synthetic cannabinoids 120710 presentation

SyntheticCannabinoids

Today’s “FAKE MARIJUANA” COMMONLY KNOWN AS

K2, SPICE, SERENITY, GENIE, TWISTED XXX

Synthetic Cannabinoids

In 1995 Dr. John W. Huffman, first experimented and synthesized the compound known as JWH018 while performing research at Clemson University. He never performed any testing with this and later other JWH chemicals on humans.

Since that time several of these synthesized compounds with varying names have been produced with a wide range of potency and effects.

History

US Legislative Profile

Nov. 24th DEA instituted an emergency Ban on 5 Synthetic Cannabinoids which become effective 1/2011 for one year

States and Municipalities have instituted various restrictions on Synthetic Cannabinoids ranging from unregulated to felony charges for possession

HU 210JWH018JWH073Salvia

ProposedLegislation

K2JWI018JWH073

K2,SpiceJWH018

Possession a Felony

JWH01811/1/2011

*Municipal Restrictions** Statewide Ban*** Proposed RegulationU Unregulated @ Marijuana Legalized

*

JWH018

8/28/10Synthetic Compounds mimic THC

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HWH018,073,015,200,250,HU210,CP47,CP497

9/3/10

**

11/1/10

**

10/15/10

**

U

U

U

U

U

*** JWH018

U

U

***

**JWH018

2/25/10**

U

U

***

U***

**8/15/10JWH018,073,CP47, 497 all synthetics

U

U

* Spice

4/13/10**

***

*

U

*** 1/11/11

U10/15/10

**

@

@ U

***

U

U

*

Texas Legislative Timeline

Proposed bill to floor 1/11/11 by Senator Florence Shapiro

Most comprehensive bill in the US with 12+ compounds

Congressional Coalition Support 9 Texas Senators 9 House of Representatives

Proposed Texas Testing Panel

1. JWH-018 2. JWH-073 DEA BANNED LIST 3. JWH-200 4. CP 47 5. CP 497 6. JWH-019 7. JWH-250 8. JWH-015 9. CP 297-C8 Homolog 10. CP 55, 940 11. HU-308 12. HU-331 13. WIN 55212-2

Research

In drug studies on rats and pigeons HU-210 was found to be 66 to 80 times more potent than THC

Human Study by NMS presented by Dr. Barry Logan shows varying degrees of impairment

Current on going human studies at St. Louis University of effects of synthetic cannabinoid use

Research

More Human Studies related to driving under the influence are ongoing to be published 2011

Synthesized to create “Lock and Key” effect with the same neurotransmitters in the brain as THC; i.e. addition

Myths

These products are herbal and incense and somehow natural substances

Not harmful Non-toxic Not for human consumption

Facts

Products created in a laboratory environment

Mixtures of herbal compounds and chemicals - No QC on what is generated

Is not detected in standard drug test panels

Easy to change Trade names and mixture ingredients

Facts

Jan 2010-July 2010500-800 cases of adverse

reactions to synthetic marijuana across the country in the past year, according to the American Association of Poison Control Centers.

At least 8 known/suspected deaths in Texas 2010 to date

Signs and Symptoms

- Profuse sweating during the day and especially at night

- Internal restlessness - Palpitations and increase blood

pressure- Reduced Body Temperature- Insomnia - Headache - Diarrhea- Altered brain function in controlling

emotions, judgment, motivation, memory and learning

Signs and Symptoms

- Nausea and vomiting- Tremors and in rare cases seizure- Anxiety and paranoia without

reason- Manic episodes (hyperactivity,

agitation)- Sudden emotional and personality

changes- Feeling of depression and

desperation- Denial

Analytical Matrices

Blood – Detection 0-24 hours

Urine – Detection 0-48 hours

Saliva- Hair –

Analytical Testing

Individual Compounds or Panels

1. JWH-018 2. JWH-073 DEA BANNED LIST 3. JWH-200 4. CP 47 5. CP 497 6. JWH-019 7. JWH-250 8. JWH-015 9. CP 297-C8 Homolog 10. CP 55, 940 11. HU-308 12. HU-331 13. WIN 55212-2

QUESTIONS?

Loretta Anderson, PresidentExperTox Laboratory

Ph. 281-476-4600Fax. 281-930-8856www.expertox.com

Contact Information:Mauri Barefoot, National Sales Rep

mbarefoot@expertox.com