systematic screen of chemotherapeutics in drosophila stem ... · pdf fileinteraction of stem...
Post on 19-Feb-2018
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rapidly dividing RAFgof ISC tumors would be sensitive to at leastsome chemotherapy drugs.
Consistent with the expectation that RAFgof ISC tumors wouldbe sensitive to human chemotherapy drugs, we identified 14drugs from the luciferase screen with putative tumor suppressoractivity. These drugs, when fed to flies with RAFgof ISC tumors,resulted in a 50% or greater loss of luciferase activity in whole-animal lysates compared with DMSO controls (rank sumP
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