Laboratories New Diagnostic Test Offerings
Digital Pathology Section Added Record Year for Residency Applications New Fellowship Program Added
Trainee Spotlight
Three Department Faculty Receive Simmons Funding Office of Academic Development Opens
NIH Awards Grant to Dr. Paul Sumby
New Department Chair
O n July 1, 2010, James M. Musser,
M.D., Ph.D. became the new
chair of the Department of Pa-
thology and Laboratory Medicine, suc-
ceeding Michael W. Lieberman, M.D.,
Ph.D. who retired in June after 22 years
as chair.
“I am extremely honored and humbled
to have been given the opportunity to
lead our Department. I applaud Dr.
Lieberman’s relentless efforts on behalf
of our patients, and his unwavering com-
mitment to excellence in all departmental
activities,” said Dr. Musser. “Our Depart-
ment is extremely fortunate to have many
world-class pathologists. We will con-
tinue to meet the many diagnostic chal-
lenges and therapeutic needs of our pa-
tients, medical staff, and community,”
said Musser.
“Dr. Musser is a tremendous asset to
Methodist and we are fortunate to have
his talents, expertise, and leadership,”
said Ron Girotto, president and chief
executive officer of The Methodist Hospi-
tal System. Dr. Musser assumes his lead-
ership role at a time when the national
pathology and health care landscapes are
undergoing a period of change. “The
effects of the Affordable Care Act on
health care and, specifically, the practice
of pathology, remain unclear. With an
outstanding and fast-growing hospital
system and new technology, the depart-
ment will be nimble, embrace change,
and innovatively solve diagnostic prob-
lems,” said Dr. Musser.
“I am especially excited about our
new initiative in digital pathology made
possible by the strong support of The
Methodist Hospital. This new technology
will help us deliver enhanced, state-of-the
-art diagnostic services to all Methodist
System hospitals,” said Dr. Musser.
Musser, a past recipient of the Chugai
Award for Excellence in Mentoring and
Scholarship from the American Society
for Investigative Pathology, also plans
to enhance already strong departmental
education and training programs. Path-
ology is home to the most ACGME-
accredited training programs of any de-
partment at Methodist. A new depart-
mental Grand Rounds was started in
2010. A post-sophomore year-out training
program will be implemented this year to
help attract the highest caliber of trainees.
Additional fellowships are under consid-
eration.
Dr. Musser holds the Fondren En-
dowed Distinguished Chair and is the co-
director and executive vice president of
The Methodist Hospital Research Insti-
tute. He also directs the Center for Mo-
lecular and Translational Human Infec-
tious Diseases Research. Dr. Musser’s
clinical emphasis is diagnostic microbiol-
ogy.
His research focuses on group A
Streptococcus and Mycobacterium tuberculo-
sis with a special emphasis on genome-
wide analyses of host-pathogen molecular
interactions. He is an elected member of
many medical societies, including the
American Society for Investigative Pathol-
ogy and Association of American Physi-
cians. Dr. Musser was recently elected vice
president of the American Society for In-
vestigative Pathology.
For more information on Dr. Musser,
please visit methodisthealth.com/Musser.
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The
LABORATORY REPORT
2
Dr. Mary Schwartz Receives Lifetime Achievement Award from CAP
she received the CAP Spotlight Service
Award.
“The hospital and the Department are
very proud of Dr. Schwartz. We con-
gratulate her on receiving this prestigious
award,” said Dr. James Musser, chair of
the Department of Pathology and Labora-
tory Medicine. “Dr. Schwartz is a world-
class pathologist and astoundingly hard
working. Our patients, our physicians
and our department are very fortunate to
have her practice at Methodist.”
While practicing in all areas of surgical
and cytopathology, Dr. Schwartz’s spe-
cific areas of interest include gastrointes-
tinal pathology, breast pathology, and
head and neck pathology. Her research
interests include discovery and validation
of tumor markers in breast and pancre-
atic cancer.
For more information on Dr. Schwartz,
visit methodisthealth.com/Schwartz. For more
information on the College of American
Pathologists, please visit cap.org.
Mary R. Schwartz, M.D.
