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A publication of UCSF Department of Anesthesia and Perioperative Care
FALL 2008
VOLUME 6.2
Anesthesia News
Special Anniversary Edition
Featured Inside
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
2 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1958
NIH Training Grant
Stuart C. Cullen
First 3-Function
Blood Gas Analyzer
John Severinghaus
Affi liation with East Bay
Children’s Hospital
Stuart C. Cullen
Chair, 1958
Dean, UCSF Medical School, 1966
Ernie Guy
Chief, SFGH, 1959
Department, 1962
Department, 2008
3 Information about 50th Anniversary Events
4 Narrative History of the UCSF Department of Anesthesia
and Perioperative Care
24 Faculty Honors, Awards & Appointments
26 New Faculty
27 Academic Department Chairs from UCSF
28 UCSF Anesthesia Residents, Class of 2011
29 Stuart C. Cullen and William K. Hamilton Awardees
30 Research Faculty Spotlight
32 Peer Reviewed Publications 2007-2008
38 Active Research Grants
Information about 50th Anniversary Events
ANESTHESIA NEWS 3
19641962
Discovery of Central Chemoreceptor
Robert Mitchell
(Loeschke HH, Severinghaus J)
Sol Shnider
Director, Obstetrical Anesthesia, 1962
Morley Singer
1st Director, ICU Moffi tt, 1964
Neri Guadagni
Interim Chair, 1966-67
Invented MAC
Edmond Eger
(Merkel G, Saidman L, Severinghaus J)
Respiratory Control
and High Altitude
John Severinghaus
UCSF Department of Anesthesia
and Perioperative Care celebrates
its 50th Anniversary
Monday, November 10 – Wednesday, November 13:
Open House Events
Please join us in celebrating our 50th Anniversary!
Department of Anesthesia and Perioperative Care staff
and faculty are invited to attend, as well as members of
the broader UCSF community, who have contributed to
the growth and success of our department. Beverages
and light fare will be served. The Department Chair, Dr.
Ronald Miller, will attend and provide opening remarks.
• Monday, November 10, 3 – 5 pm — San Francisco
General Hospital, Conference Room 2A6, Main
Hospital, 2nd Floor
• Wednesday, November 12, 12 – 2 pm — Moffi tt-
Long/Mt. Zion, Millberry Union, Parnassus Campus
• Wednesday, November 12, 3 – 5 pm — Veteran’s
Administration Hospital, Director’s Conference Room
To commemorate its fi rst fi fty years as one of the leading anesthesia departments in the world,
the UCSF Department of Anesthesia will host a week long series of events in San Francisco,
from November 10 – 15, 2008
Saturday, November 15:
Symposium
Mission Bay Conference Center,
Robertson Auditorium, 7 am – 4 pm
CME Credits are available.
The Saturday symposium will be a moderated discus-
sion featuring some of the department’s past and
present leaders, as well as national and international
luminaries. Sessions will highlight many of the ground-
breaking events in research, education, and clinical
care at UCSF – and beyond – and will also look to the
future of anesthesia.
Alumni Gala Reception and Dinner
By invitation only
Palace Hotel, Garden Court and Grand Ballroom, 6 pm
For more information, please go to the website at
http://www.anesthesia.ucsf.edu
50th Anniversary Schedule of Events
Featured Inside
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
4 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1964
First Anesthesia Faculty with Joint Appointment in
Department of Pharmacology
Walter Way
Anesthetic Effects in Fetal Lamb Model
Sol Shnider
William K. Hamilton
Chair, 1967
Associate Dean for House Staff Affairs, UCSF, 1973
Joe Lee
1st Director, ICU, SFGH, 1967
On September 4, 1957, Julius Comroe
arrived in Iowa City. The formal reason
was a meeting of the American
Physiologic Society, but Comroe, the
newly appointed director of the planned
Cardiovascular Research Institute (CVRI)
at UCSF, had other things on his mind.
THE
of a
Department
Birth
Stuart C. Cullen, Demo
ANESTHESIA NEWS 5
1969 1972Richard Schlobohm
Director ICU, SFGH, 1970
H. Barrie Fairley
Chief, VAH, 1969
Chief, SFGH, 1973
George Gregory
Director, ICU Moffi tt, 1972
C. Philip Larson
Chief, SFGH, 1972
NIH Center Grant
William K. Hamilton
VAH Affi liation with
Department of Anesthesia
At the time, anesthesia at
UCSF was a small division
in the Department of
Surgery, with few resources or
responsibilities and no research
program. Comroe – who had been
recruited to UCSF as part of an
effort to transform what was widely
regarded as a third-rate medical
school into a truly respected center
of academic medicine – believed
that the emerging discipline of
anesthesia could play an important
role both in enhancing UCSF’s
reputation and helping the CVRI
establish itself as a vital resource
and training vehicle for researchers
across the UCSF campus.
The chair at Iowa, Stuart Cullen,
had built an impressive academic
department. Cullen and Comroe
met that day; by the end of the
meeting, Comroe had asked
Cullen to lead anesthesia at UCSF.
Cullen was intrigued – he relished
the opportunity to improve upon
what he had achieved at Iowa –
but wouldn’t agree to go unless
Comroe could guarantee that
anesthesia would have its own
department, separate from surgery.
Within hours, Comroe convinced
UCSF to meet the demand. When
Cullen called John Severinghaus
(who had just completed an
anesthesia residency with Cullen)
with the news, Severinghaus
immediately agreed to join Cullen
at UCSF. Among their initial
colleagues were existing faculty
members Neri Guadagni and Frank
DeBon; Earnest Guy, who was
brought on as the chief of anesthe-
sia at San Francisco General
Hospital; and a new resident,
Walter “Skip” Way.
It was the birth of a department
that over the next fi fty years would
be at the heart of modern anesthe-
sia’s explosive growth, a depart-
ment that to this day continues to
have an enormous impact on
surgical practice and the manage-
ment of pain. The department’s
research, education, and clinical
care quickly earned and have
maintained reputations that are the
equal or better of any institution in
the world. Its faculty, fellows, and
residents have produced a steady
“This has been the era of modern anesthesia. Until the 1940’s, few physicians were
anesthetists; this was a limited specialty with primitive techniques and a slight
body of knowledge. But then this change occurred. New drugs and techniques were
developed to induce anesthesia, support breathing, relax muscles, and suppress pain.
Technology improved. Suddenly we had ventilators, ECG and anesthetic/respira-
tory gas monitors, the blood gas analyzer. All these made anesthesia safer – and
more expensive. Knowledge that forms the underpinning of any specialty grew. The
information came in a few basic forms: we measured everything affected by anes-
thetics - breathing, kidney function, cardiovascular function.”
– Edmond Eger
stream of remarkable contributions
to medical care and patient safety.
Much of this growth and
achievement is attributable to
stable and visionary leadership.
Since 1958, the department has
known only three chairs – Cullen,
William Hamilton, and Ronald
Miller. Perhaps their most impres-
sive, collective achievement is that
while managing staggering growth
and balancing clinical, research,
and educational demands, they
have never sacrifi ced the depart-
ment’s sense of collegiality and
mutual respect.
Through a series of verbal and
visual snapshots, this edition of the
newsletter attempts to tell the
department’s story.
The Birth of a Department
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
6 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1973
Complications and Coagulation Defects
associated with Massive Blood Transfusion
Ronald D. Miller
Anesthetic Uptake and Action 1st Edition
Edmond Eger
Robert Hickey
Chief, VAH, 1973
Gershon Levinson
Director, Obstetrical Anesthesia,
SFGH, 1974
Hillary Don
Director, ICU, Moffi tt;
Director, Respiratory Therapy, 1974
1958-1967T H E Cullen Years
While applying for residency
programs, Ron Miller recalls
attending the Saturday morning
rounds that Cullen had established
upon his arrival. The prime
educational event of the depart-
ment, the rounds were inviolate,
something that had earned the
deep respect of the hospital’s
surgeons. “I sat in the back of the
room and watched residents and
staff openly questioning Cullen’s
opinion…something he obviously
invited,” says Miller. “It helped me
decide that UCSF was where I
wanted to be.”
Stu Cullen’s vision – his spirit
of open exploration, political
savvy, and unwavering commit-
ment to excellence – are the
department’s birthmark.
By all accounts, Stuart Cullen was a visionary The offer to
come to UCSF presented him with an opportunity to not
just repeat, but to surpass what he had built at Iowa.
How could he refuse?
Stuart C. Cullen, MD and Ronald D. Miller, MD
With the help and support
of Julius Comroe and his
Cardiovascular Research
Institute (CVRI), Cullen proved
remarkably adept at securing
funding, attracting talent, and
initiating a research tradition that
would create an enduring list of
historic contributions. Along with
Severinghaus, Guy, and Way,
during his tenure Cullen would also
hire future luminaries that included
Edmond Eger, Ed Munson, Rudolf
deJong, and Sol Shnider. But it
wasn’t merely Cullen’s powerful
infl uence in a specialty poised to
explode that drew the best and
the brightest, it was his personal
charm, his commitment to doing
things right, and his remarkably
open mind.
19781974Robert Willenkin
Director, Resident Education, 1974
Director, Medical Student Clerkship, 1975
Phillipa Newfi eld
Director, Neuroanesthesia, 1977
George Gregory
Director, Pediatric Anesthesia, 1975
William K. Hamilton
Chief of Medical Staff,
UCSF Medical Center, 1978
CPAP for Neonatal Respiratory Distress Syndrome
George Gregory
(Kitterman JH, Phibbs RH, Tooley WH, Hamilton WK)
1st Stuart C. Cullen Visiting Professor
(Robert Dripps) and Annual Dinner
Robert Dripps
Pharmocology of Neuromuscular
Blockade and Reversal
Ronald D. Miller
Stuart C. Cullen, MD
of respiratory physiologists that
Severinghaus convened, a liver
enzyme chemist named Leland
Clark pulled from his pocket a
polarographic O2 electrode with
a polyethylene membrane. Within
days, Severinghaus had begun the
design of a water bath containing
the PCO2 and PO2 electrodes,
with a stirred cuvette for the Clark
electrode. “Clark’s electrode was
the key discovery,” says Severing-
haus. “Fifty years later, every blood
gas analyzer contains a Clark type
electrode.”
Finally, shortly after arriving at
UCSF and with the help of his
friend and colleague Freeman
Bradley, Severinghaus added a pH
electrode to this evolving device,
creating the fi rst three-function
blood gas analyzer. By 1960, he
had built and installed a clinical
blood-gas analyzer in the Moffi t
Hospital OR Suite.
“I initially failed to foresee the
immense clinical potential of blood
gas analysis,” says Severinghaus,
who developed it for his laboratory
pulmonary studies. Yet because of
the way it allows physicians to
safely monitor heavily sedated or
ventilated patients, today no
operating room goes without the
device. His original three-function
analyzer resides in the Smithsonian
as part of an exhibit on the
conquest of pain.
The Master Tinkerer and
the Blood-Gas Analyzer
John Severinghaus was originally a
physicist who had spent the latter
part of World War II designing
radar. It was only after the war that
he turned his attention to medi-
cine, receiving his MD from
Columbia and, in 1952, beginning
an anesthesia residency at the
University of Pennsylvania.
At Penn, a portable paramag-
netic oxygen analyzer fascinated
the man his friend Ted Eger calls
“a master tinkerer.” Using himself
as “human servo” he measured
the uptake of nitrous oxide at the
beginning of an anesthetic,
keeping the oxygen at 20% and
closed system volume constant
using fl ow meters. It was the fi rst
measurement of the uptake of
an anesthetic in a human, a
modest beginning to a crucial
medical advance.
Two years later at a conference,
Severinghaus heard physiological
chemist Richard Stow, describe a
carbon dioxide electrode he had
developed, but could not stabilize.
“A few days later, I built a Stow
type CO2 electrode using a bulb
type Beckman pH electrode, a
silver wire with an AgCl coat, and
a rubber glove membrane. My
contribution was pretty simple,”
says Severinghaus. “Add soda.”
The next step came in early
1956, when at an informal meeting
Discovering and
Exploring the Brain’s
Carbon Dioxide Sensor
Over the years, the Severinghaus
lab became a virtual petri dish for
leading researchers and important
research. Internist Robert Mitchell
joined the lab in 1958 and would
share the space for the next
thirty-two years.
The Birth of a Department
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
8 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1979
Optimum PEEP in Acute Pulmonary Failure
H. Barrie Fairley
(Suter P, Eisenberg M)
Michael Roizen
Director, Vascular Anesthesia;
Director, PACU, 1979
George Gregory
1st Director, Pediatric ICU, 1980
H. Barrie Fairley
Associate Dean, SFGH, 1979
SFGH Opens New Facility
Mitchell’s greatest contribution was his discovery,
with Hans Loeschke, of the medullary area that
regulates blood PCO2, keeping spinal fl uid pH
constant. Today, when patients with conditions like
COPD have abnormal CO2 levels, the results are
understood in the context of Mitchell’s chemoreceptors.
That fi nding also “promised to explain a physiologic
mystery,” says Severinghaus. “Why is it that people
acclimatized to high altitude continue to over-breathe
for days after descending?”
To answer that question, Severinghaus, Mitchell and
two colleagues piled in a car and made their way to
UC’s Barcroft Lab in the White Mountain range, east of
the Sierras. They lugged a blood-gas analyzer up there
and volunteered to have their own spinal fl uid tapped.
What they found was the fi rst confi rmation that rapid
changes of cerebrospinal fl uid acid-base explain the
mysteries of acclimatization.
The Big MAC
Ted Eger fi rst became interested in the uptake and
distribution of inhaled anesthetics after hearing a talk
by John Severinghaus when both were still at Iowa. He
spent an hour afterwards arguing with Severinghaus,
telling him he surely was wrong (he wasn’t). Later,
during a stint in the Army, Eger devised a handwritten
iterative equation on how anesthetics move into the
lungs and tissues of the body. Anxious to continue his
work in this area, in 1960 he arrived at UCSF to
become a fellow in the Severinghaus lab.
At the time, various drug companies were compet-
ing to improve upon halothane, which had revolution-
ized anesthesia. One day in Severinghaus’s small,
cramped lab overfl owing with experiments of different
kinds, Severinghaus handed Eger a bottle of some-
thing called halopropane. “He asked me to fi nd out if it
was any good,” says Eger. “And when I asked him how,
exactly, he shrugged and told me I would fi gure it out.”
Stuart C. Cullen, MD
That bottle of halopropane would prove useless as
an anesthetic, but it was the perfect vehicle for Eger to
learn how to compare one anesthetic to another. This
led to his discovery of minimum alveolar concentration
(MAC). In parallel, he enlarged his research on uptake
and distribution. The work on MAC and pharmacoki-
netics, which continues to this day, is unparalleled in its
contribution to understanding inhaled anesthetics’
effect on all aspects of human physiology: breathing,
circulation, cerebral function, neuromuscular control,
and kidney and liver well-being. It is Eger’s work that
enables clinicians to understand how much anesthesia
is required to safely do the job.
19841983Neal Cohen
Director, ICU, Moffi tt;
Director, Respiratory Therapy, 1983
William K. Hamilton
Associate Dean, Educational Affairs;
Vice Dean, School of Medicine, 1983
Sol Shnider
Interim Chair,
1983-1984
Samuel Hughes
Director, Obstetrical Anesthesia,
SFGH, 1984
Obstetrical Anesthesia Update
Sol Shnider
Mass Spectrometry for Multi-Patient
End-Tidal Gas Monitoring in the OR
John Severinghaus
(Young W, Ozanne W)
Anesthesia for Obstetrics 1st Edition
Sol Shnider
(Levinson G)
1967-1983T H E Hamilton Years
When Stuart Cullen moved from anesthesia to become Dean
of the UCSF School of Medicine, he recruited the same man
who had replaced him at Iowa to take his place at the UCSF
Department of Anesthesia. William “Bill” Hamilton proved to
be a wise choice.
