cns pathology slides

CS # 52 - Tuberculous meningitisCS # 52 - Tuberculous meningitis

CS # 52 - Tuberculous meningitisCS # 52 - Tuberculous meningitis

CS# 19 Brain Infarction

Red neurons

CS#19 Brain Infarction

Hemorrhages and necrosis

“gitter cells”

CS #19 Brain infarction

CS # 19. Brain InfarctionCS # 19. Brain Infarction

Brain infarction: Note the many macrophages (“gitter cells”) which are cleaning up the lipid debris from the liquefactive necrosis.

MedulloblastomaMedulloblastoma

Medulloblastoma : located near the midline of the cerebellum and extending into the fourth ventricle above the brainstem

cerebellum

4th V

Brainstem

CS#216 Medulloblastoma

Tumor cells forming rosettes

CS# 216 Medulloblastoma

Small round blue tumor cells

CS# 216 MedulloblastomaCS# 216 Medulloblastoma

Note the following:

1. Small round blue tumor cells forming rosettes in which the cells are concentrically arranged about a central space.

2. Tumor cells have hyperchromatic nuclei which are frequently elongated or crescent (“carrot”) shaped

pseudorosettes

EpendymomaEpendymoma

Tumor arise from the ependymal lining of the fourth ventricle above the brainstem and bulging toward the cerebellum.

cerebellum

CS#218 Ependymoma

Perivascular pseudorosettes

CS#218 Ependymoma

Perivascular pseudorosette

Perivascular pseudo rosette pattern: Tumor cells are arranged about a central vascular space

Vascular space

CS # 218 EPENDYMOMA

Meningioma-GrossMeningioma-Gross

Meningioma : circumscribed reddish-yellow firm neoplasm beneath the dura next to the falx.

CS#248 Meningioma

CS #248: MeningiomaCS #248: Meningioma

Meningioma: benign tumor composed of clusters of pink tumor cells without visible cell membranes

Glioblastoma multiforme (GBM)Glioblastoma multiforme (GBM)

Tumors are quite vascular with prominent areas of necrosis and hemorrhage..

CS# 215 Glioblastoma Multiforme

Marked cellularity with marked hyperchromatism and pleomorphism

CS# 215. Glioblastoma Multiforme

necrosis

Palisading of cells

CS# 215 Glioblastoma Multiforme

Endothelial proliferation

CS: 215: Glioblastoma MultiformeCS: 215: Glioblastoma Multiforme

Glioblastoma multiforme (GBM): Note the following:

1. Marked cellularity with marked hyperchromatism and pleomorphism.

2. Prominent vascularity

3. Area of necrosis at the left with neoplastic cells palisading around it.

#3

Glioblastoma multiforme (GBM).:

#3 Pseudopalisading necrosis of neoplastic cells

necrosis

Pseudopalisading of tumor cells