pharm 1.16 antibiotic cheat sheet - dr. c's nursey stuff...inhibit metabolism antibiotic cheat...

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Gram PositiveGram Negative

How and Where Various Antibiotics Work

Gram +Penicillins (Amoxicillin)Gram + (Strep, Syphillis)Disrupts synth of peptidoglycan

Macrolides (azythromycin, erythromycin)Gram + (URI’s, Strep, Staph)Inhibits protein synth

Lincosamides (clindamycin) Step, StaphInhibit protein synth

Gram -Aminoglycosides (streptomycin, tobramycin, gentamicin) Gram - Psuedomonas - TBInhibit protein synth

Gram + and -Tetracyclines

Outer membrane

Ribosome

DNA

Cell wall

Folic acid

Cell membrane

Lipoproteins

Peptidoglycan

Periplasmicspace

Cutoplasmicmembrane

Lipopolysaccharides Porin Protein

(tetracycline, doxycycline)Broad spectrum (Gram +/-, atypicals)Inhibit protein synth

CephalosporinsDisrupts synth of peptidoglycan1st gen: Gram + (Ke�ex)2nd gen: Gram - > Gram + (Cefzil)3rd gen: Gram - > Gram + Pseudomonas (cefdinir)4th gen: Pseudomonas (Cefepime)5th gen: MRSA (Ceftobiprole)

Fluoroquinolones(Cipro�oxacin, Levo�oxacin)Broad spectrumInhibit DNA synth

Sulfonamides(TMP-SMZ)UTIsInhibit DNA synth

Carbapenems (meropenem)Broad spectrumDisrupts synth of peptidoglycan

Metronidazole (Flagyl)Anaerobes, protozoaDisrupts DNA

Inhibition ofprotein synthesis

Inhibition ofnucleic acid synthesis

Inhibition of cell wall synthesis Disruption of cell

membrane function

Block pathways andinhibit metabolism

ANTIBIOTIC CHEAT SHEET

ANTIBIOTIC MOA