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Conference Proceedings

rth26 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

EMBC

2004

LINKAGES FOR INNOVATION

IN BIOMEPICINE

SAN FRANCISCO, USA

l~5September2004San Francisco, California

Volume IV

Conference Chair

Donna Hudson, Ph.D.Program Chair

Zhi-Pei Liang, Ph.D.

Publications Chair

GuyDumont, Ph.D.

Iwant pi Inmbluiin

EMBCO"

TIB/UB Hannover

126 450 374

89

Five-Band Microwave Radiometer Systemfor

Non-Invasive Measurement ofBrain

Temperature in New-Born Infants: SystemCalibration and its FeasibilitySugiura, T.; Kouno, Y.; Hashizume, A.; Hirata, H.;

Hand,J.W.;Okita,Y.;Mizushina,S. 2292

Images Reproducibility ofan Electrical

Impedance Tomography (EIT) Prototype.

Analysis ofthe EITSensibility in Rats in

Pathological in vivo Conditions

Gaona, Andres G.; Aguillon, Miguel A. P.;

Mendoza, A. Jesus; L6pez, Leonor M.; Gonzalez,

EvaT. 2296

Digital Phonocardiography: A PDA-based

ApproachNazeran, Homayoun; Brusco, Matias 2299

ExperimentalStudy of3D Contactless

Conductivity Detection using Microwave

Radiometry: aPossible MethodforInvestigation

ofBrain Conductivity Fluctuations

Karanasiou, Irene S.; Uzunoglu, Nikolaos K. 2303

Therapy Guidedby GastricImpedanceSpectroscopy in a Septic Shock Model in PigsGonzalez, Cesar A.; Villanueva, Cleva; Othman,

Salah; Sacristan, Emilio 2307

Session 3.7.5: PhysiologicalMeasurements II

4 Respiration Monitor Based on

Electrocardiographic and

Photoplethysmographic Sensor Fusion

Ahlstrom, Christer; Johansson, Anders; Lanne,Toste; Ask, Per 2311

Laser Doppler Method in Evaluation of

Vasovagal SyncopeInduced by Tilt Table Test

Maniewski, Roman; Szufladowicz, Ewa; Nosek,

Angelika; Walczak, Franciszek 2315

Direct Coextensive Plethysmographyfor Non-Invasive Measurement ofSystemic Pressuresand Volumes

Davis, Charles L.; Thong, Iran; Belzberg,Howard; Phillips, Charles;Holden, William E.; Thornburg, Kent L. 2318

Brain Electrical Impedance at Various

Frequencies: The Effect ofHypoxiaSeoane, Fernando; Lindecrantz, Kaj; Olsson,Torsten; Kjellmer, Ingemar;Flisberg, Anders; Bagenhokn, Ralph 2322

Continuous Blood Pressure Monitoring Utilizinga CMOS Tactile Sensor

Salo, Tomi; Kirstein, Kay-Uwe; Sedivy, Jan;Grunenfelder, Jurg; Vancura, Tobias;Zund, Gregor; Baltes, Henry 2326

A Low-Cost Optical Pachymeterfor the

Diagnosis ofGlaucoma and Ocular HypertensionShaver, Jesse H.; Shen, Jin H.; Walker, Aaron L. 2330

Measurement ofAirflow through a MeteredDose

Inhaler during MRI

Delanvar, Soheil; Schmalfiiss, Ilona; Melker,Richard J.; van Oostrom, Johannes H. 2334

Session 3.7.6: PhysiologicalMeasurements III

Visualization ofLumbar Muscle Contraction

Synergy using Surface Electrography(sEMG)Streaming TopographyHu, Yong; Mak, Joseph N. F.; Lu, W. W.; Luk, K.

D.K.

A Low Cost Doppler Systemfor Vascular DialysisAccess Surveillance

Molina, Paulo S. C.

Evanescent Cavity Ring-Down Spectroscopy (e-

CRDS) ofHemoglobin Absorption at the

Silica-Water InterfaceMartin, W. Blake; Mirov, Sergey; Marryshkin,Dmitri; Venugopalan, Ramakrishna

Autofluorescence Lifetime Measurement on Oral

CarcinogenesisChang, Chia-Lin; You, Chun; Chen, Hsin-Ming;Chiang, Chun-Pin; Chen, Chin-Tin; Wang, Chih-

Yu

Continuous Wave Doppler Methods to DialysisAccess MonitoringMolina, Paulo S. C.

Water Vapour Partial Pressure Control in

Neonatal Incubator Using Prevision by MultipleModels

Amorim, Mardson F.; Oliveira, Gustavo H. C;Silva, D.; Kiapuchinski, L.

Characteristic Properties ofImplantableAg/AgCI- and Pt-electrodes

Riistama, Jarno; Lekkala, Jukka

Development Stress Monitoring System Based on

Personal Digital Assistant (PDA)Lee, Mi-hee

2337

2341

2345

2349

2352

2356

2360

2364

Session 3.7.7: Data Acquisition Systems

Measuring Bioimpedance in the Human Uterine

Cervix: Towards Early Detection ofPreterm Labor

Hoe, Yen Shi Gillian; Gurewilsch, Edith D.;Shaahinfar, Ashkon; Hu, Elbert S.;

Sampattavanich, Somponnat; Ruffner, Melanie;

Ching, Kenny H. S.; Allen, Robert H. 2368

XXX

An ECGElectrode-Mounted Heart Rate,Respiratory Rhythm, Posture and Behavior

Recording SystemYoshimura, Takahiro; Yonezawa, Yoshiharu;Maki, Hiromichi; Ogawa, Hidekuni;Ninomiya, Ishio; Caldwell, W. Morton 2373

The Electrically Non-contacting ECGMeasurement on the Toilet Seat Using the

Capacitively-coupled Insulated ElectrodesKim, Ko Keun; Lim, Yong Kyu; Park, KwangSuk 2375

Ambulatory Instrumentation Suitablefor Long-Term Monitoring ofCattle Health

Schoenig, Scott A.; Hildreth, Tammi S.; Nagl,Luke.; Erickson, Howard; Spire, Mark;Andresen, Daniel; Warren, Steve 2379