Dr. Alberto Ayala Receives Koss Medal from ISUP
D r. Alberto Ayala, the elected
deputy chief of Pathology, was
awarded the Leopold Koss
Medal from the International Society of
Urological Pathology (ISUP) at the US-
CAP 2010 meeting in Washington, D.C.
He received the prestigious award for his
career-level achievement in promoting Dr. Ayala’s Koss Medal
bers who have made a broad and positive
impact on the pathology profession
through contributions to one or more
areas of the College over an extended
period of time. Dr. Schwartz was recog-
nized for her contributions as a superb
educator, diagnostic pathologist, and
pathology activist.
“I am deeply honored and over-
whelmed to receive the CAP Lifetime
Achievement Award,” said Dr. Schwartz.
“It has been a special privilege to be able
to participate in activities of the College
and to serve members of our specialty.”
Dr. Schwartz is actively involved in the
mentoring of residents and fellows, as
well as teaching medical students; she is
the director of the surgical pathology
fellowship in the Department.
In addition to publishing regularly, Dr.
Schwartz serves on several editorial
boards and is an associate editor of Ar-
chives of Pathology and Laboratory Medicine.
She has been named one of the Best Doc-
tors in America since 1996, and in 2009,
M ary R. Schwartz, M.D., the
medical director of Anatomic
Pathology, was one of eight
recipients of the prestigious Lifetime
Achievement Award from the College of
American Pathologists (CAP) at an
awards ceremony on September 25, 2010
at the CAP Annual Meeting in Chicago,
IL. CAP presents the award to its mem-
excellence in the field of urological pa-
thology.
“The Koss Medal is an esteemed
award. Dr. Ayala has earned this medal
for an impressive career that spans over
four decades,” said Dr. James Musser,
chair of the Department of Pathology and
Laboratory Medicine. “Dr. Ayala is a tre-
mendous asset to the Department, the
hospital, and the entire pathology com-
munity. His rare level of expertise has
made him invaluable to all of us.”
The Koss Medal is named for Dr. Leo-
pold Koss, a renowned cytopathologist
who is currently professor emeritus in the
Department of Pathology at the Albert
Einstein College of Medicine in New
York, NY.
Dr. Ayala is a surgical pathologist with
subspecialty interest in urologic and bone
cancers. He joined the Department of
Pathology at The Methodist Hospital in
2004 after a 37-year career in the Depart-
ment of Pathology at The University of
Texas M.D. Anderson Cancer Center
where he served as the director of surgi-
cal pathology and deputy chair.
For more information on Dr. Ayala,
please visit methodisthealth.com/Ayala. For
more information on the International
Society of Urological Pathology (ISUP), visit
isuporg.org.
Alberto G. Ayala, M.D.
The
LABORATORY REPORT
3
New Methodist West Houston Hospital Pathology Department Opens
Dr. Thu Ngo in the new Methodist West Houston Hospital laboratory
San Jacinto Laboratory Obtains New Instruments
T he Pathology Laboratory at San
Jacinto Methodist Hospital has
replaced its two chemistry analyz-
ers and acquired a new hemostasis ana-
lyzer to improve efficiency and address
the growth in surgical volumes at the
hospital.
“As our hospital continues to grow, we
must offer additional pathology ser-
vices,” said Joyce Maldonado, M.D., the
medical director of Laboratory Services at
San Jacinto Methodist. “New equipment
with newer technology increases labora-
tory efficiency and decreases test turn-
around times, permitting us to better
serve our patients and our medical staff.”
Dimension Vista® 500 Intelligent
Lab System
The new Dimension Vista 500 System
is used for chemistry and immunoassay
testing. The instrument has the capacity
to process up to 1,000 tests per hour. It
provides high-sensitivity immunoassays
Clinical chemistry supervisor Lucy Willis and Dr. Claudia Molina in front of one of the new Dimen-
sion Vista 500 chemistry analyzers
O n December 17, 2010, the Meth-
odist West Houston Hospital
opened its doors and admitted
its first patients. The laboratory on the 4th
floor of the hospital officially opened that
day under medical director Dr. Thu Ngo.
