dna mismatch repair happens only during a brief window of opportunityandmethylation also plays a...
Post on 01-Jul-2015
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A way to survive and maintain adequate genetic inheritance. A way to survive and maintain adequate genetic inheritance.
DNA MISMATCH REPAIR HAPPENS ONLY DURING A BRIEF WINDOW OF OPPORTUNITY.
Who quickly and accurately repair genetic errors.Who quickly and accurately repair genetic errors.
Preventing alterations in the genome that could lead to serious consequences.
Preventing alterations in the genome that could lead to serious consequences.
Is based in the ability of some proteins.Is based in the ability of some proteins.
DNA MISMATCH REPAIR HAPPENS ONLY DURING A BRIEF WINDOW OF OPPORTUNITY.
• The newly DNA produced shown temporary a signal for 10 to 15 minutes after replication.
• The newly DNA produced shown temporary a signal for 10 to 15 minutes after replication.
The researchers, led by Richard D. Kolodner, PhD, Ludwig Institute investigator and UCSD replicated DNA from Saccharomyces cerevisiae, or baker's yeast.
Allowing to be identified as a new target of MMR proteins
Allowing to be identified as a new target of MMR proteins
Visualize MMR in a living cell.Visualize MMR in a living cell.
Could explains better how eukaryotes eliminate DNA replication errors.
Could explains better how eukaryotes eliminate DNA replication errors.
Which can be interesting and helpful for many defects and the development of cancers.
Which can be interesting and helpful for many defects and the development of cancers.
DNA MISMATCH REPAIR HAPPENS ONLY DURING A BRIEF WINDOW OF OPPORTUNITY.
MMRMMR
OBSERVATION
DNA repair in my opinion it seems a fundamental process for life, because if it were not for this mechanism would have millions and millions of mutations caused mainly by external factors that perhaps life was not compatible. To me, we need to know more about the DNA repair process because we still see changes in the human genome. Perhaps behind the repair process we now know there are many more. If we can stay in the open we would have the key to correct mistakes that the body was not able to correct.
METHYLATION ALSO PLAYS A SIGNIFICANT ROLE OUTSIDE THE NUCLEUS.
Methyltransferases enzymes transfer methyl groups to the DNA. Not only there but also nuclear proteins incur methylation, mostly at the amino acid lysine
Methyltransferases enzymes transfer methyl groups to the DNA. Not only there but also nuclear proteins incur methylation, mostly at the amino acid lysine
Methylated lysines promote the formation of protein complexes that control DNA repair and replication.
Methylated lysines promote the formation of protein complexes that control DNA repair and replication.
The point is that this enzymes are not only found in the nucleus, also they are in the cytoplasm. But is not well established which proteins are methylated there and how this methylation may affect function.
The point is that this enzymes are not only found in the nucleus, also they are in the cytoplasm. But is not well established which proteins are methylated there and how this methylation may affect function.
METHYLATION ALSO PLAYS A SIGNIFICANT ROLE OUTSIDE THE NUCLEUS.
The researchers identified an enzyme that methylates the amino acid lysine in the cytoplasm. "
The researchers identified an enzyme that methylates the amino acid lysine in the cytoplasm. "
Its role is as an elastic spring in muscle cells" "Precisely this elastic region of titin is protected by the association with methylated Hsp90."
Its role is as an elastic spring in muscle cells" "Precisely this elastic region of titin is protected by the association with methylated Hsp90."
Then they searched for partners of Smyd2 enzyme and found that it methylates the protein Hsp90 . Both, form a complex with the muscle protein Titin.
Then they searched for partners of Smyd2 enzyme and found that it methylates the protein Hsp90 . Both, form a complex with the muscle protein Titin.
METHYLATION ALSO PLAYS A SIGNIFICANT ROLE OUTSIDE THE NUCLEUS.
Titin requires protection by methylated proteinsTitin requires protection by methylated proteins
Researchers altered the protection of the Titin protein by blocking Smyd2 enzyme. Hsp90 protein is repressed, so they altered the organism.
Researchers altered the protection of the Titin protein by blocking Smyd2 enzyme. Hsp90 protein is repressed, so they altered the organism.
Without methylated Hsp90, the elastic titin region was unstable and muscle function strongly affected.
Without methylated Hsp90, the elastic titin region was unstable and muscle function strongly affected.
OBSERVATION
Processes such as methylation are critical because it regulates important things (DNA and proteins.) Because of this, researches of this type show that we still need more to know the genetic field. For example, we think "X" protein has a certain function and what we do not know is that it has more functions that can be vital for normal functioning of life. Certain disease can be caused by an agent but secretly can be hundreds of processes unknown to us.
MEDICAL UTILITY
Replication mechanism brings to us an explanation that goes along with the clinic: Genetic diseases affecting the population and that trap a lot of people affect them their quality of life. Provides the ability to repair artificial mechanisms and allow for further findings
Replication mechanism brings to us an explanation that goes along with the clinic: Genetic diseases affecting the population and that trap a lot of people affect them their quality of life. Provides the ability to repair artificial mechanisms and allow for further findingsThe importance of DNA
replication and reparation is based on prevent this processes.
MEDICAL UTILITY
It is also important to know that there may be factors that alter the genetic information. If it is known that some factors may induce alterations would be important to know all that induce changes in the genetic material and a solution would be to avoid exposure.
It is also important to know that there may be factors that alter the genetic information. If it is known that some factors may induce alterations would be important to know all that induce changes in the genetic material and a solution would be to avoid exposure.
MEDICAL UTILITY
Understanding the mechanisms by which agents act as viruses, bacteria and fungi is vitally important because it bears some similarity between the functioning of these, with humans. If we know its mechanism of action we can find a way to answer questions. Many of these answers are in the mystery of the genetic code
Understanding the mechanisms by which agents act as viruses, bacteria and fungi is vitally important because it bears some similarity between the functioning of these, with humans. If we know its mechanism of action we can find a way to answer questions. Many of these answers are in the mystery of the genetic code
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