The ECG Measurement in the Bathtub Using the

Insulated Electrodes

Lim, Yong Kyu; Kim, Ko Keun; Park, KwangSuk 2383

Variable Frequency BioimpedanceInstrumentation

Tsunami, Daniel T.; McNames, James; Colbert,Agatha; Pearson, Sean; Hammerschlag, Richard 2386

Effect of UltrasoundExposure on SurfactantMicrobubbles

Soetanto, Kawan 2390

Track 3.8: Sensor Applications and

Uses

Session 3.8.1: Presence and

Cybersickness

Human Behavior and Egocentric SpatialPerception Contingent with Gravity Cue

Koga, Kazuo 2395

Effects of Virtual Body Motion on Visually-Induced Motion Sickness

Ujike, Hiroyasu; Yokoi, Takashi; Saida, Shinya 2399

Time-Varying Behavior ofMotion Vectors in

Vection-Induced Images InRelation to

Autonomic RegulationKiryu, Tohru; Yamada, Hiroshi; Jimbo, Masahiro;Bando, Takehiko 2403

Quantitative Evaluation ofthe Effect of Visually-InducedMotion Sickness Using Causal

Coherence Function between BloodPressure and

Heart Rate

Sugita, Norihiro; Yoshizawa, Makoto; Tanaka,Akira; Abe, Ken-ichi; Shigeru, Chiba;Yambe, Tomoyuki; Nitta, Sin-ichi 2407

Assessment ofEmotionalReaction Induced byVisualStimulation Based on Cross-Correlation

between Pulse Wave Transmission Time and

Heart Rate in the Mayer Wave-Band

Yoshizawa, Makoto 2411

Influence ofAttention andPredictive Visual Cueon Motion Perception andSickness in Immersive

Virtual Environment

Fujita, Kinya 2415

Session 3.8.2: New Sensor Development

Biomechanics ofCranialDynamicsDuring DailyLiving Activities

Long, Jason T.; Jannetto, Nicholas; Bakker, Sara;Smith, Stephen; Harris, Gerald F.

MEMSShear Stress Sensorfor Cardiovascular

DiagnosticsSoundararajan, Gopikrishnan; Hsiai, Tzung K.;DeMaio, Lucas

Analysis ofSurface Plasmon Resonance Data

Using a PartialLeast Square Regression Methodfor Glucose Concentration Estimation

Chu, L. H.; Zhang, Y. T.; Zhang, C.

The Design and Fabrication ofTwo-DimensionMulti-Electrodes Array Chip and SystemChen, Jian-Ming; Huang, Jhen-Gang; Lin, Chii-

Wann

Pressure Sensorsfor In Vivo Measurements on

Spinal Growth Plates

Sauser, FrankE.; Glos, D.; Bylski-Austrow, D.;Papautsky, Ian

2417

2420

2424

2426

2430

Session 3.8.3: Advances in Design and

Application of Sensor Technology!

Importance ofSkin Resistance in the Reverse

Iontophoresis-basedKim, Dong Woo; Kim, Hong Seok; Lee, DongHoon; Kim, Hee Chan

A New Position Measurement Systemfor Micro-Measurements in OrthopaedicsDiSilvestro, Mark R; Sherman, Jason C; Dietz,Terry L.

Validation ofFour MajorAlgorithmsforEstimating the Instantaneous Helical Axis with

Miniature Triaxial GyroscopeRachid, Aissaoui

Quantification ofPre-parturition Restlessness in

CratedSows Using Ultrasonic Measurement

Huang, Y. S.; Huang, Y. P.; Wang, J. S.; Wu, M.

C; Young, M. S.

A sEMG-based MethodforAssessing the DesignofComputer Mice

Agarabi, Mina; Bonato, Paolo; De Luca, C, J.

2434

2438

2442

2446

2450

xxxi

Diamond-Like Carbon Coating on MicropipettesKakuta, Naoto; Okuyama, Naoki; Watanabe,

Mayu; Imai, Yuka; Mabuchi, Kunihiko; Yamada,Yukio 2454

A New Semiconductor Lithotripsy Sensor

Singh, V.R. 2458

Material Identification Using Real andSimulatedThermal Cues

Ho, Hsin-Ni; Jones, L. A. 2462

Session 3.8.4: Advances in Design and

Application of Sensor Technology II

VibrationAbsorbing Bracefor Study of Work-Related Upper Extremity Musculoskeletal

Disorders

Pottenger, Michael; Benhaim, Prosper

SystemDesignfor a Pediatric Physical TherapyStrength Testing Glove

Hooker, Josh; Barhorst, Craig; Brausen, Joe;Devlin, Jamie; Ford, Ethan; Bailey-Van Kuren,Michael

PhysiologicalInvestigation ofAutomobileDriver's Activation Index Using SimulatedMonotonousDrivingYamakoshi, Takehiro; Yamakoshi, Ken-ichi;Tanaka, Shinobu; Nogawa, Masamichi;Kusakabe, Masahiro; Kusumi, Masashi; Tanida,Kouji

in Unobtrusive In-home Monitoring Systemfordetection ofKey Motor Changes PrecedingCognitive Decline

Hayes, Tamara L.; Pavel, Misha; Kaye, Jeffrey A,

Postural Balance Indicator andAssociated

Feedback Compensation SystemIngerson, Paul G.

A Real-Time Blood Cross-Matching SensorforIntelligentManagement ofTransfusion SafetyRamasubramanian, M. K.; Anthony, Steven R.

Track 3.9: Thermal Therapy

Session 3.9.1: Advances in Thermal

Therapy I

Evaluation ofEndorectal and Urethral CoolingDevices during MR-Guided Ultrasound Thermal

Ablation in Canine Prostate

Nau, W. E; Diederich, C. J.; Ross, A. B.; Rieke,V.; Butts, K.; Sommers, G.