When he arrived at UCSF,
Hamilton understood
what a powerful jump
start Cullen (and Comroe) had
provided to the department and to
the entire School of Medicine. In
just ten short years, as the
specialty of anesthesia grew, UCSF
had begun a parallel ascent to the
nation’s top tier of anesthesia
programs. Cullen’s support for
research efforts were a major
factor, and under Hamilton’s
leadership the research fi rsts kept
coming and the money kept
fl owing. Hamilton believed that the
next step was to enhance the
department’s clinical work and its
educational offerings.
Over the next 16 years, he
improved operating room cover-
age, negotiated a department
agreement that balanced the
needs of clinicians and researchers
and, with the help of Sol Shnider,
established a very close relation-
ship with the department of
obstetrics. His charm, infl uence in
the fi eld, and startling intelligence
also proved remarkably effective at
attracting top-notch talent and at
placing people on projects and
collaborations that would yield
important advances. Perhaps most
important, at a time when newly
established ICUs were not
William K. Hamilton, MD
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
1984Ronald D. Miller
Chair, 1984
Mark Rosen
Director, PACU, 1984
Jerome Strong
Director, Medical Student Clerkship, 1984
Combined Transcutaneous PCO2
and PO2 Blood-Gas Electrode
John Severinghaus
1st Edition Anesthesia
Ronald D. Miller
Morley Singer, MD
generating professional fees and
other anesthesia departments
were abandoning them, Hamilton
had the foresight to insist that the
department maintain control of
these units at UCSF. Today, most
hospitals have maybe one
board-certifi ed anesthesia-intensiv-
ist in critical care; UCSF has 27.
All of this contributed to the
department playing an increasingly
important role in the overall picture
of the school. Hamilton believes
that the department’s growth
during his tenure made it that
much more important to maintain a
sense of departmental camarade-
rie. The informal get-togethers at
his home were a cherished tradition.
called adoring crowds, who walked
away smiling, but armed as well
with new and important knowledge.
In fact, though his human and
animal studies were fi rst rate,
Shnider’s greatest contribution
may have been as a teacher. He
wrote the seminal text on OB
anesthesia, which began as a
refresher course for residents.
Eventually, the annual OB meeting
Shnider initiated at UCSF would
draw some 400-500 residents and
practicing physicians from all over
the world.
“It fi lled a huge need for lots of
people,” says Rosen. “The thing
about Sol is that beneath all the
showmanship he was very, very
professional; he rehearsed his talks
– even the showy parts – down to
the second and they were always
fl awless.”
Saving Newborns in
Respiratory Distress
During his time at Iowa, Bill
Hamilton had been disturbed by
the newborns he treated who were
in respiratory distress. “I could hear
the tiny alveoli popping and I found
if I kept the bag tight, I could keep
the airway from collapsing on
itself,” says Hamilton. At the time
100 percent oxygen was the
standard gas for treating patients
in respiratory distress and by
maintaining pressure using pure
oxygen, says Hamilton “We found
“We were still small enough to do
that,” says Hamilton. “My wife and
I simply continued what Dr. Cullen
and his wife had begun.”
The Pied Piper
of OB Anesthesia
After training at Columbia with
Virginia Apgar, Sol Shnider arrived
at UCSF in 1966 to begin a
division of OB Anesthesia. A giant
of a personality whose social circle
included the world’s most promi-
nent opera stars – and who the
department relied upon to organize
and enliven its social and profes-
sional events – Shnider used
engaging showmanship to
signifi cantly advance an important
sub-specialty.
“Sol’s contribution really was that
until the early 1950’s, no one paid
attention to the impact of anesthe-
sia on the fetus,” says Mark
Rosen, a Shnider protégé who
today is UCSF’s director of OB
anesthesia. “He made the world
aware of this concern.”
Shnider accomplished this in a
number of ways. Although he
didn’t invent the fetal lamb model
that enabled researchers to gain a
much better handle on how to
monitor both the fetus and the
mother, he was one of the fi rst to
understand its importance. His
lectures, with their smiling sheep
cartoons and show tune accompa-
niments, drew what could only be
ANESTHESIA NEWS 11
19861985Cedric Bainton
Chief, SFGH, 1985
Gerard Ozanne
Director, Resident Education, 1985
Judith Donegan
Director, Neuroanesthesia, 1986
Anesthesia for Fetal Surgery
Mark Rosen
Awareness during Surgery for Major Trauma
Martin Bogetz
(Katz, J)
TEE Introduced into Clinical Anesthesia
Michael Cahalan
(Kremer P, Schiller N)
Michael Cahalan
Director, Cardiac Anesthesia, 1986
dramatic and immediate respons-
es, but the results weren’t main-
tainable for more than a few
hours. It never occurred to us that
oxygen could be the cause.” When
he arrived at UCSF, however, he
found the ideal person to solve
the problem.
At the time, George Gregory
was in his last year of residency,
and Hamilton put him to work on
devising a treatment for hyaline
membrane disease. “He was
willing, probably because George
isn’t happy unless he’s underpaid,
underfed, and overworked,” says
Hamilton. Working in part from
fi ndings by a group in Boston
about oxygen toxicity, Gregory –
whose commitment to pediatric
anesthesia is legendary – con-
fi rmed that oxygen toxicity was real
and soon discovered that if you
increased airway pressure with
George Gregory, MD
30 percent oxygen, you could
keep the airways open without
harming the lungs. The result was
Continuous Positive Airway
Pressure (CPAP), which has saved
the lives of countless children in
respiratory distress.
Gregory would go on to write
the defi nitive text on pediatric
anesthesia and pediatric intensive
care and is today recognized as
among the foremost authorities on
pediatric anesthesia in the world.
Towards the Safe Use of
Neuromuscular Blockade
One day after returning to UCSF
from a tour as a battlefi eld
physician in Vietnam, Ron Miller
observed Ted Eger studying the
effect of isofl urane in human
volunteers. The two men spoke,
and “I started monitoring neuro-
muscular function in those
volunteers. From there the work
on the interaction of volatile
M&M with William K. Hamilton, MD
1985
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
12 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1987Martin Bogetz
1st Director, Ambulatory Surgery Center, 1987
Warren McKay
Director, Pain Management Center,1987
Long Hospital Opens
Pediatric Anesthesia 1st Edition
George Gregory
had it); it was the fi rst time that
drug was brought into the US and
it ended up being the dominant
muscle relaxant in the world for
many years,” says Miller.
Through the late ‘70’s and early
‘80’s Miller published numerous
pieces, including some on the
original assays he developed in
collaboration with Neal Castagnoli
at the School of Pharmacy. These
assays enabled physicians to
measure not just the concentra-
tions of muscle relaxants in the
blood, but also their metabolites;
they also helped UCSF become
the world’s analytical leader in the
kinetics of muscle relaxants.
Eventually, Miller was joined in this
work by James Caldwell, who
arrived from Scotland in 1986 to
do a one-year fellowship; he has
remained at UCSF ever since and
has been instrumental in facilitating
the breadth and depth of clinical
research on muscle relaxants.
“The modeling we did here
helped to explain the areas where
you might get into trouble in the
ICU, where the drugs can accumu-
late over days and weeks,” says
Caldwell. The group’s lead article in
the New England Journal of
Medicine, with Miller as principal
author, was in large part respon-
sible for reductions in the inappro-
priate use of these drugs in the
intensive care setting.
anesthetics and muscle relaxants
evolved,” says Miller, who had
returned from Vietnam thinking he
would continue doing seminal
research he’d begun there on
massive blood transfusions.
Over the next thirty years, Miller
and the many talented residents he
would attract played a central role in
understanding the pharmacokinetics
and dynamics of muscle relaxants
and their antagonists. It’s an under-
standing critical to performing safe
anesthesia, especially today when
hospitals are doing procedures on
ever sicker patients.
One of the most powerful drivers
of this work was the recognition
that with the advent of kidney
transplants in the 1970’s, there
was an increase in post-operative
paralysis. This led Miller to work
with a researcher at Columbia
University (Matteo) who had
developed a radio-immunoassay
for curare. With the help of Matteo’s
Columbia lab, Miller conducted
one of the fi rst kinetic studies to
defi ne how curare was eliminated.
Bill Hamilton then encouraged
Miller to attend a meeting in
London where key players who
were synthesizing new and better
muscle relaxants – and a group
from The Netherlands that had
developed a new assay for
measuring pancuronium – would
also be attending. Miller’s subse-
quent one-year sabbatical enabled
him to conduct kinetic studies with
the Holland group, and begin a
long-term collaboration with a
Scottish chemist, David Savage,
who synthesized over half of the
emerging drugs in the ‘70’s and
‘80’s. That year may also have
contributed to Miller’s inadvertent
interlude as an international “drug
smuggler.”
“I recall getting on an airplane
with a plastic bag that contained
vecuronium (without revealing he
William Hamilton, MD
Ron Miller has a question as Claire Weenig, Terry Vitez,
Neri Guadagni and Walter Way listen
ANESTHESIA NEWS 13
1988Marie Csete
Director, Liver Transplantation
Anesthesia,1988
Yung Sohn
Director, Vascular Anesthesia, 1987
Robert Hickey
Director, Clinical Anesthesia, 1988
Cerebral Hypoxia and Brain Metabolism
Lawrence Litt
Changing Practice of Anesthesia,
Annual Department CME Course
SFGH Hosts Level One Trauma and…Steve McQueen
When Dick Barber arrived in San
Francisco in 1967, the anesthesia
faculty at San Francisco General
Hospital (SFGH) “was a small,
congenial group of three: Earnest
P. Guy, Robert Hudson Smith, and
myself,” says Barber. “The eight
operating rooms were without
piped gases or vacuum. Huge
‘G’ cylinders of nitrous oxide and
oxygen were mounted on the
backside of the anesthesia
machines.”
It was a busy time. SFGH was
the only level one trauma center
for the city, so anesthesia and all
surgical specialties were in house
24 hours a day, seven days a
week, 365 days a year. “We were
all so busy with too many patients
for too few faculty, residents and
outdated equipment to appreciate
the steady increases in staffi ng,
equipment, and general support
from the city which culminated in
the mid ‘70’s with the opening of
the superbly equipped, brand new
multi-million dollar hospital we so
badly needed,” says Barber. The
new hospital enabled Barber and
his colleagues to continue their
critically important work for a
mostly underserved population.
One interesting note was that
Guy, who was chief at SFGH
during much of this time, had such
respect for his residents that he
often consulted with them about
the in-progress building plans. Ron
Miller recalls that it was during one
such consultation that residents
suggested the elevators be made
bigger so as to make it easier to
William Hamilton, MD
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
14 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1988Jeoff Benson
Director, Acute Pain Service, 1989
Mark Rosen
Director, Resident Education, 1988
NIH-Sponsored Study of Perioperative Ischemia
Dennis Mangano
(London M, Leung J)
Oak Knoll Naval
Anesthesia Residents join UCSF
Ernie Guy takes apart a Bird Mark 7 to teach Terry Vitez
and Mike Baker its function
transport patients from fl oor to
fl oor. The change was made – and
has been duly appreciated by
clinical staff ever since. “When you
look at the wide elevators at San
Francisco General, just remember
why they were built so wide: Dr.
Guy and the residents in the late
‘60s.” says Miller.
There were many lives saved
and many rewards in Barber’s
12-year stay at SFGH (“the very
best of my professional life,” he
says), but one reward was quite
unexpected. In 1969, the ICU head
nurse called Barber up to Ward 34
where a fi lm team was doing a
“Code Blue scene” for the Steve
McQueen movie, Bullitt. At fi rst
dismissive of leaving his clinical
duties for show business, Barber
eventually relented. He spent the
next few days working with the
Hollywood stars, speaking a few
lines, and joining the Screen Actors
Guild. “It was a good movie
despite my total lack of acting
talent,” says Barber. “I didn’t quit
my day job.”
On to the VA
Barrie Fairley represents one of
the most important recruiting
coups during the Hamilton era.
Originally from the U.K., Fairley
was a true critical care pioneer;
in the 1950s and 1960s, he had
instituted Canada’s fi rst interdisci-
plinary respiratory failure units,
the precursor to today’s critical
care units.
His meeting with Hamilton
happened quite by chance. The
two men shared a research and
clinical interest in respiratory
inadequacy. At a New England
meeting where Hamilton was
scheduled to speak, Fairley
appeared as an unscheduled
replacement speaker. Hamilton
wasted no time in recruiting him.
Fairley arrived at UCSF in early
1969, but had yet to obtain a
California license. Knowing that
Fairley could practice on federal
territory and that UCSF would be
taking over the anesthesia service
at the San Francisco Veteran’s
Administration Hospital, Hamilton
made Fairley that facility’s fi rst
UCSF chief.
The department’s infl uence at
the VA grew quickly under Fairley:
it took over intensive care, and for
the fi rst time placed residents there
who quickly established them-
selves as the in-house on-call
physicians. Fairley also set the
foundations for a VA research
program in anesthesia. Later, after
a year at the Moffi t Hospital, he
would become chief at San
Francisco General for twelve years
and was appointed Associate
Dean at SFGH before assuming
the chair at Stanford University
in 1985.
ANESTHESIA NEWS 15
1989Brian Cason
Chief, VAH, 1989
Lydia Cassorla
Director, Preoperative (Prepare) Clinic, 1989
William Shapiro
Director, PACU, 1989
Ambulatory Surgery Center opens
Anesthesia Research Laboratories (4th Fl) underwritten by
Anaquest, Organon, Anesthesia Research Foundation and
Anesthesia/Pharmacology Research Foundation
1983-presentT H E Miller Years
After a 10 month international search, Ron Miller took over from
Bill Hamilton (and interim chair Sol Shnider) in 1984 with an
enormous sense of responsibility to make sure the department
stayed at the forefront of the profession. To do so in a modern
era fi lled with increasing regulation and intense competition,
Miller implemented a broad and strategic approach. The
success of that approach speaks for itself, as the UCSF
Department of Anesthesia and Perioperative Care has become
one of the largest and most prestigious in the world.
Early on Miller called for an
outside evaluation of the
research program to ensure
UCSF would stay ahead of the
curve. He aligned the department
with the hospital’s goals, and built
on the strong and respectful
working relationship with surgery
that Hamilton established. Miller
also oversaw a complete revamp-
ing of the department’s fi nances,
developing rigorous systems for
professional fee billing that are still
in place today.
In addition, he has been
tirelessly responsive to external
change. As more anesthesia
sub-specialties have emerged, in
Department, 1980s
The Birth of a Department
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
16 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1990Jeffrey Katz
Chief, Mount Zion, 1990
Ken Drasner
Director, Acute Pain Service, 1991
Mark Rosen
Director, Residency Program, 1991
Pharmacokinetic and Pharmacodynamic
Research on Intravenous Anesthetics
Dennis Fisher
(Stanski D)
LMA First Used at UCSF
Martin Bogetz
Welcome Residents, 1992
to attract the most, the best, and
the brightest. This included what
was really the fi rst wave of
prominent woman anesthesiolo-
gists, many of whom remain
leaders in their fi eld such as
Pamela Palmer (leading interna-
tional authority in Pain Manage-
ment), Kathryn Rouine-Rapp
(Director of the UCSF Prepare
Clinic), Isobel Russell (Director of
Adult and Pediatric Cardiac
Surgery), Jeanine Wiener-Kronish
(Chairperson of Anesthesia at
Massachusetts General Hospital),
and Sue Carlisle (Associate Dean
of San Francisco General Hospital).