Operations in the laboratory went
flawlessly on opening day, largely as a
result of the years of planning and
months of training that prepared the fa-
cility and staff. Drs. Musser, David Ber-
nard, and Rose Anton were on site for the
opening and witnessed the inaugural
Pathology and Laboratory Medicine test
result. Test volumes have increased
steadily since opening.
“Getting the new laboratory up and
running was exciting and exhausting,”
said Dr. Ngo. “The experience I gained in
my years of practicing with Dr. Hazel
Awalt at Willowbrook helped me exten-
integrated with rapid turnaround time
using one primary sample.
This new technology will improve
laboratory efficiency by allowing more of
the San Jacinto core laboratory tests to be
performed onsite, resulting in improved
patient care.
TEG® 5000 Thrombelastograph®
Hemostasis Analyzer
The TEG 5000 System provides a com-
prehensive analysis of hemostasis includ-
ing clotting time, clot formation kinetics,
clot strength and clot lysis from one
whole-blood sample. Moreover, it in-
cludes the assessment of the effects of
antiplatelet drugs including aspirin,
clopidogrel, tirofiban and others. The real
-time hemostasis data can be viewed any-
where in the hospital, including the oper-
ating room.
The addition of the TEG 5000 comes as
the hospital opened its new cardiovascu-
lar surgical suite and hybrid operating
sively in this process. I am fortunate to
have a wealth of experience and support
from all departmental pathologists in our
system hospitals that I can call on at any
time.”
The 7,400 square foot laboratory is staffed
with 14 medical technologists and has
state-of-the-art automated instrumenta-
tion that includes two Stago STA Com-
pact hemostasis analyzers, two Radiome-
ter ABL 90 FLEX blood gas analyzers, a
Siemens Advia Centaur CP Immunoas-
say System, an Ortho Clinical Diagnostics
VITROS 5,1 Fusion chemistry system, an
IRIS IQ200 Series Automated Urinalysis
System, a Sysmex XE-5000 and XT2000i
for automated hematology testing, and
an Ortho ProVue antibody test system.
For more information on Methodist West
Houston, visit methodistwesthouston.com.
room. With this new system in place,
physicians are able to stratify the risk of
post-operative bleeding more accurately
and use transfusion algorithms more re-
liably, therefore decreasing transfusion
requirements, reducing costs and obtain-
ing improved patient outcomes.
For more information on San Jacinto
Methodist, visit sanjacintomethodist.com.
The
LABORATORY REPORT
The Methodist Sugar Land laboratory
also implemented several new tests on-
site including P2Y12 and aspirin platelet
function testing in support of inter-
ventional cardiology activities,
creatinine whole blood testing in
support of Radiology patient effi-
ciency and best practices, platelet
mapping in support of cardiovascu-
lar surgery, TSH, free T4 and rapid
HIV-1 and HIV-2 to improve service
standards, A1 subtyping in the Blood
Bank in support of the new trans-
plant evaluation program and fern
testing to support Women’s Services.
To improve outpatient satisfaction
and service, the laboratory opened a sec-
ond phlebotomy station located in Diag-
nostic Imaging (Main Pavilion).
For more information on Methodist
Sugar Land, visit methodisthealth.com/
sugarland. For more information on Meth-
odist Willowbrook, visit methodisthealth.com/
willowbrook.
H ospital growth and expansion
continue to increase demands
on all areas of the laboratories
at Methodist Sugar Land Hospital
and Methodist Willowbrook Hospi-
tal. In May of 2010, a major expan-
sion at Willowbrook was completed
that doubled the size of the hospital.
Hospital admissions have increased
17% and surgeries have increased
21% compared to 2009. Cardiovascu-
lar surgery was initiated in March of
2010, and a small pediatric unit
opened later that year.
Overall laboratory testing volumes
have increased 38%, including new
on-site testing such as the thromboelasto-
graphy with platelet mapping to support
the new cardiovascular and vascular pro-
cedures, platelet function analysis to sup-
port surgical procedures, creatinine
iSTAT to support Radiology patient effi-
ciency and best practices, and HIV-1 and
4
Hospital Growth Increases Demands on Laboratories
at Methodist Sugar Land and Willowbrook
HIV-2 and HBsAg to meet required turn-
around time standards for the Labor and
Delivery unit.