2466

2470

2476

2480

2484

2488

2492

Interstitial UltrasoundApplicators with DynamicAngular Controlfor ThermalAblation ofTumorsUnder MR-Guidance

Kinsey, Adam M.; Tyreus, Per Daniel; Rieke,Viola; Butts, Kim; Nau, William H.;Sommer, Graham; Diederich, Chris J. 2496

MRI-Temperature Mapping during UltrasoundProstate Ablation Using FatforPhaseEstimation

Rieke, Viola; Ross, Anthony B.; Nau, William H.;Diederich, Chris J.; Sommer, Graham; Butts, Kim 2500

A Devicefor Radiofrequency Assisted HepaticResection

Haemmerich, Dieter; Schutt, David J.; Will, James

A.; Striegel, Roberta M.;Webster, John G.; Mahvi, David M. 2503

Investigation ofMedical Thermal Treatment

Using a Hybrid Bio-Heat ModelWren, Joakim; Loyd, Dan; Karlsson, Marts 2507

Comparison Between a Detailed and a SimplifiedFinite ElementModel ofRadio-FrequencyLesioning in the Brain

Johansson, Johannes D.; Wren, Joakim; Loyd,Dan; Wardell, Karin 2510

Session 3.9.2: Advances in Thermal

Therapy II

Combination Applicatorfor Simultaneous HeatandRadiation

Stauffer, P. R.; Schlorff, J. L.; Taschereau, R.;Juang, T.; Neuman, D. G.; Maccarini, P. F.;Pouliot, J.; Hsu, I. C. 2514

Optimization ofa Dual Concentric ConductorAntennafor Superficial HyperthermiaApplicationsMaccarini, Paolo F.; Rolfsnes, Hans-Olav;Neuman, Daniel; Stauffer, Paul 2518

Design ofSpiralAntennasforRadiometricTemperature MeasurementRolfsnes, Hans Olav; Maccarini, Paolo; Jacobsen,Svein; Stauffer, Paul 2522

Coaxial-SlotAntennafor Interstitial MicrowaveThermal Therapy and ItsApplication to

Clinical Trial

Ito, Koichi; Saito, Kazuyuki; Yoshimura,Hiroyuki; Aoyagi, Yulaka; Horita, Hirotoshi 2526

IncreasedAcoustic and Electromagnetic EnergyDeposition in a Layered Tissue Model

Razansky, Daniel; Einziger, Pinchas D.; Adam,Dan R. 2530

rt'vVvV i'f'

Theme 4. Micro and Nano

Biotechnology

Track 4.1: Micro and Nano-Sensors for

Integrated Biotechnology: Electrical

Detection and Manipulation of SingleCells and Biomolecules

Session 4.1.1: Electrical and OpticalInterrogation Devices

Cell-Lab on a Chip: a CMOS-BasedMicrosystemfor Culturing and Monitoring Cells

Liu, Yingkai; Smela, Elisabeth; Nelson, Nicole

M.; Abshire, Pamela 2534

Optical Measurement ofTorsionalSpringModulus ofa Double-Stranded DNA Using

Half-CoatedNanoparticlesChoi, Jaehyuck; Zhao, Kai; Heller, Michael; Lo,Y.-H. 2538

Development ofBiocompatible NeurocagesTooker, Angela C; Meng, Ellis; Erickson, Jon;

Tai, Yu-Chong; Pine, Jerry 2542

Development ofa Multifunctional PlatformforExtra- and Intracellular IonicActivities

RecordingGuenat, Olivier T.; Boulard, Gaetan; Dufour, Jean-

Francois; de Rooij, Nico; Koudelka-Hep, Mlena 2546

Effects ofScaling on theSNR and Speed ofBiosensors

Hassibi, Arjang; Lee, Thomas H.; Navid, Reza;Dutton, Robert W.; Zahedi, Sina 2549

Surface Plasmon Resonance BiochipsforTuberculosis Bacillus

Huang, Jhen-Gang; Hung, Chi-Chan K.; Lai, Hsin-

Chih; Lee, Chih-Kung; Lin, Shi-Ming;Feng, Ping; Lin, Chii-Wann 2553

Electrical Detection ofthe Contact between a

Microinjection Pipette and Cells

Lukkari, Mikko J.; Karjalainen, Mikko I.;Sarkanen, Riina; Linne, Marja-Leena;Jalonen, Tuula O.; Kallio, Pasi J. 2557

Track 4.2: Micro/Nano Cytometry:Sorting of Cells/Biomolecules

Session 4.2.1: Manipulation of Cells on

Chips I

Hybrid Polymer/Thin Film Impedance SystemforLabelFree Monitoring ofCells

Mohanty, Swomitra K.; Sohn, Lydia L.; Beebe,David J. 2561

Biochemical, Biomolecular and Cellular Sensingin Microfluidics Using Flow InducedAdmittanceSpectraCollins, J.; Flanagan, L.; Jeon, N.; Monuki, E.;Lee, A. P. 2565

BiologicalSensing with an On-Chip Resistive

Pulse AnalyzerSaleh, Omar A.; Sohn, Lydia L. 2568

High-Throughput CellManipulation UsingUltrasound Fields

Kim, Deok-Ho; Haake, Albrecht; Sun, Yu;Neild,Adrian P.; Dim, Jong-Eun; Dual, Jurg;Hubbell, Jeffrey A.; Ju, Byeong-kwon; Nelson,Bradley J. 2571

Droplet-basedMagnetically Activated Cell

SeparationKim, Young Ho; Hong, Su; Kim, Byung Kyu;Yun, Seok; Kang, Yu Ri; Paek, Kyeong Kap;Lee, Jin Woo; Lee, Sang Ho; Ju, Byeong Kwon 2575

Session 4.2.2: Manipulation of Cells on

Chips II

MEMS-BasedFlow Cytometry: Microfluidics-Based CellIdentification System byFluorescentImagingWu, W.K.; Liang, C.K.; Huang, J. Z. 2579

Nanomanipulatlon and Characterization ofStructuralProteins

Layton, Bradley E.; Gupta, Rishi; Jackson, NykiaL.; Shah, Aditya J.; Stallcup, HI, Richard E.;