A Fundamentally Better
Way to Monitor Patients
One day in the early 1990’s, in
the Moffi t OR suite, Ron Miller
rushed down the hall and said to
his colleague Michael Cahalan:
“We’re losing this patient; come
take a look.”
When they arrived, Miller
showed Cahalan a septic woman
whose heart rate was 150 beats
per minute and systolic arterial
blood pressure was 50 mmHg.
Miller explained that they had
already given the woman appropri-
ate amounts of blood and still did
not know whether the problem
was hypo- or hypervolemia.
Cahalan, an expert in transesopha-
geal echocardiography (TEE), put a
scope down the woman’s throat,
revealing a nearly empty heart.
After they administered the
appropriate fl uids intravenously,
arterial blood pressure increased
and the heart slowed. The
procedure, known as rescue echo,
is rapidly becoming the standard
for life-threatening hypotension. It
also was the culmination of a
clinical research path that Cahalan
had begun a decade or so before.
In 1981, Cahalan was an
assistant professor working in the
Eger lab when Bill Hamilton asked
him to meet with a new cardiology
the tradition of his predecessors
Miller has continued to recruit the
best faculty and fellows in the
world to establish those sub-speci-
alities at UCSF. As changes in
health care fi nancing and delivery
fostered changes in hospital stays,
Miller oversaw the establishment of
adult and pediatric pre-operative
clinics, under the department’s
watchful eye.
Finally, even when there were
brief downturns in the number of
applicants for anesthesia residen-
cies nationwide, UCSF continued
William Shapiro, MD and Jeffrey Katz, MD
ANESTHESIA NEWS 17
1991 1993Charles Cauldwell
Director, Medical Student Clerkship, 1992
Scott Kelley
Director, Liver Transplantation
Anesthesia, 1992
Richard Weiskopf
Director, Spine Anesthesia, 1992
Robert Allen
Director, Pain Management Center, 1993
Mount Zion Affi liation with UCSF
Perioperative Thermoregulation
Daniel Sessler
fellow named Peter Kramer. Under
the tutelage of Nelson Schiller and
in collaboration with an outside
engineer, Cahalan and Kramer
began working with mini-ultra-
sound transducers mounted on a
gastroscope in an effort to obtain
improved pictures of the heart.
Within months, three groups
around the world received
permission to begin testing the
devices – now with two-dimen-
sional transducers – on human
subjects. Cahalan, Kramer, Schiller,
and Mike Roizen received their fi rst
2-D device in late 1981, while
working in Moffi t’s OR-10.
“We slipped the scope down
and suddenly, in real time, saw a
moving image of all four chambers
of the heart,” says Cahalan. “My
jaw hit the ground and I knew right
away this was a fundamentally
better way to monitor patients.”
Over the next couple of years,
UCSF fellows demonstrated how
TEE provided a much more
accurate measure of ventricular
fi lling than traditional measures of
ischemia. Meanwhile, the purchase
of a 19’’ black and white monitor
for the OR proved to be a critical
“epiphany for the cardio and
vascular surgeons, who saw that
this could answer important
questions about clinical care,” says
Cahalan. Their support proved
crucial, as initially TEE was
considered dangerous and the
papers about it were widely
rejected. When Cahalan returned to
UCSF in 1986, after a sabbatical in
Europe, it was the surgeons’
support that convinced the hospital
to purchase the fi rst commercial
edition of the device.
Today Cahalan, who is now the
chair at the University of Utah, sits
on a committee about to recom-
mend TEE for monitoring during all
cardiac procedures. Anesthesiolo-
gists and surgeons at UCSF had
understood its importance 25 years
ahead of the curve.
“We slipped the scope
down and suddenly, in
real time, saw a moving
image of all four
chambers of the heart.
My jaw hit the ground
and I knew right away
this was a fundamentally
better way to monitor
patients.”
–Michael Cahalan, MD
Laryngoscope Party for Graduating Residents, 1990
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
18 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1993Toni Magorian
Director, Medical Student Clerkship, 1993
Sandy Weitz
Director, Acute Pain Service,
1993
Mark Rosen
Director, Obstetrical Anesthesia,
1994
Management of Pulmonary
Pseudomonas Infection
Jeanine Wiener-Kronish
Diffi cult Airway Management Workshop
Cedric Bainton
The Importance of Being
Normal (thermic)
When he was a resident at UCLA
in the early 1980s, Daniel Sessler
found himself leafi ng through a
smattering of about thirty, mostly
ignored articles on temperature
regulation during surgery. The
consensus was that perioperative
temperature regulation was well
understood and of little conse-
quence except for postoperative
shivering. Sessler didn’t believe the
system was so simple and began a
series of several hundred studies,
mostly conducted during his fi fteen
years as a faculty member in the
UCSF Department of Anesthesia
Sessler’s team, today known as
the Outcomes Research Consor-
tium, initially focused on tempera-
ture regulation. They showed that
general anesthetics profoundly
impair thermoregulation, but do
not completely obliterate control.
Instead, control re-emerges when
patients became suffi ciently
hypothermic. The team next
addressed heat balance and
showed that hypothermia develops
with a characteristic three-phase
pattern, with each phase having a
different cause.
The third major phase of the
studies evaluated the consequenc-
es of mild perioperative hypo-
thermia. In a series of major
multi-center outcome trials, Sessler
and his team proved that even just
a couple of degrees of hypotherm-
ia — as is typical in unwarmed
surgical patients — triples the risk
of surgical wound infection,
signifi cantly increases blood loss
and transfusion requirement,
prolongs recovery, and lengthens
hospital duration.
“Once we started looking we
realized prevailing wisdom was
wrong and the consequences of
hypothermia were much more
severe than anyone realized,” says
Sessler. “Consequently, it’s now
the standard of care to keep
surgical patients normothermic.”
“Once we started looking we
realized prevailing wisdom was
wrong and the consequences of
hypothermia were much more
severe than anyone realized.
Consequently, it’s now the
standard of care to keep surgical
patients normothermic.”
–Daniel Sessler, MD
Jerome Strong, MD, Yung Sohn, MD, Joan Howley, MD
1994Ron Vale
William K. Hamilton Distinguished Professor, 1994
Arthur Wallace
Director, Preoperative Clinic VAH, 1994
Neal Cohen
President of Medical Staff,
UCSF Medical Center, 1994-96
Letterman Army
Anesthesia Residents join UCSF
Spinal Neurotoxicity of Local Anesthetics
Ken Drasner
Pupillometry and Anesthesia
Merlin Larson
The Studies in
Perioperative Ischemia
That Changed Cardiology
In the 1990’s, a group of research-
ers at the San Francisco Veteran’s
Administration Hospital led by
Dennis Mangano recognized that
anesthesia research could benefi t
from the type of large, multi-center
clinical trials done by cardiologists.
“We began with an epidemiological
study that found old, sick people
did poorly in surgery. We then
searched for risk factors we could
modulate.” says Art Wallace, part
of the original team.
A subsequent study found that
keeping people unconscious post
surgery could reduce risks, but
was expensive and problematic.
“The question then became: how
can we deliver the hemodynamic
stability of an anesthetic without
making people unconscious?”
says Wallace.
In a large, clinical trial, the group
(now dubbed McSPI for Multi-Cen-
tered Study of Perioperative
Ischemia), moved on to test 17
different drugs – brand names and
generics – from beta blockers to
Alpha 2 agonists and anesthetic
agents. In landmark piece of
research they published in the
New England Journal of Medicine,
McSPI found that the generic beta
blocker atenolol was the most
effective at reducing the risk of both
myocardial ischemia and mortality.
Though the work had – and has
– its skeptics, shortly after
implementing their beta blockade
protocols with patients at the VA,
the facility’s score from the National
Surgical Quality Improvement
Project (NSQIP) went from 1.0 to
0.6. Wallace soon found himself
being invited to various hospitals to
talk about or set up beta blockade
programs. Today, more than a
hundred hospitals across the
country have adopted the McSPI
protocols. Perioperative beta
blockade in select patients has
become a level one standard
of care.
“The question then became: how
can we deliver the hemodynamic
stability of an anesthetic without
making people unconscious?”
–Arthur Wallace, MD
Laryngoscope Party for Graduating Residents, 2008
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
1995James Caldwell
Director, Neuroanesthesia, 1995
Perioperative Medical Director, 1999
James Marks
Director, ICU, SFGH, 1996
Jeanine Wiener-Kronish
Director, Preoperative (Prepare) Clinic, 1996
Neuroprotection from Hypoxia
Philip Bickler
Vecuronium and Prolonged Paralysis in the ICU
Veronica Segredo
(Caldwell J, Matthay M, Miller RD)
of Defense (DOD) was interested
enough in having an antidote on
hand to provide some modest
funding towards discovering a
safer antitoxin. With a push from
one of his colleagues – and
because he was expert in produc-
ing antibodies – Jim Marks began
almost casually searching for a
safer antidote for botulism.
In particular, he began develop-
ing monoclonal antibodies for the
most common BoNTs: types A, B,
and E. It was complicated work,
for the antibodies not only had to
be potent enough to cope with the
extreme toxicity, but they needed
to address multiple subtypes within
each of the A, B, and E types.
Moreover, unlike many diseases,
single antibodies did not signifi -
cantly neutralize BoNTs in vivo. “It’s
impossible to achieve the required
potency unless you use a combi-
nation of antibodies that bind to
the toxins simultaneously in
different places,” says Marks.
Then 9/11 happened. With a
whole new sense of urgency and a
dramatic increase in support from
the DOD, the work in the Marks lab
accelerated.
His team has now produced a
unique combination of monoclonal
Fighting Bioterrorism
Botulinum neurotoxins (BoNTs) are
the most poisonous substance
known to man. Though actual
botulism cases are rare, they are
widely feared as a possible
biological weapon because of
their potency and the long-lasting
paralysis they cause.
In 1993, the only known
treatments were antibodies derived
from exposed hospital workers
(hard to come by) and antitoxins
derived from horses that have a
very high incidence of serious side
effects. At the time, the Department
Lundy Campbell, MD, Joan Howley, MD and Cheng Quah, MD
Ronald D. Miller, MD, and Tin-Na Kan, MD,
at Simulation Center
ANESTHESIA NEWS 21
19991995Maurice Zwass
Director, Pediatric Anesthesia Fellowship, 1997
Charles Cauldwell
Director, Pediatric Anesthesia, 1998
A. Sue Carlise
Chief, SFGH, 1999
VAH Develops Ambulatory Surgery Unit
Arthur Wallace
Discovery of Non-Immobilizer
Donald Koblin
We’re Physicians First
One of the hallmarks of the Depart-
ment of Anesthesia has been its
collective ability to not just advance
the discipline itself – a critically
important pursuit – but to advance
the entire practice of medicine.
Recruiting William Young to UCSF
in 2000 furthered that role.
In the mid 1980’s, Young was at
Columbia University when he
became interested in the hemody-
namics of how the brain functioned
during and after cerebrovascular
surgery. With strong mentorship by
Columbia’s chiefs of neurosurgery
and stroke neurology, Young and
an interdisciplinary team would
study everything from the forma-
tion and regulation
of blood vessel growth to the
epidemiology, natural history,
antibodies for type A, B, and E
BoNTs. Each type-specifi c
antibody combination binds toxin
simultaneously in three places and
engages in a novel clearance
mechanism that completely
removes the BoNT in one circula-
tory path. The antibodies can be
used for treating acute botulism or
as a vaccine providing protective
levels for between six and twelve
months. The group’s fi ndings on
combining antibodies to increase
potency could be broadly appli-
cable to a range of pathogens and
toxins. Working with a private
company funded by the NIH,
Marks is now scaling up to help
manufacture an antidote to treat A,
B, and E botulism for clinical trials
beginning in 2009.
treatment outcomes, and genetics
of cerebrovascular disease.
In 2000, attracted by “opportuni-
ties to broaden the breadth and
depth of the science,” Young and
two of his fellows (including current
faculty member Tomoki Hashimo-
to) joined the UCSF Department
of Anesthesia and set up the
Center for Cerebrovascular
Research. His was one of the few
large research groups to be recruit-
ed from outside of UCSF. The
center focuses on hemorrhagic
diseases of the brain, especially
intracranial aneurysms and brain
arteriovenous malformations
(AVMs). There are a wide range of
specialities associated with the
center, and eight of the ten core
The Birth of a Department
Walter Way's House, September 1984
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
22 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
1999Pamela Palmer
Director, Pain Management Center, 1999
Neal Cohen
Vice Dean, UCSF, 2000
John Feiner
Director, Liver Transplantation
Anesthesia, 2000
Outcomes Research: Aging and Postoperative
Delerium and Cognitive Decline
Jacqueline Leung
NIH Training Grant
Lawrence Litt
tive. What each of us do - this
defi nes anesthesiology. Ultimately,
the current status of our specialty
should be an effect – not a cause
– of the questions we ask. And our
reach should exceed our grasp.” ■
who won’t? And, second, as we
learn more about the molecular
mechanisms we can develop
more effective therapies…I think
we’re well on our way to develop-
ing pharmacological or gene
therapies that can stabilize the
blood vessels to decrease the
risk of spontaneous rupture.”
“Anesthesiologists are physi-
cians fi rst,” continues Young.
“Solving some of the critical
questions and problems in
medicine involves tackling
disease causes and cures; such
work requires interdisciplinary
study, to which anesthesiologists,
as perioperative physicians, bring
a unique and important perspec-
members are faculty in the
Department of Anesthesia.
Among its accomplishments,
the center was the fi rst to
associate human genetic
variation with non-inherited
AVMs and to establish a link
between common infl ammatory
processes and disease
progression, including hemor-
rhage. “There are two main
clinical implications for our
fi ndings,” says Young. “First,
we will be able to develop
biomarkers that can help with
prognostication and risk
stratifi cation – to rationally
answer the questions: Who will
benefi t from intervention and
“Ultimately, the current status
of our specialty should be an
effect – not a cause – of the
questions we ask. And our
reach should exceed our grasp.”
–William Young, MD
By Ronald D. Miller, MD
Anesthesia Resident Match Party 2005
ANESTHESIA NEWS 23
2000Jeffrey Katz
Director, Clinical Anesthesia, 2000
Renee Navarro
Perioperative Director, SFGH, 2000
Dorre Nicholau
Director, PACU, 2000
Linda Liu
Director, Critical Care Fellowship, 2000
Beta Blockade to Reduce Perioperative Mortality
Dennis Mangano
(Wallace A)
John Severinghaus Anesthesia Laboratory Opened
Radiometer
An Illustrious Past
Prepares the Department
for a Challenging Future
“Today, there is an increasing focus on clinical,
translational, and basic science research in the
total perioperative period, including preoperative
evaluation, intraoperative anesthesia, and
critical care and pain medicine.”
– Ronald D. Miller. MD
As this history makes clear, for fi fty
years UCSF has been a national
and international leader in academ-
ic anesthesia. We are positioned
well to assume an even more
prominent role in the years ahead
as academic medicine becomes
more sophisticated and more
central to the delivery of safe, high
quality care.
Obviously, the gifted individuals
who have staffed and led this
department have been the central
factor in our success. Yet it’s also
important to remember that we
have not accomplished all of this
on our own. We have always
depended upon the rest of the
UCSF community – the wealth of
talented people across this
campus, from brilliant basic
scientists to the fi nest clinicians in
the world. Whether it was the
CVRI, the Center for Cerebrovas-
cular Research, or any of the other
fi ne centers and initiatives at UCSF,
anesthesia’s ability to work closely
with other specialties and make
our unique contribution has been
critically important. In the years
ahead, we must expand this role.
To do so will be essential not just
for our own success, but also the
success of this entire campus.
