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Introducing Veroplex™
Ology Bioservices’ Proprietary Vero Cell PlatformNeed an established and validated platform to manufacture your vaccine candidate? Look no further than Ology Bio’s proprietary Veroplex Platform, comprised of proven Vero cells, patented processes for vaccine development and production, and experienced regulatory support.
• Reliable, stable, and proven high-yieldworking cell banks (WCBs)
• WCB passage number as low as 133
• Adapted to grow in serum-free media, andfor growth on 60-250 micron microcarriers
• Consistent density, viability and productionduring scale-up from 15L to 6000L bioreactors
• Extensive regulatory documentation and expertsupport, DMF 10336
• Accepted by regulatory authorities in more than60 countries
1. Vero Cell Propagation
2. Virus Replication
3. Harvesting and Inactivation
4. Purification
Each step is well established and standardized in the Veroplex Platform and can be manufactured in Ology Bio’s BSL-3 capable manufacturing facility.
Vero Cells on Microcarriers
Vero Cells Preinfection
Vero Cells 2-3 Days Post Infection
Capable. Collaborative. Creative.
TM
Veroplex Cells
Veroplex Patented Processes
13200 NW Nano Court | Alachua, FL 32615 | T. 386-462-9663 | F. 386-462-2087 | ologybio.com
TM
A Streamlined Manufacturing Process for Inactivated Viral Vaccines
Virus Propagation
Fermentation (Fermenter 1-3)
Cell Harvesting (Separator)
Vero CellInoculum
Production Virus Bank
Vero Working Cell Bank
Working Virus Bank
Vero Master Cell Bank
Seed Virus Bank
Benzonase Incubation
DoubleInactivation
Purification I (Ultracentrifugation)
Purification II (Ultra/Diafiltration,
Benzonase Incubation)
Inactivated Whole Virus Vaccine Drug Substance
Superior Manufacturing with Veroplex™
Ology Bio™ offers CDMO clients manufacturing licenses to the well-established and validated technology.
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