Sullivan, Stephanie M. 2582

Cytometry Microchip UsingPolymer-basedSaltbridge Electrodes

Chun, Honggu; Chung, Taek Dong; Kim, Hee

Chan 2584

Finite ElementModelling ofa 3 Dimensional

Dielectrophoretic Flow SeparatorDeviceforOptimal Bioprocessing Conditions

Fatoyinbo, Henry 0.; Hughes, Michael P. 2587

Track 4.3: Hybrid Devices IntegratingCell Machinery and Micro/Nano

Sensors

Session 4.3.1: Molecular Motors and

Biomolecules Hybrid to Chips

Novel Micro Gripping, Probing, andSensingDevicesfor Single CellSurgeryLi,WenJ.;Xi,Ning 2591

Flagellar Motor BasedMicro HybridDevices

Tung, Steve; Kim, Jin-Woo 2595

xxxiii

RETNanobiosensors using Affinity ofan Apo-Enzyme Toward its Substrate

Chinnayelka, Swetha; McShane, Michael J. 2599

Shape Recovering ofLive Endothelial Cell under

Atomic Force Microscopy Imaging

Shen, Yi; Sun, Jielin; Zhang, Aili; Hu, Jun; Xu,

LisaX. 2603

Development ofa MEMSMicrosystem to Studythe Effect ofMechanical Tension on Cerebral

Cortex NeurogenesisLin, Gisela; Wu, Vincent I.; Hainley, Ryan E.;

Flanagan, LisaA.; Monuki, Edwin S.; Tang,William C. 2607

Track 4.5: Lab-On-A-Chip for Sample

Preparation

Session 4.5.1: Micro and Nano Separation

Techniques I

Biomolecule Separation by Steric Hindrance

usingNanofluidic Filters

Han, Jongyoon; Fu, Jianping 2611

Microfluidic System Integration in Sample

Preparation Chip-Sets - a SummaryGrodzinski, Piotr; Liu, R.; Yang, J.; Ward, M. D. 2615

Microfabricated Templatesfor the

Electrodeposition ofMetallic Barcodesfor Use in

Multiplexed BioassaysTrue, Randall J. 2619

Control ofConcentration and Volume Gradients

in Microfluidic DropletArraysforProtein

Crystallization ScreeningChao, Wen-Chi; Collins, John; Wang, Szu-Wen;

Li, G. P.; Bachman, Mark; Lee, Abraham P. 2623

Separation ofBlood in MicroChannel Bends

Blattert, Christoph; Jurischka, Reinhold; Tahhan,

Isam; Schoth, Andreas; Kerth, Paul; Menz,

Wolfgang 2627

High SpeedParticles Separation UsingUltrasoundfor Micro-TAS and Lab-On-A-Chip

ApplicationLi,HoIden 2631

Session 4.5.2: Micro and Nano SeparationTechniques II

An Examination ofthe Effect of an AC Pulsed

Electric Fieldon Cell Mortality in

SWLA-2 HybridomasGross, Brooks A.; Kandlikar, Sachin S.; Oakley,Barbara A.; Hanna, Darrin M.;Rusek, Andrew; Stryker, Gabrielle A. 2635

2647

2650

A Magnetically Driven PDMS Peristaltic

MicropumpPan, Tingrui; Kai, Eleanor; Stay, Matthew;Barocas, Victor; Ziaie, Babak 2639

An Examination ofthe Effect ofDecaying

ExponentialPulse Electric Fields on Cell

Mortality in Murine Spleenocytes, Hybridomas,andHuman Natural Killer Cells

Kandlikar, Sachin S.; Oakley, Barbara A.; Hanna,Darrin M.; Stryker, Gabrielle A. 2643

Quantitative and Qualitative Analyses ofDNAFragments Based on Electrical ChargeDetection

on a Portable Electrophoresis Device

Chen, Gin Shin, Chen, Sheng Fu, Lu, Chih Cheng

A Magnetically Driven PDMS Micropump with

Micro-Ball Valves

McDonald, Scott J.; Pan, Tingrui; Ziaie, Babak

Track 4.6: Drug Delivery by Micro &

Nano Technology

Session 4.6.1: Drug Delivery Chips

BiodegradablePolymerMicroneedles:

Fabrication, Mechanics and TransdermalDrugDeliveryPark, Jung-Hwan; Allen, M. G.; Prausnitz, M, R. 2654

Remotely Adjustable Check-Valves with an

Electrochemical Release Mechanismfor

Implantable Biomedical MicrosystemPan, Tingrui; Balti, Antonio; Ziaie, Babak 2658

Real Time 3D Detection ofNanoparticleLiposomes Extravasation Using Laser

Confocal MicroscopyLiu, Ping; Zhang, Aili; Zhou, Mingjie; Xu,

Yuhong; Xu, Lisa X. 2662

In Vivo Transfection MicrosystemsRivera, Florence; Berthier, Jean; Cochet, Marline;Caillat, Patrice; Berger, Francois 2666

Implantable Microchipsfor ControlledDrug

DeliverySantini, Jr., John T.; Maloney, John M. 2668

Hydrogel-Based BioMEMS Platformsfor Smart

Drug DeliveryZiaie, Babak; Siegel, Ronald A. 2670

jorjriv

Track 4.7: Micro/Nanotechnology for

Tissue Engineering Applications

Session 4.7.1: Tissue Engineering on

Chips

CellAdhesion Testing using Novel Testbeds

Containing Micropatterns ofComplexNanoengineeredMultilayer FilmsShaikh-Mohammed, J.; DeCoster, M. A.;

McShane, Michael J. 2671

Long-term Micropatterned Cell Cultures in

Heterogeneous Microfluidic Environments

Tourovskaia, Anna; Folch, Albert; Figueroa-Masot, Xavier 2675

Real Three-Dimensional MicrofabricationforBiodegradable Polymers -Demonstration ofHigh-Resolution and BiocompatibilityforImplantable MicrodevicesBcuta, Koji; Yamada, Akira; Niikura, Fuminori 2679

Electrolytically Generated Oxygen

Microgradientsfor Cell Culture

Park, Jaehyun; Bansal, Tushar; Maharbiz, Michel

M. 2683

Theme 5. Biorobotics and

Biomechatronics

Track 5.1: Bio-Sensors for Robotic

Applications

Session 5.1.1: Rehabilitative Robotics I

Robotic Assessment ofLocomotor Recovery in

Spinal Contused Rats

Nessler, J. A.; Reinkensmeyer, D. J.; Sharp, K.;Kwak,E.;Minakata,K.;DeLeon,R. D, 2687

