ribozymes (rna enzymes)
Post on 09-Feb-2016
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Ribozymes(RNA Enzymes)
David Peterson
Enzymes•Catalyze reactions
•Very specific
•Act on substrates
•Active site
Enzymes Bind Substrates
Enzymes Bind Substrates
Enzymes Bind Substrates
Structure of RNA and DNA
DNA RNA Protein
Information Flow in CellsThe Central Dogma of Molecular Biology
Transcription Translation
Semiconservative DNA Replication
Amino acids combine to make peptides and proteins
mRNA Splicing
Ribosomes
• Site of protein synthesis
• Made of RNA and protein
Tetrahymena thermophila
Self-Splicing RNA
Cech, Zaug, and Grabowski.1981. Cell 27: 487-496
Single-Stranded RNA Can Form Intramolecular Base Pairs
Intramolecular H-bonds in the Tetrahymena Ribozyme
3D Structure of the Self-Splicing Intron
Ribosomes
• Site of protein synthesis
• Made of RNA and protein
Tom Cech Sidney Altman
Nobel Prize in Chemistry 1989
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