421 effects of slow repetitive transcranial magnetic stimulation (tms) on complex regional pain...

ing students, 10 physician assistant students and twopharmacy students.

Results. Pre-course assessment demonstrated that ineach of the programs, with the exception of pharmacy,pain education received little attention, including less than2 h within medical education. Post-course assessmentindicated satisfaction with the course, as well as the aimsof an interdisciplinary approach to pain education.

Conclusion. Goals of this project include the compila-tion of a curriculum, including teaching materials, pow-erpoints, and other tools to assist in the implementationof similar programs at other institutions.

doi:10.1016/j.ejpain.2007.03.435

421EFFECTS OF SLOW REPETITIVE TRANSCRA-

NIAL MAGNETIC STIMULATION (TMS) ON

COMPLEX REGIONAL PAIN SYNDROME (CRPS)

N.C. Moore *, P. MacMillan, M Cooper

Department Psychiatry, Quillen College Medicine, East

Tennessee State University, Johnson City, TN, USA

Background. The key symptom of CRPS is continu-ous, intense pain out of proportion to the injury. Redskin, increased temperature, sweating and swelling arecommon. These symptoms suggest an inflammatoryprocess. One theory is that an auto-immune process trig-gers the immune response. A single 20-min session ofprefrontal repetitive TMS can alleviate pain, as shownby a 40% reduction in total morphine use after gastricbypass surgery. A similar single session applied to themotor cortex can decrease the pain of CRPS, asreported by seven of 10 patients.

Aims. The aims of this study are to: (1) replicate thefinding that one session of TMS provides temporaryrelief from CRPS pain; (2) determine if 10 sessions pro-vide more lasting relief and (3) determine if molecularmarkers support the theory that CRPS is an inflamma-tory process.

Methods. Ten participants will receive 10 real and 10sham TMS treatments; five will start with real, and fivewith sham. Patients will rate the intensity of pain on avisual analogue scale. C-reactive protein and lipopro-tein-associated phosholipase A2 (known molecularinflammatory markers) will be measured at baseline,after sham TMS and after real TMS.

Results and conclusions. This study is not yet com-plete; results and conclusions will be added to theabstract by March 31, 2007.

doi:10.1016/j.ejpain.2007.03.436

422PULSED RADIOFREQUENCY TREATMENT (PRF)

WITH PASHA CATH IN NEUROPATIC PAIN

A. Orlando *, G. Sindaco, L. Ravaioli, L. Follini,

G. Pari

Medicina Del Dolore, Forli, Italy

Introduction. The Pasha Cath is a multifunctionalcatheter used for diagnostic and therapeutic aims.The catheter is placed exactly on the wished nervousroot, using the fluoroscopic images, the impedance val-ues and sensory stimulation a 50 Hz current. This cur-rent evokes paraesthesias on the metameric arearelated.

At this point it can proceed to the selective infusion ofdrugs and/or PRF.

Objective. To evaluate the analgesic effectiveness ofPRF treatment in periferic neuropathic pain.

Design. Prospective, open-label, nonrandomized trial.Setting. Department of Pain Medicine, Private Hos-

pital, Italy.Inclusion criteria. All patients affected by lumbar

radiculopathy for more than six months, with pathoge-netic diagnosis of periferic neuropathic pain.

Interventions. In all patients it has been used a PRFtreatment for 240 s using Pasha Cath, on the target root,through sensory neurostimulation.

Effectiveness assessments. NRS at rest and incident,Oswestry test, QUID test (Italian Pain Questionary) atbaseline, first and third month.

Results: Follow-up in progress.

doi:10.1016/j.ejpain.2007.03.437

423MULTICENTRIC TRIAL FOR THE ASSESSMENT

OF ANALGESIC EFFECTIVENESS OF PULSED

RADIOFREQUENCY TREATMENT (PRF) WITH

PASHA CATH IN LUMBOSACRAL MONO-

RADICULOPATHYG. Pari *, L. Follini, G. Orlandini, A. Orlando, G.

Sindaco

Medicina Del Dolore, Forli, Italy

Introduction. The Pasha Cath is a multifunctionalcatheter used for diagnostic and therapeutic aims. Thecatheter is placed exactly on the wished nervous root,using the fluoroscopic images, the impedance valuesand a sensory stimulation of a 50 Hz current. This cur-rent evokes paraesthesias on the metameric area related.

At this point we can proceed to the selective infusionof drugs and/or PRF.

Poster Presentations / Clinical – Other Treatments / European Journal of Pain 11(S1) (2007) S59–S207 S187