Passive Derivation ofBasic Walker-Assisted Gait

Characteristicsfrom Measured Forces

andMoments

Alwan, M.; Wasson, G.; Sheth, P.; Ledoux, A.;Huang, C. 2691

Gravity Balancing Rehabilitative Robotfor the

Human LegsFattah, Abbas; Agrawal, Sunil K. 2695

Virtual Walkway System and Prediction ofGaitMode Transitionfor the Control oftheGait Simulator

Shiozawa, Naruhiro; Arima, Syuichi; Makikawa,Masaaki 2699

Safety Conceptfor Robotic Gait Trainers

Schmidt, Henning; Hesse, Stefan; Bernhardt, Rolf

2703

ExperimentalDemonstration ofanActuatedExercise Machine

Zhang, X. T.; Dawson, D. M.; Dixon, W. E.; Xian,B. 2707

Session 5.1.2: Rehabilitative Robotics II

A Pneumatic MuscleHand Therapy DeviceKoeneman, E. J.; Schultz, R, S.; Wolf, S. L.;Herring, D. E.; Koeneman, J. B. 2711

Exoskeletonfor Forearm Pronation/SuppinationRehabilitation

Andreasen, D. S.; Allen, S. K; Aviles, A. A.;Jennings, B. R; Guthrie, K.B; Sprigle, S. H. 2714

Utilization ofBiomechanical Modeling in DesignofRoboticArmfor Rehabilitation of

StrokePatients

Huang, He; He, Jiping 2718

Adaptive Assistancefor Guided Force Trainingin Chronic Stroke

Kahn, Leonard E.; Rymer, W. Zev;Reinkensmeyer, David J. 2722

Spring Over Muscle (SOM) ActuatorforRehabilitation Devices

Bharadwaj, Kartik; Hollander, Kevin W.; Mathis,Christian A.; Sugar, Thomas G. 2726

Track 5.2: Intelligent Robotic Control

Session 5.2.1: Surgical Robotics

Trajectory GenerationforRoboticNeedleInsertion in Soft TissueAbolhassani, Niki; Patel, Rajni; Moallem,Mehrdad

Static and Dynamic Accuracy ofVitreoretinalSurgeonsPeral-Gutierrez, F.; Liao, A. L.; Riviere, C. N.

2730

2734

Active Tremor Compensation in MicrosurgeryAng, Wei Tech; Khosla, Pradeep; Riviere,Cameron 2738

Robotic Controlin Hand-AssistedLaparoscopicNephrectomy in Humans - a PilotStudyChatzilias, Peter; Kamarianakis, Zaxarias;Golemati, Spyretta; Christodoulou, Manolis 2742

A Haptic Guidance Toolfor CT-Directed

Percutaneous Interventions

Hagmann, Emmanuel; Rouiller, Patrice; Helmer,Patrick; Grange, Sebastien; Baur, Charles 2746

An Er: YAG Laser Bone Cutting ManipulatorforPrecise Rotational Acetabular OsteotomyKim, Daeyoung; Owada, Hideaki; Hata,Nobuhiko; Dohi, Takeyoshi 2750

XXXV

Track 5.3: Micro and Nano Robots

Session 5.3.1: Robotics in Biomedical

Applications

Determining Deformation Resistance in CuttingSoft Tissue with Non-Uniform Thickness

Chanthasopeephan, Teeranoot; Desai, Jaydev P.;Lau,AlanC.W. 2754

Soft-Tissue Material Properties under LargeDeformation: Strain Rate EffectHu, Tie; Desai, Jaydev P. 2758

Simulating ComplicatedHuman BirthforResearch and TrainingKim, Esther J.; Allen, Robert H.; Yang, Jason H.;McDonald, Mary K.;Tarn, William; Gurewitsch, Edith D. 2762

Locomotion ofaLegged Capsule in the

Gastrointestinal Tract: Theoretical Study and

Preliminary Technological Results

Menciassi, Arianna; Stefanini, Cesare; Gorini,Samuele; Pernorio, Giuseppe; Kim, Byungkyu;Park, Jong-Oh; Dario, Paolo 2767

AppliedForce during Vitreoretinal Microsurgerywith HandheldInstruments

Jagtap, Anirudha D.; Riviere, Cameron N. 2771

A Study on Implantable Urination Assist Systems-Development ofa Bladder Compression SystemKiguchi, Kazuo 2774

Theme 6. Bioinformatics and

Computational Biology

Track 6.1: Algorithm and Software

System for Bioinformatics

Session 6.1.1: Algorithm & Software

System for Bioinformatics

The BlastNP: A Novel, Sensitive SequenceSimilarity Searching Method usingOverlappingly Translated SequencesBiro, Jan C; Biro, Josephine M.K. 2777

Order Independent StructuralAlignment ofCircularly PermutedProteinsBinkowski, T. Andrew; DasGupta, Bhaskar;Liang, Jie 2781

Corpus Based Learning ofStochastic Context-Free Grammar Combined with Hidden MarkovModelsfor TRNA ModellingGarcia-Gomez, Juan M.; Benedi, Jose M. 2785

Globally Optimal Classification and Pairing ofHuman Chromosomes

Wu, Xiaolin; Biyani, Pravesh; Dumitrescu, Sorina;Wu, Qiang 2789

Finding the Best Ridge Regression Subset ByGenetic Algorithms:Applications to Multi-Locus

Quantitative Trait MappingZhang, Bin; Horvath, Steve 2793

A Software Systemfor Gene Sequence Database

Construction

Liu, Zheng; Borneman, James; Jiang, Tao 2797

Session 6.1.2: Bioinformatics for

Understanding Genes, Transcripts andProteins

An InterpolatedMarkov Model Polishes Gibbs

Sampling's Ability in DetectingRegulatory Elements

Ying, Xie X.; Sun, Xiao; Ming, Xie J.; Hong, LuZu 2801

A Three-Layer Multi-Database SystemforFunctional StatisticalAnalyses ofMicroarrayExperiment Results