Consider such initiatives as the
new medical center at Mission
Bay; a new orthopaedic institute
opening in 2009; and the 2009
opening of a new stem cell
research building at the UCSF
Parnassus campus, with construc-
tion beginning in late 2008. All of
these developments offer opportu-
nities for groundbreaking collab-
orative work, from bench research
through clinical innovation. We
must seize these opportunities.
We have been successful for half
a century through a combination of
outstanding faculty, the power of
the UCSF campus, and stable and
visionary leadership. In addition to
the examples set by Stu Cullen
and Bill Hamilton, I distinctly recall
the way Rudy Schmidt – who was
dean of the medical school when I
became chair – constantly pushed
me to make us a better depart-
ment. I can’t say I liked it at the
time, but in retrospect it was an
enormously helpful approach. In
that spirit, I challenge those of you
who will lead over the next fi fty
years to engage fully with this cam-
pus, to exert our leadership, and to
ensure that the tradition highlighted
herein will continue – and grow. ■
Faculty Awards, Honors & Appointments
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
24 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
2000Isobel Russell
Director, Cardiac Anesthesia, 2000
Thomas Shaughnessy
Director, Respiratory Therapy,
2000
Dan Swangard
Director, Preoperative (Prepare) Clinic,
2000
Incentive-Productivity-Based
Compensation System Developed
Ronald D. Miller
John Severinghaus Research Fellowship
underwritten by Radiometer
Institute of Medicine Elected Members
The Institute of Medicine of the National Academies
was chartered in 1970 to provide the nation with
science-based advice on matters of biomedical
science, medicine and health. The Institute’s members,
elected on the basis of their professional achievement
and commitment to service, serve without compensa-
tion in the conduct of studies and other activities on
matters of signifi cance to health. Election to active
membership is both an honor and a commitment to
serve in Institute affairs.
Ronald D. Miller, MD 1998
Jeanine Wiener-Kronish, MD 2002
James Marks, MD, PhD 2006
UCSF Haile T. Debas
Academy of Medical Educators
The Haile T. Debas Academy of Medical Educators is
dedicated to creating an environment that enhances
the status of teachers of medical students at UCSF,
promotes and rewards teaching excellence, fosters
curricular innovation, and encourages scholarship in
medical education. Members of The Haile T. Debas
Academy of Medical Educators actively participate in
the work the Academy performs in pursuit of its goal of
promoting educational excellence in the UCSF
community. Because of the rigor of the selection
process, Academy membership is known to be a sign
of outstanding performance; academy members are
recognized as highly accomplished educators.
Martin Bogetz, MD 2001
Manuel Pardo, MD 2001
Harriet Hopf, MD 2004
Marek Brzezinski 2007
2008 Awards and Honors
Helge Eilers, MD & Mark Schumacher, MD, PhD
Extramural Award:
First Place, 2008 IARS Kosaka Abstract Session, for:
Chu C, Schumacher MA, Bunnett NW, Eilers H.
Inhaled Anesthetics Activate TRPA1Heterologously
Expressed in HEK Cells.
Ronald D. Miller, MD, Chairman
Extramural Honors:
American Society of Anesthesiologists Distinguished
Service Award 2008
American Society of Anesthesiologists Emery A.
Rovenstine Lecturer 2008
John Severinghaus, MD, Professor Emeritus
Extramural Honor:
American Society of Anesthesiologists Eponymous
Lecture, “John W. Severinghaus Lecture on Transla-
tional Science” established 2008
Muhammad Shaikh, MD
Extramural Appointment:
NIH Grant Reviewer, Bioengineering Research
Group, 2007
NIH Grant Reviewer, NIH Fellowship (F-31; F-32)
Biomedical Engineering and Imaging Studies, 2008
ANESTHESIA NEWS 25
2001Pekka Talke
Director, Neuroanesthesia, 2000
Julin Tang
Director, Medical Student Clerkship, 2000
Mark Grabovac
Director, Spine Anesthesia, 2001
Martin Bogetz
Director, Medical Student Clerkship, 2001
Intraoperative TEE. An Interactive Text and Atlas
Michael Cahalan
Developer, Perioperative Cardiac Risk Reduction
Program at over 100 Medical Centers
Arthur Wallace
American Society
of Anesthesiologists Awards
ASA Award for Excellence in Research
This award recognizes outstanding research that has
had or is likely to have a major impact on the practice
of anesthesia and/or research representing a mature
and sustained contribution to the extension and
advancement of the science of anesthesiology.
John W. Severinhaus, MD 1986
Edmond I. Eger, MD 1989
Daniel I. Sessler, MD 2002
ASA Distinguished Service Award
Annually since 1945, ASA has determined whether to
bestow its most prestigious honor, the Distinguished
Service Award (DSA), on a member for outstanding
clinical, educational or scientifi c achievement or for
contributions to the specialty and/or exemplary service
to ASA. The DSA is presented by the president during
the ASA Annual Meeting at the time of the Emery A.
Rovenstine Memorial Lecture to the individual selected
by the House of Delegates at the previous year’s
Annual Meeting. The award is the ASA’s highest tribute
paid to an anesthesiologist for meritorious service and
achievement. This will be the fi rst year in which the
Rovenstine Lecturer is also bestowed with the
Distinguished Service Award.
Stuart C. Cullen, MD 1964
William K. Hamilton, MD 1986
Edmond I. Eger, MD 1991
Robert K. Stoelting, MD 2003
Ronald D. Miller, MD 2008
ASA Annual Emery A. Rovenstine Memorial Lecture
The Rovenstine Lecture is a longstanding high point of
the Annual Meeting and honors Dr. Rovenstine, the
distinguished past chair of the Department of Anesthe-
siology at New York University Medical Center and
Director of Anesthesiology at Bellevue Hospital in New
York City. Dr. Rovenstine was a founding member and
president of the American Board of Anesthesiology,
ASA president in 1943-44 and the 1957 recipient of
the ASA Distinguished Service Award. Because of his
seminal contributions to the specialty, especially as an
administrator and educator, this prestigious lectureship
was established in his name. The ASA president
chooses the lecturer as part of his/her duties, and the
lecture is always one of the highlights of the Annual
Meeting.
William K. Hamilton, MD 1978
Ronald D. Miller, MD 2008
ASA John W. Severinghaus Lecture
on Translational Science
In 2008 the ASA approved the naming of its Annual
Meeting Tuesday afternoon translational research
plenary session to henceforth be known as the “John
W. Severinghaus Lecture on Translational Science”,
one of only two eponymous lectures at their annual
meeting. Dr. Severinghaus will give the inaugural
lecture at the 2008 Annual Meeting.
New Anesthesia Faculty
Career Faculty
Jon Matthew Aldrich, MD
Clinical Instructor
Joined Faculty August 1, 2008
Medical School:
Stanford University School of Medicine
Palo Alto, California
Internship:
Surgery
University of California, San Francisco
Residency:
Anesthesiology
University of California, San Francisco
Fellowship:
Critical Care Medicine
University of California, San Francisco
Marla Ferschl, MD
Clinical Instructor
Joined Faculty August 1, 2008
Medical School:
University of Chicago Pritzker
School of Medicine
Chicago, Illinois
Internship:
Internal Medicine
University of Chicago
Pritzker School of Medicine
Chicago, Illinois
Residency:
Anesthesiology
University of California, San Francisco
Judith Hellman, MD
Associate Professor in Residence
Joined Faculty August 1, 2008
Medical School:
Columbia University College of
Physicians and Surgeons
New York, New York
Internship:
Internal Medicine
Oregon Health Sciences University
Portland, Oregon
Residencies:
Internal Medicine
Oregon Health Sciences University
Portland, Oregon
Anesthesiology
Massachusetts General Hospital
Boston, Massachusetts
Fellowship:
Critical Care Medicine
Massachusetts General Hospital
Boston, Massachusetts
Previous Employment:
Instructor in Anesthesia
Harvard Medical School
Boston, Massachusetts
Assistant Professor of Anesthesia
Harvard Medical School
Boston, Massachusetts
Benjamin Houseman, MD, PhD
Assistant Professor in Residence
Joined Faculty January 1, 2008
Advanced Degree:
PhD, Chemistry
University of Chicago
Chicago, Illinois
Medical School:
University of Chicago
Pritzker School of Medicine
Chicago, Illinois
Internship:
Resurrection Medical Center
Chicago, Illinois
Residency:
Anesthesiology
University of California, San Francisco
Visiting Faculty
Kerstin Kolodzie, MD
Visiting Assistant Professor
Joined Faculty December 1, 2007
Medical School:
University of Hamburg
Hamburg, Germany
Jon Matthew Aldrich, MD
Judith Hellman, MD
Benjamin Houseman, MD, PhD
Marla Ferschl, MD
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
26 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
2001Michael Gropper
Director, ICU, Moffi tt, 2001
Linda Liu
Director, Respiratory Therapy, 2001
Renee Navarro
Chief of Medical Staff, SFGH, 2001
Cardiac Protection using
Anesthetic Preconditioning
Brian Cason
(Hickey R)
Cloning of Capsaicin Receptor/Its Facilitation
Mark Schumacher
Internship:
Technion-Israel Institute of Technology,
The Ruth and Bruce Rappaport Faculty
of Medicine, Rambam Healthcare
Campus
Haifa, Israel
Residency:
Anesthesiology
University of Hamburg,
University Medical Center
Hamburg-Eppendorf
Hamburg, Germany
Previous Employment:
Attending Anesthesiologist
University of Hamburg,
University Medical Center
Hamburg-Eppendorf
Hamburg, Germany
Joerg Schaeuble, MD
Visiting Assistant Professor
Joined Faculty December 1, 2007
Medical Schools:
Johann Wolfgang v. Goethe University
Frankfurt, Germany
Albert Ludwigs University of Freiburg
Freiburg, Germany
Internship:
Internal Medicine & Surgery
Hospital Villingen-Schwenningen
Villingen-Schwenningen, Germany
Residencies:
Anesthesiology
Hospital of Waldshut
Waldshut, Germany
Anesthesiology
District Hospital
Tafers, Switzerland
Internal Medicine
District Hospital
Niederbipp, Switzerland
Anesthesiology
Cantonal Hospital of St. Gallen
St. Gallen, Switzerland
Fellowship:
Emergency Medicine
Cantonal Hospital of St. Gallen
St. Gallen, Switzerland
Previous Employment:
ICU Attending
Cantonal Hospital of St. Gallen
St. Gallen, Switzerland
Attending Anesthesiologist
University Hospital Basel
Basel, Switzerland
Bernard Brandstater American University of Beirut;
Loma Linda University
Michael Cahalan University of Utah
David Cullen St. Elizabeth's Medical Center
and Tufts University
Bruce Cullen University of California, Irvine
Gerald Edelist University of Toronto
John Eisele University of California, Davis
H. Barrie Fairley Stanford University
Greg Kronberg Wilford Hall Medical Center
C. Philip Larson Stanford University
Ronald D. Miller UCSF Anesthesia and
Perioperative Care
Musa Muallem American University of Beruit
Medical Center
Nancy Nussmeier Syracuse University
Richard Palahniuk University of Manitoba;
University of Minnesota
Michael Roizen University of Chicago;
Cleveland Clinic
Stephen Rupp Virginia Mason Medical Center
Lawrence Saidman University of California,
San Diego
David Schwartz University of Illinois
Donald Stanski Stanford University
Wendell Stevens University of Iowa;
University of Oregon
Robert Stoelting Indiana University
Gale Thompson Virginia Mason Medical Center
John Wade University of Manitoba
Jeanine Weiner-Kronish
Massachusetts General Hospital
Paul White University of Texas
Southwestern Medical Center
Academic Department Chairs from UCSF
Kerstin Kolodzie, MD
Joerg Schaeuble, MD
2001Patricia Roth
Director, Anesthesia Workroom, 2001
Julin Tang
Director, ICU, SFGH, 2001
William Young
James P. Livingston Endowed
Chair in Anesthesia, 2001
William Shapiro
Chief, Mount Zion, 2001
Incentive-Productivity-Based Compensation System
Implemented
John Feiner
Improving Wound Healing Outcomes
through Increased Oxygen Delivery
Harriet Hopf
The Birth of a DepartmentUCSF Anesthesia Residents
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
28 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
2002Daniel Burkhardt
Director, Acute Pain Service, 2002
Errol Lobo
Director, Vascular Anesthesia, 2002
Martin London
Chair, UCSF Committee on Library, 2002
Profound Isovolemic Hemodilution
Richard Weiskopf
(Feiner J, Lieberman J, Hopf H, Leung J, Kelly S)
ARDSnet Trial Published
Michael Matthay
(Gropper M)
Class of 2011
Daniel Abelson, MD
Medical School:
University of California, San Francisco,
School of Medicine
Michele Arnold, MD
Medical School:
University of California, San Francisco,
School of Medicine
Daniel Chiem, MD
Medical School:
University of California, San Diego, School
of Medicine
Joshua Cohen, MD
Medical School:
University of Illinois at Chicago College
of Medicine
Robert Ellis, MD
Medical School:
Virginia Commonwealth University
School of Medicine
Robert Feinglass, MD
Medical School:
University of California, San Francisco,
School of Medicine
Madina Gerasimov, MD
Medical School:
New York University School of Medicine
Amy Gin, MD
Medical School:
New York Medical College
Roger Hong, MD
Medical School:
Joan & Sanford I. Weill Medical College
of Cornell University
Cristina Inglis-Arkell, MD
Medical School:
University of California, San Diego,
School of Medicine
April Jung, MD
Medical School:
Drexel University College of Medicine
James Kim, MD
Medical School:
Georgetown University School
of Medicine
So Young Kim, MD
Medical School:
Columbia University College
of Physicians and Surgeons
Tse-Sun Ku, MD
Medical School:
University of California, San Francisco,
School of Medicine
Sara LaFleur, MD
Medical School:
Tufts University School of Medicine
Sarah Langley, MD
Medical School:
Stanford University School of Medicine
Meagan Lansdale, MD
Medical School:
Stanford University School of Medicine
Anuj Malhotra, MD
Medical School:
Duke University School of Medicine
Jemiel Nejim, MD
Medical School:
University of California, Los Angeles,
David Geffen School of Medicine
Swetha Pakala, MD
Medical School:
University of California, San Francisco,
School of Medicine
Jacob Pletcher, MD
Medical School:
Indiana University School of Medicine
Anna Rabinowitz, MD
Medical School:
University of Pennsylvania School
of Medicine
John Turnbull, MD
Medical School:
University of California, San Francisco,
School of Medicine
Adrienne Valesano, MD
Medical School:
Georgetown University School of Medicine
Elaine Yang, MD
Medical School:
New York University School of Medicine
Afshin Zadfar, MD
Medical School:
State University of New York at Buffalo,
School of Medicine and Biological Sciences
Stuart C. Cullen and William K. Hamilton Awardees
20042003Manuel Pardo
Sol M. Shnider Endowed Chair for
Anesthesia Education, 2003
Jeffrey Katz
Perioperative Medical Director, 2003
James Brandes
Director, Orthopedic/Regional
Anesthesia, 2004
A. Sue Carlise
Associate Dean,
SFGH, 2004
Center for Cerebrovascular Research
William Young
Anesthesia Simulator SFGH
Manuel Pardo
(Collins A)
Steven D. Jabaly, MD 1980
Glenn Plummer, MD 1981
Manuel Fernandez, MD 1982
Lydia Cassorla, MD 1983
George Lampe, MD 1983
Brian Cason, MD 1984
Edward Eisler, MD 1985
Jeanine Wiener-Kronish, MD 1986
Ginger Fegert, MD 1987
Scott Kelley, MD 1989
Isobel Muhiudeen, MD, PhD 1989
Jaul Riazi, MD 1989
Amanda Sue Carlisle, MD 1990
John R. Feiner, MD 1991
Barry D. Bergouist, MD 1992
Erin P. Foley, MD 1992
Peter S. Nosé, PhD, MD 1992
Gretchen E. Hollingsworth, MD 1993
Oscar Fernandez, MD 1993
Robert F. Hickey, MD 1973
Robert L. Willenkin, MD 1974
Robert H. Smith, MD 1975
Wendell C. Stevens, MD 1976
Marilyn Hulter, MD 1977
A. Roderick Forbes, MB 1978
Dennis T. Mangano, PhD, MD 1979
Neal H. Cohen, MD, MPH 1980
H. Barrie Fairley, MB, BS 1980
Cedric R. Bainton, MD 1981
Sol M. Shnider, MD 1982
Scott Robinson, MD 1983
H. Barrie Fairley, MB, BS 1984
Michael Cahalan, MD 1985
Stephen Rupp, MD 1986
Cedric R. Bainton, MD 1987
Donald Koblin, MD 1988
George A. Gregory, MD 1989
Maurice Zwass, MD 1990
Stuart C. Cullen Award
William K. Hamilton Award
Neil Seeley, MD 1994
Julie Nakao, MD 1994
Manuel Pardo, MD 1995
William Cammarano, MD 1996
Richard Green, MD 1997
Thomas Buchheit, MD 1998
John F. Donovan, MD 1999
Daniel M. Swangard, MD 1999
Dhanesh K. Gupta, MD 2000
Brian W. Hite, MD 2000
James Mac Sams, MD 2001
Donal P. Ryan, MD 2002
Lundy J. Campbell, MD 2003
Grete H. Porteous, MD 2004
Leonard Razzu Allmond, MD 2005
Patrick M. Fujimoto, MD 2006
Jon Matthew Aldrich, MD 2007
Scott Finkelstein, MD 2008
Isobel A. Muhiudeen, MD, PhD 1991
George A. Gregory, MD 1992
Isobel A. Muhiudeen, MD, PhD 1992
Anil De Silva, MD 1993
Anil De Silva, MD 1994
Robert W. Allen, MD 1995
James E. Caldwell, MB, ChB 1996
William Cammarano, MD 1997
William Cammarano, MD 1998
Joan E. Howley, MD 1999
Kathryn Rouine-Rapp, MD 2000
Merlin D. Larson, MD 2001
Merlin D. Larson, MD 2002
Daniel M. Swangard, MD 2003
Mark Grabovac, MD 2004
George A. Gregory, MD 2005
Mark D. Rollins, PhD, MD 2006
Lundy J. Campbell, MD 2007
John Taylor, MD 2008
Research Faculty Spotlight
Helen Kim, PhD
Susan Lynch, PhD
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
30 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
2004Andrew Gray
Director, Regional Anesthesia, SFGH, 2004
Jeremy Lieberman
Director, Spine Anesthesia,
2004
Renee Navarro
Associate Dean, Academic Affairs, 2004
Monoclonal Antibody for
Treatment of Botulinum Neurotoxins
James Marks
NIH Training Grant
Jeanine Wiener-Kronish
Helen Kim, PhD
Assistant Adjunct Professor
Education and Training:
MPH, Epidemiology, Emory University, Atlanta GA
PhD, Epidemiology, University of Washington, Seattle, WA
Postdoctoral Fellow, Genetic Epidemiology, University of Washington, Seattle, WA
Research Interests:
Genetic epidemiology of cardiovascular and neurological diseases, and in particular stroke
Epidemiology and natural history of brain vascular malformations, including AVM
and aneurysms
Functional outcome after brain injury from intracranial hemorrhage or treatment
Linkage and association studies of complex diseases and intermediate phenotypes
Methods for detecting and adjusting for population stratifi cation,
and evaluating interactions
Susan Lynch, PhD
Assistant Adjunct Professor
Education and Training:
BS, Industrial Microbiology (minors in Chemistry and Biostatistics), University College,
Dublin, Ireland
PhD, Department of Microbiology, University College, Dublin, Ireland
Postgraduate Education, Department of Microbiology and Immunology, Stanford
University School of Medicine, Stanford, CA
Research Interests:
Polymicrobial pathogenesis of respiratory diseases including, cystic fi brosis, asthma,
ventilator-associated pneumonia, chronic rhinosinusitis and chronic obstructive
pulmonary disease.
