central dogma chem edition

IS 9 Lecturethe Central Dogmain the language of Chem

deoxyribonucleic acid

less oxygen

nomenclature

deoxyribonucleic acid

five (aka pento)

nomenclature

deoxyribonucleic acid

DNA strand

the nucleic acid

the nucleic acid structure

the nucleic acid structure

IUPAC rules

number assignment is determined by the functional group

IUPAC rules

number assignment is determined by the functional group

IUPAC rules

ether (ROR)

IUPAC rules

number assignment is determined by the functional group

the lowest number will be assigned to a carbon nearest the functional group

(or substituent)

IUPAC rules

5’ and 3’ strands of DNA

directionality - of the single strand DNA where the nucleic acid are

chemically oriented

5’ and 3’ strands of DNA

directionality - of the single strand DNA where the nucleic acid are

chemically oriented

5’ and 3’ strands of DNA

the nucleic acid structure

5’ and 3’ strands of DNA

the direction of the strand is determined by the chemical orientation

of the nucleic acid

5’ and 3’ strands of DNA

deoxyribonucleic acid

5’ and 3’ strands of DNA

5’ and 3’ strands of DNA

the blue strand is assigned as 5’-end

because the phosphate group covalently bonded to the backbone is

attached to Carbon #5

5’ and 3’ strands of DNA

the red strand is assigned as 3’-end

because the phosphate group covalently bonded to the backbone is

attached to Carbon #3

the Bases

Nitrogen-containing compounds have basic properties

Base pairing

Base pairing (DNA)

number of hydrogen bonds between bases

Base pairing (RNA)

number of hydrogen bonds between bases