epithelial pathology

Epithelial pathology

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CASE 1

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HISTOPATHOLOGY

B-Bulbous rete ridges 10 X-H&E

B-Moderate dysplasia 10X-H&E

A-Break in the continuity of basement membrane-10X-H&E

A-Hyperorthokeratinised epithelium10X-H&E

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DIAGNOSIS

SQUAMOUS CELL CARCINOMA IN ASSOCIATION WITH VERRUCOUS LEUKOPLAKIA

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CASE 2

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HISTOPATHOLOGY

B-Para keratin plugging- 10x-H&E

A-Sub epithelial inflammatory infiltrate and features of mild dysplasia-40x-H&E

A-Hyperplastic epithelium- 4x-H&Ewww.rxdentistry.blogspot.com

DIAGNOSIS

VERRUCOUS CARCINOMA IN ASSOCIATION WITH ORAL SUBMUCOUS FIBROSIS

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CASE 3

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Sheets of malignant epithelial cells arranged within thin connective tissue septa-4x-H&E

Cellular and Nuclear pleomorphism 40 X-H&E

HISTOPATHOLOGY

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Vascular invasion - 40 X-H&E

HISTOPATHOLOGY

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Nuclear pleomorphism with mitotic figure- 40X-H&E

Area of necrosis 40X-H&E

HISTOPATHOLOGY

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DIAGNOSIS

SINONASAL UNDIFFERENTIATED CARCINOMA

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CASE 4

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HISTOPATHOLOGY

Epithelial plugging 10x-H&E

Broad pushing margins into the connective tissue-10x-H&E

Surface epithelium showing plugging-10x-H&E

Parakeratinised stratified squamous epithelium with dysplasia-10x-

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DIAGNOSIS

VERRUCOUS CARCINOMA. (CARCINOMA CUNICULATUM)

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CASE 5

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Sheets of spindle cells adjacent to an area of malignant epithelial cells. 10X-H&E

HISTOPATHOLOGY

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Section shows pleomorphic epithelial cells along with spindle cells-40X-H&E

HISTOPATHOLOGY

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Immunohistochemical stain, cytokeratin, epithelial cells, spindle areas

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DIAGNOSIS

SPINDLE CELL SQUAMOUS CARCINOMA

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CASE 6

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Malignant epithelial island in connective tissue-10x-H&E

Dysplastic islands showing hyperchromatism-10X-H&E

HISTOPATHOLOGY

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HISTOPATHOLOGY

Section shows numerous malignant cells with features of pleomorphism and mitotic figures-40x-H&E

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DIAGNOSIS

MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA

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CASE 7

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Island of dysplastic cells within the connective tissue-10x-H&E

Sheets of malignant epithelial cells-

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HISTOPATHOLOGY

Section shows sheets of pleomorphic malignant cells-40x-H&E

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DIAGNOSISPOORLY DIFFERENTIATED SQUAMOUS CELL

CARCINOMA

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CASE 8

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Acantholysis within malignant islands 10x-H&E

Lobular growth pattern 10x-H&E

Malignant epithelial islands and keratin pearls 10x-H&E

Dysplastic epithelium and break in continuity of basement membrane10x-H&E

HISTOPATHOLOGY

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DIAGNOSIS

ADENOID SQUAMOUS CELL CARCINOMA –Variant of Squamous cell carcinoma.

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CASE 9

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HISTOPATHOLOGY

Photomicrograph shows atypical melanocytes in the basilar layer of overlying epithelium and spindle as well as round cells in the connective tissue (H&E), 10x.

Photomicrograph shows the junctional proliferation at the epithelial–connective tissue interface along with few epitheloid cells in the connective tissue (H&E), 40x.

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Focal positivity for S100

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DIAGNOSIS

DESMOPLASTIC MALIGNANT MELANOMA

Published as “Desmoplastic malignant melanoma of alveolus – A rare entity", in Oral Oncology EXTRA (2006) 42, 291– 294

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THANK YOU

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