Biofi lm formation and virulence gene expression of the respiratory pathogen
Pseudomonas aeruginosa from both Cystic Fibrosis (CF) and ICU patients
Understanding of the response of Pseudomonas aeruginosa in a clinical setting,
improve diagnosis and provide effi cacious strain-specifi c combinatorial therapeutic
options to improve patient outcome.
Uses culture-independent tools recently developed in the fi eld of microbial ecology
together with high-throughput sequencing and statistical analysis to examine the
contribution of microbial community structure and function to pathogen behavior,
host response and clinical outcome.
Development of a rapid, multi-species, culture-independent tool to improve diagnosis
of respiratory infections and profi le antimicrobial resistance in parallel.
Examines therapeutic strategies in vitro and in vivo that target various virulence systems
of Pseudomonas aeruginosa and uses sequential clinical isolates to study how
micro- and macro-evolution affects the physiology of this opportunistic pathogen.
Ludmila Pawlikowska, PhD Hua Su, MD
ANESTHESIA NEWS 31
Jens Krombach
Director, Clinical Anesthesia, SFGH, 2005
Kathryn Rouine-Rapp
Director, Preoperative (Prepare) Clinic, 2005
James Caldwell
Director, Clinical Anesthesia, 2005
Developer of Endotracheal
Cardiac Output Monitor
Arthur Wallace
Sonography for Nerve Block Localization
Andrew Gray
(Collins A)
2005Gerard Ozanne
Acting Chief, VAH, 2004
Ludmila Pawlikowska, PhD
Assistant Adjunct Professor
Education and Training:
Ph.D. Biomedical Sciences, UCSF
Postdoctoral training: Liver Center, Cardiovascular Research Institute and Institute
for Human Genetics, UCSF
Research Interests:
Genetic studies of complex disease including brain arteriovenous malformation
and subarachnoid hemorrhage
Genetic studies of human longevity and aging-related phenotypes
Admixture mapping of metabolic syndrome traits and infl ammatory markers
in admixed populations
Molecular genetics of inherited cholestasis
Hua Su, MD
Assistant Adjunct Professor
Education and Training:
MD, Medicine, 1982, Nanjing Medical University, Nanjing, China
MS, Histology and Embryology, 1985, Xian Medical University,
Xian, China
Postdoctoral Fellow, Reproductive Physiology, 1986,
Beijing Medical University, Beijing, China
Postdoctoral Fellow, Medical Genetics, 1992,
University of California, San Francisco, CA
Research Interests:
Viral vector mediated targeted gene expression
Gene and cell based therapies for ischemic heart disease
Gene and cell based therapies for cerebral vascular diseases
Development of rodent arteriovenous malformation model
Peer Reviewed Publications 2007–2008
Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D.
Monitoring serial change in the lumen and outer wall of vertebrobasilar
aneurysms. AJNR Am J Neuroradiol. Feb;29(2):259-64, 2008.
Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF.
Acute coagulopathy of trauma: hypoperfusion induces systemic
anticoagulation and hyperfi brinolysis. J Trauma. May;64(5):1211-7, 2008.
Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner
JM. Ammonia has anesthetic properties. Anesth Analg. Jun;104(6):1430-3,
2007.
Brosnan RJ, Eger EI 2nd, Laster MJ, Sonner JM. Anesthetic properties of
carbon dioxide in the rat. Anesth Analg. Jul;105(1):103-6, 2007.
Carles M, Dellamonica J, Roux J, Lena D, Levraut J, Pittet JF, Boileau P,
Raucoules-Aime M. Sevofl urane but not propofol increases interstitial
glycolysis metabolites availability during tourniquet-induced ischaemia-
reperfusion. Br J Anaesth. Jan;100(1):29-35, 2008.
Cascio M, Xing Y, Gong D, Popovich J, Eger EI 2nd, Sen S, Peltz G, Sonner
JM. Mouse chromosome 7 harbors a quantitative trait locus for isofl urane
minimum alveolar concentration. Anesth Analg. Aug;105(2):381-5, 2007.
Champion HR, Fingerhut A, Escobar MA, Weiskopf RB. The role of data and
safety monitoring in acute trauma resuscitation research. J Am Coll Surg.
Jan;204(1):73-83, 2007.
Christian SL, Ross AP, Zhao HW, Kristenson HJ, Zhan X, Rasley BT, Bickler
PE, Drew KL. Arctic ground squirrel (Spermophilus parryii) hippocampal
neurons tolerate prolonged oxygen-glucose deprivation and maintain
baseline ERK1/2 and JNK activation despite drastic ATP loss. J Cereb Blood
Flow Metab. Jul;28(7):1307-19, 2008.
Coburn M, Kunitz O, Apfel CC, Hein M, Fries M, Rossaint R. Incidence of
postoperative nausea and emetic episodes after xenon anaesthesia
compared with propofol-based anaesthesia. Br J Anaesth.
Jun;100(6):787-91 2008.
Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early
coagulopathy after traumatic brain injury: the role of hypoperfusion and the
protein C pathway. J Trauma. Dec;63(6):1254-61, 2007.
Cohen NH. Advance directives: know what you want, get what you need.
Mayo Clin Proc. Dec;82(12):1460-2, 2007.
Du R, Keyoung HM, Dowd CF, Young WL, Lawton MT. The effects of
diffuseness and deep perforating artery supply on outcomes after
microsurgical resection of brain arteriovenous malformations. Neurosurgery.
Apr;60(4):638-46, 2007.
Dubowitz G, Peacock AJ. Pulmonary artery pressure in healthy subjects at
4250 m measured by Doppler echocardiography. Wilderness Environ Med.
Winter;18(4):305-11 2007.
Abou-Arab MH, Heier T, Caldwell JE. Dose of alfentanil needed to obtain
optimal intubation conditions during rapid-sequence induction of
anaesthesia with thiopentone and rocuronium. Br J Anaesth.
May;98(5):604-10, 2007.
Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU,
Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL.
Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2
polymorphisms with intracranial hemorrhage after brain arteriovenous
malformation treatment. Neurosurgery. Oct;61(4):731-9; discussion 740,
2007.
Afonin ON, Miller RD. Sugammadex: An analysis and update. ASEAN J.
Anaesthesiology 8:35-40, 2007.
Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson
R, Maze M, Franks NP. Determinants of the anesthetic sensitivity of two-pore
domain acid-sensitive potassium channels: molecular cloning of an
anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol
Chem. Jul 20;282(29):20977-90, 2007.
Antognini JF, Raines DE, Solt K, Barter LS, Atherley RJ, Bravo E, Laster MJ,
Jankowska K, Eger EI 2nd. Hexafl uorobenzene acts in the spinal cord,
whereas o-difl uorobenzene acts in both brain and spinal cord, to produce
immobility. Anesth Analg. Apr;104(4):822-8, 2007.
Antognini JF, Atherley RJ, Dutton RC, Laster MJ, Eger EI 2nd, Carstens E. The
excitatory and inhibitory effects of nitrous oxide on spinal neuronal
responses to noxious stimulation. Anesth Analg. Apr;104(4):829-35, 2007.
Apfel CC, Kranke P, Piper S, Rüsch D, Kerger H, Steinfath M, Stöcklein K,
Spahn DR, Möllhoff T, Danner K, Biedler A, Hohenhaus M, Zwissler B,
Danzeisen O, Gerber H, Kretz FJ. [Nausea and vomiting in the postoperative
phase. Expert- and evidence-based recommendations for prophylaxis and
therapy] Anaesthesist. Nov;56(11):1170-80, 2007.
Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA. Septate junctions
are required for ommatidial integrity and blood-eye barrier function in
Drosophila. Dev Biol. May 15;317(2):585-99, 2008.
Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU.
Remote renal injury following partial hepatic ischemia/reperfusion injury in
rats. J Gastrointest Surg. Mar;12(3):490-5, 2008.
Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI 2nd, Pearce RA.
Determination of the EC50 amnesic concentration of etomidate and its
diffusion profi le in brain tissue: implications for in vitro studies.
Anesthesiology. Jan;106(1):114-23, 2007.
Berman MF, Young WL. Commentary on: Brain arteriovenous malformation
and its implication in forensic pathology. J Forensic Sci. Sep;52(5):1225,
2007.
Boussel L, Wintermark M, Martin A, Dispensa B, VanTijen R, Leach J, Rayz V,
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
32 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
2005Atsuko Baba
Director, Pediatric Prepare Clinic,
2006
Philip Bickler
Director, Orthopedic/Regional
Anesthesia, 2006
Manual of Anesthesia Practice
(1st PDA Textbook in Anesthesia)
Manuel Pardo, James Sonner
(Primarily authored by UCSF residents)
Department of Anesthesia
First in NIH Funding
David Lee
Director, Pain Management Center, 2005
Edwards KL, Hutter CM, Yin Wan J, Kim H, Monks SA. Genome-wide Linkage
Scan for the Metabolic Syndrome: The GENNID Study. Obesity (Silver Spring).
Jul;16(7):1596-1601, 2008.
Eger EI 2nd, Lemal D, Laster MJ, Liao M, Jankowska K, Raghavanpillai A,
Popov AV, Gan Y, Lou Y. Anesthetic properties of some fl uorinated oxolanes
and oxetanes. Anesth Analg. May;104(5):1090-7, 2007.
Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. The rat vanilloid
receptor splice variant VR.5’sv blocks TRPV1 activation. Neuroreport. Jul
2;18(10):969-73, 2007.
El Solh AA, Akinnusi ME, Wiener-Kronish JP, Lynch SV, Pineda LA, Szarpa K.
Persistent infection with Pseudomonas aeruginosa in ventilator-associated
pneumonia. Am J Respir Crit Care Med. Sep 1;178(5):513-9, 2008.
Fan Y, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y.
Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res. Jul
11;1219:1-7, 2008.
Fan Y, Ye J, Shen F, Zhu Y, Yeghiazarians Y, Zhu W, Chen Y, Lawton MT, Young
WL, Yang GY. Interleukin-6 stimulates circulating blood-derived endothelial
progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab.
Jan;28(1):90-8, 2008.
Fan Y, Yang GY. Therapeutic angiogenesis for brain ischemia: a brief review.
J Neuroimmune Pharmacol. Sep;2(3):284-9, 2007.
Feiner JR, Severinghaus JW, Bickler PE. Dark skin decreases the accuracy
of pulse oximeters at low oxygen saturation: the effects of oximeter probe
type and gender. Anesth Analg. Dec;105(6 Suppl):S18-23, 2007.
Fiebig EW, Wu AH, Krombach J, Tang J, Nguyen KA, Toy P. Transfusion-
related acute lung injury and transfusion-associated circulatory overload:
mutually exclusive or coexisting entities? Transfusion. Jan;47(1):171-2,
2007.
Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological
and biochemical markers of alveolar epithelial barrier dysfunction in
perfused human lungs. Am J Physiol Lung Cell Mol Physiol. Jul;293(1):L52-9,
2007.
Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental
ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax.
Feb;63(2):147-53, 2008.
Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo
BJ, McCulloch CE, Young WL. Feasibility of minocycline and doxycycline use
as potential vasculostatic therapy for brain vascular malformations: pilot
study of adverse events and tolerance. Cerebrovasc Dis. 25(1-2):157-63,
2008.
Fuller TF, Rose F, Singleton KD, Linde Y, Hoff U, Freise CE, Dragun D,
Niemann CU. Glutamine donor pretreatment in rat kidney transplants with
severe preservation reperfusion injury. J Surg Res. Jun 1;140(1):77-83,
2007.
Gabriel RA, Yang GY. Gene therapy in cerebrovascular diseases. Curr Gene
Ther. Dec;7(6):421-33, 2007.
