announcing schrödinger first discovery 2.0

Announcing Schrodinger

FirstDiscovery 2.0

Schrodinger is pleased to announce FirstDiscovery 2.0, a major upgrade of

its premier integrated suite for structure-based drug design.

FirstDiscovery employs the latest computational chemistry technology to

accelerate the discovery and optimization of leads in pharmaceutical

research. It combines the most accurate simulations with an easy-to-use

interface that facilitates visualization, analysis, and project management.

The suite consists of three integrated modules:

• Glide: High-throughput ligand-receptor docking for fast library screening

• Liaison: Ligand-receptor binding free energies for lead optimization

• QSite: Mixed QM/MM for reactive chemistry at the enzyme active site

FirstDiscovery 2.0 features enhanced scoring functions that improve

enrichment factors, particularly for kinases, as well as lowered memory

requirements and significant increases in processing speed. The upgraded

package will be available summer 2002. We invite you to contact us and

arrange for an onsite evaluation.

Schrodinger 503.299.1150

www.schrodinger.com

info@schrodinger.com

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