networks of proteins and diseases

Networks of proteins and diseases

Lars Juhl Jensen

sequence analysis

protein networks

de Lichtenberg, Jensen et al., Science, 2005

adverse drug reactions

Campillos, Kuhn et al., Science, 2008

group leader

cofounder

data mining

proteomics

text mining

biomedical literature

electronic health records

protein networks

guilt by association

STRING

computational predictions

gene fusion

Korbel et al., Nature Biotechnology, 2004

gene neighborhood

Korbel et al., Nature Biotechnology, 2004

phylogenetic profiles

Korbel et al., Nature Biotechnology, 2004

experimental data

gene coexpression

protein interactions

Jensen & Bork, Science, 2008

curated knowledge

complexes

pathways

Letunic & Bork, Trends in Biochemical Sciences, 2008

many databases

different formats

different identifiers

variable quality

not comparable

hard work

quality scores

von Mering et al., Nucleic Acids Research, 2005

calibrate vs. gold standard

missing most of the data

text mining

>10 km

too much to read

computer

as smart as a dog

teach it specific tricks

named entity recognition

comprehensive lexicon

CDC2

cyclin dependent kinase 1

expansion rules

hCdc2

CDC2

flexible matching

cyclin-dependent kinase 1

cyclin dependent kinase 1

“black list”

SDS

augmented browsing

Reflect

browser add-on

real-time text mining

Pafilis, O’Donoghue, Jensen et al., Nature Biotechnology, 2009O’Donoghue et al., Journal of Web Semantics, 2010

information extraction

co-mentioning

within documents

within paragraphs

within sentences

text corpus

~22 million abstracts

no access

~4 million full-text articles

localization and disease

general approach

COMPARTMENTS

TISSUES

DISEASES

curated knowledge

experimental data

text mining

computational predictions

common identifiers

quality scores

visualization

compartments.jensenlab.org

tissues.jensenlab.org

dissemination

web interfaces

web services

diseases.jensenlab.org

bulk download

disease networks

medical data

electronic health records

central registries

individual hospitals

Jensen et al., Nature Reviews Genetics, 2012

structured data

Jensen et al., Nature Reviews Genetics, 2012

unstructured data

in Danish

by busy doctors

confounding factors

age and gender

reporting bias

custom dictionaries

typo rules

age/gender matching

comorbidity

Jensen et al., Nature Reviews Genetics, 2012

Roque et al., PLOS Computational Biology, 2011

temporal correlation

diagnosis trajectories

Jensen et al., in preparation, 2013

pharmocovigilance

adverse drug reactions

Eriksson et al., submitted, 2013

ADR profiles

Eriksson et al., submitted, 2013

ADR frequencies

Eriksson et al., submitted, 2013

molecular basis

protein networks

AcknowledgmentsSTRINGChristian von MeringDamian SzklarczykMichael KuhnManuel StarkSamuel ChaffronChris CreeveyJean MullerTobias DoerksPhilippe JulienAlexander RothMilan SimonovicJan KorbelBerend SnelMartijn HuynenPeer Bork

Text miningSune FrankildEvangelos PafilisKalliopi TsafouAlberto SantosJanos BinderHeiko HornMichael KuhnNigel BrownReinhardt SchneiderSean O’ Donoghue

EHR miningAnders Boeck JensenPeter Bjødstrup JensenFrancisco S. RoqueHenriette SchmockMarlene DalgaardMassimo AndreattaThomas HansenKaren SøebySøren BredkjærAnders JuulTudor OpreaPope MoseleyThomas WergeSøren Brunak

Thank you!