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Meiosis and Sexual

Reproduction

Asexual Reproduction

• Single parent produces offspring

• All offspring are genetically identical to

one another and to parent

• Produces identical somatic (body) cells

Sexual Reproduction

• Chromosomes are duplicated in germ

cells (sex cells)

• Germ cells undergo meiosis and

cytoplasmic division

• Cellular descendents of germ cells

become gametes (sperm and egg)

• Gametes meet at fertilization

Sperm and Egg Gametes

Sexual Reproduction

• Involves:

– Meiosis

– Gamete production

– Fertilization

• Produces genetic variation among

offspring

Sexual Reproduction

Shuffles Alleles

• Through sexual reproduction, offspring

inherit new combinations of alleles,

which leads to variations in traits

• This variation in traits is the basis for

evolutionary change

Homologous Chromosomes

Carry Different Alleles

• Cell has two of each chromosome

• One chromosome in each pair from

mother, other from father

• Paternal and maternal chromosomes

carry different alleles

Gamete Formation

• Gametes are sex cells (sperm, eggs)

• Arise from germ cells

testes

ovaries

anther ovary

Chromosome Number

• Sum total of chromosomes in a cell

• Germ cells are diploid (2n)

• Gametes are haploid (n)

• Meiosis halves chromosome number

Meiosis: Two Divisions

• Two consecutive nuclear divisions

– Meiosis I

– Meiosis II

• DNA is not duplicated between divisions

• Four haploid nuclei are formed

Meiosis I

Each homologue in the

cell pairs with its partner,

then the partners

separate

Meiosis II

• The two sister chromatids of each

duplicated chromosome are separated

from each other

one chromosome

(duplicated)

two chromosomes

(unduplicated)

Stages of Meiosis

Meiosis I

• Prophase I

• Metaphase I

• Anaphase I

• Telophase I

Meiosis II

• Prophase II

• Metaphase II

• Anaphase II

• Telophase II

Meiosis I - Stages

Prophase I Metaphase I Anaphase I Telophase I

Prophase I

• Each duplicated, condensed

chromosome pairs with its homologue

• Homologues swap segments

• Each chromosome becomes attached

to microtubules of newly forming spindle

Metaphase I

• Chromosomes are pushed and pulled into the middle of cell

• Sister chromatids of one homologue orient toward one pole, and those of other homologue toward opposite pole

• The spindle is now fully formed

Anaphase I

• Homologous chromosomes segregate

from each other

• The sister chromatids of each

chromosome remain attached

Telophase I

• The chromosomes arrive at opposite

poles

• The cytoplasm divides

• There are now two haploid cells

• This completes Meiosis I

Meiosis II - Stages

Prophase II Metaphase II Anaphase II Telophase II

Anaphase II

Prophase II

• Microtubules attach to the kinetochores

of the duplicated chromosomes

• Motor proteins drive the movement of

chromosomes toward the spindle’s

equator

Metaphase II

• All of the duplicated chromosomes are

lined up at the spindle equator, midway

between the poles

Anaphase II

• Sister chromatids separate to become

independent chromosomes

• Motor proteins interact with

microtubules to move the separated

chromosomes to opposite poles

Telophase II

• The chromosomes arrive at opposite

ends of the cell

• A nuclear envelope forms around each

set of chromosomes

• The cytoplasm divides

• There are now four haploid cells

Crossing Over

• Each chromosome becomes zippered

to its homologue

• All four chromatids are closely aligned

• Non-sister chromosomes exchange segments

Effect of Crossing Over

• After crossing over, each chromosome

contains both maternal and parental

segments

• Creates new allele combinations in

offspring

Random Alignment

• During transition between prophase I

and metaphase I, microtubules from

spindle poles attach to kinetochores of

chromosomes

• Initial contacts between microtubules

and chromosomes are random

Random Alignment

• Either the maternal or paternal member

of a homologous pair can end up at

either pole

• The chromosomes in a gamete are a

mix of chromosomes from the two

parents

Possible Chromosome

Combinations

As a result of random alignment, the

number of possible combinations of

chromosomes in a gamete is:

2n

(n is number of chromosome types)

Possible

Chromosome

Combinations or

or

or

1 2 3

Plant Life Cycle

multicelled sporophyte

multicelled gametophytes

zygote

gametes spores

meiosis fertilization

mitosis

mitosis

Diploid

Haploid

Animal Life Cycle

multicelled body

gametes

zygote

meiosis fertilization

mitosis

Diploid

Haploid

Spermatogenesis

Growth Mitosis I,

Cytoplasmic division

Meiosis II,

Cytoplasmic division

spermatids (haploid)

secondary spermatocytes

(haploid)

primary spermatocyte

(diploid)

spermato- gonium

(diploid male germ cell)

Oogenesis

Growth Mitosis I,

Cytoplasmic division

Meiosis II,

Cytoplasmic division

ovum (haploid)

primary oocyte (diploid)

oogonium (diploid

reproductive cell) secondary

oocyte (haploid)

first polar body

(haploid)

three polar bodies

(haploid)

Fertilization

• Male and female gametes unite and

nuclei fuse

• Fusion of two haploid nuclei produces

diploid nucleus in the zygote

• Which two gametes unite is random

– Adds to variation among offspring

Factors Contributing to

Variation among Offspring

• Crossing over during prophase I

• Random alignment of

chromosomes at metaphase I

• Random combination of gametes at

fertilization

Mitosis

• Functions

– Asexual reproduction

– Growth, repair

• Occurs in somatic

cells

• Produces clones

• 1 nuclear division

Mitosis & Meiosis Compared

Meiosis

• Function

– Sexual reproduction

• Occurs in germ cells

• Produces variable

offspring

• Two nuclear

divisions

Prophase vs. Prophase I

• Prophase (Mitosis)

– Homologous pairs do not interact with each

other

• Prophase I (Meiosis)

– Homologous pairs become zippered

together and crossing over occurs

Anaphase, Anaphase I, and

Anaphase II

• Anaphase I (Meiosis)

– Homologous chromosomes are separated

from each other

• Anaphase/Anaphase II (Mitosis/Meiosis)

– Sister chromatids of a chromosome are

separated from each other

Results of Mitosis and Meiosis

• Mitosis

– Two diploid cells produced

– Each identical to parent

• Meiosis

– Four haploid cells produced

– Differ from parent and one another