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Patient Survey Data Results: Reminder Preferences in Patient-Reported Outcomes Studies

Mark WadeDirector, Patient Focused SolutionsAlmac

@AlmacClinTech

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Objectives

Identify the most common reasons why patients can be non-compliant with their patient diaries

Identify reminder modes patients prefer and evaluate reminder strategies preferences and mode feasibility

Plan future implementation of reminders on PROs based on patient preferences and the feasibility of reminder modes

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2

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Keeping Patients Engaged

PROs keep patients

engaged by directly

involving them in patient-centered research

Reminders can be a beneficial

feature of eCOAs which

can keep patients

engaged, while also promoting

optimal compliance

Important to plan an

effective reminder

strategy that would work

best for engaging the patient during

the trial

To identify effective reminder strategies, survey data that focused on patient preferences for reminders in PROs was investigated

• Global sample; N=405 • Included patients who participated in

at least 1 clinical trial with patient diaries in the past 2 years

• Internet-based survey; ~20-30 minutes• Previous diary experiences, preferences, future

suggestions, personal technology behaviors

Patient Preferences in Completing Patient Diaries

To better understand patient preferences when participating in PROs, Almac conducted survey research in 2013

Survey Demographics

48.0%52.0%

Gender

Male

Female

12.6%

64.0%

23.4%

Region

Europe

N. America

Rest of World

N=405

N=405

N=404

32.1%

29.6%

21.2%

17.0%

Age

18-29

30-39

40-49

50+

Patient Compliance Based on Most Recent Clinical Trial

Diary-Use in Most Recent Clinical TrialPatient Compliance with Completing Diaries

• Subjects were asked to report if they were always compliant with patient diaries in their most recent clinical trial

• Compliance is often inflated when self-reported by patients• Compliance is quite low as self-reported by patients, and if

this is inflated, compliance may need some enhancement in clinical trials

46.4%53.6% Non-compliant

Compliant

N=398

Diary-Use in Most Recent Clinical TrialNon-compliance: Demographic

Characteristics

0%

20%

40%

60%

80%

100%

18-29 30-39 40-49 50+

Age

Non-compliant

Compliant

N=398

(p=.07)

0%

20%

40%

60%

80%

100%

PositiveSatisfaction

Dissatisfaction

Patient Satisfaction

Non-compliant

Compliant

N=398

(p=0.001)

Diary-Use in Most Recent Clinical TrialNon-compliance:

Overall satisfaction with diary experience

Diary-Use in Most Recent Clinical TrialNon-compliance: Negative experience factor =

hard to remember

0%

15%

30%

45%

60%

75%

Did Not Select Selected NegativeFactor

Non-compliantCompliant

N=398

(p<.01)(n=317) (n=81)

Diary-Use in Most Recent Clinical TrialReasons for Non-compliance of

Non-compliant Respondents

0%

15%

30%

45%

60%

They Forgot Too Busy DiaryAccess

Other

N=185

Planning for Future PRO TrialsBased on Patient Recommendations

Future Clinical Trials:Helpfulness Ratings of Reminders

for Patient Diaries

0%

15%

30%

45%

60%

75%

90%

High AttractivenessRating (5-7)

Low/OK AttractivenessRating (1-4)

77.2%

22.8%

N=403

0%

15%

30%

45%

60%

75%

90%

Female Male

83.9%71.4%

16.2%28.6%

Gender

High AttractivenessRating (5-7)

Ok/Low AttractivenessRating (1-4)

Future Clinical Trials:Helpfulness Ratings of Reminders

for Patient Diaries

N=403

(p<.01)

Future Clinical Trials:Helpfulness Ratings of Reminders

for Patient Diaries

0%

15%

30%

45%

60%

75%

90%

Did Not Select Selected NegativeFactor

79.0%

56.4%

21.0%

43.6%

Reminders were annoying

High AttractivenessRating (5-7)

Ok/Low AttractivenessRating (1-4)

N=398

(p<.01)

Future Clinical Trials:Preferred Reminders Modes

0%

15%

30%

45%

60%

75% 67.2%

34.3% 32.6%

18.0% 16.1%6.2% 5.7%

0.5%

N=403

Future Clinical Trials:When Patients Want To Be Reminded

to Complete Diary Entries

0%

15%

30%

45%

2.8%

39.2%

25.3%32.3%

0.5%

N=403

Future Clinical Trials:When Patients Want To Be Reminded

to take study meds

0%

15%

30%

45%

5.0%

33.8%

20.6%

5.7%

16.6%

2.5%

15.9%

N=403

Future Clinical Trials:When Patients Want To Be Reminded

of study visits

0%

15%

30%

45%

NOReminder

On day ofappt

1 dayBEFORE

2 daysBEFORE

5.0%

33.8%

20.6%

5.7%

N=403

Future Clinical Trials:When Patients Want To Be Reminded

to collect study samples

0%

15%

30%

45%

60%

NO Reminder 1 day BEFORE 1x on the day 2x on the day

5.5%

53.9%

28.8%

11.9%

N=403

Future Clinical Trials:Patient Suggested Improvements to Enhance

ePRO Experience

0%

15%

30%

45% 34.1%

28.4%27.7%

21.5% 19.8%14.6% 13.3% 12.1%

N=403

Patient Technology Behaviors

Patient Technology Behaviors:Types of Technologies/

Devices Owned by Subjects

0%

15%

30%

45%

60%

75%

90%

Computer SmartPhone

Landline Cell Phonew/

UnlimitedTexting

Tablet Cell Phonew/o

UnlimitedTexting

None

81.2%

60.5%

49.9% 49.4%37.0%

16.8%

1.0%

N=403

Patient Technology Behaviors:Hours Per Day Spent Using a Computer

0%

15%

30%

45%

<=2 hrs 3-5 hrs 6-8 hrs 9-12 hrs >=13 hrs

24.7%

42.0%

16.3%

9.1% 8.0%

N=403

Patient Technology Behaviors:Checking Text Messages vs.

Emails Upon Receipt

0%

15%

30%

45%

60%

Text Messages Emails

52.9%

15.1%

N=403

(p<.0001)

Conclusions

Planning Reminder Strategies Well

With today’s technologies, study design must keep pace with patients’ behaviors and preferences when developing effective

reminder strategies

Results suggest incorporating optimal reminder strategies can positively affect patient experience and compliance

Results show that patients prefer to be reminded

Top non-compliance reason is “forgetting” suggesting that reminders can be helpful in enhancing compliance

Patient preferences for reminders related to diaries and other study tasks should be given careful consideration

Thank you

Mark WadeDirector, Patient Focused SolutionsAlmac@AlmacClinTech

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