Gan TJ, Meyer TA, Apfel CC, Chung F, Davis PJ, Habib AS, Hooper VD, Kovac
AL, Kranke P, Myles P, Philip BK, Samsa G, Sessler DI, Temo J, Tramèr MR,
Vander Kolk C, Watcha M; Society for Ambulatory Anesthesia. Society for
Ambulatory Anesthesia guidelines for the management of postoperative
nausea and vomiting. Anesth Analg. Dec;105(6):1615-28, 2007.
Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE,
Prough DS, Baus D, Bepperling F, Warltier DC. Volume replacement therapy
during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4)
or hetastarch. Anesthesiology. Jun;106(6):1120-7, 2007.
Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D,
Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta
causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-
dependent mechanisms. Circ Res. Apr 11;102(7):804-12, 2008.
Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P,
Christiaans SC, Bir ND, Pittet JF. ngiopoietin-2, marker and mediator of
endothelial activation with prognostic signifi cance early after trauma? Ann
Surg. Feb;247(2):320-6, 2008.
Gelb AW, Craen RA, Rao GS, Reddy KR, Megyesi J, Mohanty B, Dash HH,
Choi KC, Chan MT. Does hyperventilation improve operating condition during
supratentorial craniotomy? A multicenter randomized crossover trial. Anesth
Analg. Feb;106(2):585-94, 2008.
Gelb K, Gelb AW. Sex and gender in the perioperative period: wake up to
reality. Anesth Analg. Jul;107(1):1-3, 2008.
Gropper MA, Wiener-Kronish J. The epithelium in acute lung injury/acute
respiratory distress syndrome. Curr Opin Crit Care. Feb;14(1):11-5, 2008.
Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary
delivery of bone marrow-derived mesenchymal stem cells improves survival
and attenuates endotoxin-induced acute lung injury in mice. J Immunol Aug
1;179(3):1855-63, 2007.
Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil
depletion decreases VEGF-induced focal angiogenesis in the mature mouse
brain. J Cereb Blood Flow Metab. Nov;27(11):1853-60, 2007.
Hasegawa K, Hu C, Nakamura T, Marks JD, Russell SJ, Peng KW. Affi nity
thresholds for membrane fusion triggering by viral glycoproteins. J Virol.
Dec;81(23):13149-57, 2007.
Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J,
Niemann CU. Transient hyperglycemia affects the extent of ischemia-
ANESTHESIA NEWS 33
2006Lundy Campbell
Director, Thoracic Anesthesia, 2006
James Marks
Chief, SFGH, 2006
Manuel Pardo
Vice Chair for Education, 2006
Ronald D. Miller
President of Medical Staff,
UCSF Medical Center, 2006
UCSF PainCARE - Center for Advanced
Research and Education
Pamela Palmer
Critical Care Medicine and Trauma CME Course
Michael Gropper
reperfusion-induced renal injury in rats. Anesthesiology. Mar;108(3):402-14,
2008.
Hopf HW, Rollins MD. Wounds: an overview of the role of oxygen. Antioxid
Redox Signal. Aug;9(8):1183-92, 2007.
International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds
DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM,
Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W,
Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q,
Zhao H, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A,
Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC,
Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z,
Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y,
Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB,
Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F,
Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallée C, Verner A,
Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-
Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T,
Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda
T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S,
Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de
Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe’er I,
Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC,
Varilly P, Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson
GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan
W, Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin
N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M,
Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T,
Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C, Zhao H, Matsuda I,
Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu
T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu
R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton
EW, Watkin J, Gibbs RA, Belmont JW, Muzny D, Nazareth L, Sodergren E,
Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ,
Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J,
Burton J, Carter NP, Clee CM, Griffi ths M, Jones MC, McLay K, Plumb RW,
Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg
JC, L’Archevêque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z,
Wang R, Holden AL, Brooks LD, McEwen JE, Guyer MS, Wang VO, Peterson
JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson
R, Stewart J. A second generation human haplotype map of over 3.1 million
SNPs. Nature. Oct 18;449(7164):851-61, 2007.
Kajdasz DK, Iyengar S, Desaiah D, Backonja MM, Farrar JT, Fishbain DA,
Jensen TS, Rowbotham MC, Sang CN, Ziegler D, McQuay HJ. Duloxetine for
the management of diabetic peripheral neuropathic pain: evidence-based
fi ndings from post hoc analysis of three multicenter, randomized, double-
blind, placebo-controlled, parallel-group studies. Clin Ther. 29
Suppl:2536-46, 2007.
Kessler J, Gray AT. Sonography of scalene muscle anomalies for brachial
plexus block. Reg Anesth Pain Med. Mar-Apr;32(2):172-3, 2007.
Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, Ko NU, Achrol
AS, Lawton MT, Higashida RT, Young WL; UCSF BAVM Study Project. Racial/
Ethnic differences in longitudinal risk of intracranial hemorrhage in brain
arteriovenous malformation patients. Stroke. Sep;38(9):2430-7, 2007.
Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY,
Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL. Endothelial nitric
oxide synthase polymorphism (-786T->C) and increased risk of angiographic
vasospasm after aneurysmal subarachnoid hemorrhage. Stroke.
Apr;39(4):1103-8, 2008.
Komatsu R, Turan AM, Orhan-Sungur M, McGuire J, Radke OC, Apfel CC.
Remifentanil for general anaesthesia: a systematic review. Anaesthesia.
Dec;62(12):1266-80, 2007.
Kreuer S, Bruhn J, Walter E, Larsen R, Apfel CC, Grundmann U, Biedler A,
Wilhelm W. Comparative pharmacodynamic modeling using bispectral and
narcotrend-index with and without a pharmacodynamic plateau during
sevofl urane anesthesia. Anesth Analg. Apr;106(4):1171-81, 2008.
Krombach J, Gray AT. Sonography for saphenous nerve block near the
adductor canal. Reg Anesth Pain Med. Jul-Aug;32(4):369-70, 2007.
Larson MD. Mechanism of opioid-induced pupillary effects. Clin
Neurophysiol. Jun;119(6):1358-64, 2008.
Laster MJ, Zhang Y, Eger EI 2nd, Shnayderman D, Sonner JM. Alterations in
spinal, but not cerebral, cerebrospinal fl uid Na+ concentrations affect the
isofl urane minimum alveolar concentration in rats. Anesth Analg.
Sep;105(3):661-5, 2007.
Lawton MT, Arnold CM, Kim YJ, Bogarin EA, Stewart CL, Wulfstat AA, Derugin
N, Deen D, Young WL. Radiation arteriopathy in the transgenic arteriovenous
fi stula model. Neurosurgery. May;62(5):1129-38, 2008.
Lee CZ, Xue Z, Zhu Y, Yang GY, Young WL. Matrix metalloproteinase-9
inhibition attenuates vascular endothelial growth factor-induced intracerebral
hemorrhage. Stroke Sep;38(9):2563-8, 2007.
Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay
MA. Acute lung injury edema fl uid decreases net fl uid transport across
human alveolar epithelial type II cells. J Biol Chem. Aug
17;282(33):24109-19, 2007.
Lee JW, Matthay MA. Protein permeability in lung injury: now in real time
again? J Appl Physiol. Feb;102(2):508-9, 2007.
Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR.
Apolipoprotein E e4 allele increases the risk of early postoperative delirium
in older patients undergoing noncardiac surgery. Anesthesiology.
Sep;107(3):406-11, 2007.
Lieberman JA, Lyon R, Feiner J, Hu SS, Berven SH. The effi cacy of motor
evoked potentials in fi xed sagittal imbalance deformity correction surgery.
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
34 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
2006Laura Siedman
Associate Medical Director, Ambulatory
Surgery Center, 2006
C. Spencer Yost
Director, ICU, Mount Zion, 2006
John Taylor
Director, PACU, 2006
Recovery of Airway Refl exes
following Inhaled Anesthetics
Rachel McKay Miller’s Anesthesia, 6th Edition
Spine. Jun 1;33(13):E414-24, 2008.
Liu B, Conrad F, Roth A, Drummond DC, Simko JP, Marks JD. Recombinant
full-length human IgG1s targeting hormone-refractory prostate cancer. J Mol
Med. Oct;85(10):1113-23, 2007.
Liu L, Gropper MA. Tracheostomy protocol compliance: herding cats? Crit
Care Med. Jun;36(6):1959-60, 2008.
Lynch SV, Yang K, Brodie EL, MacDougal C, Andersen GL, Wiener-Kronish JP.
Culture-Independent Bacterial Population Analysis - Clinical Implications for
Respiratory and Other Infections Curr Respir Med Rev. Feb;4(1):35-39, 2008.
Lynch SV, Wiener-Kronish JP. Novel strategies to combat bacterial virulence.
Curr Opin Crit Care. Oct;14(5):593-599, 2008.
Lynch SV, Dixon L, Benoit MR, Brodie EL, Keyhan M, Hu P, Ackerley DF,
Andersen GL, Matin A. Role of the rapA gene in controlling antibiotic
resistance of Escherichia coli biofi lms. Antimicrob Agents Chemother.
Oct;51(10):3650-8, 2007.
Mandell MS, Stoner TJ, Barnett R, Shaked A, Bellamy M, Biancofi ore G,
Niemann C, Walia A, Vater Y, Tran ZV, Kam I. A multicenter evaluation of
safety of early extubation in liver transplant recipients. Liver Transpl.
Nov;13(11):1557-63, 2007.
Marcus GM, Whooley MA, Glidden DV, Pawlikowska L, Zaroff JG, Olgin JE.
Interleukin-6 and atrial fi brillation in patients with coronary artery disease:
data from the Heart and Soul Study. Am Heart J. Feb;155(2):303-9, 2008.
McKay RE, Rapan R. Infl uence of body mass index on recover of protective
airway refl exes after anesthesia with desfl urane or sevofl urane. Eur J
Anaesthesiol. 25(Suppl 44):2AP2-7, 2008.
McKay RE, Rozner MA. Preventing pacemaker problems with nerve
stimulators. Anaesthesia. May;63(5):554-6, 2008.
Miller RD. Editorial, 4th Asian Esmeron Expert meeting (AEEM). ASEAN J.
Anaesthesiology 8:1-2, 2007.
Miller RD. Sugammadex May Replace Best Clinical Practice: A
Misconception Anesth Analg. Nov;105:(5):1507, 2007.
Miller RD. Sugammadex: an opportunity to change the practice of
anesthesiology? Anesth Analg. Mar;104(3):477-8, 2007.
Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM. Anesthetic-like
modulation of a gamma-aminobutyric acid type A, strychnine-sensitive
glycine, and N-methyl-d-aspartate receptors by coreleased
neurotransmitters. Anesth Analg. Aug;105(2):386-92, 2007.
Mok JM, Lyon R, Lieberman JA, Cloyd JM, Burch S. Monitoring of nerve root
injury using transcranial motor-evoked potentials in a pig model. Spine. Jun
15;33(14):E465-73, 2008.
Niemann CU, Serkova NJ. Biochemical mechanisms of nephrotoxicity:
application for metabolomics. Expert Opin Drug Metab Toxicol.
Aug;3(4):527-44, 2007.
Olivares M, Terwiesch C, Cassorla L. Structural Estimation of the
Newsvendor Model: An Application to Reserving Operating Room Time
Management Science 54(1):41-55, 2008.
Orhan-Sungur M, Kranke P, Sessler D, Apfel CC. Does supplemental oxygen
reduce postoperative nausea and vomiting? A meta-analysis of randomized
controlled trials. Anesth Analg. Jun;106(6):1733-8, 2008.
Ozgediz D, Kijjambu S, Galukande M, Dubowitz G, Mabweijano J, Mijumbi C,
Cherian M, Kaggwa S, Luboga S. Africa’s neglected surgical workforce crisis.
Lancet. 23;371(9613):627-8, 2008.
Ozgediz D, Galukande M, Mabweijano J, Kijjambu S, Mijumbi C, Dubowitz G,
Kaggwa S, Luboga S. The neglect of the global surgical workforce:
experience and evidence from Uganda. World J Surg. Jun;32(6):1208-15,
2008.
Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU.
Increased severity of renal ischemia-reperfusion injury with venous clamping
compared to arterial clamping in a rat model. Surgery Feb;143(2):243-51,
2008.
Phelps P, Cakmakkaya OS, Apfel CC, Radke OC. A simple clinical maneuver
to reduce laparoscopy-induced shoulder pain: a randomized controlled trial.
Obstet Gynecol. May;111(5):1155-60, 2008.
Pittet JF, Song Y, Wiener-Kronish JP. Treating lung infections with
anticoagulation: mechanisms matter. Crit Care Med. Jan;36(1):356-7, 2008.
Rayz VL, Lawton MT, Martin AJ, Young WL, Saloner D. Numerical simulation
of pre- and postsurgical fl ow in a giant basilar aneurysm. J Biomech Eng.
Apr;130(2):021004, 2008.
Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy
E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska
A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris
T, Zmuda JM, Ziv E; Health, Aging and Body Composition (Health ABC) Study.
Admixture mapping of an allele affecting interleukin 6 soluble receptor and
interleukin 6 levels. Am J Hum Genet. Apr;80(4):716-26, 2007.
Rosales CM, Young T, Laster MJ, Eger EI 2nd, Garg U. Sevofl urane
concentrations in blood, brain, and lung after sevofl urane-induced death. J
Forensic Sci. Nov;52(6):1408-10, 2007.
Roth A, Drummond DC, Conrad F, Hayes ME, Kirpotin DB, Benz CC, Marks
JD, Liu B. Anti-CD166 single chain antibody-mediated intracellular delivery
of liposomal drugs to prostate cancer cells. Mol Cancer Ther.
Oct;6(10):2737-46, 2007.
ANESTHESIA NEWS 35
2007Roland Bainton
Member, Program in Biologic
Sciences, 2007
John Kulli
Perioperative Medical Director,
2007
Lee-lynn Chen
Acting Chief, Mount Zion, 2007
Implements National Anesthesia, ICU,
Analytic Electronic Information System for VAH
Gerard Ozanne
NIH Training Grant
Jean-François Pittet
(Young W)
Serkova NJ Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell
MS. Early detection of graft failure using the blood metabolic profi le of a liver
recipient. Transplantation. Feb 27;83(4):517-21, 2007.
Shen F, Fan Y, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY. Adeno-
associated viral vector-mediated hypoxia-regulated VEGF gene transfer
promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther.
Jan;15(1):30-9, 2008.
Shiga T, Apfel CC, Wajima Z, Ohe Y. Infl uence of intraoperative conversion
from off-pump to on-pump coronary artery bypass grafting on costs and
quality of life: a cost-effectiveness analysis. J Cardiothorac Vasc Anesth.
Dec;21(6):793-9, 2007.
Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L,
Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the
organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin
Pharmacol Ther. Feb;83(2):273-80, 2008.
Singh V, Smith WS, Lawton MT, Halbach VV, Young WL. Risk factors for
hemorrhagic presentation in patients with dural arteriovenous fi stulae.
Neurosurgery. Mar;62(3):628-35, 2008.
Smith TJ, Hill KK, Foley BT, Detter JC, Munk AC, Bruce DC, Doggett NA, Smith
LA, Marks JD, Xie G, Brettin TS. Analysis of the Neurotoxin Complex Genes
in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1
Clusters Are Located within Plasmids. PLoS ONE. Dec 5;2(12):e1271, 2007.
Song Y, Pittet JF, Huang X, He H, Lynch SV, Violette SM, Weinreb PH, Horan
GS, Carmago A, Sawa Y, Bernstein XL, Wiener-Kronish JP. Role of integrin
alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa.
Infect Immun. Jun;76(6):2325-32, 2008.
Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL,
Fanselow MS, Eger EI 2nd, Homanics GE. Effect of isofl urane and other
potent inhaled anesthetics on minimum alveolar concentration, learning, and
the righting refl ex in mice engineered to express alpha1 gamma-
aminobutyric acid type A receptors unresponsive to isofl urane.