Dr. Hazel Awalt, medical director of Laboratory Ser-vices for Methodist Willowbrook (left), and histology
technician Beth Beck prepare to receive specimens
from the busy operating rooms.
New Diagnostic Test Offerings: illumigene™ C. difficile
contact Dr. James Davis at 713-441-2437
or jrdavis@tmhs.org. For more information
on illumigene molecular diagnostics sys-
tems, please visit meridianbioscience.com/
illumigene.
mits a more rapid diagnostic result for C.
difficile than conventional assays. Because
of improved sensitivity and specificity,
this test has a much lower false-negative
rate and the need for repeat testing has
been greatly reduced.
For more information on the illumi-
gene C. difficile assay at Methodist, please
Electron microscope image of Clostridium difficile bacteria
T he Methodist Hospital System has
implemented the new illumigene
Clostridium difficile molecular as-
say from Meridian Biosciences, Inc. The
assay employs Loop-Mediated Isother-
mal Amplification (LAMP) technology
for a simple, faster, and more cost-
effective testing process. This test per-
The
LABORATORY REPORT
5
T he Department will implement new digital pathology technology into specific
pathology services this year. Digital pathology has the potential to transform
anatomic pathology and assist faster and more accurate diagnoses. The new
Digital Pathology Section is under the direction of Dr. Michael Thrall. This new ini-
tiative will be the subject of an article in the next issue of The Laboratory Report.
For more information on digital pathology at Methodist, please contact Dr. Michael
Thrall at 713-441-4459 or mjthrall@tmhs.org.
Department Adds Digital Pathology Section
Department Adds New Fellowship Program
molecular genetic pathology,” said Dr.
Monzon. “Our exceptional faculty, part-
ner institutions in the Texas Medical Cen-
ter, and unique elective rotations in
emerging fields of molecular pathology
make our program unusually strong.”
Interest in the new fellowship has been
significant, and the fellowship position
has already been filled until 2013.
For more information on the training
programs offered by the Department,
please visit methodisthealth.com/pathology
training.
Record Year for Residency Applications
T he number of applicants for the
Department’s residency training
program reached an all-time high
this year. In addition to an overall in-
crease in application number, there was
also an increase in the geographic diver-
sity of the applicants and the percentage
with previous research experience. “The
growth in the number of students apply-
“Our fellowship is designed for physi-
cians who have completed pathology or
medical genetics training and are inter-
ested in pursuing a career that includes
Dr. Powell in conference with residents
T he Department recently added a
new fellowship program in mo-
lecular genetic pathology under
the direction of Dr. Federico Monzon.
The fellowship has received approval
from the Accreditation Council for
Graduate Medical Education (ACGME)
and its first fellow began training in Sep-
tember, 2010. Rotations with the medical
genetics programs at The University of
Texas Health Science Center at Houston,
M.D. Anderson Cancer Center, and
Baylor College of Medicine are also part
of the program. The program includes
basic molecular training coupled with
research experiences that produce peer-
reviewed publications.
ing for training in our Department is tes-
tament to the commitment of our faculty
and The Methodist Hospital to training
the next generation of pathologists,” said
Dr. Suzanne Powell, director of the pro-
gram.
For more information on the training
programs offered by the Department, visit
methodisthealth.com/pathologytraining.
Dr. Monzon in the Molecular Diagnostics Labora-tory with Dr. Hidehiro Takei
The
LABORATORY REPORT
therapy for the treatment of anaplastic
large-cell lymphoma (ALCL).
Brain Cancer Treatment
Suzanne Powell, M.D., director of
Neuropathology, will collaborate
with Stephen Wong, Ph.D. (TMHRI
Bioinformatics) and Chris Tsz-
Kwong Man, Ph.D. at Texas Chil-
dren’s Hospital to leverage massive
amounts of data on childhood me-
dulloblastoma to characterize the
four known subtypes of the disease
with the potential of developing
novel, more targeted therapies for
them. Other collaborators include
Dr. Rudy Guerra at Rice University, and
Drs. Pamela New and Robert Grossman
at The Methodist Hospital.
