graduiertenkolleg 2162/1: “neurodevelopment and …...research projects supervision...

Graduiertenkolleg 2162/1:“Neurodevelopment and CNS Vulnerability”

Scientific Background

Einrichtungsbegutachtung 3. Juni 2015 2(Courtesy of F.H. Gage)

MalformationsIntellectual DisabilityAutism Spectrum Disorders

MalformationsIntellectual DisabilityAutism Spectrum Disorders

CNS DevelopmentCNS Development

Scientific Background

Einrichtungsbegutachtung 3. Juni 2015 3

Scientific Background

MalformationsIntellectual DisabilityAutism Spectrum Disorders

MalformationsIntellectual DisabilityAutism Spectrum Disorders

CNS DevelopmentCNS Development

Adult neuropsychiatric /-degenerative diseasesAdult neuropsychiatric /-degenerative diseases

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Novel Concept: Developmental Impact onadult-onset CNS Diseases

MalformationsIntellectual DisabilityAutism Spectrum Disorders

MalformationsIntellectual DisabilityAutism Spectrum Disorders

CNS DevelopmentCNS Development

Einrichtungsbegutachtung 3. Juni 2015 5

Adult neuropsychiatric /‐degenerative diseasesAdult neuropsychiatric /‐degenerative diseases

Novel Concept: Developmental Impact onadult-onset CNS Diseases

MalformationsIntellectual DisabilityAutism Spectrum Disorders

MalformationsIntellectual DisabilityAutism Spectrum Disorders

CNS DevelopmentCNS Development

Disease SusceptibilityDisease Susceptibility

Einrichtungsbegutachtung 3. Juni 2015 6

MalformationsIntellectual DisabilityAutism Spectrum Disorders

MalformationsIntellectual DisabilityAutism Spectrum Disorders

CNS DevelopmentCNS Development

Disease SusceptibilityDisease Susceptibility

Adult neuropsychiatric /-degenerative diseasesAdult neuropsychiatric /-degenerative diseases

Einrichtungsbegutachtung 3. Juni 2015 7

Novel Concept: Developmental Impact onadult-onset CNS Diseases

Rethinking pathogenesis of adult-onset diseases:Common genetics and pathways with developmental disorders

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Adult-onsetCNS diseases

Developmental disorders

Genes &Pathways

Rethinking pathogenesis of adult-onset diseases:Common genetics and pathways w/ developmental disorders

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(Endele, ... Reis, et al., Nat. Genet. 2010)

(Gregor, ... Reis,...Zweier; BMC Medical Genetics, 2011)

(Zweier..., Reis, et al., AJHG, 2007)

TCF4

CNTNAP2

GRIN2B

Rethinking pathogenesis of adult onset diseases:Developmental genes as risk factors

(Stolt...and Wegner, Development, 2004)

(Sawcer et al., Nature, 2011)

(Lill et al., Brain, 2013)

Einrichtungsbegutachtung 3. Juni 2015 10

MalformationsIntellectual DisabilityAutism Spectrum Disorders

MalformationsIntellectual DisabilityAutism Spectrum Disorders

CNS DevelopmentCNS Development

Disease SusceptibilityDisease Susceptibility

Adult neuropsychiatric /-degenerative diseasesAdult neuropsychiatric /-degenerative diseases

Einrichtungsbegutachtung 3. Juni 2015 11

Aim of the RTG

Faculty

Faculty of SciencesHelmut Brandstätter Department of BiologyHanna Regus-Leidig Department of BiologyKristina Friedland Department of Chemistry and Pharmacy

Faculty of Medicine (Basic Sciences)Christian Alzheimer Institute of PhysiologyChichung Lie Institute of BiochemistryMichael Wegner Institute of Biochemistry

Faculty of Medicine (Clinics)Johannes Kornhuber Clinic for PsychiatryRalf Linker Clinic for NeurologyAndré Reis Institute of Human GeneticsJürgen Winkler Division of Molecular NeurologyBeate Winner IZKF Junior GroupChristiane Zweier Institute of Human Genetics

Einrichtungsbegutachtung 3. Juni 2015 12

Junior Faculty

Einrichtungsbegutachtung 3. Juni 2015 13

Faculty of SciencesHelmut Brandstätter Department of BiologyHanna Regus-Leidig Department of BiologyKristina Friedland Department of Chemistry and Pharmacy

