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Continuous Reactions at Albemarle

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Outline

• Albemarle Capability

• Some Existing Continuous Reactions

• Bench Scale Equipment

• Multipurpose Continuous Assets

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Albemarle Corporation 2011 Net Sales Distribution - $2.9 billion

• Global provider of value added technical solutions

• Comprised of three business segments with balanced product portfolios

• Proprietary technology and service-driven business model

• Fundamentally strong margin and cash flow businesses

Catalysts 38%

Polymer Solutions

37%

Fine Chemistry

25%

Fine Chemistry Services

Go to: www.albemarle.com

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We Offer • US-based leading cGMP and custom manufacturing production

capabilities

• Full project support (Technical, Regulatory, HSE, Information Management, Logistics)

• Extensive process development and scale-up capabilities

• Expertise in the development of complex syntheses

• Long Term Relationship / Production Partner

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We Have • Excellent safety record (top 10% of ACC)

• Innovative technical staff that says YES!

• FDA registered facilities with no 483s in last inspections

• ISO certified custom manufacturing facilities

• State-of-the-art analytical support

• Raw material sourcing assets in China

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We Have – Manufacturing Capability

• Five Commercial Scale Multipurpose Plants • South Haven, MI (cGMP) • Orangeburg, SC (including cGMP) • Tyrone, PA • Pasadena, TX • Baton Rouge, LA

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We Have – Manufacturing Capability

• cGMP capability - kilo, pilot and commercial • 25 L to 16,000 gal Reactors of all MOCs • Distillation and Wiped Film Evaporators • Most types of solids handling • Full Utilities

• Cryogenic to hot oil • Pressures to 1000 PSI

• Short lead time for Environmental Permits

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We Have – Development Capability

Customer Driven

Lab Synthesis Kilo Lab Pilot Plant

Full Scale Commercial

Plant Baton Rouge, LA South Haven, MI

Tyrone, PA LLN, Belgium

Baton Rouge, LA South Haven, MI

LLN, Belgium

Baton Rouge, LA South Haven, MI

Tyrone, PA

Baton Rouge, LA South Haven, MI

Tyrone , PA Orangeburg, SC

Pasadena, TX

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Albemarle Continuous Capability • Over 40 years of Experience

• World Scale Plants (100’s to >10,000’s TPY)

• Existing processes at Multiple Plants

• Long Term Supply

• Proven Record with Recent Successes

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Ag Chemical

• Long Term Relationship

• Expanding as Customer Grows • Started <500 TPY • Debottlenecked existing asset to > 1500 TPY • Further capacity increase with new asset

• Process Includes • Hazardous Chemicals

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Brominated Flame Retardant

• World Scale plant

• Complex process

• All Unit Ops Integrated

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Personal Care Intermediates

• Multiple Products

• Tubular Plug Flow / High Pressure

• Long Term Supplier

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Pyrophorics

• Multiple Products

• Extremely Exothermic • Adiabatic Temperature Rise > 2000 °C • Unique Technical Solutions

• Long Term Supplier

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Custom Lubricant Production

• Albemarle selected as Scale up Partner

• Commercial Plant Operational in 21 months • 15,000 TPY established in first month

• Scale up from Lab Directly to Commercial

• No Pilot Plant

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Bench Scale Equipment

• We have a Modular Multipurpose Apparatus • Multiple Reactor Configurations

• Currently up to 3 different feed streams • CSTR (single or series) • Tubular Fixedbed • Tubular Plug Flow

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Bench Scale Equipment

• Temperature range • –100 to 200 C with circulators • higher with electric heating

• Pressure range • Vacuum to 1000 PSI • >1000 PSI in High Pressure Lab

• Feed rates • 1 g/min to 100 g/min

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Bench Scale Equipment

• Versatile Feed Configurations

• Computer Interfaced Scales

• Computer Controlled Valves

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Bench Scale Equipment

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Small Pilot Scale Equipment

Loop Type CFR

Feed Pumps

Continuous Distillation

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Skid Mount Pilot Unit

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Multipurpose Continuous Assets

• Existing Idle Equipment with World Scale Logistics Support (rail and ship)

• Distillation Columns (100 PSI, 300 C)

• Continuous Hydrogenation Columns (500 PSI)

• High Pressure Reactors(1000 PSI, 300 C)

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Why Choose Albemarle? • Successfully Partner with both Small and Large

Companies

• Leading cGMP and Custom Manufacturing Facilities

• Competency in the Development of Complex Syntheses

• Extensive Process Development and Scale-up Capabilities

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Why Choose Albemarle?

• Excellent Safety and Regulatory Record

• Demonstrated Consistent Success

• Large Scale Equipment Available

• Long Term Partner

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Find out how Albemarle says YES!

to your project.

Americas • Fine Chemistry Services • Tel: +1 225 388 7402 • ALBSales@albemarle.com

Europe, Middle East, Africa • EMA Fine Chemistry Services • Tel: +32 10 48 1711 • EMASales@albemarle.com

Web: www.Albemarle.com