mdm4 mdm2 hausp 1: bt202: bt4744: bt5495: cama-1 6: du4475 7: evsa-t 8: hcc19379: hs578t p53 p300...
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Mdm4
Mdm2
HAUSP
1:
BT2
0
2:
BT4
74
4:
BT5
49
5:
CA
MA
-1
6:
DU
44
75
7:
EV
SA
-T
8:
HC
C1
937
9:
Hs5
78
T
p53
p300
pRB
ATM
CBP
p16
p21
p14ARF
Tropomysosin
Tubulin
PUMA
CDK4
Cyclin D1
10:
MC
F-7
12:
MD
A-M
B-1
57
11:
MD
A-M
B-1
34V
I
13:
MD
A-M
B-1
75V
II
14:
MD
A-M
B-2
31
15:
MD
A-M
B-3
30
16:
MD
A-M
B-3
61
17:
MD
A-M
B-4
15
18:
MD
A-M
B-4
35S
19:
MD
A-M
B-4
36
20:
MD
A-M
B-4
53
21:
MD
A-M
B-4
68
23B
: O
CU
B-M
22:
MPE
60
0
24:
SK
-BR
-3
25:
SK
-BR
-5
26:
SK
-BR
-7
27:
SU
M4
4PE
28:
SU
M5
2PE
30:
SU
M1
49PT
31:
SU
M1
59PT
32:
SU
M1
85PE
33:
SU
M1
90PT
34:
SU
M2
25C
WN
35:
SU
M2
29PE
36:
SU
M1
315
M0
2
37:
T4
7D
38:
UA
CC
-81
2
39:
UA
CC
-89
3
40:
ZR
75
-1
41:
ZR
75
-30
Supplementary Figure 1
MPE600
0 24 48 720.0
0.5
1.0
1.5
2.0
2.5
Time (hours)
Rela
tive g
row
th
MCF-7
0 24 48 720
1
2
3
4
Time (hours)
Rela
tive g
row
th
ZR75-1
0 24 48 720
1
2
3
Time (hours)
Rela
tive g
row
th
ZR75-30
0 24 48 720.0
0.5
1.0
1.5
2.0
Time (hours)
Rela
tive g
row
th
C D
A B
Supplementary Figure 2
***
**
*
******
***
*****
***
***
***
*** ***
* **
******
*********
*
**
***
***
***
MCF-7
0 24 48 720
1
2
3
4
5
Time (hours)
Rela
tive g
row
th
MPE600
0 24 48 720
1
2
Time (hours)
Rela
tive g
row
th
ZR75-1
0 24 48 720
1
2
3
Time (hours)
Rela
tive g
row
th
ZR75-30
0 24 48 720
1
2
Time (hours)
Rela
tive g
row
th
Supplementary Figure 3
A
DC
B
Mdm2
Mdm4
pSer15-p53
pSer46-p53
p53
PUMA
p21
HAUSP
Doxorubicin
+ 10 µM Nutlin-3
0 0.05 0.1 0.2 0.3 0.4 0.50.0
0.2
0.4
0.6
0.8
1.0
1.2
-
+ Nutlin-3
Doxorubicin (M)
Rela
tive c
ell
nu
mber
Supplementary Figure 4
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