Anesthesiology. Jan;106(1):107-13, 2007.
Sonner JM. A hypothesis on the origin and evolution of the response to
inhaled anesthetics. Anesth Analg. Sep;107(3):849-54, 2008.
Sonner JM. Ethnicity can affect anesthetic requirement. Anesthesiology.
Jul;107(1):4-5, 2007.
Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C. Organization
and function of the blood-brain barrier in Drosophila. J Neurosci. Jan
16;28(3):587-97, 2008.
Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A,
Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF,
Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL,
Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH,
Jankowska I, Pawłowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson
RJ. Severe bile salt export pump defi ciency: 82 different ABCB11 mutations
in 109 families. Gastroenterology. Apr;134(4):1203-14, 2008.
Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK,
Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5
regulates lung vascular permeability and pulmonary endothelial barrier
function. Am J Respir Cell Mol Biol. Mar;36(3):377-86, 2007.
Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G,
Grossman W, Kan YW. AAV serotype 1 mediates more effi cient gene transfer
to pig myocardium than AAV serotype 2 and plasmid. J Gene Med.
Jan;10(1):33-41, 2008.
Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible
gene expression in ischemic hearts. Methods Mol Biol. 366:331-42, 2007.
Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay
MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury
in mice and rats. Am J Respir Cell Mol Biol. Aug;37(2):186-92, 2007.
Talke PO, Maze M. Expecting the unexpected. Anesth Analg.
Jun;106(6):1605-6, 2008.
Tang Y, Lou J, Alpaugh RK, Robinson MK, Marks JD, Weiner LM. Regulation
of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent
affi nity for target antigen. J Immunol. Sep 1;179(5):2815-23, 2007.
Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan
K, Kwok PY, Whooley MA, Conklin BR. Gene-trapped mouse embryonic stem
cell-derived cardiac myocytes and human genetics implicate AKAP10 in
heart rhythm regulation. Proc Natl Acad Sci U S A. May 15;104(20):8461-6,
2007.
Tseng ZH, Aouizerat BE, Pawlikowska L, Vittinghoff E, Lin F, Whiteman D,
Poon A, Herrington D, Howard TD, Varosy PD, Hulley SB, Malloy M, Kane J,
Kwok PY, Olgin JE. Common beta-adrenergic receptor polymorphisms are
not associated with risk of sudden cardiac death in patients with coronary
artery disease. Heart Rhythm. Jun;5(6):814-21, 2008.
Tsui JY, Collins AB, White DW, Lai J, Tabas JA. Videos in clinical medicine.
Placement of a femoral venous catheter. N Engl J Med. Jun 26;358(26):e30,
2008.
Turatti F, Figini M, Balladore E, Alberti P, Casalini P, Marks JD, Canevari S,
Mezzanzanica D. Redirected activity of human antitumor chimeric immune
receptors is governed by antigen and receptor expression levels and affi nity
of interaction. J Immunother. Oct;30(7):684-93, 2007.
Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM,
Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic
cation transporter, OCTN1, on the renal clearance of gabapentin. Clin
Pharmacol Ther. Mar;83(3):416-21 2008.
Timeline of Sentinel
Contributions
Chairs, Chiefs,
and Directors
36 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
Susan Lee
Interim Director,
Pain Management, VAH, 2007
Renee Navarro
Director, Academic Diversity, 2007
Basics of Anesthesia, 5th Edition,
Editor, Ronald D. Miller
Most Chapters Written by
Members of the Department
Pain Management Center Award
Clinical Center of Excellence from the
American Pain Society
Pamela Palmer
2007
Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA,
Guccione JM. Magnetic resonance imaging-based fi nite element stress
analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc
Surg. May;135(5):1094-102, 1102.e1-2, 2008.
Wang Y, Jiang L, Guo X, Gelb AW, Yue Y; Chinese Society of Anesthesiology.
The Chinese Society of Anesthesiology: 2006 annual meeting. Anesth Analg.
Oct;105(4):1132-5, 2007.
Wang Y, Gelb AW, Yue Y. The Chinese Society of Anesthesiology: 2007 Annual
Meeting report. Anesth Analg. Jun;106(6):1853-4, 2008.
Weigle DS, Buben A, Burke CC, Carroll ND, Cook BM, Davis BS, Dubowitz G,
Fisher RE, Freeman TC, Gibbons SM, Hansen HA, Heys KA, Hopkins B, Jordan
BL, McElwain KL, Powell FL, Reinhart KE, Robbins CD, Summers CC, Walker
JD, Weber SS, Weinheimer CJ. Adaptation to altitude as a vehicle for
experiential learning of physiology by university undergraduates. Adv Physiol
Educ. Sep;31(3):270-8, 2007.
Weiskopf RB. Recombinant-activated coagulation factor VIIa (NovoSeven):
current development. Vox Sang. May;92(4):281-8, 2007.
Weiskopf RB. The ethics of blood management. Vox Sang. Jul;93(1):91,
2007.
Wong-Beringer A, Wiener-Kronish J, Lynch S, Flanagan J. Comparison of
type III secretion system virulence among fl uoroquinolone-susceptible and
-resistant clinical isolates of Pseudomonas aeruginosa. Clin Microbiol Infect.
Apr;14(4):330-6, 2008.
Xue Q, Schumacher MA. New insights into the role of the capsaicin receptor
(TRPV1) in infl ammatory pain. CellScience 3: 1-6, 2007.
Xue Q, Jong B, Chen T, Schumacher MA. Transcription of rat TRPV1 utilizes
a dual promoter system that is positively regulated by nerve growth factor. J
Neurochem. Apr;101(1):212-22, 2007.
Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM.
Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and
acetone. Anesth Analg. Sep;105(3):673-9, 2007.
Yang L, Sonner JM. Anesthetic-like modulation of receptor function by
surfactants: a test of the interfacial theory of anesthesia. Anesth Analg.
Sep;107(3):868-74, 2008.
Yang L, Sonner JM. The anesthetic-like effects of diverse compounds on
wild-type and mutant gamma-aminobutyric acid type A and glycine
receptors. Anesth Analg. Mar;106(3):838-45, 2008.
Yang L, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. The plasticizer
di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and
glycine receptor function. Anesth Analg. Aug;105(2):393-6, 2007.
Yoo J, Tcheurekdjian H, Lynch SV, Cabana M, Boushey HA. Microbial
manipulation of immune function for asthma prevention: inferences from
clinical trials. Proc Am Thorac Soc. Jul;4(3):277-82, 2007.
Yost CS, Gropper MA. The curse of the drinking class. Crit Care Med.
Jun;36(6):1958-9, 2008.
Young WL, Kwok PY, Pawlikowska L, Lawton MT, Kim H, Hysi PG, Marchuk
DA. Arteriovenous malformation. J Neurosurg. Apr;106(4):731-2 2007.
Young WL. Anesthesia for endovascular neurosurgery and interventional
neuroradiology. Anesthesiol Clin. Sep;25(3):391-412, vii, 2007.
Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L. Exogenous ethyl pyruvate
versus pyruvate during metabolic recovery after oxidative stress in neonatal
rat cerebrocortical slices. Anesthesiology Oct;107(4):630-40, 2007.
Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A,
Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace
AW, Ratcliffe MB. Endoventricular patch plasty for dyskinetic anteroapical
left ventricular aneurysm increases systolic circumferential shortening in
sheep. J Thorac Cardiovasc Surg. Oct;134(4):1017-24, 2007.
Zhang Y, Laster MJ, Eger EI 2nd, Sharma M, Sonner JM. Blockade of
acetylcholine receptors does not change the dose of etomidate required to
produce immobility in rats. Anesth Analg. Apr;104(4):850-2, 2007.
Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD.
Impact of single-chain Fv antibody fragment affi nity on nanoparticle
targeting of epidermal growth factor receptor-expressing tumor cells. J Mol
Biol. Aug 24;371(4):934-47, 2007.
Zhu W, Tian Y, Zhou LF, Wang Y, Song D, Mao Y, Yang GY. Development of a
novel endothelial cell-seeded endovascular stent for intracranial aneurysm
therapy. J Biomed Mater Res A. Jun 1;85(3):715-21, 2008.
Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y.
Insulin growth factor-1 gene transfer enhances neurovascular remodeling
and improves long-term stroke outcome in mice. Stroke. Apr;39(4):1254-61,
2008.
Zhu W, Khachi S, Hao Q, Shen F, Young WL, Yang GY, Chen Y. Upregulation of
EMMPRIN after permanent focal cerebral ischemia. Neurochem Int.
May;52(6):1086-91, 2008.
Zhuo H, Yang K, Lynch SV, Dotson RH, Glidden DV, Singh G, Webb WR,
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Sep;36(9):2495-503, 2008. ■
ANESTHESIA NEWS 37
Martin Stechert
Director, Respiratory Therapy, VAH, 2007
Manuel Pardo
Director, UCSF Kanbar Simulation Center, 2007
Jens Krombach
Perioperative Director, SFGH, 2008
Mechanisms of Inhaled Anesthetic Actions
James Sonner
Identifi cation of Protein C Activation as a Critical Mechanism for
Development of Early Coagulopathy in Trauma Patients
Jean-François Pittet
(Chesebro B, Cohen M)
2008
Active Research Grants
Name Project Role Agency/Source Type of Grant Project Title Project Period Total Award
Apfel, Christian Principal Investigator Merck & Co, Inc. Individual Rsch Grant Development of a Predictive Model for Post-Discharge Nausea and
Vomiting (PDNV)
06/01/07 - 05/31/08 $727,538
Apfel, Christian Principal Investigator Schering-Plough Corporation Clinical Trial A Randomized, Double-Blind, Double Dummy, Dose-Ranging, Active-and
Placebo-Controlled Study of Single-Dose Ralopitant Monotherapy for the
Prevention of Postoperative Nausea and Vomiting (PONV)
08/01/07 - 07/31/08 $116,499
Apfel, Christian Principal Investigator Anesiva, Inc Clinical Trial A multicenter, randomized, double-blind, placebo-controlled, parallel-group
study to evaluate effi cacy, safety and tolerability of a single intraoperative
localized instillation of 4975 in patients undergoing primary unilateral total
hip arthroplasty
04/30/08-06/30/09 $132,288
Apfel, Christian Principal Investigator Anesiva, Inc IndivRschGrant/Contract A Phase 3, Multicenter, Randomized, Placebo-Controlled, Parallel-Group,
Double-Blind Study to Evaluate the Effi cacy, Tolerability, Safety, and
Pharmacokinetics of 4975 in Patients Undergoing Primary Unilateral Total
Knee Arthroplasty
04/30/08 - 06/30/09 $209,282
Bainton, Roland Principal Investigator NIGMS/NIH Individual Rsch Grant Physiology aand Regulation of Drug Transport Across the Blood Brain
Barrier
08/01/07 - 05/31/12 $1,456,540
Bainton, Roland Principal Investigator EON Research Corporation Subcontract Blood Brain Barrier Modulators 04/01/08 - 09/30/09 $167,400
Behrends, Matthias Principal Investigator REAC/Springer H Mem FDN Individual Rsch Grant Reduction of Hepatic Ischemia/Reperfusion Injury by Short-Term
Pretreatment with Simvastatin
03/01/07 - 02/28/09 $25,000
Bickler, Philip Principal Investigator NIGMS/NIH Individual Rsch Grant Intracellular Signaling in Anesthetic and Hypoxic Preconditioning of
Neurons
04/01/07 - 02/28/11 $1,241,507
Bickler, Philip Principal Investigator University of Alaska Subcontract Advancing UAF SNRP 05/01/06 - 04/30/11 $368,781
Bickler, Philip Principal Investigator Various Industry Sponsors Other Clinical Contract Accuracy of Pulse Oximeters with Profound Hypoxia 09/01/86 - Present Varies per
contract
Chen, Yongmei Principal Investigator NINDS/NIH Individual Rsch Grant Del-1 Induces Therapeutic Cerebral Angiogenesis 05/01/06 - 10/30/08 $365,576
Chen, Yongmei Principal Investigator American Heart Association
(AHA)
Individual Rsch Grant Netrin-1 in Neurovascular Regeneration 07/01/08 - 06/30/10 $140,000
Dubowitz, Gerald Principal Investigator Mt. Zion Health Fund Individual Rsch Grant Safety and Acceptability of IV method (UCSF Invention SF2006-14) in
Operative and Critical Care Anesthesia Practice
04/01/08 - 03/31/09 $40,500
Eger, Edmond Principal Investigator NIGMS/NIH Specialized Center Grant Sites & Mechanisms of Inhaled Anesthetic Actions 08/01/04 - 07/31/09 $7,321,207
Eilers, Helge Principal Investigator Hellman Family Awards Individual Rsch Grant Anesthetic Effects on Peripheral Nociceptors 01/01/08 - 12/31/08 $40,000
Gelb, Adrian Principal Investigator Hospira, Inc. Individual Rsch Grant Depth of Anesthesia with the Sedline Facilitates Motor Evoked Potential
(MEP) Monitoring During Corrective Spinal Surgery
12/19/07 - 12/19/09 $80,000
Gelb, Adrian Principal Investigator Johnson and Johnson Clinical Trial A Randomize, Double-Blind, Active- and Placebo-Controlled, Parallel
Group, Multicenter Study to Evaluate the Effi cacy and Safety of Multiple
Doses of CG5503 Immediate-Release Formulation in the Treatment of
Acute Pain from Tota
12/08/06 - 06/30/08 $235,400
Gropper, Michael Project Leader #2 NHLBI/NIH Specialized Center Grant Transfusion and Lung Injury (SCCOR Grant) 09/30/05 - 08/31/10 $825,757
Hashimoto, Tomoki Principal Investigator NINDS/NIH Individual Rsch Grant Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling
and Infl ammation
02/01/07 - 01/31/11 $1,282,367
Hashimoto, Tomoki Principal Investigator American Heart Association
(AHA)
Individual Rsch Grant/
Cooperative Agreement
Pathophysiology of Intracranial Aneurysms - Roles of Macrophages and
Vascular Remodeling
07/01/07 - 06/30/09 $140,000
Houseman, Benjamin Principal Investigator Helen Diller Family
Comprehensive Cancer Center
Individual Rsch Grant Using microfl uidic technology to study dynamic kinase inhibitor therapy 07/01/08 - 06/30/09 $30,000
Howard, Marybeth Principal Investigator Academic Senate Individual Rsch Grant Regulation of STAT1 Signaling Pathway by the Stress of Protein Response 07/15/06 - 07/14/08 $28,000
Kim, Helen Principal Investigator REAC/Huntington G & S
MEM FD
Individual Rsch Grant Whole Genome Amplifi cation of Archived, Paraffi n-Embedded AVM Tissue 03/01/07 - 02/28/09 $25,459
Kim, Helen Principal Investigator American Heart Association
(AHA)
Individual Rsch Grant Genetic Infl uences on Clinical Outcome in Brain Arteriovenous
Malformations
07/01/07 - 06/30/08 $65,000
Kim, Helen Principal Investigator NINDS/NIH Instruction Grant Genetic Infl uences on Clinical Outcome in Brain Arteriovenous
Malformations
07/01/08 - 06/30/13 $782,716
Lee, Chanhung Principal Investigator American Heart Association
