gastrointestinal disorders

Presented by Dr. Sudhakar KokateDirector PPRC, India

Plantsthat cure

Gastro Intestinal disorders(GID – Part I)

Gastro-intestinal disorders (GID)

Include :Colitis

Constipation

Diarrhoea

Duodenal ulcers

Dyspepsia

Hyper-acidityPPRC/INDIA 01

In India

Plant species: 9500 Medicinal: 7500 Tribal medicinal plants: 300 For G.I. Disorders:

Bael Isabgol KurchiPale catechu Palas GingerShatavari Mandar Carrot

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Around the World

Mexico: 65 plants to treat G.I. disorders(GID)

Thailand: 38 plants for GID Germany / France: Many herbs used as

prescription drug (Sale > $ 50bn……2010)

USA: $ 4 bn……1996 India: Drug market $1bn export of plant

crude drugs $ 80 mn PPRC/INDIA 03

Knowledge of Medi-plants

Dates back to 400 B.C.

First documented in Atharva Veda datesback to 4500-1500 B.C.

119 compounds with therapeutic valuehave been identified till date

Japanese pharmacopoeia 1993 contains123 active plants of which 29 are used inWestern medicine

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Aconitum heterophyllum

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Aconitum heterophyllum Habitat: Eastern Asia, Western Himalaya

Chemicals:- Astisine- Hetratisine- Histsine- Benzoyl-heterophyllum

It is employed in as a bitter tonic andanti-periodic

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Aegle marmelos

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Aegle marmelos Habitat: India, China, Sri Lanka, Burma,

Thailand

Chemicals:

Leaves: Alkaloid, Agelin, Sterol as V-sitosterol and Coumarins, Essential oilssuch as d-limonene

Bark: Aegelinin, Marmin

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1/22/2014

Aegle marmelos Chemicals:

Fruit: Sugar, Tannin

Pulp: 2 furocoumarins-psoraen andMarmelosin

Properties: Astringent, Depurative,Alexeteric, Cooling, Anti-poison

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Amphipterygium adstringens

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Amphipterygium adstringensMost gastro-protective compounds:

3 epi-oleanolic acid

3 alpha-hydroxy mastica dienonic acid

Beta-sitosterol acid

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Arnica montana

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Arnica montana The plant is rich in Sesquiterpenes

It has advantage in states of depression,diarrhoea, dysentery, pneumonia, typhoidand excessive sweating

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Asparagus adscendens

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Asparagus adscendens Habitat: India – forests of Uttar Pradesh,

East Asia, Afghanistan, Himalayas, Iran

Chemical: Asparagine

Roots: Demulcent, Diaphoretic,Galactogogue, Stimulant are useful in thetreatment of Diarrhoea and dysentery

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Calotropis gigantea

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Calotropis gigantea Habitat: Sub-tropic & Tropic, India, Sri

Lanka, West Indies

Active principles: Saponins, Glucoside,Tannins, Lugeol, Flavonoids, Glycine,Butrin, Isobutrin, 3-o acetyl-calotropin

Root Bark extensively used for GID

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Coriandrum sativum

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Coriandrum sativum Coriander seed oil has anti-bacterial

property and is used for treating colic,neuralgia, rheumatism, diarrhoea,hemorrhoids, flatulence and abdominalpains

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Curcuma longa

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Curcuma longa Active principle: Curcumin

diferuoylemethane

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Daucus carota

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Daucus carota Chemicals: Lutenolin-7-glucoside,

Mevolonic acid, Pyrolidine daucine &Essential oils

Used in stomach & intestinal problems

Carrot soup remedy for diarrhoea

Properties: Anthelmintic, Carminative,Diuretic and Stimulant

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Eugenia jambolana

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Eugenia jambolana Seed powder effective in diarrhoea,

dysentery and diabetes

Habitat: India, Queensland

Chemicals: Oleanolic acid, Glucosideshowed significant reduction & G.I.motility

Fruit: Astringent, Stomachic, Carminative,Diuretic, Spleen enlargement, Chronicdiarrhoea & Urine retention PPRC/INDIA 25

Helicteres isora

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Helicteres isora Chemicals:

- Phytosterol

- Hydroxy-carboxylic acid

- Phytolobotannins

Effective against G.I. disorders

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Melissa officinalis

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Melissa officinalis In Germany, Lemon balm is used as a

medicinal tea to treat G.I. disorders

Chemicals: 0.05% Volatile oil, Rosemaryacid

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Ocimum sanctum

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Ocimum sanctum Phyto-chemicals: Essential oils, Eugenol,

Methyl ether, Terbinene-4-01, Spigennins,Apigenin-7-0-glucuronide

Pharmacological action: Hypotensiveactivity, Inhibition of smooth musclecontraction induced by Acetylcholine,Carbachol and Histamine

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Pueraria lobata

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Puerata lobata In China, Japan; leaves, roots and shoots

are used for treating Alcoholism, Coldflu, G.I. disorders

Flowers and tubers are used for treatingFever, Cold, Diarrhoea, Dysentery andAcute intestinal ailments

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Phyto-drugs* for curing G.I. Disorders

Drugs/Chemical Plant used

Aesculetin Frazinus rhychophylla

Andrographolide Andrographis paniculata

Berberine Berberis vulgaris

Hemsleyadin Hemsleya amabilis

Neoandrographolide Andrographis paniculata* Commercial PPRC/INDIA 34

Thank You !!