www.worldcancercongress.org

Disclosure of Interest: None Declared Abstract Code: RF. 526

Alternative strategies for primary cervical cancer screening in sub-Saharan Africa: a systematic review and meta-analysis of tests performance for VIA, VILI and HPV testing

Joel FOKOM DOMGUE, MD, MPH University of Yaoundé, Cameroon

Background Sub Saharan Africa (SSA)… -  Highest incidence of and mortality from cervical cancer

worldwide -  Failure of cytology based screening programs -  Introduction of alternatives to cytology (VIA, VILI, HPV test) -  Many accuracy studies performed in SSA, but variable

methodologies and conflicting results à how do these tests perform and compare to each other in SSA?

Joel FOKOM DOMGUE Melbourne, 05 December 2014

Methods Data sources - Systematic litterature search (Medline, EMBASE, Scopus…) - Accuracy studies on VIA, VILI and/or HPV test in SSA - Between 1994 and 2014 -  VIA, VILI and/or HPV test used as standalone tools -  Study population not at risk of cervical cancer -  Screening performed by paramedical providers -  Reference test: colposcopy guided biopsies

Joel FOKOM DOMGUE Melbourne, 05 December 2014

Inclusion criteria

Results Pooled analyses

Joel FOKOM DOMGUE

VIA

VILI

Conclusions

-  Accuracy measures overestimated for VIA and VILI, and underestimated for HPV test (colposcopy based gold standard)

-  VILI is a simple, affordable and more viable alternative to cytology than VIA for primary cervical cancer screening in SSA

Joel FOKOM DOMGUE Melbourne, 05 December 2014

Random cervical biopsies’ histology should be used as gold standard

VILI can serve just like VIA for primary cervical cancer screening

In practice… VILI VIA

Joel FOKOM DOMGUE Melbourne, 05 December 2014

Thank you for your attention

Joel FOKOM DOMGUE Melbourne, 05 December 2014