circadian rhythms

Circadian rhythms

&

Human health

Presented by Dr. Sudhakar KokateDirector PPRC, India

Circadian rhythms .…

Also known as the “Body clock”

Physical, mental and behavioural changes that

follow a roughly 24 hrs. cycle responding to light

and darkness in the organism

Found in living things, plants, animals and even

among tiny microbesPPRC/INDIA 01

Circadian rhythms .…

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Circadian rhythms ….

Related to biological cycle

Study of Circadian rhythms and health is known

as “Chronobiology”

Biological cycle controls Circadian rhythms –

governing of interacting molecules in cells

throughout the bodyPPRC/INDIA 03

Master clock ….

Master clock: Brain

A group of nerve cells ‘Suprachiasmatic nucleus’

(SCN) containing 20,000 nerve cells are located

in hypothalamus

Location: above optic nerves from eyes cross

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Brain

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Suprachiasmatic nucleus

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About CR ….

Circadian rhythms influence sleep wake cycles,

hormone release and other bodily functions

CR – linked to sleep disorders e.g. Insomnia,

Obesity, Diabetes, Depression, Bipolar disorders

and Seasonal Affective Disorder (SAD)

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Insomnia

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Obesity

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Diabetes

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Depression

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Bipolar disorders

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Seasonal Affective Disorder (SAD)

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About CR ….

CR tells our body when to sleep and regulate

many other physiological processes

This internal body clock is affected by

environmental cues like sunlight and

temperature

When CR is disrupted, sleeping & eating

patterns can run amokPPRC/INDIA 14

Physiological disruption leads to ….

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Research ….

A growing body of research is examining the

adverse health effects like increasing cardio-

vascular events, observing neurological problems

like depression and bipolar disorders.

It also affects immune and metabolic systems

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Immune system

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Metabolic system

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Research ….

Scientists are looking into:

1. How brain-neuro system works in disorder?

2. What are effective remedies without side effects

with minimum duration of time span?

3. Behaviour of Human being in disrupted CR

positionPPRC/INDIA 19

Research ….

4. Treatment of sleep disorders, Jet lag and other

health related issues

5. Do Ayurvedic plants control Circadian rhythms

in plants, animals and microbes? If so how and

at what level of output?

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Research ….

6. Are there any natural control for strengthening

nerves and muscle? If so how and what

mechanism does it possess?

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Remedies ….

Change or modify lifestyle

Ideal diet plan – implementation

Yoga, exercises and meditation

Use of herbal technology

Well disciplinary actions in exact time

Strengthen and calm – nerves and musclesPPRC/INDIA 22

Yoga

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Exercise

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Meditation

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Cryobiology

Study of cell preservation technology with low

temperature

Applied science

Rule: Every 10°C reduction in temperature

= 50 % decrease in oxygen consumption

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Cryobiology

Temperature ranges 32 to 37°C

and -80 to -196°C

Many Journals, Societies study Cryobiology

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Neurochemicals ….

Organic molecules participating in Neural activity

Neuropeptide: Oxytocin signifies maternal

behaviour, stress wound healing

Glutamate

GABA: Inhibits neurotransmission

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Neurochemicals

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Neuropeptide

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Oxytocin

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Glutamate

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GABA

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Neurochemicals ….

Organic molecules participating in Neural activity

Dopamine: Function of the limbic system,

emotional function and control

Serotonin: Mood, sleep and alertness, sensation

of pleasure

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Dopamine

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Serotonin

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Neurochemicals ….

Organic molecules participating in Neural activity

Acetylcholine: Memory

Nitric oxide

Endocannabinoids: Eicosanoids

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Acetylcholine

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Nitric oxide

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Endocannabinoids

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Foods for healthy nerves ….

₪ Milk

₪ Yogurt

₪ Honey

₪ Apple

₪ Mangoes

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₪ Potatoes

₪ Bananas

₪ Herbal tea

₪ Whole grain

₪ Sweet potatoes

Foods for healthy nerves ….

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Foods for healthy nerves ….

₪ Pineapples

₪ Beet salad

₪ Grape fruits

₪ Oranges

₪ Almonds

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₪ Green salad

₪ Dates

₪ Cashew nuts

₪ Coconut water

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₪ Tulsi

₪ Sunflower

₪ Papaya

₪ Peppermint

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₪ Avocado

₪ Cabbage

₪ Cauliflower

₪ Asparagus

Tulsi (Ocimum sanctum)

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Sunflower

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Papaya

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Peppermint

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Avocado

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Cabbage

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Cauliflower

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Asparagus

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₪ Alfalfa

₪ Parsley

₪ Garlic

₪ Beet

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₪ Kale

₪ Hemp

₪ Fenugreek

₪ Lime

Alfalfa

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Parsley

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Garlic

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Beet

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Kale

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Hemp

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Fenugreek

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Lime

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Thank You !!

“BE WITH US”