chaga report #1-3
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http://cafe.daum.net/cancerchaga
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1980 . . 1980 15 . 1980 1983 .
()
. 1994 - . ,
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, , .
(Kirst Kahlos) . 1987 1997 . . .
.
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(Chaga) 16, 17 (Minaeva 1970).
,
1950 1960 . 1950 1960 . . (, 1966).
[ 1]
- (Kirsti Kahlos) 1987
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. :
1.
2.
.
, , , . , .
, . (1963) ,
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. (1963) , 18 . . .
1950 ,
. (Befungin) , , 1955 . ( 1973). , .
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(1962) , . , , . 180, MOP 755 .
granylosytic , mycolocytes . , RC 83 . Kier(1961) , . 180 755 .
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. . (23 ), 45 (40-80 ) .
. , 13C NMR .
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[ ]
180
755(3) . (1), (2) (3) - .
13C-NRM ,
, .
[ 2]
- , R. M. v. Schantz
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[ ]
(Pers. ex Fr.) , , 3-hydroxylanosta-8, 24-dien-21- (1, 2) .
[ 3]
- R.
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[ ] 3, 21-
dihydroxy-lanosta-8, 24- diene 3, 22, 25-trihydroxy-lanosta-8, 23-diene n- . . IR, MS, 1H NMR 13C NMR .
[ 4] ,
- - , SF-00170 ,
, , -
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[ ] 3, 22-dihydroxy-lanosta-8,
24-dien-7-one . IR, MS, 1H NMR 13C NMR . 7- NMR . .
[ 5] 3,22-DIHYDROXY-LANOST A-8,24-DIEN-7-ONE, 7-
- - , SF-00170 , ,
,
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[ ] , 3, 22-dihydroxy-lanosta-8, 24-
diene (Pers. ex Fr.) n- , . Walker 256 carcinosarcoma ( ) MCF-7 adenocarcinoma mammae ( ) . 50g/ml 100% .
[ 6]
- - -
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, 3, 22-dihydroxy-lanosta-8, 24-diene (Pers. ex Fr.) . .
. (ascites fluid) (4). HTC 373 (5).
Walker 256 rat carcinosarcoma MCF-7 human breast cancer( ) . MCF-7 , , .
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, . IR, MS 1H NMR . Walker 256 , , . 50g/ml Walker 256 , 30% .
5 , ,
. Walker 256 MCF-7 2, 4, 5 ; MCF-7 , 50g/ml .
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[ ] (Pers.
ex Fr.) ( 1959). .
[ 7] n-
- - - - , 00170 , ,
, - , Farmos LTD,
P.O. Box 425, 00100 Turku,
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( 1966). , ( 1961) , ( 1983) (Ludwiczak Wrzeciono 1960, 1985) .
(1962)
, .
Alnusoregona Nutt.
Walker 256(5WAI6) , Sarracenia flava L. nasopharynx(KB)(Steth 1973, 1974) . Walker 256 carcinosarcoma MCF-7
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humal adenocarcinoma mammary 100% ( 1986).
n-
MCF-7 Walker 256 , P 388 .
rat Walker 256 carcinosarcoma (gift of
Prof. Osswald, Deutsches Krebsfor-schungszentrum, , FRG) MCF-7 (, , ).
[ ] MCF-7 Walker 256
MCF-7 Walker 256
4,5 . ,
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(G-J) . 4,5 2-4 II .
3-hydroxy-lanosta-8,24-dien-21-al Walker
256 . MCF-7 . 4 30%.
3,21-dihydroxy-lanosta-8,24-diene
. , Walker 256 carcino -sarcoma 80%, MCF-7 human mammary adenocarcinoma 60%.
Wawlker 256
, MCF-7 . 50g/ml 90% .
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3, 22, 25-trihydroxy-lanosta-8, 23-diene Walker 256 . MCF-7 , 50g/ml 4 .
(G-J) MCF-7
. 3, 22-dihydroxy-lanosta-8, 24-dien-7-one(Fr. G), 3, 22-dihydroxy-lan osta-7, 9(11), 24-triene(Fr. I) (Fr. H J) 50g/ml 4 .
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,
methione . . MCF-7 (adenocarcinoma) mammae : C-21 (trametenolic ) > C-21 > C-21
[ 8] cysteine cysteine C-21 (Inonotus obli-quus)
- - V.H. Tikka
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> methyltramenenolate > > . Methylation (methyltrametenolate) c-21 5 95% , .
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[ 9]
- - , P.O Box 56, (Viikinkaari 5),
00014, Biocenter 2, , .
- A. LESNAU, W. LANGE - Nationales Referenzzentrum fur Influenza,
Robert Koch Institut, D-13353, Nordufer 20, , .
- U. LINDERQUIST - Institut fur Pharmazeutische Biologie,
Friedrich Ludwig Jahn Str. 15a, D-17487, Greifswald, Germany.
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. . .
. . .( )
A B, A(A/H1N1, A/H3N2, A/Equine2, B//16/18 ) .
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(100%) . betulin lupeol, mycosterols .
(Betula)
, . .
, .
. .
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triterpenes , lunapes triterpenes . Inotodiol(3, 22--8, 24-diene) (3--8, 24-diene) C-21 triterpenes .
triterpenes .
Inotodiol Walker 256 carcinosarcoma MCF-7 , .
A B .
EtOH(
2%) . 40g/ml .
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20g/ml . . A . B . [ ]
.
intodiol, , 3--8, 24-dien-21-al 3 , 21--8, 24- diene( 1) .
, , taraxerone, ,
, fungisterol, -7, 22-dien-3-ol, -, 3, 22--7, 9(11), 24-triene .
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( 1) (A) (B) triterpenes GC (%)*
A B 0.8 0.4
0.8 0.8 Taraxerone 3.5 -7,22-dien-3--ol 1.1 1.3 Fungisterol 0.2 Lupenone 5.8 12.6 0.5 - 0.9 1.9 Lupeol 4.2 1.9 3, 22--7,9(11),24-triene-Inotodiol 3.8 1.7
3, 21--8,24-diene 39.9 23.5 +3--8,24-dien-21-al 14.9 36.3 2.1 11.7 Triterpene () 3.8 2.6
* triterpenes A: B: -7, (9)11, 24-triene 8-
lanostanes . triterpenes
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, .
2.1% betulin
betulin . Lano-stanes , . Taraxerone(3.5%) . Betulin triterpene . lupines, lupeol lupanone . Taraxeranes, lupanes -sitosterol Alnus .
betulin
, pentacyclic . 30% betulin 8.5% lupeol , (B.b ) lanostanes .
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.
40g/ml A B A .( 2)
( 2) (A/H1N1, A/H3H2) (A/Equine2)
n- (%) ( ) (g)
( ) A/H1N1 Q/H3H2 A/Equine2
A B B.a B.b
0.42 0.34 0.25 0.26
0.1081 1.0430 0.0747 0.1294
0.21 0.60 0.13 0.23
0 0 100 0
0 0 100 0
35 0 100 0
*A: (A. glutinosa); B: (B pubescens); B.a:;B.b:
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20g/ml A/H1N1/86 1.7 log 10 ID50, B/Yamagata/88 1.8 log 10 ID50 . 1 log 10 ID50 .
Betulin, mycosterols,
, A/H1N1 (60-100%). . .
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