espectroscopia de prÓtons por ressonÂncia
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Claudia da Costa Leite, MD, PhD Thomas Bouldin, MD
NEURORADIOLOGY-NEUROPATHOLOGY CONFERENCE
CASE 1
21 y-o female Partial epilepsy since 6 years old with poor seizure
control in the last 5 months Frontal mass diagnosed for 6 years, unchanged on
imaging studies
Ganglioglioma, WHO grade I (not large bi nucleus neuroons (arrow) and glial cells (arrow).
Ganglioglioma
Intracranial tumor composed of dysplastic neurons and neoplastic glial cells Most of them are WHO grade I and located in the
temporal lobe Often circunscribed, cortical or cortico/subcortical lesion Classical imaging: combination of intracortical cysts, and
hyperintensity on FLAIR with enhancement. Calcifications can occur in 1/3 of cases.
Urbach H. Seminars in Ultrasound CT and MRI 2008; 29: 40-46.
CASE 2
13 y-o female with diabetes insipidus,
panhypopituitarism, hypocortisolism, growth hormone deficiency and hypothyroidism
Xanthogranuloma
Tumors of pituitary and sellar region
Pituitary adenoma 82% Atypical adenoma 3.0 Pituitary carcinoma 0.1 Craniopharyngioma 3.2
Adamantinomatous 2.9 Papillary 0.3
Rathke’s cyst 2.0 Meningioma 1.0 Chordoma 0.5 Metastasis 0.6 Lymphocytic hypophysitis 0.3 Other lesions 4.1
Saeger W, Ludecke DK, Buchfelder M, Fahlbusch R, Quabbe H-J, and Petersenn S. Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. European Journal of Endocrinology (2007) 156 203–216
Xanthogranuloma of sellar region
Rare, also know as cholesterol granuloma
Relatively more common in childhood but seen at all ages
May have suprasellar extension
Better prognosis than craniopharyngioma or Rathke cleft cyst
Etiology unclear—from craniopharyngioma, Rathke cleft cyst, or de novo
Amano K, et al. Brain Tumor Pathol. 2013;30(4):233-41.
Jung CS, et al. Acta Neurochir (Wien) (2006) 148: 473–477.
Muller HL, et al. J Clin Endocrinol Metab 97: 3935–3943, 2012.
CASE 3
79 y-o female, progressive altered mental status for 3 months
Diabetes mellitus and high blood pressure
Gliomatosis
Gliomatosis Rare, diffuse infiltrative glioma involving at least 3
cerebral lobes, usually bilateral involving cerebral hemispheres and/or deep gray matter and extending to brain stem, cerebellum and even spinal cord Can be de novo or secondary. It is a heterogenous
disease Can occur in any age Imaging ill infiltrative lesion, mass effect and variable
enhancement
Rudà et al. Curr Treat Options Neurol 2014; 16:273
CASE 4
64 y-o male with back pain and lower extremity weakness for 4-5 months Symptoms have been progressing lately
Ependymoma grade II
Ependymal tumors 54%
Ependymoma 42%
Myxopapillary ependymoma 9
Subependymoma 3
Astrocytic tumors 23
Pilocytic astrocytoma 12
Astrocytoma, grade 2 5
Anaplastic Astrocytoma 3
GBM 1
Other gliomas 2
Ganglioglioma 2
Hemangioblastoma 12
Epidermoid 5
Dermoid 2
Melanocytoma 2
Adenal cortical adenoma 1
102 intramedullary tumors at Duke between 1998-2009
Karikari, IO et al. Neurosurgery 68:188–197, 2011.
TABLE 3: Histological type of 430 primary tumors of the spinal cord, spinal meninges, or cauda equina
Histological Type No. of Tumors (%)
astrocytoma* 41 (9.5) glioblastoma 8 (1.9) oligodendroglioma & mixed oligoastrocytoma 4 (0.9) other glioma 14 (3.3) ependymoma 102 (23.7) lymphoma & plasmacytoma 18 (4.2) PNET 4 (0.9) schwannoma 91 (21.2) chordoma 7 (1.6) neurofibroma & other nerve sheath tumor 6 (1.4) meningioma 105 (24.4) hemangioblastoma 7 (1.6) teratoma, dermoid, lipoma & other benign 8 (1.9) other and unclassified 15 (3.5)
* WHO Grades I–III.
Engelhard HH, et al. J Neurosurg Spine 13:67–77, 2010
Case 5
45 y-o male with right side hearing loss. He also recently
developed headaches, double and blurry vision, and balance and gait difficulties
Plasmacytoma
Cranial plasmacytoma
Plasma cell tumors include solitary plasmacytoma, multiple plasmacytoma and multiple myeloma (MM). Plasmacytoma may convert to MM. Plasmacytoma may be intramedullary or extramedullary Bone or soft tissue mass arising from cranial vault skull
base, orbits, paranasal sinus Meningeal involvement is usually due to extension of
bone/soft tissue lesions Intraaxial brain lesions without osseous or dural contact
have been sporadicaly described
Cerase A, et al. Neuroradiology 2008; 50: 665-674.
Cranial plasmacytoma
CT: hyperdense mass, with bone erosions MRI: iso to hyperintense on T1-WI and iso-hypointense
on T2-WI Restricted diffusion is described in some cases
Cerase A, et al. Neuroradiology 2008; 50: 665-674.
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