For more information about the Vir-
ginia and L.E. Simmons Family Founda-
tion Collaborative Research Fund, visit
collaborativeresearchfund.org.
Trainee Spotlight: Blythe Gorman, M.D.
D r. Blythe Gorman was the recipient of the first Department of
Pathology and Laboratory Medicine Trainee Leadership and In-
novation Award. She received this award for her overall initia-
tive, leadership and commitment to excellence in patient care.
Dr. Gorman was also awarded the first place medal for her platform talk,
“Comparison of Breast Prognostic/Predictive Markers on Cell Blocks Ob-
tained by Various Methods: Cellient, Formalin and Thrombin,” presented
at the January 2011 Texas Society of Pathologists meeting held in San Anto-
nio. Dr. Gorman received her M.D. degree from Louisiana State University
Health Sciences Center in New Orleans in 2005 and completed her resi-
dency in anatomic and clinical pathology at The University of Texas Medi-
cal Branch in Galveston, Texas.
Dr. Dina Mody, medical director of Cytopathology, Dr. Gor-man and Dr. James Musser at the Texas Society of Patholo-
gists Annual Meeting in San Antonio, TX
Three Department Faculty Receive Research Funding
From Simmons Family Foundation
6
T hree faculty members in the De-
partment have received research
funding from the Virginia and
L.E. Simmons Family Foundation
Collaborative Research Fund.
Through a five-year initiative to
discover new ways to diagnose and
treat diseases, the fund supports
collaboration among researchers at
Rice University, Texas Children’s
Hospital and The Methodist Hospi-
tal Research Institute.
Stem Cell Research
Aleksandar Babic, M.D., Ph.D.,
associate medical director of Trans-
fusion Medicine, will lead a team of
investigators to evaluate whether stem
cells can be obtained from human amni-
otic fluid, thus avoiding the limitations of
harvesting them from embryos or other
sources. Dr. Babic will collaborate with
Dr. Malcolm Brenner from the Center for
Cell and Gene Therapy and Drs. Kenneth
Moise and Eric Yvon from Texas Chil-
dren’s Hospital.
Lymphoma Nanotherapy
Youli Zu, M.D., Ph.D., co-director of
Hematopathology, will collaborate with
Michael Wong, Ph.D. at Rice University
to develop a unique nanoparticle-based
Dr. Zu in his laboratory at TMHRI
The
LABORATORY REPORT
Stockbauer, Ph.D., manager of the
OAD. “Let us know how we can
help you and if you have sugges-
tions for additional services we can
provide.”
Philip Randall will be providing
writing and editorial services for
the OAD, and will assist Dr. Stock-
bauer with the development of the
training classes.
For more information about the Of-
fice of Academic Development, call
713-441-5889 or visit our department
website at methodisthealth.com/OAD.
Dr. Paul Sumby Receives NIH Grant for Strep Studies
D r. Paul Sumby, an investigator
in the Department’s Center for
Molecular and Translational
Human Infectious Diseases Research, has
received a five-year R01 grant from the
National Institute of Allergy and Infec-
tious Diseases (NIAID) to study the mo-
lecular mechanisms that determine group
A Streptococcus (GAS) virulence, and
identify new drug targets. GAS causes a
broad spectrum of diseases, including
7
Medicine symposium held on February
18 to commemorate the opening of The
Methodist Hospital Research Institute
building.
For more information on Dr. Sumby
and his laboratory, visit methodisthealth.com/
Sumby.
pharyngitis, rheumatic fever and ne-
crotizing fasciitis, also known as flesh-
eating disease.
Dr. Sumby will use genomic, transcrip-
tomic and proteomic methods to investi-
gate how GAS uses small RNA molecules
to regulate production of virulence-
enhancing proteins, with a view to inhib-
iting this regulation as a novel therapeu-
tic approach. He recently spoke about his
discoveries at the Frontiers in Translational
New Office of Academic Development Opens
Philip Randall
Scientific Writer, OAD
open for business and look forward to
providing services that will help our
department to succeed,” said Kathryn
A new Office of Aca-
demic Development
(OAD) was opened in
January to help our trainees
and faculty increase their schol-
arly contributions. OAD staff
provide manuscript, grant and
poster editing services; assist in
identifying new research fund-
ing opportunities; and present
seminars and training in areas
such as grantsmanship and
scientific writing. The office
and its initial menu of services
arose from a departmental needs
assessment conducted in the fall of 2010.