Masseroli, Marco; Martucci, Dario; Pinciroli,Francesco 2805

EGOMiner: A Comprehensive Genomics and

Proteomics Data Analysis and BiologicalFunction Interpretation SystemFeng, Weimin; Henning, Peter; Wang, May D. 2809

A General Probabilistic Model ofthe PCRProcess

Saha, Nilanjan; Watson, Layne T.; Kafader,Karen; Onufriev, Alexy; Ramakrishnan, Naren;Vasquez-Robinet, Cecilia; Watkinson, Jonathan 2813

A Parallel Implementation of the Smith-Waterman Algorithmfor Massive SequencesSearchingLiao, Hsien-Yu; Yin, Meng-Lai; Cheng, Yi 2817

Identifying Gene Ontology Concepts in Natural-

Language Text

Crangle, Colleen E.; Zbyslaw, A. 2821

Track 6.2: Computational Genomics

and Proteomics

Session 6.2.1: Computational Genomicsand Proteomics I

The Search for the Optimal Ribosome 3' Tail

EndinEcoli

Ponnala, L.; Barnes, T. M.; Bitzer, D. L.; Vouk,M. A. 2824

xxxvi

OptimalNonlinear Scoring Functionfor Global

Fitness Landscape ofProtein DesignHu, Changyu; Li, Xiang; Liang, Jie 2828

Representability ofGenomic SignalsCristea,PaulDanA. 2832

Splice Site Detection using PrunedMaximumLikelihood Model

Lai, Anuradha; Radhakrishnan, Srirekha; Srinivas,Shiva S.;Najarian, Kayvan; Mays, Larry E. 2836

Linear Reduction Methodsfor Tag SNP

Selection

He, Jingwu; Zelikovsky, Alex 2840

Building Phylogenetic Treesfrom BinaryOligonucleotide Fingerprint Vectors

Figueroa, Andres; Liu, Z.; Mancini-Jones, R;Borneman, J.; Jiang, T. 2844

Session 6.2.2: Computational Genomicsand Proteomics II

Free Energy Periodicity InProkaryotic Codingand its Role in Identification of+1 Ribosomal

Frameshifting in the Escherichia ColiK-12 Gene

prfBMishra, M.; Vu, S. K.; Bitzer, D. L.; Vouk, M. A.

Automatic Segmentation ofDNA Bands in One

Dimensional GelImages Produced byHybridizing TechniquesAkbari, Akbar; Albregtsen, Fritz

Improvement ofTRANSFACMatrices UsingMultiple LocalAlignment ofTranscriptionFactor Binding Site SequencesFu, Yutao; Weng, Zhiping

Codes in the Codons: Construction ofaCodon/Amino AcidPeriodic Table and a Study ofthe Nature ofSpecific Nucleic Acid - Protein

Interactions

Benyo, Balazs; Biro, Jan C; Benyo, Zoltan

Accelerating Phylogenetics Computing on the

Desktop: Experiments with UPGMA

Davis, James P.; Akella, Sreesa; Waddell, Peter J.

RNAMAT:An Efficient Method to Detect Classes

ofRNA Molecules

Horesh, Yair; Amir, Amihood; Michaeli,

Shulamit; Unger, Ron

2848

2852

2856

2860

2864

2869

Track 6.3: Regulatory Elements, GeneNetworks and Simulation of Cell

Session 6.3.1: Regulatory Elements,Regulatory Networks and Protein

Structures I

Consequences ofDeterministic andStochastic

Modeling ofa Promoter

Zhou, Zhan Huan; Davies, Stephen W. 2873

Synthetic Gene Oscillators by Negative FeedbackNetworks

Wang, Ruiqi; Zhou, Tianshou; Chen, Luonan 2877

Cellular Function Prediction andBiologicalPathway Discovery in Arabidopsis thaliana UsingMicroarray Data

Joshi, Trupti; Chen, Yu; Alexandrov, Nickolai;Xu, Dong 2881

Kernel BasedApproachforProtein FoldPredictionfrom SequenceLanglois, Robert E.; Diec, Alice; Dai, Yang; Lu,Hui 2885

Prediction ofProtein SolventProfile Using SVR

Yuan, Zheng; Bailey, Timothy L. 2889

Estimation ofProtein Secondary StructurefromSynchrotron Radiation Circular

Dichroism SpectraProcopiou, Andreas; Allinson, Nigel; Jones,Gareth; Clarke, David 2893

Session 6.3.2: Regulatory Elements,Regulatory Networks and Protein

Structures II

Modeling of The Suprachiasmatic Nucleus Basedon ReducedMolecular Clock Mechanisms

Nakao, Mitsuyuki; Nishimura, Yoshinari; Aoki,Kazufumi; Katayama, Norihiro 2897

Analysis ofthe Transforming Growth Factor-

Betal Pathway and Extracellular Matrix

Formation as a Hybrid SystemMusters, Mark W. J. M.; van Riel, Natal A. W. 2901

Inference ofGenetic Regulatory Networks with

Recurrent Neural NetworkModels

Xu, Rui; Hu, Xiao; Wunsch, Donald C. 2905

Parameter Optimization Technique Using The

Response Surface MethodologyKoyamada, Koji; Sakai, Koji; Itoh, Takayuki 2909

Dynamic Pathway Modeling ofSphingolipidMetabolism

Henning, Peter; Merrill, Alfred; Wang, May D. 2913

xxxvii

Automated Characterization ofGene Expression

Patterns with anAtlas oftheMouse Brain

Carson, James P.; Ju, Tao; Thaller, Christina;

Warren, Joe; Bello, Musodiq;Kakadiaris, Ioannis; Chiu, Wah; Eichele, Gregor 2917

Track 6.4: Gene Expression and

Micorarray Analysis

Session 6.4.1: Gene Expression and

Microarray Analysis I

A NovelStepwise Normalization MethodforTwo-Channel cDNA MicroarraysXiao, Yuanyuan; Hunt, C. Anthony; Segal, Mark