(AHA)
Individual Rsch Grant Infl uence of Matrix Metalloproteinase on Brain Arteriovenous Malformation
Hemorrhage
01/01/07 - 12/31/10 $260,000
Lee, Jae Woo Principal Investigator Foundation for Anesthesia
Education & Research (FAER)
Instruction Grant Mesenchymal Stem Cells in the Treatment of Acute Lung Injury in Primary
Cultures of Human Alveolar Epithelial Type II Cells and in the Ex Vivo
Perfused Human Lung
01/01/08 - 12/31/08 $115,000
Lee, Jae Woo Principal Investigator NHLBI/NIH Individual Rsch Grant Mesenchymal Stem Cells in the Treatment of Acute Lung Injury 08/04/08 – 07/31/13 $608,850
Leung, Jacqueline Principal Investigator Anesthesia Patient Safety
Foundation (APSF)
Individual Rsch Grant Pathophysiology of Postoperative Delirium 01/01/08 - 06/30/09 $149,800
Litt, Lawrence Principal Investigator NIGMS/NIH Individual Rsch Grant 2D NMR of Energy Rescue from PARP in Brain Slice Hypoxia 06/01/04 - 05/31/09 $1,332,605
Liu, Bin Principal Investigator NCI/NIH Individual Rsch Grant Mapping a Clinically Signifi cant Internalizing Tumor Epitope Space 03/07/06 - 1/31/11 $1,334,984
Liu, Bin Principal Investigator DOD/Army Ovarian Cancer
Research Program
Individual Rsch Grant Defi ning and Targeting of an Ovarian Cancer Spefi cic Internalizing Epitope
Space
01/01/04 - 10/31/08 $664,066
Liu, Bin Principal Investigator Mesothelioma Applied
Research Foundation (MARF)
Individual Rsch Grant Identifi cation of Mesothelioma Specifi c Cell Surface Antigens 01/01/07 - 12/31/08 $100,000
Liu, Bin Principal Investigator American Association for
Cancer Research/AACR
Individual Rsch Grant Internalizing Human Antibodies Targeting Pancreatic Tumor Cells in Situ 07/01/08 - 06/30/10 $100,000
London, Martin Principal Investigator Anesthesia Patient Safety
Foundation (APSF)
Individual Rsch Grant Perioperative Pharmacologic Prophylaxis for Cardiovascular Events in the
Dept of Veterans Affairs: A Pharmacoepidemiologic Pilot Project
01/01/06 - 12/31/08 $75,000
Lynch, Susan Principal Investigator American Lung Association
(ALA)
Individual Rsch Grant Analysis of Bacterial Community Dynamics in Adult Patients with
Exacerbations of Chronic Objective Pulmonary Disease: The Effect of
Microbial Community Composition on Pathogen Abundance and Patient
Health
07/01/07 - 06/30/09 $80,000
Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc Individual Rsch Grant Collection of Clinical Respiratory Samples and Pseudomonas Aeuruginosa
for Validation of a Novel Culture Independent Diagnostic
01/07/08 - 10/16/08 $54,647
Lynch, Susan Principal Investigator NIAID/NIH Individual Rsch Grant Resequencing Microarray for Rapid Detection & Antimicrobial Resistance
Profi ling
08/01/07 - 07/31/12 $3,562,568
Lynch, Susan Principal Investigator NHLBI/NIH Individual Rsch Grant Gene Expression and Pathogenicity of P. Aeruginosa 12/11/03 - 11/30/08 $1,465,957
Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Effect of Humanized anti PcrV Antibody on Total Bacterial Community
Composition of Adult Patients with Cystic Fibrosis
03/01/08 - 02/28/09 $152,415
38 UCSF DEPARTMENT OF ANESTHESIA AND PERIOPERATIVE CARE
Name Project Role Agency/Source Type of Grant Project Title Project Period Total Award
Lynch, Susan Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Project #2: Effect of Humanized anti PcrV Antibody on Total Bacterial
Community Composition of Adult Patients with Cystic Fibrosis
07/01/08 - 06/30/09 $133,514
Marks, James Principal Investigator DTRA/DOD Defense Threat
Reduction Agency
IndivRschGrant/Contract Antibody Based Therapy for Botulism 01/18/07 - 01/17/10 $1,187,549
Marks, James Principal Investigator PHS Centers for Disease
Control (CDC)
Individual Rsch Grant Preparation of High Affi nity Monoclonal Antibodies for Use with the
Endopep MS Assay to Detect and Differentiate Botulinum Neurotoxins
07/01/06 - 05/31/09 $1,075,166
Marks, James Project Leader #5 NCI/NIH Specialized Center Grant Phage Display Antibodies (SPORE-BREAST) 03/01/03 - 06/30/08 $1,060,697
Marks, James Principal Investigator NIAID/NIH Individual Rsch Grant Development of Botulinum Neurotoxin Immunotherapy 07/15/03 - 12/31/08 $5,040,609
Marks, James Principal Investigator NIAID/NIH Individual Rsch Grant Development of Botulinum Neurotoxin Immunotherapy, Setotypes C, D,
F, and G
08/15/07 - 07/31/12 $3,782,514
Marks, James Principal Investigator CHDI, Inc. IndivRschGrant/Contract Development of Murine-Specifi c Targeting Ligands for Transcytosis
Through the Blood-Brain Barrier
06/01/07 - 05/31/08 $108,731
Marks, James Principal Investigator CHDI, Inc. IndivRschGrant/Contract Development of Novel Human-Specifi c Targeting Ligands for Transcytosis
Through the Blood-Brain Barrier
06/01/07 - 05/31/09 $472,763
Marks, James Principal Investigator XOMA Subcontract Development of a Final Drug Product for a Mixture of Monoclonal
Antibodies for Type A Botulinum Neurotoxins
09/06/06 - 07/27/09 $956,891
Marks, James Principal Investigator Genomic Systems IndivRschGrant/Contract Human Antibodies to PDGFR for Cancer Therapy 06/28/07 - 06/27/12 $102,359
Marks, James Principal Investigator DOD/IDEA Individual Rsch Grant Engineering Anti-EGFR Antibodies for Treatment of Brease Cancers With
Poor Prognosis
09/01/07 - 09/30/10 $463,144
Marks, James Principal Investigator Fox Chase Cancer Center Subcontract Adaptive Immunity from High Affi nity Anti-HER2/neu Monoclonal Antibodies 09/01/06 - 06/30/11 $382,832
Marks, James Principal Investigator Fox Chase Cancer Center Subcontract Defi ning the Role of Affi nity in Antibody-Based Tumor Targeting and
Therapy
02/05/07 - 01/31/12 $812,588
Marks, James Principal Investigator Functional Genetics Subcontract Determining the Impact of Epitope and Affi nity of TSG101 Antibodies on
Anti-Viral Activity
06/23/06 - 09/01/08 $263,922
Marks, James Principal Investigator The Lustgarten Foundation for
Pancreatic Research
Individual Rsch Grant Lustgarten Foundation for Pancreatic Cancer Research Biomarker Initiative 04/01/08 - 09/30/09 $306,171
McKay, Rachel Principal Investigator Schering-Plough Corporation Clinical Trial A Randomized, Double-Blind, Double-Dummy, Dose-Ranging, Active-and
Placebo-Controlled Study of Single-Dose Ralopitant Monotherapy for the
Prevention of Postoperative Nausea and Vomiting (PONV)
09/01/07 - 08/31/08 $113,399
Niemann, Claus Principal Investigator International Anesthesia
Research Society (IARS)
Individual Rsch Grant Ischemia Reperfusion Injury During Total Knee Athroplasty: The Impact of
Metabolic Syndrome
01/01/07 - 12/31/08 $80,000
Niemann, Claus Principal Investigator HRSA Individual Rsch Grant Intensive Insulin Therapy in Deceased Donors to Improve Renal Allograft
Function and Transplanted Allograft Outcomes
09/01/08 - 08/31/11 $821,251
Palmer, Pamela Principal Investigator The Mayday Fund Instruction Grant Pain CARE Center 06/01/05 - 05/31/08 $179,400
Pittet, Jean Principal Investigator NIGMS/NIH Individual Rsch Grant Stress Preconditioning and Alveolar Epithelial Injury 12/01/06 - 11/30/10 $1,045,089
Pittet, Jean Project Leader #4 NIGMS/NIH Specialized Center Grant TGF-Beta and Lung Epithelial Injury (SCCOR GRANT) 09/30/03 - 06/30/08 $1,769,262
Pittet, Jean Program Director NIGMS/NIH Training Grant Comprehensive Anesthesia Research Training 07/01/07 - 06/30/12 $933,595
Pittet, Jean Principal Investigator InCode BioPharmaceutics, Inc. IndivRschGrant/Contract Compliment Inhibition and Protein C Pathway 5/13/08-5/12/09 $29,355
Rollins, Mark Principal Investigator Foundation for Anesthesia
Education & Research (FAER)
Instruction Grant A Comparison of Tissue Oxygen Levels in Multiple Organs During
Isovolemic Hemodilution with Right and Left-Shifted Hemoglobin-Based
Blood Substitutes
01/01/06 - 12/31/08 $255,000
Rollins, Mark Principal Investigator Anesthesia Patient Safety
Foundation (APSF)
Individual Rsch Grant Supplemental Oxygen: A Reduction in Pulse Oximetry Sensitivity or an
Increased Margin of Safery
01/01/08 - 12/31/08 $150,000
Roux, Jeremie Principal Investigator American Lung Association
(ALA)
Fellowhsip Grant Role of Stress Protein Response on IL-1 Beta-Mediated Inhibition on ENaC
Expression and Function in Lung Epithelial Cells
07/01/06 - 06/30/08 $65,000
Sall, Jeffrey Principal Investigator Foundation for Anesthesia
Education & Research (FAER)
Instruction Grant Volatile Anesthetic Toxicity in Hippocampal Derived Progenitor Cells 01/01/07 - 12/31/08 $255,000
Schumacher, Mark Principal Investigator National Headache Foundation Individual Rsch Grant Regulation of Capsaicin Receptor (TRPV1) Expression in Meningeal
Sensory Neurons Under Infl ammatory Conditions
04/01/08 - 03/31/09 $16,000
Song, Yuanlin Principal Investigator Academic Senate Individual Rsch Grant Role of PAI-1 in Acute Lung Injury Induced by P. Aeruginosa 03/01/08 - 02/28/09 $23,876
Song, Yuanlin Principal Investigator KaloBios Pharmaceuticals, Inc IndivRschGrant/Contract Effi cacy of MAB166 as an Adjuvant Therapy to Standard of Care
Antimicrobial Therapy in a Mouse Model of Acute Lung Injury
01/08/08 - 07/08/08 $86,884
Sonner, James Principal Investigator NIGMS/NIH Individual Rsch Grant Genes Underlying the Response to Inhaled Anesthetics 07/15/04 - 06/30/09 $2,061,572
Stratmann, Greg Principal Investigator Anesthesia Patient Safety
Foundation (APSF)
Individual Rsch Grant Effectiveness of Three Clinically Applicable Strategies to Improve Safety of
Neonatal Anesthesia
01/01/07 - 12/31/08 $150,000
Su, Hua Princpal Investigator American Heart Association
(AHA)
Individual Rsch Grant Bone Marrow Mesenchymal Stem Cell Mediated Hypoxia-Responsive
Angiogenic Gene and Cell Therapy for Ischemic Heart
07/01/05 - 06/30/09 $260,000
Tang, Julin Principal Investigator Pfi zer US Pharmaceuticals Clinical Trial Linezolic in the Treatment of Subjects with Nosocomial Pneumonia Proven
to be Due to Methicillin-Resistant Staphylococcus Aureus
03/24/06 - 12/31/08 $207,194
Tang, Julin Principal Investigator Hospira, Inc. Individual Rsch Grant A Prospective, Randomized, Controlled Study on the Use of
Dexmedetomidine to Facilitate Extubation in Surgical Intensive-Care Unit
Patients Who Failed Previous Weaning Attempts Following Prolonged
Mechanical Ventilation
09/24/07 - 09/23/10 $154,966
Tang, Julin Principal Investigator Ortho-McNeil, Inc Clinical Trial A Phase 2, Open-Label, Non-Comparative Study of Doripenem in the
Treatment of Nosocomical and Ventillator-Associated Pneumonia in
Hospitals Where Pseudomonas Aeruginosa May Be A Prevalent Pathogen
05/21/07 - 8/31/08 $121,705
Yang, Guo-Yuan Principal Investigator The Sturge-Weber Foundation Individual Rsch Grant Development of Cerebrovascular Dysplasia Model for SWS Study 08/01/07 - 07/31/08 $60,000
Yost, Charles Principal Investigator NIGMS/NIH Individual Rsch Grant Background Potassium Channels as Anesthetic Targets 03/03/06 - 02/28/09 $888,576
Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Upstream Regulators of the Prothrombotic State 07/01/08 - 06/30/13 $1,974,062
Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Hemodynamics of Cerebral Arteriovenous Malformations 06/01/05 - 04/30/09 $1,302,842
Young, William Principal Investigator NINDS/NIH Individual Rsch Grant Upstream Regulators of the Prothrombotic State 09/01/05 - 06/30/09 $1,401,376
Young, William Program Director NINDS/NIH Program Project Grant Integrative Study of Brain Vascular Malformations 09/30/03 - 06/30/09 $6,487,825
Young, William Principal Investigator Columbia University Clinical Trial Sub Award A Randomized Trial of Unruptured Brain Arteriovenous Malformations 01/13/06 - 07/31/11 $288,600
Young, William Principal Investigator The Aneurysm and AVM
Foundation/TAAF
Individual Rsch Grant PET and Magnetic Resonance Modeling to Assess the Risk of
Aneurysm Rupture
11/01/07 - 10/31/09 $50,000
Young, William and
Yang, Guo-Yuan
Project Leaders California Institute for
Regenerative Medicine/CIRM
Specialized Center Grant Human Stem Cell Derived Oligodendrocytes for Treatment of
Stroke and MS
08/01/07 - 07/31/11 $200,000
ANESTHESIA NEWS 39
UCSF Center For
Cerebrovascular
Research CCR/PPG
Seminars
Presented by the Center for
Cerebrovascular Research
Department of Anesthesia and
Perioperative Care
University of California, San Francisco
San Francisco General Hospital
For a list of upcoming seminars:
http://avm.ucsf.edu/
For a list of past seminars:
http://avm.ucsf.edu/research/recent_seminars.html
Critical Care Medicine and
Trauma 2009
May 28-May 30, 2009
InterContinental Mark Hopkins Hotel
San Francisco, California
Course Director:
Michael A. Gropper, MD, PhD
Professor and Vice Chair
Department of Anesthesia and
Perioperative Care
Director, Critical Care Medicine
UCSF Medical Center
Course Co-Chairs:
Rochelle Dicker, MD
Assistant Professor in Residence
Department of Surgery
San Francisco General Hospital
Mark Eisner, MD, MPH
Associate Professor
Department of Anesthesia, Department
of Medicine Division of Occupational and
Environmental Medicine and Division of
Pulmonary and Critical Care Medicine
UCSF Medical Center
Julin Tang, MD, MS
Clinical Professor
Department of Anesthesia
Director, Critical Care Medicine
San Francisco General Hospital
Program and registration information:
www.cme.ucsf.edu
Department Chairman
Editor-in-Chief
Ronald D. Miller, MD
Executive Editor:
Marge O’Halloran
Editor:
Morgen Ahearn
Designer:
UCSF Documents, Media & Mail
Principal Writer:
Andrew Schwartz
Photographers:
Michael Lee
Christine Jegan
Marco Sanchez
Richard Schlobohm
Brant Ward
Various UCSF Anesthesia Staff
Anesthesia NewsNon-Profi t Org.
U.S. Postage
PAID
University of California
San Francisco
Department of Anesthesia and
Perioperative Care Grand Rounds
First and Third Wednesdays
of every month
6:30 a.m.-8:00 a.m.
Room C 701,
521 Parnassus Ave.
San Francisco, California
www.anesthesia.ucsf.edu
Department of Anesthesia and
Perioperative Care
310
University of California
San Francisco
Box 0648
San Francisco, CA 94143-0648
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