“Our goal is to help the academic ef-
forts of all faculty and trainees. We are
Kathryn Stockbauer, Ph.D.
Manager, OAD
Dr. Sumby in his laboratory at TMHRI
The
LABORATORY REPORT
Beck D, Ayers S, Wen J, Brandl MB, Pham TD, Webb P, Chang CC, Zhou X. Integrative analysis of next generation sequencing for
small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes. BMC Med Genomics. 2011 Feb 23;4(1):19.
Cagle PT. Pathologists as leaders, innovators, and devoted physicians: special section on pathology in resource-poor nations. Arch
Pathol Lab Med. 2011 Feb;135(2):170.
Cagle PT, Allen TC, Dacic S, Beasley MB, Borczuk AC, Chirieac LR, Laucirica R, Ro JY, Kerr KM.
Revolution in lung cancer: new challenges for the surgical pathologist. Arch Pathol Lab Med. 2011 Jan;135(1):110-6. Review.
Cantley RL, Kapur U, Truong L, Cimbaluk D, Barkan GA, Wojcik E, Gattuso P. Fine-needle aspiration diagnosis of metastatic urothe-
lial carcinoma: A review. Diagn Cytopathol. 2011 Jan 6.
Cruz AT, Geltemeyer AM, Starke JR, Flores JA, Graviss EA, Smith KC. Comparing the tuberculin skin test and T-SPOT.TB blood test
in children. Pediatrics. 2011 Jan;127(1):e31-8.
Cuirolo A, Canigia LF, Gardella N, Fernández S, Gutkind G, Rosato A, Mollerach M. Oxacillin- and cefoxitin-susceptible meticillin-
resistant Staphylococcus aureus (MRSA). Int J Antimicrob Agents. 2011 Feb;37(2):178-9.
Hu Y, Ma X, Graviss EA, Wang W, Jiang W, Xu B. A major subgroup of Beijing family Mycobacterium tuberculosis is associated with
multidrug resistance and increased transmissibility. Epidemiol Infect. 2011 Jan;139(1):130-8.
Jang SJ, Gardner JM, Ro JY. Diagnostic approach and prognostic factors of cancers. Adv Anat Pathol. 2011 Mar;18(2):165-72.
Jung SY, Jeong J, Shin SH, Kwon Y, Kim EA, Ko KL, Shin KH, Ro J, Lee KS, Park IH, Lee S, Kim SW, Kang HS. Accumulation of p53
determined by immunohistochemistry as a prognostic marker in node negative breast cancer; analysis according to st gallen consen-
sus and intrinsic subtypes. J Surg Oncol. 2011 Mar 1;103(3):207-11.
Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohisto-
chemical study of 3 cases. Hum Pathol. 2011 Feb 18.
King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA. Polymorphic allele of human IRGM1 is associated with susceptibil-
ity to tuberculosis in African Americans. PLoS One. 2011 Jan 21;6(1):e16317.
Kosarac O, Takei H, Zhai QJ, Schwartz MR, Mody DR. S100P and XIAP expression in pancreatic ductal adenocarcinoma: potential
novel biomarkers as a diagnostic adjunct to fine needle aspiration cytology. Acta Cytol. 2011;55(2):142-8.
Kwon Y, Ro J, Kang HS, Kim SK, Hong EK, Khang SK, Gong G, Ro JY. Clinicopathological parameters and biological markers predict-
ing non-sentinel node metastasis in sentinel node-positive breast cancer patients. Oncol Rep. 2011 Jan 21.
Mody DR, Nayar R, Thrall M. 2001 Bethesda system classification of glandular lesions on cervical cytology. Monogr Clin Cytol.
2011;20:5-14.
