crystallization & solid state - rise - research institutes ... · crystallization & solid...

SP

Tech

nica

l Res

earc

h In

stitu

te o

f Sw

eden

Crystallization & Solid State

Your Solid – from Calculations to Process

Solid State Investigations Crystallization Development Crystallization Scale-Up

In-Silico Studies Analysis of Solid Materials Troubleshooting

Pycnometry, Tap Density

Gas Adsorption

Bulk Properties

Particle Size Distribution

Porosity

Specific Surface Area

Crystal Habit

Density & Bulk Density

Dissolution Rate

Hydrofilicity & Hydrophobicity

Gravimetric Vapour Sorption

Bulk Property Calculations

Scanning Electron Microscopy, Light Microscopy

Sieving, Laser Diffraction

Gas Adsorption

SXRD*

PLM*

Calorimetry, DSC*, TGA,* Hot-Stage PLM*

GVS*

XRPD*, FTIR*, FT-Raman

Crystal Structure Determination

Structure Informatics

Crystal Growth

Solubility & Phase Diagrams

Solid Form Screening

Chirality

Optical Properties

PROTEUS*

Salts, Co-Crystals, Polymorphs, Solvates

Crystallization Design & Scale-Up

Molecular Properties

Solid Phase Identity

Solid - Solvent Interactions

Thermal Properties

Crystallinity & Amorphicity

PLM*, XRPD*, GVS*, Calorimetry

Eidothea*

DSC = Differential Scanning Calorimetry, Eidothea = Automated Solubility = f(temperature), GVS = Gravimetric Vapour Sorption, PLM = Polarized Light Microscopy, PROTEUS = Automated Crystallization Screening Robot, SXRD = Single Crystal X-ray Diffraction, TGA = Thermogravimetric Analysis, XRPD = Powder X-Ray Diffraction.