germ cell tumors - cdn.ymaws.com...embryonal ca 10% teratoma 3% yolk sac tumor 0.4% polyembryoma...
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Germ Cell TumorsPure 67%
Seminoma 53%Typical 52%Spermatocytic 1%
Embryonal ca 10%yTeratoma 3%Yolk sac tumor 0.4%Polyembryoma 0.3%Choriocarcinoma 0.3%
Mixed 33%
Seminoma
Seminoma
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Seminoma
Seminoma
Seminoma
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Seminoma Granulomas
Necrotic Seminoma
Seminoma+SynT
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Seminoma Oct 3/4
YSTOct 3/4
OCT 3/4
Seminoma – Differential Diagnosis
• Spermatocytic seminoma• Embryonal carcinoma y• Choriocarcinoma• Solid yolk sac tumor• Lymphoma• Sertoli cell tumor
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Spermatocytic Seminoma
Spermatocytic Seminoma
Spermatocytic Seminoma
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Spermatocytic Seminoma
Emb CA
Emb CA
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Emb CA
Emb CA
Emb CA
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Emb CA
Immunostains for Seminoma vs. Embryonal Carcinoma (EC)
Stain Sem. EC
*AE1/AE3 + ++
*CD30 ++
C-kit ++ +
Podoplanin ++ +
Mixed GCT
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Chorio
Chorio
Emb CA + Seminoma
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YST + Sem
YST + Sem
YST + Sem – OCT 3/4
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Regressed GCT
Regressed GCT
Regressed GCT
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Regressed GCT
Testicular Tumors in Children
•Teratomas 48%•Yolk sac tumor 15%•Epidermoid cyst 14%•Epidermoid cyst 14%•Sex cord tumors 13%•Miscellaneous 10%
Pohl et al. J Urol 172:2370, 2004
YST
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YST
Teratoma
Epidermoid Cyst
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Epidermoid Cyst
Sex Cord-Stromal Tumors
Leydig cell tumorsSertoli cell tumorsSertoli-Leydig cell tumorsGranulosa cell tumors, adult and juvenileMixed and unclassified tumors
Leydig Cell Tumor
1-3 % of testicular neoplasms2-94 (mean 36) years of ageUnilateral in 99 %Occasional gynecomastia2-5% malignant
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LCT
LCT
TESTICULAR SERTOLI CELL TUMORS
• Sertoli cell tumor, not otherwise specified
• Large cell calcifying
• Sclerosing
• Tumors in Peutz-Jeghers syndrome
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Sertoli cell tumor (SCT)
SCT
SCT
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SCT
Juvenile GCT (JGCT)
JGCT
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JGCT
Testicular Tumors in the50 + Age Group
• Lymphoma
• Metastases
• Spermatocytic Seminoma
Lymphoma
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Lymphoma
Mets To Testis
• Prostate 43%
• Lung 15%
• Colon 10%
• Kidney 10%
• Stomach 7%
• Melanoma 4%
• Misc. 11%
Prost. Ca
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Met Melanoma
Paratesticular Tumors
Sertoliform rete cystadenomacystadenoma
Rete carcinomaAdenomatoid tumorMalignant mesotheliomaMullerian carcinomas
Adenomatoid Tumor (ADT)
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ADT
Mesothelioma
Mesothelioma
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Mesothelioma
Retinal anlage tumor (RAT)
RAT
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Testicular tumor of adrenogenital syndrome (TTAGS)
TTAGS
TTAGS
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Malakoplakia
Malakoplakia
Viral orchitis
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Viral orchitis
Sertoli cell nodule
Fibromatous periorchitis
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Fibrous pseudotumors
Fibrous pseudotumor
Fibromatous periorchitis
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Meconium periorchitis
Meconium periorchitis
Vanishing testis syndrome
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Vanishing testis syndrome
Hemorrhagic infarction
Infarction of appendix testis
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Granulomatous orchitis
Sclerosing lipogranuloma
Sclerosing lipogranuloma
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