Montes M, Sanchez C, Lewis DE, Graviss EA, Seas C, Gotuzzo E, White AC Jr. Normalization of FoxP3(+) regulatory T cells in re-
sponse to effective antiretroviral therapy. J Infect Dis. 2011 Feb 15;203(4):496-9.
Nelson MI, Tan Y, Ghedin E, Wentworth DE, St George K, Edelman L, Beck ET, Fan J, Lam TT, Kumar S, Spiro DJ, Simonsen L, Vi-
boud C, Holmes EC, Henrickson KJ, Musser JM. Phylogeography of the spring and fall waves of the H1N1/09 pandemic influenza
virus in the United States. J Virol. 2011 Jan;85(2):828-34.
Nese N, Martignoni G, Fletcher CD, Gupta R, Pan CC, Kim H, Ro JY, Hwang IS, Sato K, Bonetti F, Pea M, Amin MB, Hes O, Svec A,
Kida M, Vankalakunti M, Berel D, Rogatko A, Gown AM, Amin MB. Pure epithelioid PEComas (so-called epithelioid angiomyoli-
poma) of the kidney: A clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification. Am J Surg
Pathol. 2011 Feb;35(2):161-76.
Olsen RJ, Watkins ME, Cantu CC, Beres SB, Musser JM. Virulence of serotype M3 Group A Streptococcus strains in wax worms
(Galleria mellonella larvae). Virulence. 2011 Mar 1;2(2).
Ozcan A, Shen SS, Hamilton C, Anjana K, Coffey D, Krishnan B, Truong LD. PAX 8 expression in non-neoplastic tissues, primary
tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011 Feb 11.
Pflughoeft KJ, Sumby P, Koehler TM. Bacillus anthracis sin locus and regulation of secreted proteases. J Bacteriol. 2011 Feb;193(3):631-9.
Continued page 9
8
RECENT PUBLICATIONS
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LABORATORY REPORT
Serpa JA, Graviss EA, Kass JS, White AC Jr. Neurocysticercosis in Houston, Texas: an update. Medicine (Baltimore). 2011 Jan;90(1):81-6.
Shea PR, Beres SB, Flores AR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-
Gonzalez M, Fittipaldi N, Ayers SD, Webb P, Willey BM, Low DE, Musser JM. Distinct signatures of diversifying selection revealed
by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci USA. 2011 Mar 7. [Epub ahead of print].
Truong LD, Gaber L, Eknoyan G.Obstructive uropathy. Contrib Nephrol. 2011;169:311-26.
Truong LD, Shen SS. Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med. 2011 Jan;135(1):92-109. Review.
Wen J, Feng Y, Bjorklund CC, Wang M, Orlowski RZ, Shi ZZ, Liao B, O'Hare J, Zu Y, Schally AV, Chang CC. Luteinizing Hormone-
Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo. Mol Cancer Ther. 2011 Jan;10
(1):148-58.
Yang Q, Wang H, Cho HY, Jung SJ, Kim KR, Ro JY, Shen SS. Carcinoma of müllerian origin presenting as colorectal cancer: a clinico-
pathologic study of 13 Cases. Ann Diagn Pathol. 2011 Feb;15(1):12-8.
Zhao J, Wang Y, Wang H, Jiang C, Liu Z, Meng X, Song G, Cheng N, Graviss EA, Ma X. Low agreement between the T-SPOT®.TB
assay and the tuberculin skin test among college students in China. Int J Tuberc Lung Dis. 2011 Jan;15(1):134-6.
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RECENT PUBLICATIONS continued
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The Laboratory Report is a publication
of The Methodist Hospital System
Department of Pathology and Labo-
ratory Medicine.
Editor-in-Chief
April A. Ewton, M.D.
Editorial Committee
Hazel L. Awalt, M.D.
Christopher Leveque, M.D.
Claudia P. Molina, M.D.
Seema Mullick, M.D.
Thu Ngo, M.D.
Steven Shen, M.D., Ph.D.
Paul Sumby, Ph.D.
Ping Wang, Ph.D.
Editorial Coordinator
Philip Randall
The Methodist Hospital
Clare Rose, M.B.A.
Manuel Hinojosa, M.H.A.
The Laboratory Report
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