microneedle patch technology for long-acting...

Microneedle patch technology for long-acting contraception

Mark R. Prausnitz Georgia Institute of Technology

© Mark Prausnitz, Georgia Tech .

Disclosure

Mark Prausnitz is a co-founder and has a significant financial interest in Micron Biomedical. This conflict of interest is managed by the Georgia Institute of Technolgy.

© Mark Prausnitz, Georgia Tech

Introduction to microneedle patches

Long-acting contraception

Outline

© Mark Prausnitz, Georgia Tech

Microneedle patch ©

Mark Prausnitz, G

eorgia Tech

Microneedle patch ©

Mark Prausnitz, G

eorgia Tech

Microneedle patch

© Mark Prausnitz, Georgia Tech

Microneedle patch meets public health needs

Patient administration Minimally-trained personnel No applicator, no reconstitution Painless delivery, no fear of needle

Manufacturing Low-cost, scalable fabrication

Transportation and storage Small package size Improved thermostability

Waste disposal No sharps waste Difficult or impossible reuse © Mark Prausnitz, Georgia Tech

Microneedle clinical trials

Microneedle patch vaccination

• Influenza vaccine o Phase 1 (Lancet 2017)

• Measles-rubella vaccine o Phase 1 (summer 2020)

• Others, Phase 1 and 2 o (2020, 2021)

© M

ark Prausnitz, Georgia Tech

Outline

Long-acting contraception

This abstract is made possible by the generous support of the American people through USAID, provided to FHI 360 through cooperative agreement number AID-OAA-A-15-00045. The contents of this abstract are the responsibility of the authors and do not reflect the views of the U.S. Agency for International Development (USAID) or the United States Government.

© M

ark Prausnitz, Georgia Tech

Need for long-acting contraception

Provide increased access to family planning resources

Every year there are

• 212 million pregnancies

• 56 million (27%) abortions

• 85 million (40%) pregnancies unintended

© Mark Prausnitz, Georgia Tech

Design of separable microneedle patch for long-acting contraception

B

skin

microneedle patch

A

release layer

© Mark Prausnitz, Georgia Tech

Separable microneedles for long-acting contraception

fluid from skin Goal:

Approach: water-soluble air bubble effervescent

material © Mark Prausnitz, Georgia Tech

Design and fabrication of rapidly separable MNPs

Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech

Incorporation of bubble in rapidly separable MNPs

Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech

Mechanical performance of rapidly separable MNPs

Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech

Application of MNPs to porcine skin ex vivo

Wei Li et al., Nature Biomedical Engineering, 2019

© M

ark Prausnitz, Georgia Tech

Histological image of MNs in porcine skin ex vivo

Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech

Release kinetics of LNG from MNPs

Wei Li et al., Nature Biomedical Engineering, 2019 LNG = levonorgestrel

© M

ark Prausnitz, Georgia Tech

Imaging of dye release from MNPs in rats

Wei Li et al., Nature Biomedical Engineering, 2019

© M

ark Prausnitz, Georgia Tech

Release of LNG from MNPs in rats

Wei Li et al., Nature Biomedical Engineering, 2019

LNG = levonorgestrel

© Mark Prausnitz, Georgia Tech

Wei Li et al., Scientific Reports, 2019

Design and fabrication of rapidly separable effervescent MNPs

© Mark Prausnitz, Georgia Tech

Microneedles rapidly separate by effervescence

Wei Li et al., Scientific Reports, 2019 © Mark Prausnitz, Georgia Tech

Pharmacokinetics of LNG from MNPs in rats

Wei Li et al., Scientific Reports, 2019 © Mark Prausnitz, Georgia Tech

Tolerability of placebo effervescent patch in humans (n = 10)

Wei Li et al., Scientific Reports, 2019 © Mark Prausnitz, Georgia Tech

Preferences of human participants (n = 10)

Wei Li et al., Scientific Reports, 2019

Monthly patch vs. monthly injection Monthly patch vs. daily pill

© Mark Prausnitz, Georgia Tech

Microneedle patch with larger dose

Microneedle patch with longer-acting contraception

Future work

© Mark Prausnitz, Georgia Tech

Acknowldegements ©

Mark Prausnitz, G

eorgia Tech

Questions?

© Mark Prausnitz, Georgia Tech .