ce ll- cu lture real time mo nitoring system analog design contest 2013
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Cell-Culture real time Monitoring system
Analog Design Contest 2013
Team: José A. Maldonado, Juan N. Olmo, Gloria Huertas, Alberto Yúfera
Cecumo
“The important thing is not to stop questioning”. Albert Einstein
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AGENDA
Motivation Theoretical background
Simulations System description
Implementation Features Results
Final conclusions Questions and comments
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
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MOTIVATION
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
Cecumo
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THEORETICAL BACKGROUND
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
Z(w)/A Rs
Z(w)/(A-Ac) RsCELL
Z(w)/Ac Rgap
Low-Pass Behaviour function of cell-culture occupation area (Ac)
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HBP(s)
Zcell-electrode(s)
RinVoutVout2
THEORETICAL BACKGROUND: SIMULATIONS
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
Oscillation-Based Test approach
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SYSTEM DESCRIPTION: IMPLEMENTATION
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
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SYSTEM DESCRIPTION: RESULTS
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
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SYSTEM DESCRIPTION: RESULTS
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
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SYSTEM DESCRIPTION: FEATURES
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
Real time monitoring “Cell friendly” (Max. 30mV/30μA)
Immediate result Up to 8 cultures Wireless connectivity Data logging Long battery lifetime (100mA/10mA@±5V)
Compact and light-weight design (160x80x25mm)
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CONCLUSIONS
Low cost & reusable “biological” oscillator for Cell Culture growing measurements.
Amplitude and frequency to characterize occupation. AGC for better noise inmunity Frequency and AGC control voltage (Vg) to extract Fill
Factor (ff) parameter. Potential fields of application: medicine and biology
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
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QUESTIONS AND COMMENTS
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
Thank you for your attention!
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SYSTEM DESCRIPTION: IMPLEMENTATION
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
Band Pass Filter
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SYSTEM DESCRIPTION: IMPLEMENTATION
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
AGC
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SYSTEM DESCRIPTION: IMPLEMENTATION
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
BioZ Interface
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SYSTEM DESCRIPTION: IMPLEMENTATION
Analog Design Contest 2013 José A. Maldonado, Juan N. Olmo
High Pass Filter & Comparator
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