Faculty of Medicine (Basic Sciences)Christian Alzheimer Institute of PhysiologyChichung Lie Institute of BiochemistryMichael Wegner Institute of Biochemistry

Faculty of Medicine (Clinics)Johannes Kornhuber Clinic for PsychiatryRalf Linker Clinic for NeurologyAndré Reis Institute of Human GeneticsJürgen Winkler Division of Molecular NeurologyBeate Winner IZKF Junior GroupChristiane Zweier Institute of Human Genetics

Interdisciplinarity of the RTGExpertise in

• Psychiatry and Neurology• Human Genetics• Molecular Biology• Cell & Developmental Biology• Biochemistry• Neurophysiology• Behavioral Neurobiology• Genomics• Disease models• Pharmacology

Qualification program Research projects Supervision

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Interdisciplinarity of the RTG

Cell Biological Processes

Cell Biological Processes

Neural CircuitsNeural Circuits

Disease modelsDisease models

Experimental Therapies

Experimental Therapies

Clinical Neurobiology &

Human Genetics

Clinical Neurobiology &

Human Genetics

MolecularPathwaysMolecularPathways

Expertise in

• Psychiatry and Neurology• Human Genetics• Molecular Biology• Cell & Developmental Biology• Biochemistry• Neurophysiology• Behavioral Neurobiology• Genomics• Disease models• Pharmacology

Qualification program Research projects Supervision

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RTG Research Areas:

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Alzheimer, Friedland, Kornhuber(ASM-Pathway in development & neuropsychiatric disease)

Winkler, Winner(Neurodegenerative disease genesin development)

Linker, Wegner(Developmental Genes in Dys- and Demyelination)

Lie, Reis, Zweier, Postdoctoral Project(Common pathways intellectual disability & neuropsychiatric disease)

Brandstätter, Regus-Leidig(Synapse and neurodegeneration)

Promoting Clinician-Scientist Careers:

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MD StudentExperimental

Thesis

ResidentDevelopment of Scientific Expertise

Clinician-Scientist

Independent Research

Clinician-Scientists are important cornerstones for• Communication between basic and clinical research• Development of new treatment strategies

CL4

Folie 17

CL4 Quality assurance könnte man weglassen, da wir hier nicht darauf eingehen? Hier der Link für das DFG Statementhttp://www.dfg.de/download/pdf/dfg_im_profil/reden_stellungnahmen/2015/empfehlungen_clinician_scientists_0415.pdfChichung Lie; 22.05.2015

MD StudentExperimental

Thesis

ResidentTranslational

Expertise

Clinician-Scientist

Independent Research

Promoting Clinician-Scientist Careers:

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Clinician-Scientist in the RTG:

● 6 clinician-scientist principal investigators (50%)

● 1 associated clinician-scientist ● 2 MD rotation positions

● 13 MD thesis fellowships

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Clinical Neuroscientists

Clinical Neuroscientists

Basic Neuroscientists

Basic Neuroscientists

Promoting Clinician-Scientist Careers:

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MD StudentExperimental

Thesis

ResidentDevelopment of Scientific Expertise

Clinician-Scientist

Independent Research

Recruitment: RTG meets MD student seminar Lab internships Doctoral fellowships

Promoting Clinician-Scientist Careers:

Einrichtungsbegutachtung 3. Juni 2015 21

MD StudentExperimental

Thesis

ResidentDevelopment of Scientific Expertise

Clinician-Scientist

Independent Research

Clinician-scientist fellowships Research infrastructure Mentoring Training Methods and Soft-Skills

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Mandatory

• Lectures• Colloquium / Retreat / Conference

Facultative

• Neuroscience Lecture• Career Options and Excursions• Method Courses• Soft Skill Courses

Methods, Theory, Concepts in Neuroscience

Qualification Program

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Daten

GRK Start 1. Juli 2016

Rekrutierung 1. Kohorte MD Studenten Spätsommer 2016 (2-3 Plätze)

7-monatiges Stipendium

www.grk2162.med.fau.deEmail: grk2162@fau.de