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Loss of sav/hpo/wts/mob increases cell division
Loss of sav/hpo/wts/mob decreases apoptosis
merlin and expanded function redundantly to control proliferation
Overexpression of expanded or hippo
Hyperactivate Hpo signaling pathway
Hippo acts downstream of expanded/merlin
Hippo acts upstream of warts
Dong et al., Cell 2007
Course of Wallerian axon degeneration.
Wang J T et al. J Cell Biol 2012;196:7-18
© 2012 Wang et al.
Fig. 1 Identification of mutations that suppress Wallerian degeneration.
J M Osterloh et al. Science 2012;337:481-484
Published by AAAS
Fig. 2 Mutations in dsarm block Wallerian degeneration.
J M Osterloh et al. Science 2012;337:481-484
Published by AAAS
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