R.;Yang,YeeH. 2921

An Application ofZero-suppressed BinaryDecision Diagrams to ClusteringAnalysis ofDNA Microarray Data

Yoon, Sungroh; De Micheli, Giovanni 2925

A New Distance Measurementfor ClusteringTime-Course Gene Expression Data

Chen, Guanrao; Dai, Yang 2929

A Bayesian Approach to Expression Network

ComponentAnalysisSabatti, Chiara; Rohlin, Lars 2933

Network Component Analysis ofSaccharamycescerevisiae Stress ResponseLiao, James C; Yang, Young-Lyeol 2937

Discovering Dynamic Regulatory Pathway by

Applying an Auto Regressive Model to Time

Series DNA Microarray Data

Darvish, Alireza; Hakimzadeh, R.; Najarian,Kayvan 2941

Session 6.4.2: Gene Expression and

Microarray Analysis II

Genetic Data Acquirement, Construction and

Analysis Based on Microarray TechnologyHong, Lu Zu 2945

Association ofBeta-Adrenoceptor SingleNucleotide Polymorphisms with Resting HeartRate

Xie, Zheng Xiang; Niu,Yong Hong; Ma, Hou Xun;Yin, Yue Hui; Liu, Zeng Zhang; Li, Zhang Yong 2948

Using Multi-Agent Systemfor Gene ExpressionClassificationStiglic, Gregor; Kokol, Peter 2952

A DNA-basedPattern Recognition TechniqueforCancerDetection

Peterson, David J.; Lee, Charles H. 2956

Comparative Study ofMicroarray DataforCancer Research

Phan, John H.; Quo, Chang F.; Wang, May D. 2960

Track 6.5: Structural and Functional

Bioinformatics

Session 6.5.1: Structural and Functional

Bioinformatics I

Protein Secondary Structure Prediction with

Semi Markov HMMs

Aydin, Zafer; Altunbasak, Yucel; Borodovsky,Mark

Parallel Protein Secondary Structure Prediction

Based on NeuralNetwork

Zhong, Wei; Altun, Gulsah; Tian, Xinmin;

Harrison, Robert; Tai, Phang C; Pan, Yi

A Bipartite Graph Matching FrameworkforFinding Correspondences between Structural

Elements in Two Proteins

Wang, Yuhang; Makedon, Fillia; Ford, James;

Huang, Heng

Potential Function ofSimplified Protein Models

for Discriminating Native Proteinsfrom Decoys:Combining Contact Interaction and Local

Sequence-Dependent GeometryZhang, Jinfeng; Chen, Rong; Liang, Jie

Computational Prediction ofBinding HotspotsTong, Weiwei; Li, L.; Weng, Zhiping

2964

2968

2972

2976

2980

Session 6.5.2: Structural and Functional

Bioinformatics II

Linking Molecular Function and BiologicalProcess Terms in the Gene Ontologyfor Gene

Expression Data AnalysisDeJongh, Matthew; Van Dort, Pamela; Ramsay,Benjamin 2984

Protein Secondary Structure Prediction usingNeuralNetwork andSimulatedAnnealing

AlgorithmAkkaladevi, Somasheker; Katangur, Ajay K.;Belkasim, Saeid; Pan, Yi

PRISM: Protein Integration ofSequence Metrics

Addison, Edwin R.

Comparison ofSkin Resistance between

Biological Active Points ofLeft and Right handswith various Contact Pressures

Fang, Qiang; Bedi, Raji; Ahmed, Becna; Cosic,Irena

Clustering Protein-Protein Docking Predictions

Tong, Weiwei; Weng, Zhiping

2987

2991

2995

2999

xxxviii

Binding Modes of Two Highly Potent andNon¬

toxic Inhibitors ofHIV-1 IntegraseZhu, Hai Mei; Chen, Wei Zu; Wang, Cun Xin 3003

A CentralPartition ofMolecular Conformational

Space. II. Embedding 3D Structures

Gabarro-Arpa, Jacques 3007

Knowledge-BasedAlgorithmsfor Chemical

Structure andProperty AnalysisVolarath, Patra; Wang, Hao; Fu, Haihua; Harrison,Robert 3011

Track 6.6: Novel Technologies for

Computational Biology andBioinformatics

Session 6.6.1: Novel Technologies for

Computational Biology andBioinformatics I

Maximum a Posteriori (MAP) Estimatorfor

Polymerase Chain Reaction (PCR) Processes

Kakavand, Hossein 3015

Domain Specific Languagesfor Cellular

Interactions

Harrison, William; Harrison, Robert 3019

Biodynamic Modeling andSimulation ofMulti¬

stage CarcinogenesisAhangar, Reza; Iqbal, Kamran 3023

Computationally Efficient Cardiac BioelectricityModels Toward Whole-Heart Simulation

Wedge, Nathan A.; Branicky, Michael S.;

Cavusoglu, M. Cenk 3027

Bayesian Networks ofBI-RADSDescriptors ofBreast Lesions

Fischer, Ernest; Lo, Joseph; Markey, Mia K. 3031

The Genetic Profile ofa Tumor as aDeterminant

ofIts Response to Radiotherapy: A ComputerSimulation ofTwo DifferentRadiotherapeuticSchemes

Dionysiou, Dimitra D.; Peristeris, T.; Stamatakos,

Georgios S.;Nikita, Konstantina S.; Uzunoglu, Nikolaos K. 3035

Session 6.6.2: Novel Technologies for

Computational Biology andBioinformatics II

Stochastic Modeling and Validation ofGrowth

Saturation and Radiotherapeutic Response of

Multicellular Tumor SpheroidsZacharaki, E. I.; Stamatakos, G. S.; Nikita, K. S.;Uzunoglu, N.K. 3039

DNA SequenceMatchingProcessor Using FPGAand JAVA InterfaceBrown, Ben; Yin, Meng-Lai; Cheng, Yi 3043

A Software Environmentfor Simulators Suitable

for Complex Biological AnalysisShimayoshi, Takao; Hori, Kenta; Lu, JianYin;Amano, Akira; Matsuda, Tetsuya 3047

Track 6.7: Computational Methods

Session 6.7.1: Computational Methods for

Proteomics

StatisticalAssessmentfor Mass-spec Protein

Identification Using Peptide FingerprintingApproachGanapathy, Ashwin; Wan,Xiu-Feng; Wan,Jinrong; Thelen, Jay; Emerich, David W.;

Stacey, Gary; Xu, Dong 3051

Modeling Protein Tandem Mass SpectrometryData withAn ExtendedLinearRegression

StrategyLiu, Han; Bonner, Anthony; Emili, Andrew 3055

Reducing the Cost ofProtein IdentificationsfromMass Spectrometry Databases

Logan, Beth T.; Kontothanassis, Leonidas;Goddeau, David; Moreno, Pedro;Hookway, Ray; Sarracmo, David 3060

Protein Seer: A Web ServerforProtein

Homology Detection

Logan, Beth T.; Karaoz, Ulas; Moreno, Pedro;

Weng, Zhiping; Kasif, Simon 3064

Analysis andRobot PipelinedAutomationforSELDI-TOFMass SpectrometryAlterovitz, Gil; Aivado, Manuel; Spentzos,Dimitrios; Libermann, Towia A.;Ramoni, Marco; Kohane, Isaac S. 3068

Theme 7. Healthcare Information

Technology

Track 7,1: Telemedicine Technology

Session 7.1.1: Telemedicine TechnologyandDeployment I

Modeling Telehealth and Telemedicine:A Global

GeosociopoliticalPerspectiveStamm, B. Hudnall 3072

Improving Heart Failure Care by Using a

Telemedicine SystemSantamore, William P.; Homko, Carol; Marble,

Judith; Wald, Joyce; Bove, Alfred A. 3076

xxxix

3093

A Novel Mobile Telemedicine SystemforAmbulance Transport. Design and Evaluation

Mandellos, G. J.; Lymberopoulos, D. K.; Koukias,M. N.; Tzes, A.; Lazarou, N.; Vagianos, C. 3080

Using Telehealth Technology to Improve the

Delivery ofHealth Services to People who are

DeafHughes, Glen; Hudgins, Bernard; MacDougall,James 3084

Networking Technology and Health Care in

Eastern North Carolina

Brinn,JackE. 3088

Establishing a Rural Telehealth Project: the

WyomingNetworkfor Telehealth

Gantenbein, Rex E.; Cadez, Fran; Stamm, Beth

Hudnall 3089

Session 7.1.2: Telemedicine Technologyand Deployment II

Design ofan Interoperability Framework in a

Regional Healthcare SystemBerler, Alexander A.; Pavlopoulos, Sotiris;Koutsouris, Dimitris

Integration ofMonitoringDevices in the e-Vital

Service

Sakka, Eleni; Prentza, Andriana; Lamprinos, Ilias

E.; Leondaridis, Lefteris; Koutsouris, Dimitris

Bio-Stream: A System Architecturefor Real-

TimeProcessing ofPhysiological SignalsBar-Or, Amir; Goddeau, David M.; Healey,Jennifer A.; Kontothanassis, Leonidas; Logan,Beth;Nelson, Alex; Van Thong, Jean-Manuel

Using Handheld Devicesfor Real-Time Wireless

Teleconsultation

Banitsas, Konstantinos A.; Georgiadis, P.;

Tachakra, S.; Cavouras, D.

Design ofMultimedia Telemedicine SystemforInter-hospital ConsultationSun K. Yoo, Kwang M. Kim, Suck M. Jung,Kyung Joung Lee, Nam H. Kim

TM-Provider: a New Communicatory ModelforTelemedicine Services SupportKolovou, Lamprini T.; Triantafyllou, George N.;Chassomeris, Constantine A.;Karavatselou, Evy I.; Lymberopoulos, Dimitris K,

A Front-end Platform ofthe Network-based

Intelligent Home Healthcare Embedded SystemTang, Shuo; Chan, Weng Chi; Vai, Mang I.; Mak,Peng Un

3097

3101

3105

3109

3112

3116

Track 7.2: Virtual and AugmentedReality Technology in Healthcare

Session 7.2.1: Telesurgery and Virtual

Reality Technology in Healthcare I

Modeling Liver Physiology: Combining Fractals,Imaging andAnimation

Lin, Debbie 3120

Virtual Planning ofMulticatheter BrachytherapyImplantsfor Accelerated Partial

BreastIrradiation

Schmidt-Ullrich, P. N.; Todor, D. A.; Cuttino, L.

W.; Arthur, D. W. 3124

Linking Ontologies with Three-Dimensional

Models ofAnatomy to Predict the Effects ofPenetrating InjuriesRubin, Daniel L.; Bashir, Yasser; Grossman,David; Dev, Parvati; Musen, Mark A. 3128

A Novel Navigation Principle in Computer-AssistedSurgery

Buzug, Thorsten M.; Hering, Peter; Bongartz,Jens; Ivanenko, Michael 3132

Session 7.2.2: Telesurgery and Virtual

Reality Technology in Healthcare II

Content-Based Video Codingfor Remote

Monitoring ofNeurosurgeryXu, Jian; Ilgin, Hakki; Liu, Qiang; Kassam, Amin;Sclabassi, Robert J.; Chaparro, Luis F.; Sun,

Mingui 3136

Networked Interaction Therapy: Relieving Stress

in Memory-ImpairedPeople and Their

Family MembersKuwahara, Noriaki; Kuwabara, Kazuhiro; Utsumi,Akira; Yasuda, Kiyoshi; Tetsutani, Nobuji 3140

Identification ofLenke Spine DeformityClassification By Simplified 3D Spine ModelLin, Hong; Sucato, Dan 3144

Track 7.4: Electronic Health Records

and Medical Databases

Session 7.4.1: Electronic Health Records

and Medical Databases I

Personal Recognition using Head-Top ImageforHealth-Monitoring System in the Home

Nakajima, Kazuki; Sasaki, Kazuo 3147

A Home Health Monitoring System IncludingIntelligent Reporting and Alerts

Garsden, Hugh; Basilakis, Jim; Celler, Branko G.;

Huynh, Khang; Lovell, Nigel H. 3151

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